Chronic Graft-vs-HostVersus host diseaseDiseasePolymerase chain reHematopoieticAcuteCGVHDTumorsAutologousDonor cellsProphylaxisClinical Trials2021RejectionOrganRecipientPatientsToleranceRenalImmune responseTransplantationAllergicBoneTransfusionClinicallyCellularDiseasesAdverse2023SkinBiologicalOccurFunctionalInjectionStemPlateletDevelopmentAuthorChemicalChain
Chronic Graft-vs-Host1
- Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease. (nih.gov)
Versus host disease20
- Both patients had consistent infectious pneumonia and graft-versus-host disease after stem cell transplantation. (biomedcentral.com)
- Because the patient developed concomitant intestinal graft-versus-host disease (GVHD), cyclosporine, sirolimus, and mycophenolate mofetil were administered to maintain immunosuppression. (biomedcentral.com)
- Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. (nih.gov)
- This is chronic graft versus host disease. (nih.gov)
- Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia. (nih.gov)
- Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. (nih.gov)
- The HERACLES trial investigates the use of lead biotherapeutic MaaT013 in steroid-resistant, gastrointestinal-predominant, acute Graft-versus-Host-Disease (SR GI aGvHD) after allogeneic Hematopoietic Stem-Cell Transplantation (allo-HSCT). (microbiometimes.com)
- NEW YORK, NY / ACCESSWIRE / July 16, 2021 / Kadmon Holdings, Inc. (Nasdaq:KDMN) today announced that the U.S. Food and Drug Administration (FDA) has approved REZUROCK ™ (belumosudil) 200 mg once daily (QD) for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy. (yahoo.com)
- Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
- Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
- GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
- Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
- In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
- In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
- [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
- Graft versus host disease (GVHD) is an immune-mediated condition resulting from a complex interaction between donor and recipient adaptive immunity. (medscape.com)
- Autologous graft versus host disease (GVHD) involving the skin of a patient's arm appeared shortly after signs of engraftment appeared. (medscape.com)
- My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
- Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
Disease3
- Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry. (smw.ch)
- Not to be confused with Host-versus-graft disease . (wikipedia.org)
- Complex multi-organ disease that occurs 3-5 months or later after allogeneic hematopoietic stem cell transp. (altmeyers.org)
Polymerase chain re5
- The diagnosis of BKPyV-associated pneumonia was confirmed by metagenomic next-generation sequencing and polymerase chain reaction after the sudden worsening of the pulmonary infection signs and symptoms concomitant with renal dysfunction and systemic immune weakening. (biomedcentral.com)
- Meanwhile, his urinary BKPyV load was 3.25 × 10 9 copies/mL, as shown by polymerase chain reaction (PCR). (biomedcentral.com)
- Whereas multicolour flow cytometry (MCFC) and polymerase chain reaction (PCR) based methods constitute the two most commonly used techniques for MRD detection, next generation sequencing will certainly be widely employed in the future. (smw.ch)
- The tissue tested positive for T-cell receptor gene rearrangement by polymerase chain reaction analysis. (biomedcentral.com)
- Epidemiologic, immunologic, and virus characteristics in patients with paired SARS-CoV-2 serology and reverse transcription polymerase chain reaction testing. (cdc.gov)
Hematopoietic1
- Treatments up to now focused largely on suppressing the immune reaction induced by the donor cells derived from the hematopoietic stem cell graft against the host and have remained clinically unsuccessful in most cases, with mortality rates around 80% after twelve months in steroid-resistant cases. (microbiometimes.com)
Acute5
- Hemolytic reactions may be acute (within 24 hours) or delayed (from 1 to 14 days). (merckmanuals.com)
- Allergic reactions The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (merckmanuals.com)
- Because fever and chills also herald a severe hemolytic transfusion reaction, all febrile reactions must be investigated as for acute hemolytic transfusion reaction, as with any transfusion reaction. (merckmanuals.com)
- About 20 people die yearly in the US as a result of acute hemolytic transfusion reaction. (merckmanuals.com)
- ABO incompatibility is the most common cause of acute hemolytic transfusion reaction. (merckmanuals.com)
CGVHD1
- He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (04-C-0281) and Principal Investigator of a therapeutic study of topical ruxolitinib for cutaneous cGVHD (18-AR-0035). (nih.gov)
Tumors2
- The enthusiasm for the PDX approach is high because it allows not only for stable persistence of the tumor in vivo (in the mouse) but also because serial transplantation from one mouse host to others provides a tremendous opportunity to assay tumors over the long term. (thewellbio.com)
- However, in cases of large defects, fractures with loss of segment and resection of tumors, the use of grafts (autografts, allografts and xenografts) or bone substitutes may be indicated to contribute to healing [ 1 1. (scielo.br)
Autologous1
- The autologous graft is still considered the gold standard, as it has the necessary properties for bone regeneration, in terms of combined osteoconduction, osteoinduction and osteogenesis [ 5 5. (scielo.br)
Donor cells1
- The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
Prophylaxis1
- It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
Clinical Trials1
- In this setting, PDX clinical trials (PCTs) address drug resistance issues that single-host scenarios cannot. (thewellbio.com)
20211
- Kadmon to Host Conference Call on Monday, July 19, 2021 at 8:00 a.m. (yahoo.com)
Rejection3
- Graft rejection. (lookformedical.com)
- Major such obstacles include labile cell preparation and graft rejection. (thewellbio.com)
- Solid organ transplantation has been increasingly performed in recent years with the use of highly potent immunosuppressive agents to avoid rejection by the host. (biomedcentral.com)
Organ2
- Both patients eventually died of systemic multi-organ failure caused by severe pneumonia. (biomedcentral.com)
- The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)
Recipient2
- or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
Patients5
- In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are assessed and treated. (nih.gov)
- A DLS model based on multi-panels of somatic mutations was trained and validated to predict OS in patients treated without IO and PFS in patients treated with IO. (bvsalud.org)
- The HERACLES study is a multi-center, single-arm, open-label study, enrolling 32 patients to evaluate the efficacy and safety of MaaT Pharma's lead microbiome restoration drug candidate, MaaT013, in steroid-resistant gut predominant aGvHD patients. (microbiometimes.com)
- Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients. (who.int)
- La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
Tolerance1
- In particular, the strength of RAFT chemistry lies in its high tolerance to functional monomers and the non-demanding reaction conditions (e.g. tolerance to oxygen and low temperatures) under which the polymerizations can be carried out. (unimib.it)
Renal1
- We report a case of Epstein Barr Virus (EBV)-positive T-cell lymphoma in a patient, who underwent cadaveric renal transplant 17 years ago and was on chronic multi-drug immunosuppression. (biomedcentral.com)
Immune response1
- An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Transplantation2
- The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
- In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
Allergic1
- occasional allergic reactions to skin, respiratory tract and gastrointestinal tract. (altmeyers.org)
Bone2
Transfusion3
- Early recognition of symptoms suggestive of a transfusion reaction and prompt reporting to the blood bank are essential. (merckmanuals.com)
- Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (merckmanuals.com)
- More than two million grafting procedures are performed worldwide per year, the second most frequent tissue transplant after blood transfusion [ 3 3. (scielo.br)
Clinically1
- Clinically, febrile reactions consist of a temperature increase of ≥ 1 ° C, chills, and sometimes headache and back pain. (merckmanuals.com)
Cellular1
- A patient-derived xenograft (PDX) is obtained when a tumor sample is removed from a patient, implanted into an immunosuppressed murine host, and then queried for cellular or molecular characteristics that could be of therapeutic value to the patient. (thewellbio.com)
Diseases1
- Especially during and after steroid pulse therapy or immunosuppressive therapy for graft versus host diseases, BKPyV load in blood/urine needs to be regularly measured, and the immunosuppressive intensity should be adjusted properly after the BKPyV reactivation diagnosis. (biomedcentral.com)
Adverse1
- Plus, many non-xeno-free (non-animal-origin-free) hydrogels raise the specter that there will be an adverse reaction upon injection. (thewellbio.com)
20231
- Follow-up results will be featured in an oral presentation (Abstract #OA14.03) and have been selected for the official press program at the IASLC 2023 World Conference on Lung Cancer (#WCLC23) hosted by the International Association for the Study of Lung Cancer on September 11, 2023, from 2:32 a.m. to 2:42 a.m. (advfn.com)
Skin2
- Host-Pathogen Interactions in Human Polyomavirus 7‒Associated Pruritic Skin Eruption. (nih.gov)
- The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin. (lookformedical.com)
Biological3
- Obstruction of flow in biological or prosthetic vascular grafts. (lookformedical.com)
- Studies the principles of combined mass transport in homogeneous and heterogeneous reaction systems as applied to biological processes. (washington.edu)
- Introduces chemical and biochemical reaction kinetics, methods of evaluating kinetic parameters for reaction rate data, and prediction of the performance of biological and biochemical processes. (washington.edu)
Occur1
- Febrile reactions may occur without hemolysis. (merckmanuals.com)
Functional3
- He recovered and the allo-grafted kidney is fully functional. (biomedcentral.com)
- Similar to other living radical polymerization techniques, block copolymers, star and comb polymers, as well as graft polymers are accessible by attaching the controlling moiety to a (multi)functional core linking moiety. (unimib.it)
- Unique to the RAFT process are the possible modes of attaching the RAFT group covalently to the (multi)functional moiety. (unimib.it)
Injection1
- Typically, the sample from the patient--and this could be derived from a biopsy, from primary tumor tissue, from metastatic tumor tissue, or from blood or lymph circulating tumor cells--is suspended in an animal-derived matrix (Matrigel®) to augment the actual injection procedure into the host. (thewellbio.com)
Stem1
- They gain entrance into the seed, leaf, stem, and root of a plant and they are not harmful to the host plant ( Yadav, 2018 ). (frontiersin.org)
Platelet1
- This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
Development1
- Editorial: Codon Usage and Dinucleotide Composition of Virus Genomes: From the Virus-Host Interaction to the Development of Vaccines. (cdc.gov)
Author1
- Graff is the author of multiple books, including The First Campaign: Globalization, the Web, and the Race for the White House , which examined the role of technology in the 2008 presidential race, and The Threat Matrix: Inside Robert Mueller's FBI , which traces the history of the FBI's counterterrorism efforts. (livewriters.com)
Chemical1
- Chemical recycling of plastics assisted by microwave multi-frequency heating. (ki.si)