Mucin 2. Medical search. Frequent questions

The upper layer of the colonic mucus is a niche for a subset of the microbiota which utilise the mucin glycoproteins as a nutrient source and mucin grazing by the microbiota appears to play a key role in maintaining barrier function as well as community stability. (biorxiv.org)
Mucins, the main constituents of the mucus layer, are glycoproteins synthesized by goblet cells. (scielo.br)
Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)

Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
Furthermore, the enhanced airway mucins in the MyD88- deficient mice were not due to defective secretion, as the mucin secretory capacity of MyD88-KO mice remained intact. (cdc.gov)
Formulated with 96% Snail Secretion Filtrate(Mucin), this essence protects the skin from moisture loss while keeping the skin texture smooth and healthy. (natureandpure.com)

Overexpression of TM mucins reduced SARS-CoV-2 infection, in comparison to cells with a non-targeting guide (NTG). (breathinglabs.com)

Peripheral lung sections from smokers with COPD (n = 9) and age-matched controls including smokers (n = 11) and lifelong non-smokers with normal lung function (n = 6) were stained with alcian blue, periodic acid-Schiff (PAS) and by immunohistochemistry of mucins (MUC): MUC2, MUC4, MUC5AC, MUC5B and MUC6. (nih.gov)
Within the bronchiolar lumen, the predominant mucin was MUC5B. (nih.gov)
COPD is specifically associated with increased expression of MUC5B in the bronchiolar lumen and of the mucin MUC5AC in the bronchiolar epithelium. (nih.gov)
MUC5AC and MUC5B are gel-forming mucins that clear pathogens by mucociliary clearance. (breathinglabs.com)
ODE primarily increased mucin (Muc)5ac levels relative to Muc5b. (cdc.gov)
2017 ) Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: Implication of the Wnt/β-catenin pathway. (academictree.org)

Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
A bone biopsy specimen was taken in the Department of Oral and Maxillofacial Surgery and the histopathology revealed pseudo-cystic and ductal mucin pooled spaces lined by mucous cells and squamous or epidermoid cells. (bvsalud.org)

Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. (wikipedia.org)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
1, 2 This review approaches the role of mucin degrading enzymes from the potential interaction of micro-organisms with the cervical mucus barrier, and discusses the contribution that mucin degrading enzymes may make to microbial colonisation of the reproductive tract. (bmj.com)
We have examined surface-functionalized gold nanoparticles (Au NPs) within mucin/mucus matrices to gain a better understanding of the mechanical and chemical interactions, as these systems are model nanoparticle-based therapeutics. (confex.com)
In addition, we have examined the bulk rheological effects for synthetic mucus solutions-based on pig gastric mucin (PGM) and different stabilizers-in response to GC-Au nanoparticle addition at different concentrations. (confex.com)
Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence. (bvsalud.org)

TM mucins MUC16 and MUC4 and secreted mucin MUC5AC were almost undetectable. (breathinglabs.com)

But this little skincare gem - called snail mucin - has won over a legion of sceptics, many who thought the same but now can't get enough of the stuff. (metro.co.uk)
While a third said: 'Right, I KNOW the sound of putting 'snail mucin' on your face sounds horrible, but honestly this stuff is AMAZING! (metro.co.uk)
Before we look at how snail mucin works, it's worth mentioning that COSRX and other brands that work with snail mucin say no snails are harmed. (metro.co.uk)
So, what's in snail mucin that makes it great for skin? (metro.co.uk)
Since snail mucin is relatively new in the skincare world there aren't that many clinical studies for academic proof - so for now you'll have to take the word of its evangelical followers. (metro.co.uk)
We even tried snail mucin, with Metro's Jess Lindsay enthusing she's noticed an improvement in glow and texture since using COSRX Advanced Snail 96 Mucin Power Essence Gel (£12) for the last month. (metro.co.uk)
Some people might find the snail mucin element a little gross, but having ADORED Elizavecca's Milky Piggy EGF Elastic Retinol Cream (which has literal bird's nest extract as the main ingredient) I'm picking up whatever the K-beauty world is putting down. (metro.co.uk)
Snail mucin helps repair the skin after breakouts and soothes irritation by replenishing moisture. (natureandpure.com)
Our snail mucin products are also 100% cruelty free, causing no harm to any animals in the process. (natureandpure.com)
Use COSRX Advanced Snail 96 Mucin Power Essence after cleansing and having applied toner. (natureandpure.com)
Take proper amount (2-3 pumps) of COSRX Advanced Snail 96 Mucin Power Essence. (natureandpure.com)
My holy-grail serum is the COSRX Advanced Snail 96 Mucin-this stuff has changed my life, really. (natureandpure.com)
This essence is created from nutritious, low-stimulation filtered snail mucin in order to keep your skin moisturized all day while bringing back your skin's vitality. (natureandpure.com)
The filtered snail mucin replenishes and revitalizes nutrients with looking healthy skin. (natureandpure.com)
Snail Mucin Regenerating Tonic. (tiande.ru)

Meanwhile, MUC1, MUC4, and MUC16 are transmembrane (TM) mucins that can facilitate or restrict microbial invasion at the apical surface of the epithelium. (breathinglabs.com)
However, given the current state of research, it is difficult to conclude whether some specific mucins, such as MUC1, MUC4, or MUC16, or TM mucins in general are protective or contribute to severe disease, within the complexity of the body, during different stages of pathogenesis. (breathinglabs.com)
2017 ) Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells. (academictree.org)
2015 ) miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer. (academictree.org)

Enemas with curcumin preserve the content of neutral and acidic mucins in the colonic epithelium without fecal stream. (scielo.br)
Collectively, the interaction of mucins , pathogens, epithelium , and inflammatory cells promotes proteomic and glycomic changes that reflect a persistent mucoobstructive, infectious, and inflammatory state . (bvsalud.org)

This gene encodes a member of the mucin protein family. (wikipedia.org)
The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces. (wikipedia.org)
The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. (wikipedia.org)
Additionally, proteolytic cleavage of the spike protein, mediated by the transmembrane serine protease 2 (TMPRSS2), is required for viral entry. (breathinglabs.com)
The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. (nih.gov)
Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. (bvsalud.org)

Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. (wikipedia.org)
Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
A recent PLOS Pathogens study analyzed the role played by host mucins and mucin glycans with regard to SARS-CoV-2 entry into the airway epithelial cells. (breathinglabs.com)
[ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
A transmembrane mucin that is found in a broad variety of epithelial tissue. (bvsalud.org)

The study found that during SARS-CoV-2 infection, endogenously expressed TM mucins MUC1 and MUC16 played a protective role. (breathinglabs.com)
It was concluded that during SARS-CoV-2 infection of human respiratory Calu-3 cells the MUC1 extracellular domain prevents the binding of the virus to the underlying receptor. (breathinglabs.com)
2015 ) Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. (academictree.org)
2014 ) The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. (academictree.org)

Viral infection was enhanced with enzymatic removal of extracellular mucin domains, but not individuals' fucose sugars or sialic acid. (breathinglabs.com)

Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
We found that only a capsule-free mutant of S. pneumoniae TIGR4 binds to salivary proteins, most prominently to mucin MUC7, but that this binding was not mediated through PsrP or recognition of sialic acid. (lu.se)
MEC is the most commonly occur r ing malignant salivary gland neoplasm comprising 2.8% -15% of all salivary gland tumors 2 . (bvsalud.org)
Aberrant salivary gland neoplasms arising within the jaws as primary central bony lesions are extremely rare comprising 2%-4.3% of all MEC reported 4,8 . (bvsalud.org)

This study analyzed the role played by transmembrane mucins and their terminal glycans in the SARS-CoV-2 entry process in primary airway cultures and a respiratory cell line. (breathinglabs.com)

There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. (wikipedia.org)
Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
Mucins are a family of high molecular weight O-glycosylated proteins. (breathinglabs.com)

Objective 2: Develop innovative strategies for increasing disease resistance and improving immunity to foodborne pathogens of poultry using egg shell membrane technology. (usda.gov)
Here we determine the effect of the CF airway milieu, with persistent mucoobstruction, resident pathogens, and inflammation , on the mucin quantity and quality that govern lung disease pathogenesis and progression. (bvsalud.org)
Mucin glycomic analysis revealed significantly more sialylated glycans in CF, and the total abundance of nonsulfated O- glycans correlated with the relative abundance of pathogens. (bvsalud.org)

T cell immunoglobulin and mucin domain 3 (Tim-3) is a key checkpoint receptor responsible for exhaustion and dysfunction of T cells and plays a critical role in immunosuppression. (medscimonit.com)
T-cell immunoglobulin and mucin domain-containing. (joplink.net)

Am J Respir Cell Mol Biol;67(2): 253-265, 2022 08. (bvsalud.org)

These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
Epimorphin/syntaxin-2 complex mediates branching of ductal structures by influencing cell adhesion and gene activation. (medscape.com)

After confirming the successful synthesis of GC-Au nanoparticles, mucin aliquots were added to the GC-Au nanoparticle solution. (confex.com)

The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)
Bhasker in 1963 reported 2 cases and analyzed the criteria for their central origin, histology and pathogenesis 1 . (bvsalud.org)

Here we describe the discovery and characterisation of endo-acting family 16 glycoside hydrolases (GH16s) from prominent mucin degrading gut bacteria that specifically target the oligosaccharide side chains of intestinal mucins from both animals and humans. (biorxiv.org)
The data suggest a new paradigm for mucin breakdown by the microbiota and the endo-mucinases provide a potential tool to explore changes that occur in mucin structure in intestinal disorders such as inflammatory bowel disease and colon cancer. (biorxiv.org)

Influence of the application of enemas with oily extract of curcumin ( Curcuma longa ) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream ☆ ☆ Study conducted at Universidade São Francisco (USF), Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Investigação Médica (LIM), Bragança Paulista, SP, Brazil. (scielo.br)
To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream. (scielo.br)
Tissue quantification of neutral and acid mucins in the mucosa of the colon with and without fecal stream in rats. (scielo.br)

A deeper knowledge of host factors influencing viral entry is important to elucidate host-SARS-CoV-2 interactions and identify novel therapeutic targets. (breathinglabs.com)
Changes in the particle size were monitored using DLS to examine complex formation and binding interactions between the GC-Au nanoparticles and mucin. (confex.com)

Secreted by the liver, bile is composed largely of bile salts, bile pigments and small amounts of organic materials such as cholesterol, lecithin, fatty acid and mucin. (cdc.gov)

The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. (rsc.org)

Despite the importance of mucin breakdown for gut health, the mechanisms by which gut bacteria access this complex glycoprotein are not well understood. (biorxiv.org)
A glycoprotein that forms mucin. (wordinfo.info)

Some glands or spaces showed mucin-like or basophilic material. (hindawi.com)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus caused the devastating coronavirus disease 2019 (COVID-19) pandemic. (breathinglabs.com)
Coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is still threatening the human life and society throughout the world. (techscience.com)

Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. (jci.org)

These findings were consistent with a mucin producing adenocarcinoma, most likely from the gastrointestinal tract. (ispub.com)

Fig. 2: Human lung function over the course of 24 h of xenogeneic cross-circulation. (nature.com)
Immunostaining for components of those pathways and mucins were performed on lung tissue obtained from patients with IPF (n=20), chronic obstructive pulmonary disease (n=13), idiopathic pulmonary artery hypertension (n=5) and from organ donors (n=6). (bmj.com)
Thus, asymmetry of lung buds (3 main bronchi on the right, 2 on the left) is apparent in the embryonic phase. (medscape.com)

Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II. (buffalo.edu)

Capable of bringing about the hydrolysis (splitting of a compound into fragments by the addition of water) of mucin, as by a mucinase (an enzyme that acts upon mucin). (wordinfo.info)

Although significantly more proteolytic cleavages were detected in CF mucins , their macromolecular properties (e.g., size and molecular weight ) were not significantly different than control mucins , likely reflecting the role of S-S bonds in maintaining multimeric structures. (bvsalud.org)

Presence of mucin in the urine, suggesting vaginal contamination. (wordinfo.info)

At higher magnification, the tumor cells showed minimal cytological atypia, scant cytoplasm, fine chromatin, small inconspicuous nucleoli, and rare mitotic figures (Figure 2 ). (hindawi.com)

Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
Many factors have contributed to the persistence and increase in the occurrence of infectious diseases, such as societal changes, health care, food production, human behaviour, environmental change, public health infrastructure and microbial adaptation [2]. (who.int)

StcE, which is the mucin-selective protease, cleaves the glycosylated extracellular portion of the mucins without disturbing the underlying domains. (breathinglabs.com)

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. (nih.gov)
Sub-objective 1C: Reduce the incidence of Campylobacter in pre and postharvest poultry using mucin-adapted bacteriophage and genome targeting CRISPR-Cas system. (usda.gov)

Excess accumulation and overproduction of gel-forming mucins in the lungs of SARS-CoV-2-infected patients could lead to life-threatening situations. (breathinglabs.com)

Documenting the function of specific mucins during in vivo infections will be important for future research. (breathinglabs.com)

Mucin concentrations significantly correlated with the age and sputum human neutrophil elastase activity. (bvsalud.org)

There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. (scielo.br)

2 2 Gaudier E, Hoebler C. Physiological role of mucins in the colonic barrier integrity. (scielo.br)

When two genomes from the same primate species are compared with each other, structural variants constitute 2 to 7 times more base pair differences than single nucleotide variants 2 . (nature.com)
No differences in mucin parameters were detected at baseline versus during exacerbations. (bvsalud.org)
In this cohort of healthcare workers where we would not anticipate vaccine type to be related to health status, we found no substantial differences in the incidence of SARS-CoV-2 infection or covid-19 disease up to 20 weeks after vaccination. (cdc.gov)

By varying pH, complexation time, concentration, and temperature, the stability of the mucin-chitosan Au nanoparticle complexes was evaluated. (confex.com)

1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 There are previous reports of biliary tract disease metastastic to a hernia sac, but none of them has the gallbladder as a primary tumor. (ispub.com)

Mucin parameters did not correlate with hypertonic saline, inhaled corticosteroids , or antibiotics use. (bvsalud.org)

2022 Nov 2;110(21):3597-3626. (nih.gov)
67(2): 253-265, 2022 08. (bvsalud.org)

Capable of hydrolyzing or dissolving mucin. (wordinfo.info)

Expression levels were normalized to GAPDH and fold- change of expression level was calculated using the comparative Ct method (2-Ct), as described previously ( 3 ). (cdc.gov)

Anatomy5

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science1

Glycoproteins3

Secretion3

Reduced SARS-CoV-2 infection1

MUC5B6

Mucous2

Mucus6

MUC5AC1

Snail15

MUC44

Epithelium2

Protein7

Epithelial6

MUC14

Fucose1

Salivary5

Transmembrane1

Proteins3

Pathogens3

Immunoglobulin2

Biol1

Gene2

Synthesis1

Pathogenesis2

Intestinal2

Mucosa3

Interactions2

Fatty1

Gastric1

Glycoprotein2

Glands1

20192

MRNA1

Adenocarcinoma1

Lung3

Glycans1

Mucinase1

Molecular weight1

Urine1

Mitotic1

Microbial2

Protease1

Genome2

Lungs1

Infections1

Human1

Tissue1

Barrier1

Differences3

Stability1

Tumor1

Saline1

20222

Capable1

Expression1