PemphigoidMucusMoistEndodermal originSkinAntibodiesTissueLungsUlcersContact with infectedSalivaMucosalEyesNose and throatMouthBodyOralDrynessCellsFunctionCommonSiteDisordersAvoidBasement membrane zoneNasalImmune systemRespiratoryIrritationLymph nodesSinusesChronicInfectiousAffectsCavitiesClinicalTreatmentPainDiseaseInvolvement
Pemphigoid30
- Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, refers to a group of rare chronic autoimmune blistering diseases that predominately affect the mucous membranes, including the conjunctiva, and occasionally the skin. (medscape.com)
- The first international consensus on mucous membrane pemphigoid was published in 2002. (medscape.com)
- See the illustration below depicting ocular mucous membrane pemphigoid. (medscape.com)
- Ocular manifestations of cicatricial pemphigoid (mucous membrane pemphigoid) include symblepharon, demonstrated in this photograph by the tethering of the lower lid to the cornea. (medscape.com)
- Classification of mucous membrane pemphigoid patients has been difficult because some patients with other autoimmune blistering diseases, including bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA),and anti-p200 pemphigoid, may have mucosal involvement. (medscape.com)
- By direct immunofluorescence (DIF) study, antibodies bound in a linear band at the epidermal-dermal junction have been found in patients with mucous membrane pemphigoid (MMP), as depicted below. (medscape.com)
- Different epithelial membrane zone components have been recognized by antibodies in patients with mucous membrane pemphigoid, including BP antigens 1 and 2 (BP230 and BP180), laminin-332, laminin-311, type VII collagen, b4 integrin subunit, and antigens with unknown identities (a 45-kd protein, uncein, a 168-kd epithelial protein, and a 120-kd epithelial protein). (medscape.com)
- Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease associated with autoantibodies directed against basement membrane zone target antigens. (medscape.com)
- The two major antigens associated with mucous membrane pemphigoid are BP180 and laminin-332. (medscape.com)
- Patients with clinical features of mucous membrane pemphigoid may have antibodies directed against BP230 or type VII collagen. (medscape.com)
- Patients with mucous membrane pemphigoid react with epitopes on BP180 distinct from those associated with BP and linear IgA bullous dermatosis, particularly the C-terminal of the protein. (medscape.com)
- A subset of patients with mucous membrane pemphigoid reacts with laminin-332. (medscape.com)
- Laminin-332 contains disulfide-linked alpha, beta, and gamma chains, of which the alpha subunit is the major site of mucous membrane pemphigoid reactivity. (medscape.com)
- Mucous membrane pemphigoid is an autoimmune disorder that causes blisters to form in the mucous membranes of the body. (msdmanuals.com)
- Mucous membrane pemphigoid occurs when the immune system attacks the mucus membranes and causes blisters and sores. (msdmanuals.com)
- Doctors diagnose mucous membrane pemphigoid by examining tissue samples under a microscope. (msdmanuals.com)
- Ocular Mucous Membrane Pemphigoid Ocular mucous membrane pemphigoid is an autoimmune disorder that scars the conjunctiva and cornea. (msdmanuals.com)
- In mucous membrane pemphigoid, the antibodies react with the mucous membranes of the mouth (or other mucous membranes), which blister and break down, forming open sores (ulcers). (msdmanuals.com)
- The major symptom of mucous membrane pemphigoid is the development of painful blistering that causes redness, swelling, and breakdown of the mucous membranes, eventually forming open sores (ulcers). (msdmanuals.com)
- In some people with mucous membrane pemphigoid, actual blisters form on the skin. (msdmanuals.com)
- Vortex Keratopathy as a Presenting Feature of Ocular Mucous Membrane Pemphigoid. (bvsalud.org)
- The aim of this study was to describe the presenting feature of vortex keratopathy in 3 patients with biopsy -proven ocular mucous membrane pemphigoid (OMMP). (bvsalud.org)
- The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment and pronostic indicators. (jomos.org)
- Williams GS, Goodwin R, Hughes D. Amlopidine as a cause of mucous membrane pemphigoid: first report of amlopidine as a causative agent in MPP. (jomos.org)
- Kanjanabuch P, Arporniem S, Thamrat S, Thumasombut P. Mucous membrane pemphigoid in a patient with hypertension treated atenolol. (jomos.org)
- Mucous Membrane Pemphigoid (MMP) is an autoimmune subepithelial blistering disorder usually affecting older individuals. (bvsalud.org)
- A group of autoimmune blistering diseases affecting primarily the mucous membranes is termed mucous membrane pemphigoid (MMP) (also termed cicatricial pemphigoid ). (medscape.com)
- Whereas the pemphigus subset of diseases is mediated by autoantibodies that target the extracellular skin components that link one epidermal cell to another, the pemphigoid subset is mediated by autoantibodies that target the extracellular skin components that link the skin basement membrane components either to the lowermost layer of epidermal cells or to the dermal components. (medscape.com)
- Does mucous membrane pemphigoid have positive Nikolsky sign? (moviecultists.com)
- Nikolsky's sign is present in pemphigus and mucous membrane pemphigoid , but not in bullous pemphigoid. (moviecultists.com)
Mucus9
- Some mucous membranes secrete mucus, a thick protective fluid. (wikipedia.org)
- Protecting the body from infection: The mucus produced by the mucous membrane helps to trap bacteria and viruses, preventing them from entering the body. (askanaudiologist.com)
- Keeping the airways moist: The mucus produced by the mucous membrane helps to keep the airways moist, which is important for breathing. (askanaudiologist.com)
- Removing dust and debris: The mucus produced by the mucous membrane helps to remove dust and debris from the airways. (askanaudiologist.com)
- The mucous membrane makes mucus, that sticky stuff in your nose you might call snot . (kidshealth.org)
- These can irritate mucous membranes, signaling the body to produce more mucus. (healthline.com)
- What's the difference between mucus and mucous? (healthline.com)
- The answer is not medical: Mucus is a noun, and mucous is an adjective. (healthline.com)
- For example, mucous membranes secrete mucus. (healthline.com)
Moist4
- Mucous membranes are moist, soft tissues that line many parts of the body, including the nose, throat, and ears. (askanaudiologist.com)
- The inside of your nose is lined with a moist, thin layer of tissue called a mucous membrane (say: MYOO-kus MEM-brayne). (kidshealth.org)
- The mucous membranes are the moist surfaces of the body. (msdmanuals.com)
- This hole is actually a break in the moist tissue (mucous membrane) that lines the mouth. (webmd.com)
Endodermal origin3
- 437 Some examples include: Endometrium: the mucosa of the uterus Gastric mucosa Intestinal mucosa Nasal mucosa Olfactory mucosa Oral mucosa Penile mucosa Respiratory mucosa Vaginal mucosa Frenulum of tongue Anal canal Conjunctiva Developmentally, the majority of mucous membranes are of endodermal origin. (wikipedia.org)
- Developmentally, the majority of mucous membranes are of endodermal origin. (goldrally118.click)
- The mucous membranes are linings of mostly endodermal origin, covered in epithelium, which are involved in absorption and secretion. (absoluteastronomy.com)
Skin7
- but other mucous membranes (such as the inside the throat and the genitals) and the skin also may be affected. (msdmanuals.com)
- Bacteria can also enter wounds in the skin/mucous membranes through contact with infected animals. (cdc.gov)
- Essential oils can irritate sensitive skin, mucous membranes and eyes. (wholefoodsmarket.com)
- People contract herpes by touching infected saliva , mucous membranes, or skin . (webmd.com)
- Primary infection: The virus enters your skin or mucous membrane and reproduces. (webmd.com)
- It causes blisters on the skin and mucous membranes throughout the body. (moviecultists.com)
- The reaction may start with a persistent fever and nonspecific, flu-like symptoms followed by appearance of erythematous macules (red spots) that may cover a large part of the body, and painful blistering of the skin and mucous membranes. (rarediseases.org)
Antibodies1
- OMMP was diagnosed based on conjunctival signs and confirmed on direct immunofluorescence positivity, demonstrating antibodies characteristic and diagnostic of OMMP in the basement membrane zone. (bvsalud.org)
Tissue1
- This tissue is called the mucous membrane. (webmd.com)
Lungs1
- It's produced by mucous membranes that run from your nose to your lungs. (healthline.com)
Ulcers2
- Wearing down of the mucous membranes causes ulcers that burn or sting. (msdmanuals.com)
- In other mucous membranes, such as in the nose, down the throat, or on the surface of the genitals and anus, the ulcers heal, often with scarring. (msdmanuals.com)
Contact with infected1
- Direct contact with infected secretions or mucous membranes. (montana.edu)
Saliva1
- A pus-producing (purulent) cough that also brings up mucous, phlegm and saliva (sputum) may also occur. (rarediseases.org)
Mucosal1
- It usually does not affect oral and other mucosal membranes. (medscape.com)
Eyes4
- The mucous membranes most often affected are the mouth and eyes. (msdmanuals.com)
- Avoid contact with the eyes and mucous membranes. (nih.gov)
- Sjögren's syndrome is a disease in which the body's defense system (immune system) attacks healthy tissues causing dryness of the mouth, eyes and other membranes of the body that secrete mucous. (moviecultists.com)
- Keep away from eyes and mucous membranes. (youngliving.com)
Nose and throat2
- The mucous membranes line the middle ear and the nasopharynx, which is the area behind the nose and throat. (askanaudiologist.com)
- People only fall ill more often in the winter because, when it is cold outside, they tend to spend their time in warm and closed rooms where the air is so dry that the mucous membranes in the nose and throat dry out. (pari.com)
Mouth1
Body3
- A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. (wikipedia.org)
- The function of the membrane is to stop pathogens and dirt from entering the body and to prevent bodily tissues from becoming dehydrated. (wikipedia.org)
- 5, 813 Mucous membranes also protect the body from itself. (wikipedia.org)
Oral1
- The results indicate that emission from dental light curing units can affect the oral mucous membrane and may reduce its functional abilities. (who.int)
Dryness1
- The sensation of dryness of the mucous membranes is most frequently reported, but the dryness of Bryonia extends to the emotional and mental levels as well. (hpathy.com)
Cells2
Function1
- What is the function of the mucous membrane? (askanaudiologist.com)
Common1
- Scarring of the mucous membranes is common, hence the designation cicatricial, which can lead to decreased vision, blindness, and supraglottic stenosis with hoarseness or airway obstruction. (medscape.com)
Site1
- Dry the mucous membranes with gauze over the site to be anesthetized. (medscape.com)
Disorders4
- CMCC is a heterogeneous group of disorders characterized by chronic candidal infections of the nails, skin, and mucous membranes. (medscape.com)
- Disorders of the mucous membranes. (medlineplus.gov)
- So blue-eyed people may be more prone to conditions like troublesome hyperplasia of the tonsils in childhood, arthritis and rheumatoid illnesses, disorders of mucous membranes and allergies and sensitivities. (positivehealth.com)
- Chronic mucocutaneous candidiasis (CMC) refers to a group of disorders that feature persistent, debilitating, and recurrent infections of the skin, nails, and mucous membranes. (medicalnewstoday.com)
Basement membrane zone3
- In reality, these are names given to a heterogeneous group of autoimmune blistering diseases that express a unique phenotype and have been shown to have small variances in the basement membrane zone autoantibodies they produce. (pediagenosis.com)
- Linear immunoglobulin G and complement C3 immunofluorescent staining is present along the basement membrane zone. (pediagenosis.com)
- OMMP was diagnosed based on conjunctival signs and confirmed on direct immunofluorescence positivity, demonstrating antibodies characteristic and diagnostic of OMMP in the basement membrane zone. (bvsalud.org)
Nasal4
- 437 Some examples include: Endometrium: the mucosa of the uterus Gastric mucosa Intestinal mucosa Nasal mucosa Olfactory mucosa Oral mucosa Penile mucosa Respiratory mucosa Vaginal mucosa Frenulum of tongue Anal canal Conjunctiva Developmentally, the majority of mucous membranes are of endodermal origin. (wikipedia.org)
- Mucous membrane disease is typically the initial sign: Patients present with painful erosions in the nasal passages, oropharynx, genitalia, and pulmonary tree. (pediagenosis.com)
- The nasal passages are lined on either side with mucous membranes. (medicalnewstoday.com)
- The most common symptoms of a deviated septum are difficulty breathing and ongoing sinusitis , infection, or inflammation of the nasal mucous membranes. (medicalnewstoday.com)
Immune system2
- Mucous plays a key role in your immune system - it's basically a bouncer that blocks microbes from entering the body. (yahoo.com)
- The natural active ingredients of Cran-Max and Calcium Ascorbate help support the immune system, Marhmallow Root helps lubricate mucous membranes and Oregon Grape Root is a natural anti-microbial. (medi-vet.com)
Respiratory1
- Mucous membrane of respiratory epithelium. (nih.gov)
Irritation1
- Exposure to mucous membranes can cause severe irritation, pain, and burning. (medicinenet.com)
Lymph nodes1
Sinuses2
- If your sinuses remain inflamed, sinus membranes can thicken and swell. (webmd.com)
- The low humidity "dries out the mucous membranes in your nose, sinuses, and throat, leaving you susceptible to infection," Sanford Vieder, DO, medical director and founder of Lakes Urgent Care clinics in Michigan, tells Yahoo Health. (yahoo.com)
Chronic1
- In recalcitrant chronic paronychia, en bloc excision of the proximal nail fold is an option. (aafp.org)
Infectious1
- In August 1983, CDC initiated prospective surveillance of health-care workers with documented parenteral or mucous-membrane exposures to potentially infectious body fluids from patients with definite or suspected acquired immunodeficiency syndrome (AIDS). (cdc.gov)
Affects1
- At dosages greater than required for beta blockade, propranolol also exerts a quinidine-like or anesthetic-like membrane action, which affects the cardiac action potential. (nih.gov)
Cavities1
- A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. (wikipedia.org)
Clinical1
- Factors that should weigh into the decision include whether the patient is clinically stable enough to travel (i.e., whether the patient's condition is likely to deteriorate during transport and if there is reasonable capability to manage en route), and whether personnel providing care during transport are trained in clinical management, infection control, and correct use of PPE. (cdc.gov)
Treatment1
- The significance of the membrane action in the treatment of arrhythmias is uncertain. (nih.gov)
Pain1
- TRPV1 are ion channels on nerve cell membranes and desensitizing them prevents transmission of pain. (medicinenet.com)
Disease1
- Cutaneous disease, when present, most frequently accompanies mucous membrane disease. (logicalimages.com)
Involvement1
- Mucous membrane involvement is rare. (msdmanuals.com)