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  • MUC17
  • Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization. (wikipedia.org)
  • located on chromosome
  • This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. (wikipedia.org)
  • This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. (wikipedia.org)
  • peptide
  • The M1-b epitope is found located on a 58 kD and 40 kD peptide after trypsin treatment of native M1 mucin. (abcam.co.jp)
  • human
  • Mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification) Human. (abcam.co.jp)
  • AGR2 is the human homolog of XAG-2. (wikipedia.org)
  • The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. (wikipedia.org)
  • A recently identified human mucin gene is MUC21, previously known as chromosome 6 open reading frame 205. (wikipedia.org)
  • mucosal
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)
  • linkages
  • The cysteine residues participate in establishing disulfide linkages within and among mucin monomers. (wikipedia.org)
  • Keratan sulfate II (KSII) and keratan sulfate III (KSIII) are O-linked, with KSII linkages identical to that of mucin core structure, and KSIII linked to a 2-O mannose. (wikipedia.org)
  • expression
  • To investigate the involvement of AITC on the intestinal barrier function, the effect on the intercellular tight junction was evaluated in the Caco-2 cell line while mucin expression was assessed in the LS174T cell line. (mdpi.com)
  • Oh, S.H. Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression. (mdpi.com)
  • XAG-2 expression gathers at the anterior region of the dorsal ectoderm, and this region corresponds to the cement gland anlage. (wikipedia.org)
  • oligosaccharides
  • The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. (wikipedia.org)
  • The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. (wikipedia.org)
  • N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)
  • Cancer
  • When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
  • extracellular
  • MUC-4 mucins consist of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. (wikipedia.org)
  • These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. (wikipedia.org)
  • genomic
  • Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. (wikipedia.org)
  • high
  • In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. (springer.com)
  • distinct
  • Mature mucins are composed of two distinct regions: The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. (wikipedia.org)
  • epithelial
  • The mucin acts to smooth out the epithelial surface, as well as binding the aqueous component of the tear film to the hydrophobic epithelium. (vin.com)
  • However, as is now known, considerable change occurs in all compartments of the plasma membrane of uterine epithelial cells and these changes occupy most of early pregnancy in the rat and mouse with long, regular microvilli being converted into short, irregular structures as early as d 3, 2 to 3 days before the blastocyst even enters the uterus. (wikipedia.org)
  • species
  • Moreover, as we have also seen, there are molecular alterations in the plasma membrane during early pregnancy which have common aspects across species and here some of the large mucin molecules (such as MUC-1) are particularly instructive. (wikipedia.org)
  • Akkermansia muciniphila is a species of human intestinal mucin-degrading bacterium, the type species for a new genus, Akkermansia, proposed in 2004 by Muriel Derrien and others. (wikipedia.org)
  • A. muciniphila is able to use mucin as its sole source of carbon and nitrogen, is culturable under anaerobic conditions on medium containing gastric mucin, and is able to colonize the gastrointestinal tracts of a number of animal species. (wikipedia.org)
  • sequence
  • The site of autoproteolysis is a conserved GSVVV sequence located at the ends of beta-sheets 2 and 3 where the resulting N- and C-terminal residues become integrated parts of these sheets after cleavage. (openthesis.org)
  • Type
  • This include sites for N-acetyltransferase (NetAcet 1-), glycation of ε amino groups of lysines (NetGlycate 1.0), mucin type GalNAc O-glycosylation (NetOglyc 4.0), phosphorylation (NetPhos 2.0), sumoylation (SUMOplot Analysis Program) and O-ß-GlcNAc attachment(YinOYang WWW). (wikipedia.org)
  • Granuloma annulare may be divided into the following types: Localized granuloma annulare Generalized granuloma annulare Patch-type granuloma annulare Subcutaneous granuloma annulare Perforating granuloma annulare Because granuloma annulare is usually asymptomatic and self-limiting with a course of about 2 years, initial treatment is generally topical steroid creams, followed by oral steroids and finally intradermal injections at the site of each ring. (wikipedia.org)
  • Researchers have discovered that A. muciniphila may be able to be used to combat obesity and type 2 diabetes. (wikipedia.org)
  • large
  • SRCCs are named due to their resemblance to signet rings, which result from the formation of large vacuoles full of mucin that displace the nucleus to the cell's periphery. (wikipedia.org)
  • clinical
  • The clinical course of biliary sludge can do one of three things: (1) it can resolve completely, (2) wax and wane, or (3) progress to gallstones. (wikipedia.org)
  • properties
  • This significantly influences on the physical, chemical and mechanical properties of the material [1,2]. (inp.nsk.su)
  • structure
  • This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. (githubusercontent.com)