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  • treatment
  • This is a multicenter, double-blind, randomized, vehicle-controlled study including an open-label standard of care arm, to determine the effectiveness and safety of benezydamine hydrochloride 0.15% oral rinse as compared with vehicle oral rinse, and vehicle oral rinse as compared to the care normally used in the treatment of radiation-induced oral mucositis. (clinicaltrials.gov)
  • Mucosal
  • Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). (nih.gov)
  • To raise awareness of plasma cell mucositis as a rare differential diagnosis for oral mucosal ulceration and its macroscopic similarity to malignancy. (hindawi.com)
  • There really is not a specific test for mucositis that would generally be utilized and instrumenting a patient to directly visualize mucosal breakdown in the setting of cancer therapy would be discouraged due to bleeding and infection risks. (healthtap.com)
  • Mucositis or inflammation and irritation of the mucosal tissues can be due to a number of causes. (healthtap.com)
  • incidence
  • Incidence of mucositis is higher with certain chemotherapy or total body irradiation, which is often used for bone marrow transplants. (clinicaladvisor.com)
  • Povidone-iodine showed significant reduction in onset, incidence, total duration, and worst grade of mucositis for patients with head and neck cancer undergoing radiation with carboplatin in two studies. (ons.org)
  • The European Medicine Agency (EMEA)'s decision is based on a pivotal Phase III double-blind study which found that Kepivance reduced the incidence of grade 4 oral mucositis to 20% from 62% in the placebo arm. (pharmatimes.com)
  • mouthwash
  • The most effective measure to treat radiation-induced mucositis was frequent oral rinsing with a bland mouthwash such as saline or sodium bicarbonate. (ons.org)
  • Mucositis pain during the first 4 hours decreased by 11.6 points in the doxepin mouthwash group, by 11.7 points in the diphenhydramine- lidocaine-antacid mouthwash group and by 8.7 points in the placebo group, for a 2.9-point difference between doxepin mouthwash and placebo and a 3.0-point difference between diphenhydramine- lidocaine-antacid mouthwash and placebo. (curetoday.com)
  • sores
  • It's very reasonable to hope that this line of research will result in a drug that patients can self-administer topically to oral mucositis sores, or use to prevent them altogether, thus significantly improving the quality of life for many cancer patients," Wang ways. (innovations-report.com)
  • therapeutic
  • Global Markets Direct's, 'Mucositis - Pipeline Review, H1 2013', provides an overview of the indication's therapeutic pipeline. (sbwire.com)
  • This report provides information on the therapeutic development for Mucositis, complete with latest updates, and special features on late-stage and discontinued projects. (sbwire.com)
  • It also reviews key players involved in the therapeutic development for Mucositis. (sbwire.com)
  • A snapshot of the global therapeutic scenario for Mucositis. (sbwire.com)
  • Wang and collaborators including Qinghong Zhang, PhD, Yosef Refaeli, PhD, and radiation oncologist David Raben, MD, are pursuing further research with the goal of developing Smad7 as a therapeutic agent for human oral mucositis. (innovations-report.com)
  • oral hygiene
  • Also, in addition to palliative and curative remedies, does anyone have practical recs as to the safest way for patients with mucositis to pursue their routine oral hygiene (brushing their teeth)? (geripal.org)
  • Consistent oral care, dental care, oral assessment, and standardized oral hygiene were the suggested approaches to managing oral mucositis. (ons.org)
  • Management of oral mucositis involves good oral hygiene, including brushing with a soft toothbrush, gargling with salt and soda gargles, and avoiding alcohol, smoking and acidic, salty, or dry foods. (oncologynurseadvisor.com)
  • pipeline
  • Mucositis - Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. (sbwire.com)
  • Coverage of the Mucositis pipeline on the basis of route of administration and molecule type. (sbwire.com)
  • Devise corrective measures for pipeline projects by understanding Mucositis pipeline depth and focus of Indication therapeutics. (sbwire.com)
  • To assist investigators and funding and regulatory organizations, the publisher has come up with a comprehensive report on Oral Mucositis pipeline. (researchandmarkets.com)
  • Current status, developmental phase, participating companies and entities, recent developments, orphan drug/ fast track/ other designations, drug class are provided for each Oral Mucositis pipeline product. (researchandmarkets.com)
  • In addition to complete details of each product, the report provides key trends in Oral Mucositis pipeline studies. (researchandmarkets.com)
  • high dose
  • Based on our experience with velafermin in Phase I, we are pleased to be taking part in the Phase II trial to evaluate this investigational drug for the prevention of OM," stated Michael W. Schuster, M.D. "Oral mucositis is a severe side effect that frequently occurs as a result of the high-dose chemotherapy administered to patients prior to bone marrow transplantation. (rxpgnews.com)
  • Data on 30 patients dosed with velafermin (CG53135) were presented in a poster entitled, "Phase I Trial of CG53135-05 (Velafermin) to Prevent Mucositis in Patients Undergoing High-dose Chemotherapy (HDCT) and Autologous Peripheral Blood Stem Cell Transplantation (PBSCT). (rxpgnews.com)
  • assessment
  • To obtain preliminary data on the most optimal method of scoring the severity of oral mucositis by comparing the results obtained using the IR thermometer to the World Health Organization (WHO) mucositis grading system and the patient self-assessment questionnaire. (clinicaltrials.gov)