The MUC5AC Antibody detects for mucin 5AC (MUC5AC), a secretory-type mucin found in columnar mucous cells of surface gastric epithelium, in goblet cells of the fetal, and in precancerous colon, but is not found in normal colon cells. (neuromics.com)
Monoclonal antibody3
Ensituximab (NPC-1C) is a chimeric monoclonal antibody under development for as a candidate for treatment of cancers. (wikipedia.org)
The present study reports the characterization of a humanized anti-carcinoembryonic antigen monoclonal antibody conjugated to a PEGylated near-infrared dye, that targets and brightly labels human CRC tumors in metastatic orthotopic mouse models. (bvsalud.org)
METHODS: The hT84.66-M5A (M5A) monoclonal antibody was conjugated with a polyethylene glycol (PEG) chain that incorporated a near infrared (NIR) IR800 dye to establish M5A-IR800 Sidewinder (M5A-IR800-SW). (bvsalud.org)
Polyclonal antibody1
The rabbit anti-mouse Muc6 polyclonal antibody seems highly specific to the mouse mucin and will be useful to study pancreatic pathology in cystic fibrosis. (ox.ac.uk)
MUC22
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
The most overexpressed genes included Fc Fragment of IgG Binding Protein ( FCGBP , logFC = 3.01, pFDR = 0.015), Mucin 2 ( MUC2 , logFC = 2.78, pFDR = 0.015), and Alpha 1B Defensin ( DEFA1B , logFC = 2.73, pFDR = 0.024). (biomedcentral.com)
Secretion1
Furthermore, the enhanced airway mucins in the MyD88- deficient mice were not due to defective secretion, as the mucin secretory capacity of MyD88-KO mice remained intact. (cdc.gov)
Muc5b2
ODE primarily increased mucin (Muc)5ac levels relative to Muc5b. (cdc.gov)
Among them, the most studied and validated genetic risk factor is represented by the single nucleotide polymorphism in the promoter region of the mucin 5B (MUC5B) responsible for sporadic and familial IPF [ 12 ] . (encyclopedia.pub)
Airway1
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
Antigens1
The target of the antibody is uncertain and is described as "human colorectal and pancreatic carcinoma-associated antigens", a set of tumor antigens isolated from human cancers. (wikipedia.org)
Mice2
The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. (ox.ac.uk)
In order to further study Muc6 in mice, our aims were to obtain a specific Muc6 antibody, to validate it and to test it in Cftr deficient mice. (ox.ac.uk)
TISSUE2
In Western blot experiments, the antibody detected a high-molecular weight molecule secreted by the gastric tissue. (ox.ac.uk)
The centroacinar cells of pancreatic tissue also reacted with the antibody. (ox.ac.uk)
Gastric1
Using immunohistochemistry, we showed that the antibody reacted strongly with deep glands of duodenum and ileum and mucous neck cells of gastric body. (ox.ac.uk)
Human1
Five orthologous gel-forming mucins have been cloned in human and mouse. (ox.ac.uk)
Responsible1
Gel-forming mucins are large high-molecular weight secreted O-glycoproteins responsible for the gel-properties of the mucus blanket. (ox.ac.uk)
Monoclonal4
Ensituximab (NPC-1C) is a chimeric monoclonal antibody under development for as a candidate for treatment of cancers. (wikipedia.org)
Immunohistochemistry using NCL-MUC1 and NCL-MUC2 monoclonal antibodies was performed on sections of paraffin-embedded tissues. (ncl.ac.uk)
16. Prevalence of Barrett's esophagus and expression of mucin antigens detected by a panel of monoclonal antibodies in Barrett's esophagus and esophageal adenocarcinoma in Japan. (nih.gov)
Chromocyte's Antibody Database and Antibody Library provides details on all of the monoclonal and polyclonal antibodies that are included in the LOCATE flow cytometry Antibody Panel Design and Antibody Search interfaces. (chromocyte.com)
Epithelial Cells4
Specialized gastrointestinal epithelial cells secrete large amounts of mucin glycoproteins and antimicrobial molecules that, together, form the mucus barrier to infection. (nature.com)
These mucins limit binding of pathogens to epithelial cells by steric hindrance and by acting as releasable decoys for microbial adhesins. (nature.com)
Objective To investigate the effects of mechanical stretching on the expression of mucin(MUC)5AC in airway epithelial cells, and explore its mechanism of signaling pathway. (shsmu.edu.cn)
Gene expression2
Purpose: The repertoire of mucin (MUC) gene expression in the normal human urothelium is poorly defined and the alterations in MUC gene expression following transposition of intestinal segments into the urinary tract has not previously been studied. (ncl.ac.uk)
9. Mucin gene expression and cell differentiation in human normal, premalignant and malignant esophagus. (nih.gov)
MUC5B1
ODE primarily increased mucin (Muc)5ac levels relative to Muc5b. (cdc.gov)
Flow cytometry1
The Antibody Database also provides direct links to the appropriate Product Datasheets and offers a new approach for viewing information on antibodies that can be used for flow cytometry and other techniques such as Western Blot, Immunoprecipitation, ELISA and Neutralization. (chromocyte.com)
Protein2
Same gel probed with anti ß-actin antibody, a control for protein loading. (medscape.com)
Mucins are highly glycosylated protein molecules of linear and flexible amino acid polymers composed of subunits joined by disulphide bonds [ 11 - 13 ]. (hindawi.com)
Chimeric1
Herein, we establish the utility of targeting a post-cleavage generated, surface-tethered oncogenic MUC16 carboxy-terminal (MUC16-Cter) domain by using a novel chimeric antibody in human IgG1 format, ch5E6, whose epitope expression directly correlates with disease severity in both cancers. (bvsalud.org)
All eight mucin genes were expressed in an area of pyloric-type metaplasia found in one transposed ileal segment. (ncl.ac.uk)
Mucin production is controlled by mucin genes (MUCs). (hindawi.com)
ELISA1
Antigenic identity of purified sinus mucins was determined by ELISA. (hindawi.com)
Conclusion1
Conclusion Anti-PNAS-2 single chain antibody can specifically bind PNAS-2 antigen and induce apoptosis of U937 cells, which may be related to the inactivation of PNAS-2 after closure of the functional site. (shsmu.edu.cn)
Proline1
Amino acid analysis was characteristic of mucins with high serine, threonine, and proline contents and reduction and proteolysis increased relative proportions of these amino acids. (hindawi.com)
Mucus4
Mucins represent the major constituent responsible for mucus viscoelastic properties [ 10 ] which enables the mucus layer to achieve its protective function for the underlying mucosa. (hindawi.com)
As sinus mucus is made up from multiple mucin gene products, it is important to understand the structure and composition of sinus mucins and how their distribution varies in sinus mucus. (hindawi.com)
We studied the sinus mucin fragmentation as this will help in the understanding of the physical and biological properties of sinus mucins in CS and could help to develop therapeutic modalities to alter these properties and facilitate mucus drainage and relieve relevant CS symptoms such as rhinorrhea, chronic cough, and globus pharyngeus. (hindawi.com)
During their biosynthesis, mucins homo-oligomerize into complex polymeric networks that, when secreted, give mucus its viscoelastic properties. (nature.com)
Species2
Reduction, trypsin digestion, and papain digestion produced progressively smaller mucin species. (hindawi.com)
The Antibody Database provides an easy approach to browse information on antibodies that are specific for a given target antigen, irrespective of the Host and Target Species. (chromocyte.com)
Expression6
The potency of WS compared with CS in inducing mucin expression may explain the increased risk for chronic bronchitis in participants exposed to WS. (nih.gov)
7. Expression profile and cellular localizations of mucin proteins, CK7, and cytoplasmic p27 in Barrett's esophagus and esophageal adenocarcinoma. (nih.gov)
10. Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. (nih.gov)
12. Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus. (nih.gov)
Methods The pMIG-PNAS-2ScFv, anti-PNAS-2 single chain antibody expression vector, was transfected into U937 cell line by retroviral transfection method. (shsmu.edu.cn)
Single chain antibody expression and ScFv-antigen specific binding were measured by laser confocal microscopy. (shsmu.edu.cn)
Lung1
Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSCLC). (bvsalud.org)
Asthma1
2. AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. (nih.gov)
Sequence1
Results Anti-PNAS-2 single chain antibody coding sequence was successfully transfected into U937 cells and its expressed single chain antibody could bind to PNAS-2 antigen with a high specificity. (shsmu.edu.cn)
Cell1
Deficiencies in secreted or cell surface mucins in animal models lead to increased pathology during infection. (nature.com)
To date, most anti-MUC16 antibodies are directed towards the extracellular domain of MUC16 (CA125), which is usually cleaved and shed in the circulation hence obscuring antibody accessibility to the cancer cells. (bvsalud.org)
Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance. (unmc.edu)
Host1
In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection. (nature.com)