AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
MucinsMucin-5BGastric MucinsMucin-2Mucin 5ACMucin-4Mucin-3Mucin-6Mucin-1Goblet CellsMucusConjunctivaEar, MiddleRNA, MessengerMolecular Sequence DataTumor Markers, BiologicalTumor Necrosis Factor-alphaTumor BurdenTracheaEpithelial CellsCell Line, TumorBase SequenceGene ExpressionRespiratory MucosaColonic NeoplasmsGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionAdenocarcinomaAmino Acid SequenceIn Situ HybridizationWilms TumorNeoplasms, ExperimentalBronchiChromosomes, Human, Pair 11Genes, Tumor SuppressorEpitheliumCell LineTumor Suppressor Protein p53Carcinoid TumorIntestinal MucosaChinchillaImmunohistochemistryRepetitive Sequences, Nucleic AcidNeuroendocrine TumorsBlotting, NorthernTumor Suppressor ProteinsIntestine, SmallBrain NeoplasmsDNA PrimersTumor MicroenvironmentAntigens, NeoplasmMammary Neoplasms, ExperimentalUp-RegulationIntestinesPromoter Regions, GeneticDNA, ComplementaryCloning, MolecularNeovascularization, PathologicNeoplasm MetastasisSialomucinsTranscription, GeneticMice, Inbred BALB CTransplantation, HeterologousGenomic LibraryAntigens, Tumor-Associated, CarbohydrateNeoplasm ProteinsAntibodies, MonoclonalCell ProliferationPancreatic NeoplasmsGlycosylationGastrointestinal Stromal TumorsMice, Inbred C57BL
MicroenvironmentSolid tumorsMUC1MetastasisProteinsAntigenBiomarkersLymphocytesAntigensProteinImmunotherapyEpithelial cellsNecrosis factor alphaPancreaticPrognosisMUC16MUC5ACSolitary Fibrous TumorSecretion2022Aberrant expressionDifferentiated adenocarcinoma2023ReceptorCytotoxicImmunohistochemistryGlycoproteinsMUC3CancersCheckpointRecurrenceMacrophagesImmunosuppressiveLymphocyteApoptosisTissueAnti-tumorCellsPrimary tumorMalignant tumorGastric cancerSystemicSignaling pathwayImmunoglobulinMetastaticOncogenesGlycoproteinImmune-related genesCellTherapiesHumansInterleukinBreast cancerMutationSuppressionVariantsColorectalCancerConclusions
Microenvironment12
  • Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
  • Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
  • Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
  • Different tumor types can also design their specific microenvironment by encouraging tumor angiogenesis and stimulating peripheral immune tolerance. (biomedcentral.com)
  • Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)
  • Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
  • Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. (biomedcentral.com)
  • Furthermore, a comprehensive IPM-based analysis of how MUC16 mutation affected the tumor immune microenvironment (TIME) of LUAD was performed. (aging-us.com)
  • Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
  • Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
  • UCARTFAP, which is an allogeneic CAR-T product candidate targeting cancer associated fibroblasts (CAFs) in the tumor microenvironment. (thesavvynurse.com)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Solid tumors5
  • What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)
  • We continue to advance all of our UCART programs and, with the announcement of exciting new preclinical programs, we are now targeting solid tumors. (thesavvynurse.com)
  • The event provided an inside look at the Company's current and new product candidate pipeline, manufacturing capabilities, and proprietary technologies, including four new UCART preclinical programs targeting B-cell lymphomas and solid tumors. (thesavvynurse.com)
  • Our findings have immediate implications in the clinical treatment of advanced solid tumors. (bmj.com)
  • Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)
MUC112
  • The authors examined several loci (ERBB2, INT2, MUC1) for gene amplification or loss of heterozygosity by Southern blotting and for gene expression by immunohistochemistry in breast tumors from patient groups selected by survival. (nih.gov)
  • Loci on other chromosomes, 1 (muc1) and 17 (cmm86), also are being investigated in groups selected for differences in survival. (nih.gov)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • Patients who maintained high immunoreactivity for anti-MUC1 antibody had a better prognosis, whereas those with an increase in anti-MUC3 immunoreactivity had a poorer prognosis, as judged by tumour size, serosal invasion, and metastasis. (bmj.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • 3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
  • Various kinds mucin (MUC1, MUC3, MUC4, MUC5AC) and glycoprotein tumor antigens such as for example CA19-9 could be portrayed in PDAC [7C9]. (mslideas.com)
  • The transmembrane mucin MUC1 co- localizes with CFTR. (healthdrugpdf.com)
  • The expression of MUC1 was significantly lower in non-cardia and cardia tumor tissues than that in normal tissues. (biomedcentral.com)
  • Mucin 1 ( MUC1 ) is a kind of cell surface mucins and is abundant in mucosal tissues, especially in normal gastric epithelial cells [ 9 ]. (biomedcentral.com)
  • This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)
Metastasis13
  • The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
  • These tumors and accessories represent the hallmark characteristics that support tumor progression and lead to metastasis. (biomedcentral.com)
  • The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)
  • The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
  • The processes of tumor initiation, expansion, and metastasis are governed by the TIME, where immunosuppressive and antitumor immune crosstalk play an important role. (biomedcentral.com)
  • During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
  • BC is a highly heterogeneous disease that has been classified according to a variety of characteristics, such as histology, anatomical features (Tumor-Node-Metastasis staging system) ( 4 ), tumor grade and molecular traits. (spandidos-publications.com)
  • MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)
  • In particular, the overexpression of ERBB2 enhances the properties of tumour cells associated with increased cancer metastasis (invasiveness, angiogenicity, enhanced survival). (biomedres.us)
  • In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
  • Rat Muc4, a homologue of human MUC4, has been extensively studied in mammary gland tumours and has been shown to play an important role in epithelial growth, cell differentiation, cell-cell adhesion, metastasis, and tumour apoptosis. (bmj.com)
  • The primary microscopic differential medical diagnosis includes PDAC precursor lesions, various other malignant pancreatic tumors (Desk?1), adenocarcinoma and pancreatitis metastasis. (mslideas.com)
  • sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
Proteins8
  • Mucus is a hydrogel composed of water, salts, large mucin polymers, non-mucin proteins, lipids, and cellular debris [ 9 ] [ 10 ] . (encyclopedia.pub)
  • Lysine-specific demethylase 1 (LSD1) is a protein that modifies histone and non-histone proteins and is known to influence a wide variety of physiological processes. (biomedcentral.com)
  • Two A-770041 tumors did not communicate MUC2 or MUC5AC proteins. (healthyconnectionsinc.com)
  • The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
  • The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
  • it achieves this feat due to its unique gel-like texture imparted by proteins called mucins. (news-medical.net)
  • Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
  • In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
Antigen11
  • The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibodies (mAbs), has shaped therapeutic landscape of some type of cancers. (nih.gov)
  • Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
  • Note 1:** Carbohydrate Antigen 125 (CA-125), also known as cancer antigen 125, mucin 16, or MUC16, is a protein which in humans is encoded by the MUC16 gene. (cancer.gov)
  • Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
  • Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
  • One such mechanism involves the upregulation of immune checkpoints, such as programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), cluster of differentiation 86 (CD86)/cytotoxic T-lymphocyte antigen 4 (CTLA-4) [ 16 ]. (biomedcentral.com)
  • Antibodies of the IgG sub-class are bi-functional molecules, possessing a F(ab) domain, variable in sequence and responsible for the binding of antigen, and an Fc domain, constant in sequence and responsible for mediating a range of antibody effector functions [ 1 ]. (bmj.com)
  • In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
  • NEW YORK, Aug. 05, 2021 (GLOBE NEWSWIRE) - Cellectis S.A. (NASDAQ: CLLS - EURONEXT GROWTH: ALCLS) (the "Company"), a gene-editing platform company with clinical-stage immuno-oncology programs using allogeneic chimeric antigen receptor (CAR) T-cells and gene therapy programs for genetic diseases, today announced results for the three-month and first six-month periods ending June 30, 2021. (thesavvynurse.com)
  • Isolated B cells also imparted T cells with the CpG-associated phenotype and improved tumor immunity without the aid of additional antigen-presenting cells or other immune cells in the culture. (bmj.com)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
Biomarkers5
  • This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
  • A promising approach is measuring the presence of biomarkers to detect tumors at various stages and determine their specific characteristics, thus allowing for more personalized treatment. (spandidos-publications.com)
  • MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
  • The data on the prognostic and predictive role of the tumor molecular biomarkers, as well as on clinically used and cellular therapy approaches and developing targeted drugs are presented, and the prospects for the future research are outlined. (cttjournal.com)
  • Conclusion: The current experiment revealed changes in expression level of mucin genes and lncRNAs in CRC and its different stages, showing that they can be considered as biomarkers for diagnosis of this cancer. (sabanciuniv.edu)
Lymphocytes4
  • 4. CpG oligodeoxynucleotides enhance the activities of CD8+ cytotoxic T-lymphocytes generated by combined hMUC1 vaccination and hNIS radioiodine gene therapy. (patentschool.co.kr)
  • 4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
  • Methods In this study we investigated how tumor-specific murine CD8 + T cells and human tumor infiltrating lymphocytes (TILs) are impacted when expanded ex vivo with the TLR9 agonist CpG. (bmj.com)
  • Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
Antigens3
  • There are still significant barriers to therapeutic success because of tumor-specific antigens (TA) and toxicities associated with treatment [ 19 ]. (biomedcentral.com)
  • Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
  • Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
Protein7
  • Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. (wikipedia.org)
  • AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
  • These include the T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), TIGIT, and B-and T-lymphocyte-associated protein (BTLA) receptors associated with T cell exhaustion and V-domain immunoglobulin suppressor of T cell activation (VISTA), a receptor found on tumor-infiltrating myeloid cells. (biomedcentral.com)
  • 2. A novel chimeric DNA vaccine: enhancement of preventive and therapeutic efficacy of DNA vaccine by fusion of Mucin 1 to a heat shock protein 70 gene. (patentschool.co.kr)
  • The finding is the first time shown pro-tumour gene ERBB2 enable to modulate coagulation protein expression and clotting kinetics in breast cancer cells, it is via the PI3k/Akt pathways, which further supports the proposal that the state of the coagulation system in cancer is directly influenced by oncogenic transformation. (biomedres.us)
  • Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
  • A highly expressed protein in tumor cells, encoded by Tpt1 gene. (bvsalud.org)
Immunotherapy5
  • The complex interplay between cancer cells and the TIME influences the outcome of immunotherapy and other anticancer therapy (Fig. 1 ). (biomedcentral.com)
  • 5. In Vivo Scintigraphic Imaging of Antitumor Effects by Combined Radioiodine Therapy and Human Sodium Iodide Symporter Gene Immunotherapy. (patentschool.co.kr)
  • Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
  • Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
  • Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
Epithelial cells6
  • 15-Lipoxygenase-1 (15LO1) which is an enzyme in the fatty acid metabolism and its metabolite, 15-HETE, are highly expressed in asthma (which lead to the overexpression of MUC5AC) and are induced by IL-13 in human airway epithelial cells. (wikipedia.org)
  • 16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
  • The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
  • Mucin glycoprotein expression in IMPN epithelial cells within the cyst lining is routinely used to help characterize these IPMN subtypes by immunohistochemistry [ 12 ]. (gastrores.org)
Necrosis factor alpha1
  • Additionally, supplementing YH linearly and/or quadratically reduced jejunal crypt depth (Compact disc), tumor necrosis factor-alpha (TNF-) focus aswell as mucin 2, interleukin-6 (IL-6), IL-1, TNF-, nuclear aspect kappa B, and myeloid differentiation aspect 88 gene appearance amounts (p 0.05). (ubatubasat.com)
Pancreatic11
  • Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
  • We used the pancreatic adenocarcinoma cell line PANC-1 as a model to apply different chemotherapeutic protocols (monotherapy and combined therapy) using 5-Fluorouracil, Oxaliplatin, Irinotecan, Gemcitabine and Abraxane. (isciii.es)
  • After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them. (isciii.es)
  • Although surgical resection can be applied when the tumor is well defined (20% of cases) 1 , most patients with pancreatic cancer are treated with chemotherapy. (isciii.es)
  • We observed similar metabolic alterations that correlated with MUC16 expression in primary tumor tissue specimens from human pancreatic adenocarcinoma cancer patients. (oncotarget.com)
  • Pancreatic cancer is one of the deadliest malignancies and is the fourth leading cause of cancer-related deaths in the United States [ 1 ]. (oncotarget.com)
  • Within this review, histology, epigenetics and genetics of malignant pancreatic tumors and potential goals for treatment are discussed. (mslideas.com)
  • of most malignant pancreatic neoplasms and takes place at a indicate age group of 66?years [1]. (mslideas.com)
  • Open up in another home window Fig. 1 a Macroscopic appearance of the pancreatic ductal adenocarcinoma displaying a badly demarcated company white tumor in the pancreatic parenchyma (Tumor, pancreatic parenchyma, duodenum). (mslideas.com)
  • c Positive TP53 immunohistochemistry in pancreatic ductal adenocarcinoma indicative of gene mutation. (mslideas.com)
  • An elevated expression of CCN2 has also been detected by Northern blotting in human invasive mammary ductal carcinomas, dermatofibromas, pyogenic granuloma, endothelial cells of angiolipomas and angioleiomyomas, and in pancreatic tumors. (neuromics.com)
Prognosis4
  • Diploid tumors have been associated with a better clinical outcome, and increased ploidy correlates with other indicators of poor prognosis. (nih.gov)
  • Not only are there epidemiological differences in BC, there are also differences in tumor biology that affect the prognosis and response to treatment. (spandidos-publications.com)
  • Development and validation of a MUC16 mutation-associated immune prognostic model for lung adenocarcinoma %K MUC16, lung adenocarcinoma, immune prognostic model, prognosis, signature %X Mucin 16 (MUC16) mutation ranks third among all common mutations in lung adenocarcinoma (LUAD), and it has a certain effect on LUAD development and prognostic outcome. (aging-us.com)
  • ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
MUC162
  • This research aimed to analyze the effects of MUC16 mutation on LUAD immunophenotype regulation and determine the prognostic outcome using an immune prognostic model (IPM) built with immune-related genes. (aging-us.com)
  • Therefore, the aim of the present study was to investigate the expression of MUC15, MUC16, MUC20, PCAT1, CCAT1 and HOTAIR genes in colorectal cancer and its relationship with clinicopathological variables. (sabanciuniv.edu)
MUC5AC4
Solitary Fibrous Tumor1
  • The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
Secretion2
  • A number of processes are essential to maintain effective MCC including regulation of ion channel activity, ciliary beat frequency (CBF), mucin expression and secretion and mucus viscosity [ 8 ] . (encyclopedia.pub)
  • Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. (biomedcentral.com)
20222
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • Journal of translational medicine 2022 8 20 (1): 371. (cdc.gov)
Aberrant expression3
  • Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • It is believed that dysfunction in the expression of mucins and aberrant expression of some lncRNAs are associated with the occurrence and development of CRC. (sabanciuniv.edu)
Differentiated adenocarcinoma2
  • A carcinosarcoma neoplasm is a biphasic tumor in which the carcinomatous component is usually a poorly differentiated adenocarcinoma, an undifferentiated carcinoma, or a squamous cell. (medscape.com)
  • In the images below, the sarcomatous (spindle cell sarcoma) component of the tumor is dominant, with the smaller portion being poorly differentiated adenocarcinoma. (medscape.com)
20231
  • Scientific reports 2023 9 13 (1): 16302. (cdc.gov)
Receptor1
  • Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor α-Positive Breast Cancer. (accdis.cl)
Cytotoxic4
  • 1.The combination of ANT2 shRNA and hNIS radioiodine gene therapy increases CTL cytotoxic activity through the phenotypic modulation of cancer cells: combination treatment with ANT2 shRNA and I-131. (patentschool.co.kr)
  • 6. Human Sodium/Iodide Symporter (hNIS)-Mediated Radioiodine Gene Therapy Enhances the Killing Activities of Cytotoxic T Cells in a Mouse Tumor Model. (patentschool.co.kr)
  • On the one hand, tumor cells are under immunosurveillance in the presence of various proinflammatory cells, such as CD8 + cytotoxic T cells, CD4 + type 1 helper T (Th1) cells, and natural killer cells. (biomedcentral.com)
  • T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)
Immunohistochemistry1
  • METHODS: Expression of mucin genes in the UACL from small bowel tissue of patients with Crohn's disease was detected by in situ hybridisation, and localisation of the products by immunohistochemistry. (embl.de)
Glycoproteins2
  • The role of mucins, high molecular weight glycoproteins that comprise the mucus, in the pathophysiology of cystic fibrosis is currently being investigated. (healthdrugpdf.com)
  • BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)
MUC33
  • 05). Functional studies identified MUC3 as a candidate gene for the second association signal on 7q22.1. (ox.ac.uk)
  • In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1. (ox.ac.uk)
  • namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
Cancers1
  • The remarkable achievements witnessed in various cancers using monoclonal antibodies (mAb) targeting CTLA-4 and PD-1, exemplify the effectiveness and power of ICB therapy strategies [ 17 , 18 ]. (biomedcentral.com)
Checkpoint5
  • Recent studies have identified several new immune checkpoint targets, like lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), T cell immunoglobulin and ITIM domain (TIGIT), V-domain Ig suppressor of T cell activation (VISTA), and so on. (nih.gov)
  • 10, and be from the coding regions or canonical splice sites of 1,810 immune-related genes, including immune checkpoint genes ( 2 ). (cdc.gov)
  • The benefit of dual checkpoint blockade with anti CTLA-4 and anti PD-1 inhibitor over monotherapy with a CTLA-4 inhibitor has been shown, with durable disease control and improved overall survival (OS). (biomedcentral.com)
  • The present review focuses on circulating miRNAs in patients with TNBC, with an emphasis on their interaction with the immune response checkpoint genes PD‑1, PD‑L1 and CTLA4. (spandidos-publications.com)
  • Based on the findings of this literature review and the in silico analysis performed as part of this review, it is concluded that circulating hsa‑miR‑195 and hsa‑miR‑155 in TNBC interact with checkpoint genes involved in the immune response. (spandidos-publications.com)
Recurrence1
  • Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. (isciii.es)
Macrophages1
  • The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
Immunosuppressive1
  • While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)
Lymphocyte1
  • Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. (biomedcentral.com)
Apoptosis3
  • 3. The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1. (patentschool.co.kr)
  • 5. Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo. (patentschool.co.kr)
  • 6. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. (patentschool.co.kr)
Tissue5
  • Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)
  • In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
  • It has been proposed that oncogenes (EGFR (ERBB), MET) and tumor suppressors (PTEN, TP53) may also be capable of altering the vesicular release of tissue factor (TF) from cells [4-6]. (biomedres.us)
  • Matched Molecular Profiling of Cell-Free DNA and Tumor Tissue in Patients With Advanced Clear Cell Renal Cell Carcinoma. (cdc.gov)
  • However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
Anti-tumor2
  • TIGIT is known to exert immune suppressive functions, such as inhibiting T cell activation, proliferation, and functions that inhibit inflammation and anti-tumor responses. (cdc.gov)
  • Alternative inhibitory receptors have been identified that may also be targeted for anti-tumor immune therapy. (biomedcentral.com)
Cells22
  • Goblet cells are filled with mucin (MUC). (wikipedia.org)
  • We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
  • The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
  • Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
  • During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
  • The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
  • A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. (cdc.gov)
  • We investigated TIGIT gene expression in T cells of the patient from our study (Co45), a 43-year-old man, and compared it with 2 other sex- and age-matched patients who had severe COVID-19 (Co6 and Co84) ( Appendix ). (cdc.gov)
  • We collected peripheral blood mononuclear cells (PBMCs) from each of the patients 1 month after they recovered. (cdc.gov)
  • Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
  • This innovative approach enhances the patient's immune system to target and eliminate tumor cells. (biomedcentral.com)
  • However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)
  • There are considerable evidences suggested that a hypercoagulable or prothrombotic state of malignancy occurs due to the ability of tumor cells to activate the coagulation system. (biomedres.us)
  • 201T and CALU-3 airway tumor cells were grown to confluency in cell culture plates and Transwell (Costar) filters, respectively, at 37°C in Dulbecco's Modified Eagle's medium with 15% fetal bovine serum. (healthdrugpdf.com)
  • Results Herein we reveal a new way to reverse the tolerant state of adoptively transferred CD8 + T cells against tumors using TLR-activated B cells. (bmj.com)
  • In agreement with CCN2 playing a role in brain tumor angiogenesis, immunocytochemistry studies indicated that both glioblastoma tumor cells and proliferating endothelial cells stained positive for CCN2. (neuromics.com)
  • Gene profiling analysis allowed to identify a set of about 50 genes whose expression might account for the proliferative activity of CCN2 in these cells. (neuromics.com)
  • Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
  • A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
  • Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
  • This process theoretically provides a line of T cells with greater tumor specificity than those obtained from the blood. (msdmanuals.com)
  • TAAs) with high specificity to tumor cells. (msdmanuals.com)
Primary tumor1
  • In adults, myxomas are the most common primary tumor of the heart. (medscape.com)
Malignant tumor2
  • By definition, carcinosarcoma is a biphasic malignant tumor with a carcinomatous component and a sarcomatous component. (medscape.com)
  • BC is a heterogeneous malignant tumor that develops in the mammary gland. (spandidos-publications.com)
Gastric cancer1
  • α1,4- Linked N- acetylglucosamine suppresses gastric cancer development by inhibiting Mucin-1-mediated signaling. (tamagawa-seiki.com)
Systemic2
  • Moreover, ~1% of the ingested HMOs are absorbed, reach the systemic circulation and are excreted in urine without being metabolized ( 2 ). (frontiersin.org)
  • Venous thromboembolism (VTE) and cancer are strongly associated, as the local or systemic activation of blood coagulation can be produced by tumor products and favours tumor spread. (biomedres.us)
Signaling pathway1
  • 1. Mucin 1 enhances the tumor angiogenic response by activation of the AKT signaling pathway. (patentschool.co.kr)
Immunoglobulin1
  • Of note, we identified a heterozygous nonsense variant (rs1386709957) in the T-cell immunoglobulin and ITIM domain ( TIGIT ) gene in 1 patient ( Appendix Figure 1). (cdc.gov)
Metastatic1
  • The inhibition of two immune checkpoints, LAG-3 using relatlimab and PD-1, improved progression-free survival (PFS) to a greater extent than inhibition of PD-1 alone in patients with previously untreated metastatic or unresectable melanoma. (biomedcentral.com)
Oncogenes1
  • Attempts to define molecular markers have used probes of different chromosomal sites, some chosen because of logical associations with hormonal activity, known oncogenes, or tumor-suppressor genes, and some by chance. (nih.gov)
Glycoprotein1
  • However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
Immune-related genes1
  • An IPM was then constructed using differentially expressed immune-related genes (DEIRGs) in MUC16MUT LUAD cases, and the data were compared with those of MUC16WT LUAD cases. (aging-us.com)
Cell25
  • Once, in the nucleus, STAT6 heterodimer molecule regulates gene expression of cell types critical to the balance between host immune defense and allergic inflammatory responses such as the development of Th2. (wikipedia.org)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
  • Gotte et al hypothesized that the tumor originates from a myoepithelial cell precursor. (medscape.com)
  • Therefore, understanding the TME and its immune cell components are equally important as cancer cell characteristics for tumor eradication. (biomedcentral.com)
  • Renal cell carcinoma (RCC) is diagnosed annually in around 430,000 cases worldwide, resulting in approximately 179,000 deaths [ 1 ]. (e-crt.org)
  • Antibodies targeting T-cell inhibitory pathways, such as CTLA-4 and PD-1/PD-L1, are emerging as an important class of cancer therapeutics, and a next generation of immunomodulatory therapies targeting alternative inhibitory (e.g. (bmj.com)
  • The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
  • The two types of tumors A-770041 developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation. (healthyconnectionsinc.com)
  • In macroscopic type Become can be classified for as long when the columnar epithelium can A-770041 be much longer than 3 cm and brief when is leaner than 3 cm [1 2 Become can be a complicated mosaic of cell gland and architectural types displaying variable examples of atrophy and maturation toward intestinal and gastric epithelium. (healthyconnectionsinc.com)
  • Although the mechanisms underlying this association are not completely understood, the blood coagulation system is now known to have an influence on a wide range of differing aspects of tumor cell biology that are associated with clotting factor dependent signaling within the tumor cell. (biomedres.us)
  • A Rare Case of Synchronous Fumarate Hydratase-Deficient Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma With Fumarate Hydratase and von Hippel-Lindau Gene Mutations: A Clinicopathologic and Molecular Study. (cdc.gov)
  • Exploring the Characteristics of Circulating Tumor DNA in Pt1a Clear Cell Renal Cell Carcinoma: A Pilot Study. (cdc.gov)
  • Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden found that this human-specific gene, when introduced into the developing brain of ferrets, can cause an enlargement of their neocortex. (biotechnology.report)
  • Poseida is engaged in the research and development of cell and gene therapies for cancer and rare genetic diseases by leveraging its proprietary genetic editing platforms. (biotechnology.report)
  • In oncology, Poseida has a broad pipeline of allogeneic CAR-T cell therapy product candidates for both solid and liquid tumors, including P-MUC1C-ALLO1, which is in Phase 1 development for the treatment of multiple solid tumor indications. (biotechnology.report)
  • We are excited to enter this strategic relationship with Astellas, a premier biopharmaceutical company that shares our long-term vision that cell and gene therapies represent an exciting growth area for the development of innovative medicines for improving patient care,' said Mark Gergen, Poseida's Chief Executive Officer. (biotechnology.report)
  • Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)
  • Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
  • Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. (biomedcentral.com)
  • Cellectis presented preliminary translational data from the first group of patients enrolled in the MELANI-01 trial of UCARTCS1 at the virtual American Society of Gene and Cell Therapy (ASGCT) 24th annual meeting. (thesavvynurse.com)
  • Module III contains sequences sharing identity with the Thrombospondin type 1 repeat (TSP1) (WSXCSXXCG), which is thought to be implicated in the binding of sulfated glycoconjugates and to be important for cell adhesion. (neuromics.com)
  • In astrocytomas, CCN2 expression was particularly elevated in high grade tumors, with a marked effect of CCN2 on cell proliferation. (neuromics.com)
  • For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs. (news-medical.net)
  • He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
  • Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)
Therapies1
  • PD-1 and CTLA-4 targeting therapies increase average life expectancy for cancer patients. (biomedcentral.com)
Humans1
Interleukin1
  • The chicken-specific enzyme-linked immuno sorbent assay quantification sets (Position Gene, Nanjing, China) had been used to gauge the concentrations of tumor necrosis aspect (TNF-) and interleukin 10 (IL-10) in the jejunal mucosal examples predicated on the producers instructions. (ubatubasat.com)
Breast cancer6
  • Identifying markers that have the potential to predict tumor behavior is important in breast cancer because of the variability in clinical disease progression. (nih.gov)
  • TNFα-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer. (accdis.cl)
  • Impact of High-to-Moderate Penetrance Genes on Genetic Testing: Looking over Breast Cancer. (cdc.gov)
  • According to the global cancer database (GLOBOCAN), 34650951 cases of breast cancer were detected in the world in 2020, and 11210413 patients died from this disease [1, 2]. (cttjournal.com)
  • Molecular defects are often represented by hereditary BRCA (Breast cancer gene) mutations leading to altered DNA repair, thus presuming higher efficiency of DNA-damaging agents, such as platinum drugs and poly-ADP-ribose polymerase (PARP) inhibitors. (cttjournal.com)
  • The inclusion criteria were (abnormal serum levels of CEA or breast cancer [1-3]. (who.int)
Mutation2
  • Analysis revealed marked genomic and immunogenic heterogeneity, but immune gene expression profiles highly correlated with mutation profiles. (bvsalud.org)
  • and and and or gene mutation are delicate to poly ADP ribose polymerase (PARP)-inhibitors [19C21]. (mslideas.com)
Suppression1
  • Also, Tpt1 identified as a direct target gene of P53 tumor suppression. (bvsalud.org)
Variants4
  • Overall, salivary gland type-tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high-grade variants exist for many of these tumour types. (bvsalud.org)
  • In our patient cohort, exome sequencing identified no variants in type I interferon genes, which previously have been commonly observed in patients with severe COVID-19 ( 4 ). (cdc.gov)
  • We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. (ox.ac.uk)
  • UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)
Colorectal2
  • Results: The results of the present study showed that the expression of MUC15 (P = 0.0012), MUC20 (P = 0.009) and CCAT1 (P = 0.001) genes in patients with colorectal cancer were significantly different from tumor margin samples. (sabanciuniv.edu)
  • There were also associations between the expression of the studied genes and clinicopathological variables such as grade and stage of colorectal cancer tumor as well as the age of the patients. (sabanciuniv.edu)
Cancer4
  • 1 Michigan Cancer Foundation, Cancer Genetics/Cytogenetics, Detroit. (nih.gov)
  • During the thrombophilic state observed in cancer patients of different origins, the presence of circulating TF-bearing MVs in plasma has been used to explain why cancer patients may present a thromboembolic event distant from the location of tumour development [1]. (biomedres.us)
  • Associations between Arsenic (+3 Oxidation State) Methyltransferase (AS3MT) and N-6 Adenine-specific DNA Methyltransferase 1 (N6AMT1) Polymorphisms, Arsenic Metabolism, and Cancer Risk in a Chilean Population. (accdis.cl)
  • Cancer Gene Therapy. (elsevierpure.com)
Conclusions1