AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
MucinsAdenocarcinomaGastric MucinsAdenocarcinoma, MucinousPancreatic NeoplasmsLung NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalStomach NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarMucin-5BMucin-1ImmunohistochemistryCardiaColonic NeoplasmsMucin-4Tumor Markers, BiologicalEsophagogastric JunctionMucin-6Cell Line, TumorNeoplasm StagingPrognosisKeratin-7Gene Expression Regulation, NeoplasticMucin-3MetaplasiaCarcinoma, Squamous CellPrecancerous ConditionsGoblet CellsEndometrial NeoplasmsIntestinal NeoplasmsTumor Cells, CulturedNeoplasms, Multiple PrimaryImmunoenzyme TechniquesCarcinoma, Signet Ring CellProstatic NeoplasmsNeoplasm InvasivenessMammary Neoplasms, ExperimentalDuodenal NeoplasmsGastric MucosaCarcinoma, EndometrioidCecal NeoplasmsColorectal NeoplasmsAdenocarcinoma, Clear CellAntigens, Tumor-Associated, CarbohydrateRectal NeoplasmsRNA, MessengerMucusNeoplasm ProteinsSialomucinsAdenomaAntigens, NeoplasmKeratin-20Ampulla of VaterTissue Array AnalysisGenes, rasCommon Bile Duct NeoplasmsIntestinal MucosaCarcinoma, AdenosquamousIleal NeoplasmsCarcinoembryonic AntigenColonReverse Transcriptase Polymerase Chain ReactionNeoplasm MetastasisDNA, NeoplasmPancreaticoduodenectomyNeoplasm TransplantationSurvival RateLymphatic MetastasisCarcinoma, Acinar CellJejunal NeoplasmsEsophagusDisease ProgressionCarcinoma, Non-Small-Cell LungMolecular Sequence DataReceptor, Epidermal Growth FactorPeriodic Acid-Schiff ReactionMice, NudeEpithelial CellsBiopsySurvival AnalysisRetrospective StudiesAppendiceal NeoplasmsMutationPancreatic DuctsCarcinoma in SituGastrectomyKaplan-Meier EstimateAntineoplastic AgentsParanasal Sinus NeoplasmsGastrointestinal NeoplasmsCell ProliferationAntibodies, MonoclonalGene Expression ProfilingPancreatectomyFatal OutcomeGlycosylationTreatment Outcome
TumorsTumorCarcinomaNeoplasmLymphomaCarcinomas as well as malignantOvarianGlandularHistologicalDuctal adenocarcinomasMetastasisPrognosisPancreatic ductal adenocarcinomaMajority of malignantColorectalNeoplasmsIntracytoplasmicImmunohistochemicalGastrointestinal tractGlandsPrimarySignetEpitheliumLesionIntestinal typeAbstractNestsAdenomaMuc1CancersPrecursorCellsLungCervicalCA125MUC4AdjacentGeneEntericGallbladderExaminationProstaticEndometrioid
Tumors26
  • A study of SRCC colorectal cancers compared mucin-rich SRCC tumors and mucin-poor SRCC tumors. (wikipedia.org)
  • In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Clinically, such tumors were highly malignant and the prognosis was poor. (elsevierpure.com)
  • Tumors were classified according to the mucins in gastric type in 7/13 (MUC5AC positive) and intestinal type in 4/13 (MUC2 positive). (healthyconnectionsinc.com)
  • The pattern of mucin mainly indicated in the adjacent epithelium was connected to the mucin expression profile in the tumors p = 0.047. (healthyconnectionsinc.com)
  • The two types of tumors A-770041 developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation. (healthyconnectionsinc.com)
  • Within this review, histology, epigenetics and genetics of malignant pancreatic tumors and potential goals for treatment are discussed. (mslideas.com)
  • The primary microscopic differential medical diagnosis includes PDAC precursor lesions, various other malignant pancreatic tumors (Desk?1), adenocarcinoma and pancreatitis metastasis. (mslideas.com)
  • The study involved 17 patients, including 11 with malignant tumors and six with benign neoplasms. (medscape.com)
  • Malignant tumors of the appendix can be classified into mucinous epithelial neoplasms, neuroendocrine tumors (typical carcinoids), goblet cells or composite carcinoids, lymphomas, adenocarcinomas and lymphoid or mesenchymal sarcomas. (rojes.org)
  • Histologically, more than half of appendicular tumors are of neuroendocrine origin, while the rest are adenocarcinomas (mucinous, signet ring or non-mucin-secreting). (rojes.org)
  • others include papillary, medullary, and metaplastic carcinomas as well as malignant phyllodes tumors. (radiopaedia.org)
  • When compared with other malignant breast tumors, they show lower signal intensity on DWI and increased ADC values. (radiopaedia.org)
  • The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • This antibody is a useful aid for classification of a variety of tumors, such as some adenocarcinomas of the colon, breast carcinomas, malignant mesothelioma, uterine adenomatoid tumor, lung bronchoalveolar carcinoma, and ovarian endometrioid and serous carcinomas. (neobiotechnologies.com)
  • Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. (bmj.com)
  • Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein. (bmj.com)
  • Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
  • However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
  • Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)
  • mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
Tumor11
  • We report a case of 68-year-old woman who developed this very uncommon malignant tumor. (hindawi.com)
  • Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. (hindawi.com)
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
  • Various kinds mucin (MUC1, MUC3, MUC4, MUC5AC) and glycoprotein tumor antigens such as for example CA19-9 could be portrayed in PDAC [7C9]. (mslideas.com)
  • Open up in another home window Fig. 1 a Macroscopic appearance of the pancreatic ductal adenocarcinoma displaying a badly demarcated company white tumor in the pancreatic parenchyma (Tumor, pancreatic parenchyma, duodenum). (mslideas.com)
  • Signet ring cell carcinoma (SRC) is an adenocarcinoma in which more than 50% of the tumor consists of isolated or small groups of malignant cells containing intracytoplasmic mucins [ 1 ]. (biomedcentral.com)
  • There were scant epithelial components with residual normal ductules among chondromyxoid stroma, epithelial cells intermingled with mucin-positive cells, and calcified areas merging with viable and necrotic tumor. (scirp.org)
  • Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
Carcinoma11
Neoplasm6
  • The term fibroma is inappropriate because the neoplasm exhibits defined histologic features that differ from those of fibromas and may express malignant behavior. (medscape.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • A limited battery of immunoperoxidase stains (with appropriate positive and negative controls) was performed to determine the likely primary site for this malignant neoplasm. (cancer.org)
  • Malignant cells were of glandular structure, consistent with a neoplasm. (ispub.com)
  • It is considered the second commonest malignant ovarian neoplasm. (radiologycases.my)
Lymphoma2
  • Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. (medscape.com)
  • Accurate clinicopathologic recognition is crucial, particularly because KFD can be mistaken for malignant lymphoma. (medscape.com)
Carcinomas as well as malignant1
  • They are preferentially expressed by a variety of adenocarcinomas, including breast, prostate, ovarian and pancreatic carcinomas as well as malignant plasma cells of multiple myelomas. (sigmaaldrich.com)
Ovarian2
  • Ovarian cancer (OC) is the primary malignant gynecological cancer and accounts for the fifth leading cancer in women, mostly found in advance stage. (biomedcentral.com)
  • Microscopy: Section from the solid area of left ovarian mass show a malignant tumour infiltrating the stroma. (radiologycases.my)
Glandular2
  • Sections show fibrous connective tissue with dissecting pools of mucin associated with scanty strips of malignant glandular epithelium in keeping with metastatic mucinous adenocarcinoma. (cancer.org)
  • The tumour is composed of malignant cells arranged in glandular structures with back to back pattern and solid papillary with very scanty intervening stroma. (radiologycases.my)
Histological3
  • Histological examination showed metastatic adenocarcinoma of gallbladder origin. (ispub.com)
  • Background/Aim: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. (iiarjournals.org)
  • The aim of this study is to detect the expression of Notch-1 and analyze its clinicopathological or prognostic significance in different histological subtypes of Lung Adenocarcinomas (LADs). (biomedcentral.com)
Ductal adenocarcinomas1
  • Poorly differentiated ductal adenocarcinomas have significantly more smaller sized and irregular glands and significant pleomorphism. (mslideas.com)
Metastasis2
  • The most common primary site of colorectal metastasis is the breast, followed by the lung and malignant melanoma [ 1 ]. (hindawi.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Prognosis2
Pancreatic ductal adenocarcinoma5
Majority of malignant1
  • The majority of malignant tumours arise from epithelial tissue and metastasise to the lungs or other organs [1]. (scienceexhibitions.org)
Colorectal1
Neoplasms6
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • of most malignant pancreatic neoplasms and takes place at a indicate age group of 66?years [1]. (mslideas.com)
  • Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998. (rojes.org)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
Intracytoplasmic1
  • The cells have basally located and benign looking nucleoli with abundant intracytoplasmic mucin. (radiologycases.my)
Immunohistochemical1
  • In the tissue an immunohistochemical staining pattern was observed in 34 (68%) of the malignant tumours. (scienceexhibitions.org)
Gastrointestinal tract3
  • These findings were consistent with a mucin producing adenocarcinoma, most likely from the gastrointestinal tract. (ispub.com)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
  • Mucin genes are indicated throughout the human being gastrointestinal tract in a niche site specific way [13]. (healthyconnectionsinc.com)
Glands2
  • They showed, in addition, sharp outpouching and distension of the malignant glands by mucin, as well as leakage into stroma. (elsevierpure.com)
  • Some glands or spaces showed mucin-like or basophilic material. (hindawi.com)
Primary5
  • Primary adenocarcinomas of the vulva are rare and especially the villoglandular mucinous adenocarcinoma of intestinal type is rare variant of vulvar adenocarcinoma. (hindawi.com)
  • We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder. (biomedcentral.com)
  • Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers [ 1 ]. (biomedcentral.com)
  • We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder. (biomedcentral.com)
  • The patient developed a new left lung mass 5 years ago, which was diagnosed as a primary lung adenocarcinoma. (hindawi.com)
Signet2
  • SRCCs are named due to their resemblance to signet rings, which result from the formation of large vacuoles full of mucin that displaces the nucleus to the cell's periphery. (wikipedia.org)
  • The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. (biomedcentral.com)
Epithelium4
Lesion3
  • Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies [ 2 ]. (biomedcentral.com)
  • The mucin to cell ratio can vary from lesion to lesion. (radiopaedia.org)
  • Biopsy of any ulcerated lesion should include at least six specimens taken from around the lesion because of variable malignant transformation. (medscape.com)
Intestinal type3
Abstract1
  • abstract = "Eight cases of extremely well-differentiated adenocarcinoma of the cervix were collected for clinicohistopathologic study. (elsevierpure.com)
Nests2
  • Banal appearing columnar cells lined these mucous lakes, and nests of these cells were seen floating in the mucin (Figure 1 ). (biomedcentral.com)
  • Bladder washings and biopsies revealed copious amounts of mucin with associated malignant nests and single cells also consistent with mucinous adenocarcinoma. (biomedcentral.com)
Adenoma1
  • Kaku, T & Enjoji, M 1983, ' Extremely well-differentiated adenocarcinoma ("Adenoma malignum") of the cervix ', International Journal of Gynecological Pathology , vol. 2, no. 1, pp. 28-41. (elsevierpure.com)
Muc12
  • The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
  • Mucin 1 (Muc1) exhibits protective action by binding to pathogens and is also associated with cell signaling capacity. (sigmaaldrich.com)
Cancers3
  • Stomach cancers with both adenocarcinoma and some SRC (known as mixed-SRCC) exhibit more aggressive behavior than purely SRCC or non-SRCC histologies. (wikipedia.org)
  • On MRI, they are one of the few cancers that have very high signal intensity on T2-weighted images 2 which relates to the water component in mucin. (radiopaedia.org)
  • Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
Precursor1
Cells4
  • The pathology report showed that the hernia sac contained clusters of malignant cells adjacent to the lining. (ispub.com)
  • CEA was focally positive, Calretinin stains, mesothelial cells and mucin stains were positive. (ispub.com)
  • At pathological examination, the dominant feature is the presence of mucin within and surrounding cancer cells. (radiopaedia.org)
  • Microscopically, it is formed by large mucin lakes surrounded by mucus-producing cancer cells. (radiopaedia.org)
Lung1
  • According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, the diagnosis of LAD is changing from simple morphology into a comprehensive multidisciplinary classification. (biomedcentral.com)
Cervical1
CA1251
MUC41
  • citation needed] Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
Adjacent1
  • However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
Gene1
Enteric1
  • There is the hypothesis that such misplaced remnants transformed into a tubulovillous adenocarcinoma of enteric type. (hindawi.com)
Gallbladder3
  • Patients with adenocarcinoma of the gallbladder were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2016. (biomedcentral.com)
  • Of 22,781 gallbladder adenocarcinomas retrieved, 377 (1.7%) were SRC and the other 22,404 were non-SRC. (biomedcentral.com)
  • The adenocarcinoma of the gallbladder part in the SEER database diagnosed from 1973 to 2016 was the source of present analysis. (biomedcentral.com)
Examination2
  • On histologic examination, lakes of infiltrating mucin dissected through the muscularis propria of the bladder and into the perivesicular fat (Figure 2 ). (biomedcentral.com)
  • The histopathological examination of the appendectomy specimen established the diagnosis of infiltrative mucinous adenocarcinoma at the level of the adventitia. (rojes.org)
Prostatic1
  • Prostate biopsies showed mucinous adenocarcinoma in six of eight cores with large collections of mucin dissecting the prostatic parenchyma. (biomedcentral.com)
Endometrioid1