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  • anti-mucin
  • For example, specific knowledge of cancer-associated changes in the expression and glycosylation of various mucins, which can aid in the diagnosis as well as prognosis of GI cancers, has not yet led to the use of a panel of anti-mucin antibodies as a standard diagnostic tool. (nih.gov)
  • MUC20
  • Mucin-20 (MUC20) was identifiied as a gene that is up-regulated in the renal tissues of patients with immunoglobulin A nephropathy [ PMID: 14565953 ]. (ebi.ac.uk)
  • MUC5B
  • MUC5B, the predominate mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans , a bacteria with the potential to form cavities. (wikipedia.org)
  • Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans , Helicobacter pylori , and even HIV . (wikipedia.org)
  • therapies
  • Similarly, many more opportunities exist for using mucin-based therapies than are currently being considered in the clinic. (nih.gov)
  • secretory
  • Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). (dovepress.com)
  • vesicles
  • Fusion of the vesicles to the plasma membrane causes release of the mucin, which as it exchanges Ca 2+ for Na + expands up to 600 fold. (wikipedia.org)
  • This work provides new insight into mucin condensation, which could lead to new delivery strategies mimicking cell release of macromolecules condensed in vesicles such as mucins and heparin. (diva-portal.org)
  • Protocols
  • In, Mucins: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study Mucins. (springer.com)
  • These include methods and techniques for the best approaches to analysing each specific area of mucin biochemistry, physiology and biophysics before providing individual detailed experimental protocols together with troubleshooting and interpretation tips. (springer.com)
  • Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology. (springer.com)
  • species
  • Most of the snail mucin used for skin care involves the Cryptomphalus aspersa species, a.k.a. the common garden snail. (nymag.com)
  • The mucin domains often contain tandemly repeated sequences and vary to a great extent in sequence and length depending on allele, species, and individual mucin ( 1 , 2 ). (pnas.org)
  • tissues
  • Mucin also lubricates the tissues and teeth in the mouth and protects them against pathogens and toxins. (reference.com)
  • Kesimer
  • This is why Kesimer and his UNC mentor, the late John Sheehan, PhD, Distinguished Professor of Biochemistry and Biophysics, suspected that something must happen to mucins in the CF lung. (eurekalert.org)
  • Through this separation, Kesimer and Henderson's team isolated the mucins and simultaneously measured their concentration using a refractometer. (eurekalert.org)
  • bronchial
  • 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. (dovepress.com)
  • tandem
  • Mucins share a common structural feature which is a tandem repeat domain comprising a variable number of tandem repeats (VNTRs) of identical or highly similar sequences rich. (springer.com)
  • dense
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers. (wikipedia.org)
  • bacteria
  • The gel-forming mucins are instrumental in the protection of the underlying epithelia and in trapping and elimination of bacteria. (pnas.org)
  • biology
  • Moreover, we will discuss the recent advances about the biology of both secreted and membrane-bound mucins and their key roles in pancreatic carcinogenesis and resistance to therapy. (mdpi.com)
  • family
  • The mucin family has been under study by molecular biologists, biochemists, pathologists and immunologists interested in cancer because of the role these molecules can play in the diagnosis and treatment of cancer. (nih.gov)