• Description: A sandwich ELISA kit for detection of Mucin 7, Secreted from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (pharmas-eu.org)
  • Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation , apoptosis , [3] metabolism , homeostasis , immune response , wound repair , [4] and endocrine function. (wikidoc.org)
  • We found that apoptosis and pyroptosis occurred in MUC20-silenced gastric SRCC cells. (sdlifesciences.com)
  • Our data clearly reflect such tumor promotion, showing that deregulation of key proteins involved in apoptosis (BCL2-related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1, and NIN), and metastasis (matrix metalloproteinase 1) is closely correlated with the levels of EBV gene expression in NPC. (gsea-msigdb.org)
  • MUC20, an upregulated novel gene in the renal tissues of patients with IgA nephropathy (IgAN), was recently identified. (scienceopen.com)
  • To identify the molecular mechanisms by which EBV-associated epithelial cancers are maintained, we measured the expression of essentially all human genes and all latent EBV genes in a collection of 31 laser-captured, microdissected nasopharyngeal carcinoma (NPC) tissue samples and 10 normal nasopharyngeal tissues. (gsea-msigdb.org)
  • Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney , thymus , stomach , breast , adult liver and erythrocyte. (wikidoc.org)
  • The two homologous genes, NIA1 and NIA2 , encode nitrate reductases in Arabidopsis , which govern the reduction of nitrate to nitrite. (sdlifesciences.com)
  • Exons 1, 2 and most of exon 3 encode the N-terminal extracellular domain while the remainder of exon 3 and exon 4 encode transmembrane and cytoplasmic domains. (wikidoc.org)
  • In a study of this gene among the Hominoidea two finding unique to humans emerged: (1) an excess of non-synonymous divergence among species that appears to be caused solely by accelerated evolution and (2) the ability of the single GYPC gene to encode both the GPC and GPD proteins. (wikidoc.org)
  • Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue. (gsea-msigdb.org)
  • [10] In addition, both complexes are derived from the same family of related genes and proteins but differ in their subunit composition. (wikidoc.org)
  • In vivo, we examined chemoresistance using MUC20 variant 2 (MUC20v2)-overexpressing non-SRCC cells to construct a xenograft mouse model. (sdlifesciences.com)
  • Among the human genes whose inhibition was most strongly correlated with increased EBV gene expression were multiple MHC class I HLA genes involved in regulating immune response via antigen presentation. (gsea-msigdb.org)
  • The frequencies of the alleles and genotypes of MUC20 VNTR polymorphisms did not differ between patients with IgAN and healthy controls. (scienceopen.com)
  • A gene expression dataset of breast cancer patients was used to construct a network identifying key regulators in breast cancer. (bvsalud.org)
  • In the present study, we investigated a possible association of MUC20 VNTR polymorphism with the clinical manifestations and progression in patients with IgAN. (scienceopen.com)
  • by direct sequencing and investigated the role of MUC20 in GC progression using GC cells with MUC20 silencing and forced expression. (sdlifesciences.com)
  • We focused on MUC20 and investigated its role in GC progression. (sdlifesciences.com)
  • The present study revealed that there is no association between the VNTR polymorphism of the MUC20 gene and the clinical manifestations in IgAN patients at the time of renal biopsy. (scienceopen.com)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
  • The association between EBV gene expression and inhibition of MHC class I HLA expression implies that antigen display is either directly inhibited by EBV, facilitating immune evasion by tumor cells, and/or that tumor cells with inhibited presentation are selected for their ability to sustain higher levels of EBV to take maximum advantage of EBV oncogene-mediated tumor-promoting actions. (gsea-msigdb.org)
  • B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
  • Overexpressed genes were identified with BioXpress, and then curated genes were used to construct the BC interactome network. (bvsalud.org)
  • Survival analysis revealed that GC patients with high MUC20 expression exhibited a poor prognosis and that MUC20 expression was significantly correlated with SRCC histological type. (sdlifesciences.com)
  • Global gene expression profiles clearly distinguished tumors from normal healthy epithelium. (gsea-msigdb.org)
  • Expression levels of six viral genes (EBNA1, EBNA2, EBNA3A, EBNA3B, LMP1, and LMP2A) were correlated among themselves and strongly inversely correlated with the expression of a large subset of host genes. (gsea-msigdb.org)
  • In melanocytic cells Glycophorin C gene expression may be regulated by MITF . (wikidoc.org)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • Human KIM-1 exhibits homology to a monkey gene, hepatitis A virus cell receptor 1 (HAVcr-1), which was identified recently as a receptor for the hepatitis A virus. (scienceopen.com)
  • The gene for human PF4 is located on human chromosome 4 . (wikidoc.org)
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikidoc.org)
  • Glycophorin C (GPC) is a single polypeptide chain of 128 amino acids and is encoded by a gene on the long arm of chromosome 2 (2q14-q21). (wikidoc.org)
  • Mucins in cancer: protection and control of the cell surface. (scienceopen.com)
  • As a result of selecting the genes with the highest degree from the BC network and tracing them, three of them were identified as novel key regulators, since they were involved at all network levels, thus serving as the backbone. (bvsalud.org)
  • Originally it was thought that glycophorin C and D were the result of a gene duplication event but it was only later realised that they were encoded by the same gene. (wikidoc.org)
  • The present study aims to identify discrete inference of FTO alpha-ketoglutarate dependent dioxygenase gene linkage disequilibrium block SNPs rs9940128 and rs9939609 as prognostic genetic elements in defining the disease course either as BrC or NIDDM in Pakistani population. (bvsalud.org)
  • We analyzed a comprehensive GC cell line database to identify the specifically expressed genes in gastric SRCC. (sdlifesciences.com)
  • These mucins can be broadly classified into either secreted gel-forming mucins, those that provide the structural backbone for the mucus barrier, or transmembrane mucins, those that form the glycocalyx layer covering the underlying epithelial cells. (frontiersin.org)
  • The mucus layer, particularly through its transmembrane components, also influences several cell signaling pathways that can modulate inflammatory responses, impact cell-cell interactions as well as regulate proliferation, differentiation and apoptosis ( 4 - 6 ). (frontiersin.org)
  • Goblet cells dispersed among the intestinal epithelial cells are chiefly responsible for the synthesis and secretion of mucins within the gut and are heavily influenced by interactions with the immune system. (frontiersin.org)
  • The current review aims to highlight the structural and functional features as well as the production and immunological regulation of mucins and the impact these key elements have within the context of barrier function and host defense in intestinal inflammation. (frontiersin.org)
  • The intestinal mucus layer is principally comprised of a subset of high molecular weight glycoproteins called mucins, which play a crucial role in physical protection as well as in regulating the concentration and passage of water, ions, and other immune mediators such as antimicrobial peptides (AMPs) and immunoglobulin-A (IgA) within the gut ( 2 , 3 , 7 ). (frontiersin.org)
  • The GB is composed of the intestinal epithelial barrier (IEB) and of the mucus layer containing mucins and antimicrobial peptides (AMPs) that are crucial to maintain immune tolerance. (bvsalud.org)
  • Mucus layer alterations correlated with reduced relative abundance of short chain fatty acids (SCFA)-producing bacteria such as Bifidobacterium dentium, Clostridium butyricum and Roseburia intestinalis that regulate mucin expression and intestinal immune homeostasis. (bvsalud.org)
  • Mechanistically, the loss of p300 in Tet2-deficient HSPCs altered enhancer accessibility and the expression of genes associated with differentiation, proliferation, and leukemia development. (jci.org)
  • FINDINGS: Our data show a GB damage with mucus layer alterations and reduced mRNA expression of several mucins (MUC2, MUC12, MUC13, MUC15, MUC20, MUC21) and AMPs (HD4 and HD5) in T1D patients. (bvsalud.org)
  • The signaling pathways and cellular processes associated with the mutated genes were identified with gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. (nih.gov)
  • 13. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. (nih.gov)
  • 4. Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. (nih.gov)
  • 1, 3, 4] Some cases (19%) have been reported in the submandibular gland. (medscape.com)