• In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • IT-Ks20.10 represents an excellent marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin. (progen.com)
  • Very sensitive detection of intestestinal and gastric foveolar epithelium, urothelial umbrella cells, Merkel cells of epidermis as well as tumors originating therefrom (e.g. primary and metastatic colorectal carcinoma). (progen.com)
  • Adenocarcinomas of breast, lung, endometrium and ovary (non-mucinous) as well as neuroendocrine tumors of the lung are essentially negative. (progen.com)
  • By contrast, a rare subset of CRC tumors that show microsatellite instability (MSI-high) demonstrate marked responses to PD-1 therapy, similar to or exceeding that observed in other highly mutated cancers such as melanoma and lung adenocarcinoma. (cancer.gov)
  • With recent advancements in pathology, gene expression profiling, identification of subtypes and various modalities available for exploring the GI tract, it has become possible to find the precise origin of mucinous tumors. (thieme-connect.de)
  • The two main types of appendix cancer are called carcinoid tumors and carcinomas. (mskcc.org)
  • Background: Diagnosis of mucinous carcinomas in the lung on transbronchial biopsy or fine-needle aspiration (FNA) samples can be difficult for the pathologist, because primary and metastatic tumors can have similar morphological, immunohistochemical, and molecular characteristics. (wustl.edu)
  • Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in two extended kindreds and named it cancer family syndrome. (medscape.com)
  • women with mixed histologies including mucinous tumors combined with endometrioid, serous, clear-cell, and/or other histologic types were excluded. (biomedcentral.com)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • KRAS mutations are more commonly observed in cecal cancers than colorectal cancers located in any other places from ascending colon to rectum. (wikipedia.org)
  • As of 2008, the most reliable way to predict whether a colorectal cancer patient will respond to one of the EGFR-inhibiting drugs was to test for certain "activating" mutations in the gene that encodes KRAS, which occurs in 30%-50% of colorectal cancers. (wikipedia.org)
  • Roughly 95 percent of colorectal cancers are adenocarcinomas. (suamaytinhhaiphong.com)
  • Immunotherapy with antibodies targeting checkpoint blockade molecules PD-1 and CTLA-4 has not demonstrated clinical activity in the vast majority of colorectal cancers (CRC). (cancer.gov)
  • Endometrioid adenocarcinomas account for about 75 to 80% of endometrial cancers. (msdmanuals.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least two or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)
  • See Colorectal Cancer: Prevention, Diagnosis, and Therapeutic Options , a Critical Images slideshow, to help identify the features several types of colorectal cancers. (medscape.com)
  • Colorectal cancer (CRC) is one of the most common cancers worldwide, and one of the most common causes of cancer deaths. (org.sa)
  • Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. (hindawi.com)
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
  • [ 1 ] Colorectal cancer is the third most common tumor in both men and women and constitutes 10% of all tumor types globally. (medscape.com)
  • At least 50% of the Western population will develop a colorectal tumor by age 70 years. (medscape.com)
  • A small 0.5 cm diameter ulcer on the upper lip developed after 42 months following the removal of the primary tumor, and biopsy confirmed metastasis of the colorectal adenocarcinoma (Figure 1a . (biomedcentral.com)
  • The widespread implementation of colorectal tumor testing helps to identify families with HNPCC or Lynch syndrome. (medscape.com)
  • Colorectal tumor testing could yield substantial benefits at acceptable cost. (medscape.com)
  • However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
  • In contrast, metastases located in the axillary region are more likely to be related to a primary tumor in the breast while metastases on the lower trunk are mostly seen in colorectal carcinomas. (asploro.com)
  • We wondered whether the worse prognosis associated with mucinous histology is also valid when age, tumor grade, substage of disease, and extent of RD are matched with serous histology in women with stage III EOC who have undergone primary CRS followed by standard intravenous paclitaxel plus carboplatin chemotherapy. (biomedcentral.com)
  • The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal cancer. (wikipedia.org)
  • Somatic KRAS mutations are found at high rates in leukemias, colorectal cancer, pancreatic cancer and lung cancer. (wikipedia.org)
  • As of 2006, KRAS mutation was predictive of a very poor response to panitumumab (Vectibix) and cetuximab (Erbitux) therapy in colorectal cancer. (wikipedia.org)
  • METHODS: In a multi-institutional study prospective databases of patients with peritoneal carcinomatosis (PC) from colorectal cancer and pseudomyxoma peritonei (PMP) treated according to the Dutch HIPEC protocol, a uniform approach for the CRS and HIPEC treatment, were reviewed. (lu.se)
  • Metastasis to the abdominal wall including port sites after laparoscopic surgery for colorectal cancer is rare. (biomedcentral.com)
  • In conclusion, this case suggests an important role of 18 F-FDG PET/CT in early diagnosis and decision-making regarding therapy for recurrent disease in cases where a firm diagnosis of recurrent colorectal cancer is difficult to make. (biomedcentral.com)
  • Five-year survival in patients with stage I (localized) colorectal cancer is approximately 90%, 70% for stage II (regional), but only 13% for patients with distal spread. (medscape.com)
  • The American Cancer Society 2018 guideline for colorectal cancer screening recommends that average-risk adults aged 45 years and older undergo regular screening with either a high-sensitivity stool-based test or a structural (visual) exam, based on personal preferences and test availability. (medscape.com)
  • The US Multi-Society Task Force on Colorectal Cancer issued screening recommendations that divide screening tests into 3 tiers, based on their effectiveness. (medscape.com)
  • Serum and tissue markers in colorectal cancer: State of art. (novodiax.com)
  • Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. (novodiax.com)
  • Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis. (novodiax.com)
  • In adults, colorectal cancer is the second leading cancer that causes death worldwide. (medscape.com)
  • These include polyps, sporadic colorectal carcinoma (CRC) and familial colon cancer (familial adenomatous polyposis [FAP]), and hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
  • When discovered in children, they suggest one of several types of inherited colorectal cancer. (medscape.com)
  • Other kinds of cancer that may occur here include mucinous carinomas and adenosquamous carcinomas. (suamaytinhhaiphong.com)
  • The Continuous Update Project Panel judged there was convincing evidence that consuming steak, processed meat and alcoholic drinks (men) body fatness, abdominal fatness and adult achieved height increase the chance of colorectal cancer. (suamaytinhhaiphong.com)
  • Preventability estimates using the brand new findings in the Continuous Update Project reveal that about 47% of installments of colorectal cancer within the United kingdom could be avoided when you eat and consuming healthily, being physically active and looking after a proper weight. (suamaytinhhaiphong.com)
  • The countries using the top 20 greatest incidence of colorectal cancer this year receive within the tables below. (suamaytinhhaiphong.com)
  • Republic of Korea had the greatest rate of colorectal cancer, adopted by Slovakia and Hungary. (suamaytinhhaiphong.com)
  • About 54 percent of colorectal cancer cases happened in additional civilized world. (suamaytinhhaiphong.com)
  • The greatest incidence of colorectal cancer is at Oceania and Europe and also the cheapest incidence in Africa and Asia. (suamaytinhhaiphong.com)
  • Slovakia had the greatest rate of colorectal cancer this year, adopted by Hungary and Republic of Korea. (suamaytinhhaiphong.com)
  • Norwegian had the greatest rate of colorectal cancer this year, adopted by Denmark and also the Netherlands. (suamaytinhhaiphong.com)
  • It is difficult to separate epidemiological considerations of rectal cancer from those of colon cancer because studies often consider colon and rectal cancer together (i.e., colorectal cancer). (cancer.gov)
  • Worldwide, colorectal cancer is the third most common form of cancer. (cancer.gov)
  • In 2020, there were an estimated 1.93 million new cases of colorectal cancer and 935,173 deaths. (cancer.gov)
  • Colorectal cancer affects men and women almost equally. (cancer.gov)
  • Among all racial groups in the United States, Black individuals have the highest sporadic colorectal cancer incidence and mortality rates. (cancer.gov)
  • Family history of colorectal cancer in a first-degree relative. (cancer.gov)
  • Evidence supports screening for rectal cancer as a part of routine care for all adults aged 50 years and older, especially for those with first-degree relatives with colorectal cancer. (cancer.gov)
  • For more information, see Colorectal Cancer Screening . (cancer.gov)
  • Background: Breast's Invasive Ductal Carcinoma (IDC), which is the commonest type of malignancy in females worldwide, can be characterized using immunohistochemistry in view of personalized cancer therapy. (bvsalud.org)
  • BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in Nigeria, and it affects mostly persons in their middle age. (bvsalud.org)
  • OBJECTIVES: To evaluate the expression of COX-2 and HER2 and determine their correlation with clinicopathologic parameters in surgically resected histologically diagnosed cases of colorectal cancer. (bvsalud.org)
  • Colorectal cancer patients with lung metastasis had a higher risk of bone (10.0% vs 4.5%) or brain metastasis (3.1% vs 0.1%) than patients without lung metastases. (oncotarget.com)
  • Knowledge of these differences in metastatic patterns may help to better guide pre-treatment evaluation of colorectal cancer patients, especially in making determinations regarding curative-intent interventions. (oncotarget.com)
  • Colorectal cancer (CRC) is the third most commonly diagnosed cancer among men and women in the United States [ 1 , 2 ]. (oncotarget.com)
  • Though colon and rectum cancer are often referred to as colorectal cancer, they are actually distinct disease entities. (oncotarget.com)
  • Colorectal cancer is the third-leading cause of cancer related mortality in the United States. (mdpi.com)
  • Objective To evaluate the clinicopathological features and survival outcomes of mucinous ovarian cancer (MOC) patients in an Asian population. (thieme-connect.de)
  • 1 ] Mucinous ovarian cancer (MOC) is a rare subtype of malignant ovarian cancer. (thieme-connect.de)
  • In univariate analyses, there is significant (8.0 months vs. 41.0 months, P = 0.000) difference in OS between patients with gastrointestinal cancer origin from breast origin, and between patients with gastric origin from colorectal origin (7.4 months vs. 8.8 months, P = 0.036). (biomedcentral.com)
  • Capecitabine, a prodrug of 5-fluorouracil, is an FDA-approved drug for adjuvant treatment of colon, metastatic colorectal, and breast cancer. (nih.gov)
  • Liver and lungs are common locations of distant metastases of colorectal cancer. (biomedcentral.com)
  • Skin metastases of colorectal cancer are very rare, and facial lesions are extremely uncommon. (biomedcentral.com)
  • Skin metastases in the face from colorectal cancer are very rare and may indicate tumour relapse several years after primary resection. (biomedcentral.com)
  • We report the second case of the metastasis of the colorectal cancer to the lip. (biomedcentral.com)
  • Postoperative histological examination showed moderately differentiated metastasis of the colorectal cancer G2. (biomedcentral.com)
  • We have found only 15 articles describing metastases of colorectal cancer to the skin of head and neck. (biomedcentral.com)
  • One manuscript of these described facial metastasis involving oral commisure [ 5 ] and our manuscript report the second case of the metastasis of the colorectal cancer to the lip. (biomedcentral.com)
  • The most frequent localization of skin metastases of the colorectal cancer is abdomen, especially in the postoperative scars - up to 0.6% of all patients [ 3 ]. (biomedcentral.com)
  • Established cancer cell lines are widely used for developing biomarkers for the patient-specific treatment of colorectal cancer and predicting prognoses. (bslonline.org)
  • 2 × 10 5 cells/mL of each colorectal cancer cell was seeded into a 35 mm cell culture dish. (bslonline.org)
  • These results will be helpful in investigating the molecular basis of colorectal cancer. (bslonline.org)
  • However, surgery treatment, the most important method of colorectal cancer treatment, can cause complications such as intestinal obstruction, intra-abdominal infection, and changes in bowel movements. (bslonline.org)
  • With recent developments in medical technology, the introduction of the Clinical Pathway [CP], and the hospital's efforts to increase the surgical bed turnover rate, the period of hospitalization and treatment for colorectal cancer patients is becoming shorter. (bslonline.org)
  • Colorectal cancer dramatically impacts the patient's quality of life and various basic studies are being conducted to address this problem, which occurs partly because of the lack of biochemical, molecular, and biological biomarkers for early cancer detection and the monitoring of treatment progress. (bslonline.org)
  • Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
  • Загальні джерела літератури Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
  • Increasing evidence suggested that CD73 highly expressed in a wide range of cancer types, including breast cancer, colorectal cancer, glioblastoma, melanoma, prostate cancer, ovarian cancer, and non-small-cell lung cancer (NSCLC). (biomedcentral.com)
  • The younger patient had a greater frequency of advanced signs, later stages of cancer and mucoid carcinoma. (unboundmedicine.com)
  • Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. (medscape.com)
  • Before molecular genetic diagnostics became available in the 1990s, a comprehensive family history was the only basis from which to estimate the familial risk of colorectal cancer. (medscape.com)
  • In hereditary nonpolyposis colorectal cancer (HNPCC), an inherited mutation in one of the DNA mismatch repair (MMR) genes appears to be a critical factor. (medscape.com)
  • Wenhui Zhou, MD, PhD reviews a recent AJR article which compares the efficacy and safety of delayed versus upfront thermal ablation in the treatment of colorectal cancer liver oligometastases. (arrs.org)
  • Despite recent advances in the treatment of both early and advanced colorectal cancer, it remains the second leading cause of cancer deaths in the western world. (omicsonline.org)
  • Sprouty1 (SPRY1) appears to act as a tumour suppressor in cancer, whereas we demonstrated that SPRY2 functions as a putative oncogene in colorectal cancer. (omicsonline.org)
  • Colorectal cancer also has the highest number of new cancer cases (4007 cases) in the 2020 period. (org.sa)
  • Molecular pathology of colorectal cancer syndromes from Saudi patients. (org.sa)
  • Genetic risks for colorectal cancer in Saudi patients. (org.sa)
  • Somatic mutations in colorectal cancer from Saudi patients. (org.sa)
  • Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. (genomeweb.com)
  • Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. (genomeweb.com)
  • The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner. (biomedcentral.com)
  • PURPOSE: This nationwide study evaluated results of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis of colorectal origin in the Netherlands following a national protocol. (lu.se)
  • CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. (novodiax.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • Histopathological examination of the resected nodule confirmed the diagnosis of metastatic mucinous adenocarcinoma. (biomedcentral.com)
  • Therefore, Patients with mucinous adenocarcinoma should be followed carefully after surgery, and receive rapid diagnosis and treatment if recurrence is suspected. (biomedcentral.com)
  • We report a case in which 18 F-fluorodeoxyglucose positron emission/computed tomography ( 18 F-FDG PET/CT) was very useful for early diagnosis and planning a theraupetic strategy for a case of mucinous adenocarcinoma metastasis at a laparoscopic port site. (biomedcentral.com)
  • A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
  • pathologic diagnosis of adenocarcinoma of the colon. (medscape.com)
  • A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. (novodiax.com)
  • Aruj Chawla, DO discusses a study that brings about a novel method to analyze vascular involvement in pancreatic ductal adenocarcinomas. (arrs.org)
  • According to the data of one of the largest reviews of colorectal skin metastases, in 3 (3.9%) out of 77 patients they occurred at the site of postoperative scar [ 2 ]. (biomedcentral.com)
  • The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
  • Improving resectability of hepatic colorectal metastases: expert consensus statement. (cancercentrum.se)
  • Prognosis of intestinal mucinous adenocarcinoma is reported to be poorer than that of non-mucinous adenocarcinoma. (biomedcentral.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • Primary adenocarcinomas of the vulva are rare and especially the villoglandular mucinous adenocarcinoma of intestinal type is rare variant of vulvar adenocarcinoma. (hindawi.com)
  • In the published articles [ 2 ], intestinal type mucinous adenocarcinoma was also taken as a synonymous with villoglandular mucinous adenocarcinoma. (hindawi.com)
  • Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. (oncotarget.com)
  • To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
  • Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
  • Adenocarcinoma, Upper Gastro-Intestinal Tract. (booksdo.com)
  • Mucinous Carcinoma, Upper Gastro-Intestinal Tract. (booksdo.com)
  • Less common tumours of the appendix include signet-ring cell adenocarcinoma and paraganglioma . (cancerindex.org)
  • In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. (wjgnet.com)
  • She underwent appendicectomy and unilateral salpingo-oophorectomy.Histopathology revealed signet ring cell carcinoma and a right hemicolectomy was done. (wjgnet.com)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • E-cadherin, Gastric Carcinoma. (booksdo.com)
  • Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. (genomeweb.com)
  • HNPCC, accounts for 2-5% of all colorectal carcinomas. (medscape.com)
  • CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)
  • Locoregional therapies for hepatocellular carcinoma perform differently when compared by rates of complete pathologic necrosis of lesions. (arrs.org)
  • Special guest Dr. Zachary Berman, an interventional radiologist who specializes in locoregional therapies for hepatocellular carcinoma, joins us to discuss the implications for clinical practice. (arrs.org)
  • A 57-year-old man, who underwent laparoscopic surgery for advanced mucinous adenocarcinoma of the cecum 6 years prior, developed a nodule in the surgical wound at the lower right abdomen. (biomedcentral.com)
  • A 57-year-old man received curative laparoscopic ileocecal resection and lymph node dissection for carcinoma of the cecum in May 2004. (biomedcentral.com)
  • CT colonography shows a large polypoid adenocarcinoma in the cecum adjacent to the ileocecal valve. (medscape.com)
  • Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
  • Methods: The authors examined the staining characteristics and heterogeneity of CK7, TTF-1, NapsinA, CK20, CDX2, and SATB2 in resection specimens of pulmonary adenocarcinomas with mucinous features and metastatic colorectal adenocarcinoma. (wustl.edu)
  • A 2-cm, firm, ill-defined, tender mass was palpable in the incision site, and was suspected to be a recurrence of the cecal mucinous adenocarcinoma. (biomedcentral.com)
  • We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
  • A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
  • Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)
  • Mucinous cystadenocarcinoma account for about a fifth of appendix tumours, these produces mucin (a jelly-like substance). (cancerindex.org)
  • METHODS: Fifty-three paraffin-embedded tissue blocks of colorectal resections and corresponding patient information were retrieved from the archives of the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital.A 4-micron slide section was obtained from each specimen and immunohistochemistry for COX-2 and HER-2 expression was performed. (bvsalud.org)
  • Despite its drawbacks, immunohistochemistry is often employed to help assign a primary site for mucinous adenocarcinomas in the lung. (wustl.edu)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
  • Data queried for this analysis include colorectal adenocarcinoma (2010-2011) from the Surveillance, Epidemiology, and End Results Program (SEER) database. (oncotarget.com)