• Bacteria colonizing the mucus layer have evolved to use mucin as a carbon and energy source. (asm.org)
  • Akkermansia muciniphila ( A. muciniphila ) is a gram-negative, mucin-degrading bacterium and is naturally present in the human microbiota. (r-biopharm.com)
  • One of the members of the mucosa-associated microbiota is Akkermansia muciniphila , which is capable of producing an extensive repertoire of mucin-degrading enzymes. (asm.org)
  • The model-supported predictions were validated by in vitro experiments, which showed A. muciniphila to be able to utilize the mucin-derived monosaccharides fucose, galactose, and N -acetylglucosamine. (asm.org)
  • In conclusion, these findings provide molecular insights into the lifestyle of A. muciniphila and further confirm its role as a mucin specialist in the gut. (asm.org)
  • A. muciniphila is a mucin-degrading microbe. (bridgetownnutrition.com)
  • In this thesis, the ability of A. muciniphila to utilize the host-derived glycans mucin and human milk oligosaccharides was studied in detail. (wur.nl)
  • The model predicted A. muciniphila to be able to synthesize all the essential amino acids, with the exception of threonine, which was added to the mucin-free medium designed to test A. muciniphila growth on single sugars. (wur.nl)
  • A. muciniphila was able to individually metabolize all the main monomeric sugars present in mucin, albeit with limited efficiency in comparison to mucin. (wur.nl)
  • As mucin shares structural similarities with human milk oligosaccharides (HMOs), which stimulate the bacterial community colonizing the gut in early life, growth of A. muciniphila on human milk and its components was tested. (wur.nl)
  • The uptake of these sugars, as well as the nonmucin sugar glucose, was enhanced in the presence of mucin, indicating that additional mucin-derived components are needed for optimal growth. (asm.org)
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