Mucosal th17 responses. Medical search. Frequent questions

In this review we summarize the available literature on the role of mucosal immunity in the prevention of B. pertussis infection. (frontiersin.org)
As of today, only one vaccine designed to induce potent mucosal immunity is in clinical development. (frontiersin.org)
Due to its ability to induce mucosal immunity it is expected that this approach will contribute to improved control of pertussis. (frontiersin.org)
Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. (hindawi.com)
Here we review the characteristics of mucosal immunity of the female genital tract, its alterations due to HIV/AIDS, and the characteristics of coinfections between HIV/AIDS and the most prevalent STDs. (hindawi.com)
The immune system of the female genital tract is part of the integrated mucosal immune system, but with some particular characteristics that differentiate the immunity of these regions from the systemic immunity [ 2 - 4 ]. (hindawi.com)
Mucosal immunity consists of innate and adaptive immune responses that can be influenced by systemic immunity [ 15 ] and by hormonal changes during the menstrual cycle. (hindawi.com)
This review will highlight the roles of monocytes in the immune response to some of the major fungi that cause invasive human disease, including Aspergillus, Cryptococcus, Candida, Histoplasma, Blastomyces , and Coccidioides , and discuss potential strategies to manipulate monocyte responses in order to enhance anti-fungal immunity in susceptible hosts. (frontiersin.org)
Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity. (southernbiotech.com)
Mucosal immunity is often required for protection against respiratory pathogens but the underlying cellular and molecular mechanisms of induction remain poorly understood. (uu.nl)
show that defense against OPC is more dependent on Th17- than Th-1-type immunity ( 6 ). (rupress.org)
Using a pre-clinical mouse model of colitis, the mechanistic impact of these TIM in shaping mucosal immunity and in guiding the response to UC was defined. (medicom-publishers.com)
Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity. (jefferson.edu)
Key amongst these is recent data indicating that the immune responses induced by aP vaccines differ fundamentally from those induced by the whole cell pertussis (wP) vaccines, and do not lead to mucosal immunity. (biomedcentral.com)
Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 43 , 541-553 (2015). (nature.com)
Th17 cells are a subset of T cells that secrete the cytokine IL-17 and play a part in mucosal immunity. (biospraysehatalami.com)
In addition, it will explore the mechanisms of interaction between the microbiome and host immunity in allergic diseases, including changes induced by microbial-associated infections, cytokines, and immune responses. (frontiersin.org)
The humoral response in adaptive immunity involves the release of IgA and IgG by the activated B Lymphocytes or Plasma cells as described above. (glucagon-receptor.com)
The results suggest that intramuscular vaccination with the live-attenuated vaccine VC2 primes a mucosal immune response predisposing the adaptive expression of transcripts associated with a Th17 response to challenge and these responses contribute to antiviral immunity. (precisionvaccinations.com)
Given the challenges posed by ectoparasites and gill diseases in fish farms, this study underscores the importance of optimal rearing densities for immunocompetence, particularly for mucosal immunity. (cardiff.ac.uk)
Proposed studies will provide important insights into molecular correlates of frontline gut mucosal responses that may identify novel targets for therapeutically enhancing DC functions and improving mucosal immunity against both virus and secondary pathogens. (grantome.com)
VIENNA, Austria - Fecal microbiota transplants (FMT) can reset gut microbiota leading to strengthened gut barrier function and mucosal immunity, along with improved ammonia metabolism in patients with cirrhosis, show data from a pilot study now expanded into a large multisite UK trial. (medscape.com)

This immune response protects hosts from pathogens at epithelial and mucosal tissues including the skin, lung, and intestine. (wikipedia.org)
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
Monocytes and their derivatives, including macrophages and dendritic cells, play diverse roles in the response to fungal pathogens. (frontiersin.org)
The relative roles of mucosal Ag presentation cells in directing Th cell immune responses against oral pathogens and their contribution to destruction of alveolar bone remain unknown. (bvsalud.org)
MIEP is basically focused on the characterization of the mechanisms underlying immune responses to enteric pathogens by integrating mathematical and computational modeling approaches with experimental data (Figure 2). (nimml.org)
ILCs are present at the mucosal site where they quickly initiate cytokine response against pathogens. (wustl.edu)
Th17 cytokines (IL-17 specifically) as a bridge involving innate and adaptive immune responses in host defences against various pathogens in the mucosal surfaces (29).Each TH1and TH2Helper cells regulate the functioning of every single other by means of the cytokines they release. (glucagon-receptor.com)
T-helper 17 (Th17) cells have been implicated in host defense and control of mucosal pathogens, including B. pertussis. (sjsu.edu)
pDCs are activated during lung inflammation in response to pathogens, but their role during B. pertussis infection is understudied. (sjsu.edu)
The immune system can be divided into two overlapping mechanisms to destroy pathogens: the innate immune response, which is relatively rapid but nonspecific and thus not always effective, and the adaptive immune response, which is slower in its development during an initial infection with a pathogen, but is highly specific and effective at attacking a wide variety of pathogens (see Figure 1). (clicksold.com)
A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. (frontiersin.org)
The frontline mucosal immune defenses are crucial in preventing and limiting HIV infection and controlling spread of enteric pathogens and microbial translocation. (grantome.com)
We hypothesize that SIV infection causes DC dysfunction in the gut mucosa that leads to blunting of the Th17 CD4+ T cell response and contributes to the inability to prevent enteric pathogens and microbial translocation leading to chronic immune activation. (grantome.com)
The overall objective of this competing continuation application is to investigate HIV induced dysfunction in the frontline gut mucosal defense mechanisms to bacterial pathogens in the SIV infected rhesus macaque model. (grantome.com)
Our investigation will utilize an innovative ligated ileal loop model that creates up to 12 independent, isolated in vivo experimental settings within the small intestine of the same animal to investigate the molecular mechanisms of dendritic cells and CD4+ Th17 cell responses to challenge from either enteric pathogens or luminal probiotic bacteria in SIV infected animals and healthy uninfected controls (Specific Aim 2). (grantome.com)
The proposed studies will investigate HIV induced dysfunction in the frontline gut mucosal responses to bacterial pathogens in the SIV infected rhesus macaque model and determine the mechanisms contributing to the inability of the host to control these infections. (grantome.com)

The interleukin 17 family members are among the effector cytokines of Th17 immune response. (wikipedia.org)
Pigr) in addition to local and systemic secretion of Th1/Th17-promoting cytokines. (uu.nl)
After macrophage recognize they will produce cytokines to produce an inflmmation response. (freezingblue.com)
Cytokines are P factor that work with cells to trigger an innate response. (freezingblue.com)
Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. (bioxcell.com)
and 2) early host response cytokines down-regulate NLRX1 expression through a negative feedback circuit. (nimml.org)
However, chlortetracycline regulated transcription levels of Th1 and Th17 inflammatory cytokines in a temporal manner in C. rodentium-inoculated mice, and ameliorated weight loss associated with infection. (uleth.ca)
TH17 cells secrete critical cytokines IL-17, IL-21, IL-22. (glucagon-receptor.com)
Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. (cdc.gov)
CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)

Nowatzky J, Manches O, Khan SA, Godefroy E, Bhardwaj N. Modulation of human Th17 cell responses through complement receptor 3 (CD11?b/CD18) ligation on monocyte-derived dendritic cells. (jefferson.edu)
For example, mucosal CD103+ dendritic cells (DCs), which are influenced by gut microbiota, promote the differentiation of regulatory T cells (Tregs) and attenuate OVA-induced allergic inflammation. (frontiersin.org)
Dendritic cells (DC) are an important component of the mucosal frontline defense but are under-investigated in HIV pathogenesis. (grantome.com)

Yet, compared to systemic responses, mucosal immune responses have attracted relatively little attention in the context of pertussis vaccine development. (frontiersin.org)
induced mucosal immunoglobulin A (IgA) and T helper type 17 (Th17) responses, and in addition evoked elevated systemic immunoglobulin G (IgG) antibody levels, IgG-producing plasma cells, memory B cells, and Th17 cells. (uu.nl)
Bypassing LCs with systemic immunization of P. gingivalis resulted in a predominantly P. gingivalis-specific Th1 response regardless of whether LCs were present. (bvsalud.org)
Consistently, long-term dosing of broad-spectrum antibiotics (ABXs) in Rag2R229Q mice ameliorated intestinal and systemic autoimmunity by diminishing the frequency of mucosal and circulating gut-tropic CCR9+ Th1 and Th17 T cells. (hunimed.eu)
in mice compared with mice, ensuing in an abrogated Ag-specific Th17 response in the colon after mucosal immunization that could become rescued by systemic delivery of recombinant IL-6. (biospraysehatalami.com)
Here we tested whether a heterologous immunization strategy with systemic priming and mucosal booster (prime-pull) would reduce nasal colonization. (figshare.com)
Tissue-resident memory (TRM) responses in the respiratory tract were quantified by flow cytometry, and mucosal and systemic antibodies were quantified by ELISA. (figshare.com)
Our previous studies identified blunted Th17 CD4+ T cell responses to Salmonella typhimurium infection in gut mucosa and systemic dissemination of the bacteria in SIV infected rhesus macaques but not in SIV-negative animals. (grantome.com)
Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)

Lymphocytes were sufficient for disease induction, as intestinal CD4 T cells with a Th1/Th17 phenotype reproduced the pathological picture when transplanted into immunocompromised hosts. (hunimed.eu)
Induction of intestinal Th17 cells by segmented filamentous bacteria. (nature.com)
Our findings revealed that Fp -EVs attenuated DSS-induced colitis by modulating the intestinal mucosal barrier function and immunological profile. (biomedcentral.com)
Nevertheless, the mechanisms by which F. prausnitzii regulates the intestinal mucosal barrier and immune responses are not fully understood. (biomedcentral.com)
IFX markedly downregulated Th1/Th17-mediated immune response but promoted IL-25 production in intestinal mucosa from remission group. (johnshopkins.edu)
In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. (frontiersin.org)
We propose to utilize a novel in vivo intestinal loop model in SIV infected rhesus macaques to capture early events of host-microbe interactions at the mucosal site and characterize the responses of the key components of mucosal defense and the correlates of protection. (grantome.com)
The proposal capitalizes on our experience of enteropathogenic studies in the SIV model;immunophenotypic analysis by multi-color flow cytometry;ligated intestinal loop model for in vivo studies of mucosal responses and bacterial translocation;high throughput gene expression profiling of isolated mucosal cells, and imaging technologies to visualize multiple cell types. (grantome.com)

IL-17F as an effector cytokine of Th17 cells is involved in host defense against bacterial infections. (wikipedia.org)
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. (thermofisher.com)
The decision as to whether the TH0 will create into an inflammatory TH1 cell, a helper TH2 cell, or possibly a TH17 cell depends on cytokine environment at the web-site of priming [24,25]. (glucagon-receptor.com)
Type I IFN has been well characterized as an antiviral cytokine, but recent studies linking it to the inhibition of Th17 differentiation have led to investigation of whether type I IFN may be detrimental during bacterial infections. (sjsu.edu)
The recruitment and cytokine secretion of lung pDCs during infection with B. pertussis correlate with the delayed Th17 responses, suggesting a role for pDCs in Th17 differentiation that may account for a longer-lasting disease. (sjsu.edu)

Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. (uni-ulm.de)
Dendritic cell frequency increased in PP regardless of the TiO 2 treatment, while regulatory T cells involved in dampening inflammatory responses decreased with E171 only, an effect still observed after 100 days of treatment. (nature.com)
In all TiO 2 -treated rats, stimulation of immune cells isolated from PP showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased. (nature.com)
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction. (bvsalud.org)
We tested the contribution of mucosal Langerhans cells (LCs) to alveolar bone homeostasis in mice following oral colonization with a well-characterized human periodontal pathogen, Porphyromonas gingivalis We found that oral mucosal LCs did not protect from or exacerbate crestal alveolar bone destruction but were responsible for promoting differentiation of Th17 cells specific to P. gingivalis. (bvsalud.org)
Interestingly, we find that in vivo clonal expansion of P. gingivalis-specific Th cells and induced regulatory T cells does not depend on mucosal LCs. (bvsalud.org)
Furthermore, destruction of crestal alveolar bone induced by P. gingivalis colonization occurred regardless of the presence of mucosal LCs or P. gingivalis-specific Th17 cells . (bvsalud.org)
Our data indicate that both LCs and Th17 cells are redundant in contributing to alveolar bone destruction in a murine model of periodontitis . (bvsalud.org)
In a substudy of STOP-Colitis, response to faecal microbiota transplantation (FMT) in ulcerative colitis (UC) patients was associated with a significant increase in mucosal gut-homing Treg cells and butyrate metabolism, along with a reduction in Th17 cells and multiple anti-microbial and pro-inflammatory pathways [1]. (medicom-publishers.com)
Th17 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Th17 Cells" by people in this website by year, and whether "Th17 Cells" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Th17 Cells" by people in Profiles. (jefferson.edu)
As shown in figure 1, the inflammatory response towards H. pylori is initiated through the interaction between the pathogen lipopolysaccharides (LPS) and the Toll-like receptors (TLR) expressed on gastric epithelial cells [ 6 ]. (nimml.org)
Currently, the model is able to predict the distinct time-dependent behavior of the three main CD4+ T cells (Th1, Th17 and iTreg) showing an increased Th17 response at the early stage of infection that switches to a Th1 predominance in the chronic phase of the infection. (nimml.org)
These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. (nature.com)
In balancing the activity of Th1, Th2, and Th17 cells, the microbiome is important in developing effector or tolerogenic responses to different antigens. (frontiersin.org)
The production of IFN- by NK cells may possibly influence the CD4+ T cell response to infectious cells, and they differentiate into pro-inflammatory TH1 cells in a position to activate macrophages(26,27). (glucagon-receptor.com)
Na e T cells stimulated with TGF, and IL-6 differentiate in to TH17 cells. (glucagon-receptor.com)
Using a murine infection model of B. pertussis, we tested the hypothesis that the functions of pDCs can manipulate the rise of Th17 cells during infection. (sjsu.edu)
We used multicolor flow cytometry to characterize the immune cells in our infection model and to study the effects of IFNa on Th17 differentiation. (sjsu.edu)
Lung Th17 cells increased significantly in B. pertussis-infected mice only at 10 days post-infection (dpi) and later. (sjsu.edu)
In addition, blocking IFNa production in mice restored an early increase in Th17 cells during B. pertussis infection. (sjsu.edu)
Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections.IFNs also have various other functions: they activate immune … Response of neighboring cells to interferon helps stem the infection. (clicksold.com)
Since the early mucosal response is well orchestrated, highly regulated and involves a rapid cross talk among the frontline mucosal cells, an experimental model representing an in vivo gut microenvironment is required to investigate early mucosal responses to HIV and microbes. (grantome.com)
We found that the proteins produced after FMT enhance the antibacterial response of [gut] cells," Edwards pointed out. (medscape.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
In addition to Th1 and Th2 cells, Th17, Treg and T Fh cells have also been described 7 , Treg cells are associated with reduction of clinical scores of disease in soft and hard tissues 8 . (bvsalud.org)
Usually, protective and destructive roles are assigned to the Th1 and Th17 3,9-11 cells, while Th2 and Treg cells are more involved in processes that reduce the destruction of the periodontium 10 . (bvsalud.org)

Mucosal Immunol. (uni-ulm.de)

The mucosal surfaces primarily affected by candidiasis are the oral cavity, esophagus, angles of the mouth, and genitals (causing vulvovaginitis in females, balanitis in males). (medscape.com)
Except for Candida species, which are commensal organisms found on the skin and mucosal surfaces, these fungi are environmental microorganisms that are typically acquired after inhalation into the lungs. (frontiersin.org)
Because the microorganism remains the same, and the presence of C. albicans in tissues of immunocompetent individuals with intact mucosal surfaces and microbiota is not usually associated with inflammation or damage, the transition between commensalism and disease is almost certainly caused by the immune response. (rupress.org)
Results: C. rodentium was transformed with the tetracycline resistance gene, tetO, and continuous oral administration of a non-therapeutic dose of chlortetracycline to mice did not affect densities of C. rodentium CFU in feces throughout the experiment or associated with mucosal surfaces in the colon (i.e. at peak and late infection). (uleth.ca)

This is achieved by immune responses that also block acquisition, replication and transmission of the pathogen in or from the host, regardless of whether that infection actually led to clinical illness. (biomedcentral.com)
The next step is to evoke a more powerful response called adaptive immune response (after pathogen invades) which causes T and B lymphocyte response. (freezingblue.com)
Development of memory immune reponse so that nect time you are infected with the same pathogen the response is faster and more effective. (freezingblue.com)
Using overlapping gene ontology enrichment and gene ortholog analyses, we found that density-related stress similarly impacted salmon and tilapia in key immune pathways, altering the expression of genes vital to inflammatory and Th17 responses to pathogen challenge. (cardiff.ac.uk)

Figure 1: Induction of IgA in mucosal tissues. (nature.com)

Monocytes can also present fungal antigens to elicit adaptive immune responses. (frontiersin.org)
The gut needs to produce a strong protective immune response to resist the invasion of pathogenic antigens, while similar reactions to harmless antigens such as dietary proteins or symbiotic microorganisms, may lead to chronic inflammatory diseases. (frontiersin.org)

They exert effector functions in innate antiviral defenses, adaptive immune responses, antitumor responses, and autoimmunity. (clicksold.com)

In another study, Dr Lasha Gogokhia (Weill Cornell Medicine, New York, USA) and colleagues attempted to unravel the mechanisms of clinical response to FMT by identifying a distinct, immune-reactive, core transferable microbiota [2]. (medicom-publishers.com)
The Rag2R229Q microbiota further contributed to the immunopathology because its transplant into WT recipients promoted Th1/Th17 immune response. (hunimed.eu)
The microbiota regulates the immune response. (frontiersin.org)

In contrast to vaccination, natural infection in humans and experimental infections in animals induce strong secretory IgA responses in the naso-pharynx and in the lungs. (frontiersin.org)
During inflammation or infection, classical monocytes are mobilized from bone marrow reserves in response to chemokines that bind to the CCR2 receptor, such as CCL2 and CCL7 ( Shi and Pamer, 2011 ). (frontiersin.org)
Given the complexity of the host- H. pylori interactions at the systems level and the broad range of possible outcomes, our team has developed a computational model of the gastric mucosal immune response towards H. pylori infection. (nimml.org)
To accomplish our aim, we will use different Mtb -infected mouse strains lacking particular B cell subsets or functions, and characterize their response to Mtb infection. (wustl.edu)
During chronic H. pylori infection hosts develop complex immune responses to cope with bacterial persistence that result in a variety of outcomes ranging from peaceful co-existence to detrimental disease. (nimml.org)
Utilising an interspecific comparative transcriptomic (RNAseq) approach, we compared gill gene expression responses of Atlantic salmon (Salmo salar) and Nile tilapia (Oreochromis niloticus) to rearing density and Saprolegnia parasitica infection. (cardiff.ac.uk)
Wu, Victoria, "Plasmacytoid dendritic cell-derived IFNa modulates Th17 differentiation during Bordetella pertussis infection in mice" (2014). (sjsu.edu)
[ 9 ] Cx3cr1 is dispensable for the induction of IL-17A, IL-22, and IL-23 in the tongue after infection, as well as for the clearance of mucosal candidiasis from the tongue or lower gastrointestinal (GI) tract colonization. (medscape.com)

The Th17-type immune response is directed primarily against extracellular bacteria. (wikipedia.org)

HIV causes breach in the mucosal defense leading to colonization and microbial translocation of enteric and luminal microbes. (grantome.com)

New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. (rupress.org)
TH17 cell also produces other vital effector molecules, for example IL-21, IL-22, IL-26, IL-6 and CCL20(28). (glucagon-receptor.com)

These proteins have revealed many aspects of the relationships between the bacteria, the gastric mucosal surface, and the final outcome of the disease. (nimml.org)

These results provide further evidence of induction of immune responses to fungi based on their ability to invade host tissue. (cdc.gov)

Mucosal immunoglobulin A (IgA) deficiency in the gut resulted in enhanced absorption of microbial products and altered composition of commensal communities. (hunimed.eu)

It is a quick response (innate immune response) and the response evoke is inflammation. (freezingblue.com)
Inflammatory bowel disease (IBD) is a multifactorial progressive disease characterized by chronic and recurrent inflammation of the gastrointestinal (GI) tract, disturbance of the gut microbiome and exacerbated immune responses [ 1 , 2 ]. (biomedcentral.com)

We showed previously that modification of a commercial aPV (Boostrix) by addition of the Th1/17 polarizing adjuvant Bordetella Colonization Factor A (BcfA) attenuated Th2 responses elicited by alum and accelerated clearance of B. pertussis from mouse lungs. (figshare.com)
These results suggest that TH17 polarized TRM generated by aPV/BcfA may reduce nasal colonization thereby preventing pertussis transmission and subsequent resurgence. (figshare.com)

We report that bacterial interaction with the host intracellular environment caused significant suppression of regulatory NLRC3 and NLRX1 in a pattern inverse to early regulatory responses. (nimml.org)

In mice lacking LCs the Th17 response was suppressed and a Th1 response predominated. (bvsalud.org)

He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
Type I Interferon (IFN) has recently been documented to inhibit Th17 differentiation and IL-17 production. (sjsu.edu)

Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)

These adaptive responses were preceded by unique local expression of genes of the innate immune response related to Th17 (e.g. (uu.nl)

Additionally, response was associated with a significant downregulation of host antimicrobial defence response, and with a significant upregulation of butyrate and propionate (2 short-chain fatty acids) metabolic pathways. (medicom-publishers.com)

4. Arnaboldi PM, Roth-Walter F, Mayer L. Suppression of Th1 and Th17, but not Th2, responses in a CD8 + T cell mediated model of oral tolerance. (southernbiotech.com)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)

Patients should be counseled about smoking, and they should be warned about the risk of developing mucosal candidiasis after taking medications that impair salivation, antibiotics, corticosteroids, and other immunosuppressants. (medscape.com)
Mouse models of candidiasis, including models of OPC, vaginitis, and disseminated disease, have been invaluable in advancing our understanding of the immune response to C. albicans . (rupress.org)

In a substudy, changes in host colonic mucosal immune cell subsets and gene expression following FMT were explored. (medicom-publishers.com)
Our data suggest that mechanisms of mononuclear phagocyte response to H. pylori occur sequentially and may depend on the location of the bacterium with respect to the host cell. (nimml.org)
Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). (cdc.gov)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO 2 from dietary sources. (nature.com)
Although the precise aetiology of IBD is unclear, compelling evidence have indicated that multiple factors are involved in the pathogenesis of IBD, including genetic susceptibility, dysregulated immune responses, microbial dysbiosis and environmental factors [ 4 ]. (biomedcentral.com)

We present the first ever time-series global gene expression dataset for H. pylori infected macrophages identifies three novel response modules: early transient, sustained and late waves. (nimml.org)

Conclusions: These results indicate that the Th2 response may have a protective role during the pathogenesis of experimental periodontal disease, and that the IFN-γ R1 subunit may not be associated with periodontal disease progression. (bvsalud.org)

In 2019, in a seminal study published in Nature, we along with the Leslie Lab, AHRI, showed that an IL-17/IL-22 producing ILC subset, namely ILC3s, play a crucial role in early innate immune response to TB. (wustl.edu)

Gaining insights into the mucosal immune defenses critical in maintaining gut mucosal health will be crucial in identifying therapeutic targets for mucosal protection against the virus and co-infections. (grantome.com)

In a 2018 study conducted at Louisiana State University examined the immune response generated by intramuscular injection of the VC2 vaccine in guinea pigs. (precisionvaccinations.com)

Host responses toward the bacterium can result in asymptomatic, pathogenic or even favorable health outcomes, however, mechanisms underlying the dual role of H. pylori as a commensal versus pathogenic bacterium are not well characterized. (nimml.org)

150. Clinical response was assessed by a decrease in CDAI ≥ 70, and the failure as a CDAI was not significantly changed or increased. (johnshopkins.edu)
Ten weeks after therapy, 61 (57.5%) patients achieved clinical remission, 17 (16.0%) had clinical response, and the remaining 28 (26.4%) were failed. (johnshopkins.edu)
Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions. (johnshopkins.edu)

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