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MucinsAdenocarcinomaGastric MucinsAdenocarcinoma, MucinousPancreatic NeoplasmsLung NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalStomach NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarMucin-5BMucin-1ImmunohistochemistryCardiaColonic NeoplasmsMucin-4Tumor Markers, BiologicalEsophagogastric JunctionMucin-6Cell Line, TumorNeoplasm StagingPrognosisKeratin-7Gene Expression Regulation, NeoplasticMucin-3MetaplasiaCarcinoma, Squamous CellPrecancerous ConditionsGoblet CellsEndometrial NeoplasmsIntestinal NeoplasmsTumor Cells, CulturedNeoplasms, Multiple PrimaryImmunoenzyme TechniquesCarcinoma, Signet Ring CellProstatic NeoplasmsNeoplasm InvasivenessMammary Neoplasms, ExperimentalDuodenal NeoplasmsGastric MucosaCarcinoma, EndometrioidCecal NeoplasmsColorectal NeoplasmsAdenocarcinoma, Clear CellAntigens, Tumor-Associated, CarbohydrateRectal NeoplasmsRNA, MessengerMucusNeoplasm ProteinsSialomucinsAdenomaAntigens, NeoplasmKeratin-20Ampulla of VaterTissue Array AnalysisGenes, rasCommon Bile Duct NeoplasmsIntestinal MucosaCarcinoma, AdenosquamousIleal NeoplasmsCarcinoembryonic AntigenColonReverse Transcriptase Polymerase Chain ReactionNeoplasm MetastasisDNA, NeoplasmPancreaticoduodenectomyNeoplasm TransplantationSurvival RateLymphatic MetastasisCarcinoma, Acinar CellJejunal NeoplasmsEsophagusDisease ProgressionCarcinoma, Non-Small-Cell LungMolecular Sequence DataReceptor, Epidermal Growth FactorPeriodic Acid-Schiff ReactionMice, NudeEpithelial CellsBiopsySurvival AnalysisRetrospective StudiesAppendiceal NeoplasmsMutationPancreatic DuctsCarcinoma in SituGastrectomyKaplan-Meier EstimateAntineoplastic AgentsParanasal Sinus NeoplasmsGastrointestinal NeoplasmsCell ProliferationAntibodies, MonoclonalGene Expression ProfilingPancreatectomyFatal OutcomeGlycosylationTreatment Outcome
CarcinomaMucinousTumorsPrognosisDuctal adenocarcinomaIntracytoplasmic mucinPatients with adenocarcinomaCarcinomasNeoplasmsSignet-ringEpitheliumMetastatic adenocarcinomaEndocervical adenocarcinomaIntestinal-typeEpithelialAdenomaCancerGlandularMUC2MUC1CarcinogenesisHistologicMalignancyProgressionCancersEndometrioidAbstractGastrointestinal tractBarrett'sPrognosticExpressionCDX2FindingsPathologyCribriformUterineMitoticMembraneMetastasesPrimaryGeneStainsCompositeGlandsSubtypesPeripheral
Carcinoma11
  • The most common paraneoplastic syndromes associated with adenocarcinoma of the lung are described below: Hypercalcemia of malignancy is more common in squamous cell carcinoma of the lung, but can occur in adenocarcinoma as well. (wikipedia.org)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion (SMILE). (techscience.com)
  • 2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)
  • Hazara virus (HAZV) and Dugbe virus (DUGV), and par- man adrenal cortex carcinoma), HeLa (human cervical tial sequences are available for many other members of the adenocarcinoma), HUH-7 (human hepatocarcinoma), and C6/36 ( Aedes albopictus mosquito) cells in culture. (cdc.gov)
Mucinous10
Tumors4
Prognosis2
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • Development and validation of a MUC16 mutation-associated immune prognostic model for lung adenocarcinoma %K MUC16, lung adenocarcinoma, immune prognostic model, prognosis, signature %X Mucin 16 (MUC16) mutation ranks third among all common mutations in lung adenocarcinoma (LUAD), and it has a certain effect on LUAD development and prognostic outcome. (aging-us.com)
Ductal adenocarcinoma3
  • Pancreatic ductal adenocarcinoma (PDAC) accounts for about 95% of pancreatic cancer cases and is considered the most aggressive type of pancreatic cancer [ 2 ]. (oncotarget.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
  • Surveillance after resection of pancreatic ductal adenocarcinoma: How to do it and what are the benefits? (lu.se)
Intracytoplasmic mucin1
  • The cells have basally located and benign looking nucleoli with abundant intracytoplasmic mucin. (radiologycases.my)
Patients with adenocarcinoma2
Carcinomas3
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • They are preferentially expressed by a variety of adenocarcinomas, including breast, prostate, ovarian and pancreatic carcinomas as well as malignant plasma cells of multiple myelomas. (sigmaaldrich.com)
  • Under a microscope, large cell carcinomas do not resemble adenocarcinomas or squamous cell carcinomas. (mesolawsuitafterdeath.com)
Neoplasms1
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Signet-ring1
Epithelium3
  • In specific Become there is solid manifestation of MUC2 in the goblet cells (intestinal mucin A-770041 design) and MUC5AC in the superficial columnar epithelium (gastric mucin design) [14]. (healthyconnectionsinc.com)
  • From these pathological findings, we concluded that the disease was an intraepithelial adenocarcinoma, possibly derived from multipotential cells in squamous epithelium of ovarian mature cystic teratoma. (nih.gov)
  • A fourth case had glandular and papillary formations with pseudostratified columnar epithelium and mucin secretion, showing positivity for CK7, ER, and P16, and negativity for prostatic markers, suggesting serous differentiation (although negative for PAX8 and WT1). (johnshopkins.edu)
Metastatic adenocarcinoma1
Endocervical adenocarcinoma1
Intestinal-type2
Epithelial4
  • Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
  • In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
  • namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
  • The intestinal epithelial cell layer mediates selective protection against luminal contents by forming junctional complexes and releasing protective components like phospholipids, mucins, trefoil factor proteins, defensins, and secretory dimeric immunglobulins. (uni-regensburg.de)
Adenoma1
Cancer4
  • Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by distinct cellular and molecular features. (wikipedia.org)
  • Adenocarcinoma is more common in patients with a history of cigarette smoking, and is the most common form of lung cancer in younger women and Asian populations. (wikipedia.org)
  • citation needed] Adenocarcinoma, like other forms of lung cancer, is usually advanced or metastatic at time of diagnosis. (wikipedia.org)
  • We observed similar metabolic alterations that correlated with MUC16 expression in primary tumor tissue specimens from human pancreatic adenocarcinoma cancer patients. (oncotarget.com)
Glandular1
  • Adenocarcinoma arises from the glandular cells that line the inner surface of the colon and rectum. (ashishealth.com)
MUC21
  • Bei der allelischen Diskriminierung von Mucin Polymorphismen ergab sich für MUC2-V116M (P=0,003) eine statistisch signifikante Assoziation mit Morbus Crohn, während MUC4-A585S (P=0,025) und MUC13-R502S (P=0,0003) mit Colitis ulcerosa assoziiert waren, was eine kausale Rolle der Mucine in der Prädisposition von CED vermuten lässt. (uni-regensburg.de)
MUC12
  • The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
  • Mucin 1 (Muc1) exhibits protective action by binding to pathogens and is also associated with cell signaling capacity. (sigmaaldrich.com)
Carcinogenesis2
Histologic2
  • The pathophysiology of adenocarcinoma is complicated, but generally follows a histologic progression from cells found in healthy lungs to distinctly dysmorphic, or irregular cells. (wikipedia.org)
  • We describe the histologic, immunohistochemical, and clinical findings of 4 patients with Skene's gland adenocarcinoma retrieved from the Johns Hopkins Urologic Pathology Consult Service from 1984 to 2017. (johnshopkins.edu)
Malignancy1
  • It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs). (nih.gov)
Progression1
Cancers2
Endometrioid1
Abstract1
Gastrointestinal tract3
  • Mucin genes are indicated throughout the human being gastrointestinal tract in a niche site specific way [13]. (healthyconnectionsinc.com)
  • These findings were consistent with a mucin producing adenocarcinoma, most likely from the gastrointestinal tract. (ispub.com)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
Barrett's1
Prognostic1
Expression2
  • The pattern of expression of mucin gene products in adenocarcinoma arising in BE has yet to be known. (healthyconnectionsinc.com)
  • Im intestinalen LS174T Zellkulturmodell führten Stimulationen mit den Zytokinen Tumor Nekrose Faktor alpha (TNFa) und Transformierender Wachstumsfaktor beta (TGFb) zu einer Induktion der Mucin Expression, die durch die beiden NFkB Hemmer Caffeic Acid Phenethyl Ester (CAPE) und Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal (MG132) verhindert werden konnte. (uni-regensburg.de)
CDX21
  • Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. (hindawi.com)
Findings1
  • Our findings demonstrate that Skene's gland adenocarcinomas recapitulate morphologies and immunohistochemical markers seen in prostatic adenocarcinoma. (johnshopkins.edu)
Pathology1
  • Tregnago, AC & Epstein, JI 2018, ' Skene's Glands Adenocarcinoma: A Series of 4 Cases ', American Journal of Surgical Pathology , vol. 42, no. 11, pp. 1513-1521. (johnshopkins.edu)
Cribriform1
  • Three of our cases were morphologically consistent with prostatic acinar adenocarcinoma with variable cribriform, fused, and poorly formed glands, analogous to Gleason score 4+4=8. (johnshopkins.edu)
Uterine2
Mitotic1
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
Membrane1
  • MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract. (nih.gov)
Metastases1
  • Therefore, the aim of this study was to evaluate the capacity of a concise panel of known BC markers together with GCDFP-15 and HNF4A to accurately distinguish primary gastric adenocarcinoma from metastases to stomach in the Brazilian population. (biomedcentral.com)
Primary3
  • On multiple and serial sections, underlying adenocarcinomas were not found either in the ovary or other primary sites. (nih.gov)
  • Moreover, our data confirmed HNF4A as a potential marker in primary gastric adenocarcinoma and suggest the utility of a four-marker immunohistochemistry panel. (biomedcentral.com)
  • The patient developed a new left lung mass 5 years ago, which was diagnosed as a primary lung adenocarcinoma. (hindawi.com)
Gene1
  • Association between Gene Polymorphisms of T Cell Immunoglobulin Domain and Mucin Domain-3 and Risk of Asthma: A Systematic Review and Meta-analysis. (cdc.gov)
Stains1
  • CEA was focally positive, Calretinin stains, mesothelial cells and mucin stains were positive. (ispub.com)
Composite1
  • Zusätzlich war dieser Transkriptionsfaktor in Mucin Promotoren überrepräsentiert und Bestandteil einer spezifischen Kombination von Transkriptionsfaktoren (composite Modul), welche Mucin Promotoren im Vergleich zu Promotoren von bei CED nicht regulierten Genen deutlich unterscheiden kann. (uni-regensburg.de)
Glands1
  • Some glands or spaces showed mucin-like or basophilic material. (hindawi.com)
Subtypes1
Peripheral1