MUC5ACMucusGenesGastric mucinEpithelial CellsProteinsAirway mucinGene expressionMUC5BProteinSecretoryGoblet CellsMUC2MiceRespiratory tractAmino acidsSecretionMUC1EpitheliumGlycoproteinsPancreatic cancerAlterationsProgressionConcentrationTherapeuticPathologyMolecularChronic bronchitisSmokersDiseasesExpressionAirwaysDensityProductionLarge
MUC5AC12
- Mucin-5AC (MUC-5AC) is a protein that in humans is encoded by the MUC5AC gene. (wikipedia.org)
- Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? (wikipedia.org)
- Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure. (nih.gov)
- 13. Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. (nih.gov)
- 17. Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. (nih.gov)
- Secreted mucin 5AC (MUC5AC) is the most abundantly overexpressed member of the mucin family within the early pancreatic intraepithelial neoplasia stage I (PanIN-I) of pancreatic cancer. (aacrjournals.org)
- Fragmentation patterns of a MUC5AC rich sample mucin were analysed by Sepharose CL-2B gel chromatography. (hindawi.com)
- On SDS-PAGE, digested MUC5AC rich mucin produced four distinct products. (hindawi.com)
- MUC5AC rich mucins contained more protein than MUC2 rich mucins. (hindawi.com)
- Amino acid contents of MUC2 and MUC5AC mucins are different. (hindawi.com)
- Several studies have shown that the major mucins expressed in chronic sinusitis (CS) are MUC2, MUC5AC, and MUC5B [ 5 - 9 ] and an inverse relationship was found between MUC2 and MUC5AC expression levels and this was strong in the presence of nasal polyps [ 6 ]. (hindawi.com)
- In 148 of these participants, the respiratory secreted mucins MUC5AC and MUC5B were quantitated by means of mass spectrometry. (spiromics.net)
Mucus6
- Specialized gastrointestinal epithelial cells secrete large amounts of mucin glycoproteins and antimicrobial molecules that, together, form the mucus barrier to infection. (nature.com)
- During their biosynthesis, mucins homo-oligomerize into complex polymeric networks that, when secreted, give mucus its viscoelastic properties. (nature.com)
- Mucins represent the major constituent responsible for mucus viscoelastic properties [ 10 ] which enables the mucus layer to achieve its protective function for the underlying mucosa. (hindawi.com)
- As sinus mucus is made up from multiple mucin gene products, it is important to understand the structure and composition of sinus mucins and how their distribution varies in sinus mucus. (hindawi.com)
- We studied the sinus mucin fragmentation as this will help in the understanding of the physical and biological properties of sinus mucins in CS and could help to develop therapeutic modalities to alter these properties and facilitate mucus drainage and relieve relevant CS symptoms such as rhinorrhea, chronic cough, and globus pharyngeus. (hindawi.com)
- In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation of transport in persons with muco-obstructive lung diseases. (spiromics.net)
Genes4
- 9. Differential expression of the chromosome 11 mucin genes in colorectal cancer. (nih.gov)
- Mucin production is controlled by mucin genes (MUCs). (hindawi.com)
- Both WSSs induced concentration- and time-related hypersecretion of mucins 5AC and 5B, accompanied by up-regulation of the respective mucin genes. (cdc.gov)
- All eight mucin genes were expressed in an area of pyloric-type metaplasia found in one transposed ileal segment. (ncl.ac.uk)
Gastric mucin1
- 20. Immunohistochemical detection of gastric mucin in normal and disease states. (nih.gov)
Epithelial Cells3
- Cell surface mucins are heavily O -glycosylated transmembrane glycoproteins that are present on the apical surface of all gastrointestinal epithelial cells. (nature.com)
- These mucins limit binding of pathogens to epithelial cells by steric hindrance and by acting as releasable decoys for microbial adhesins. (nature.com)
- Objective To investigate the effects of mechanical stretching on the expression of mucin(MUC)5AC in airway epithelial cells, and explore its mechanism of signaling pathway. (shsmu.edu.cn)
Proteins2
- 4. Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study. (nih.gov)
- Mucin 5AC was originally identified as two distinct proteins, however a single gene encodes the protein which gives rise to the mucin 5A and mucin 5C variants. (nih.gov)
Airway mucin2
- Airway Mucin Concentration as a Marker of Chronic Bronchitis. (spiromics.net)
- Airway mucin concentrations may quantitate a key component of the chronic bronchitis pathophysiologic cascade that produces sputum and mediates disease severity. (spiromics.net)
Gene expression8
- Epithelial mucin stores, mucin immunostains, and goblet cell morphology were quantified in bronchial biopsy samples using stereology, and mucin gene expression was quantified in epithelial brushings using real-time reverse transcriptase-polymerase chain reaction. (nih.gov)
- Epithelial mucin stores are increased in habitual smokers because of goblet cell hypertrophy and hyperplasia, and the pattern of mucin gene expression is abnormal. (nih.gov)
- 2. Heterogeneity of mucin gene expression in normal and neoplastic tissues. (nih.gov)
- 3. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. (nih.gov)
- 6. Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. (nih.gov)
- 7. Mucin gene expression in colonic tissues and cell lines. (nih.gov)
- 8. Pattern of mucin gene expression in normal and neoplastic lung tissues. (nih.gov)
- Purpose: The repertoire of mucin (MUC) gene expression in the normal human urothelium is poorly defined and the alterations in MUC gene expression following transposition of intestinal segments into the urinary tract has not previously been studied. (ncl.ac.uk)
MUC5B1
- ODE primarily increased mucin (Muc)5ac levels relative to Muc5b. (cdc.gov)
Protein2
- Increased mMUC5AC transcripts and mucin protein were diminished in gene-targeted Mmp9 mice [Mmp9((-/-))] or in mice treated with an epidermal growth factor receptor (EGFR) inhibitor, erlotinib. (nih.gov)
- Mucins are highly glycosylated protein molecules of linear and flexible amino acid polymers composed of subunits joined by disulphide bonds [ 11 - 13 ]. (hindawi.com)
Secretory2
- Furthermore, the enhanced airway mucins in the MyD88- deficient mice were not due to defective secretion, as the mucin secretory capacity of MyD88-KO mice remained intact. (cdc.gov)
- Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness. (aacrjournals.org)
Goblet Cells3
- Secreted mucins are large, heavily O -glycosylated glycoproteins that are produced by goblet cells. (nature.com)
- With the rationale that relevant tissue responses can be measured to evaluate the adverse health effects of tobacco products, we assessed changes in mucin secretion and the density and size of goblet cells in an in vitro human air-liquid-interface (ALI) airway tissue model after exposure to a tobacco smoke solution. (cdc.gov)
- Mucin-secreting goblet cells exhibited increased cell density and decreased size after 5 daily treatments then recovered to their normal size, but with decreased cell density, 14 days after the last treatment. (cdc.gov)
MUC23
- 12. Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours. (nih.gov)
- 16. [Expression of mucin MUC1 and MUC2 in colorectal carcinoma and their clinical significance]. (nih.gov)
- In patients with clam enterocystoplasty there was evidence of increasing up-regulation of MUC2, 3, 4 and 5AC expression in the urothelium toward the anastomotic site. (ncl.ac.uk)
Mice2
- WS at 25-fold lower concentration than CS increased mucin expression more efficiently in mice and in human AECs in a p53 pathway-dependent manner. (nih.gov)
- Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. (aatbio.com)
Respiratory tract1
- A gel-forming mucin that is primarily found on the surface of gastric epithelium and in the RESPIRATORY TRACT . (nih.gov)
Amino acids1
- Amino acid analysis was characteristic of mucins with high serine, threonine, and proline contents and reduction and proteolysis increased relative proportions of these amino acids. (hindawi.com)
Secretion2
- Mucin secretion returned to baseline levels following a 14-day recovery period. (cdc.gov)
- Taken together, our results indicate that ALI cultures can be used to measure the modulation of mucin production, secretion, and clearance, disturbances that are manifested in tobacco smoke-related diseases, such as chronic obstructive pulmonary disease. (cdc.gov)
MUC12
- 15. Cystic fibrosis and pancreatic cancer cells synthesize and secrete MUC1 type mucin gene product. (nih.gov)
- 18. Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells. (nih.gov)
Epithelium1
- 0.05), leading to a 2.2-fold increase in the volume of stored mucin in the epithelium per surface area of basal lamina (1.94 +/- 0.31 microm(3)/microm(2) vs 4.32 +/- 0.55 microm(3)/microm(2) in control subjects vs smokers, p = 0.001). (nih.gov)
Glycoproteins1
- Mucin glycoproteins are the major component of these barriers. (nature.com)
Pancreatic cancer1
- Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance. (unmc.edu)
Alterations2
- In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection. (nature.com)
- Many cigarette smoke-associated airway diseases involve alterations in mucin homeostasis. (cdc.gov)
Progression1
- Under this model, it is postulated that a high mucin concentration produces the sputum and disease progression that are characteristic of chronic bronchitis. (spiromics.net)
Concentration1
- Receiver-operating-characteristic curve analysis of the association between total mucin concentration and a diagnosis of chronic bronchitis yielded areas under the curve of 0.72 (95% confidence interval [CI], 0.65 to 0.79) for the SPIROMICS cohort and 0.82 (95% CI, 0.73 to 0.92) for the independent cohort. (spiromics.net)
Therapeutic1
- Studies designed to explore total mucin concentrations in sputum as a diagnostic biomarker and therapeutic target for chronic bronchitis appear to be warranted. (spiromics.net)
Pathology1
- Deficiencies in secreted or cell surface mucins in animal models lead to increased pathology during infection. (nature.com)
Molecular1
- Sinus mucin fragmentation produced mucin subunits and glycopeptide units of smaller molecular sizes which are likely to have lower viscoelastic properties. (hindawi.com)
Chronic bronchitis2
- The potency of WS compared with CS in inducing mucin expression may explain the increased risk for chronic bronchitis in participants exposed to WS. (nih.gov)
- Data from chronic-bronchitis questionnaires and data on total mucin concentrations in sputum were also analyzed in an independent 94-participant cohort. (spiromics.net)
Smokers3
- Stored mucin was significantly higher in the subgroup of smokers with airflow obstruction (p = 0.029) and correlated with FEV(1)/FVC even when controlling for diffusing capacity as a measure of emphysema (p = 0.034). (nih.gov)
- The highest epithelial mucin stores are found in smokers with airflow obstruction, suggesting a mechanistic link between epithelial mucin dysregulation and airflow obstruction. (nih.gov)
- Mean (±SE) total mucin concentrations were higher in current or former smokers with severe COPD than in controls who had never smoked (3166±402 vs. 1515±152 μg per milliliter) and were higher in participants with two or more respiratory exacerbations per year than in those with zero exacerbations (4194±878 vs. 2458±113 μg per milliliter). (spiromics.net)
Diseases1
- Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease, and has also been associated with greater protection against influenza infection. (wikipedia.org)
Expression1
- 10. Expression of mucin 3 and mucin 5AC in arthritic synovial tissue. (nih.gov)
Airways1
- Chronic obstructive pulmonary disease (COPD), a global public health problem, is characterized by progressive difficulty in breathing, with increased mucin production, especially in the small airways. (nih.gov)
Density1
- Native/polymeric mucins were isolated by 2 rounds of caesium chloride density gradient centrifugation [ 19 ] followed by extensive dialysis and freeze-drying. (hindawi.com)
Production1
- Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. (nih.gov)
Large1
- MUC-5AC is a large gel-forming glycoprotein. (wikipedia.org)