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  • found
  • Mucins that are found on the surface of the gastric epithelium. (ucdenver.edu)
  • We found that both cysteinyl leukotriene (CysLT) receptors, CysLT(1) and CysLT(2,) were present in rat conjunctiva and in rat and human cultured conjunctival goblet cells. (blogspot.com)
  • surface
  • Chronic inflammatory diseases such as allergic conjunctivitis and early dry eye lead to increased goblet cell mucin secretion into tears and ocular surface disease. (blogspot.com)
  • gene
  • Mucins are glycoproteins with high molecular weight, responsible for cell growth, differentiation, and signaling, and were proposed to be correlated with gene heterogeneity of lung cancer. (springer.com)
  • In histopathology, the product of the MUC-1 gene is commonly referred to as epithelial membrane antigen or EMA. (wikipedia.org)
  • The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. (wikipedia.org)
  • Dual oxidase 1, also known as DUOX1 or ThOX1 (for thyroid oxidase), is an enzyme which in humans is encoded by the DUOX1 gene. (wikipedia.org)
  • The hepatitis A virus cellular receptor 1 (HAVCR1/TIM-1), is a member of the TIM (T cell transmembrane, immunoglobulin, and mucin) gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection. (wikipedia.org)
  • Subsequently, it was demonstrated that members of the TIM gene family including TIM-1 participate in host immune response. (wikipedia.org)
  • The mouse TIM gene family contains eight members (TIM-1-8) while only three TIM genes (TIM-1, TIM-3, and TIM-4) have been identified in humans. (wikipedia.org)
  • In addition, the Dengue virus susceptibility of different cell lines was consistent with endogenous expression level of TIM-1 gene in such cell lines, suggesting that TIM-1 is crucial for Dengue virus entry. (wikipedia.org)
  • glycoprotein
  • In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122) is an enzyme that catalyzes the chemical reaction UDP-galactose + glycoprotein N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine Thus, the two substrates of this enzyme are UDP-galactose and glycoprotein N-acetyl-D-galactosamine, whereas its two products are UDP and glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine. (wikipedia.org)
  • carbohydrate
  • This enzyme cleaves the carbohydrate structure from the peptide, leaving behind a diagnostic sign: the Asn residue is hydrolyzed to Asp, inducing a mass shift of +1 Da. (mcponline.org)
  • cell
  • In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. (fishersci.no)
  • Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. (wikipedia.org)
  • TIM-1 is preferentially expressed on Th2 cells and has been identified as a stimulatory molecule for T-cell activation. (wikipedia.org)
  • Moreover, reducing expression of endogenous TIM-1 in highly permissive cell lines decreased Ebola virus infectivity. (wikipedia.org)
  • TIM-1 has been identified as a cellular factor for Dengue virus entry by overexpression of TIM-1 on poorly susceptible cell lines for Dengue virus infection. (wikipedia.org)
  • glandular
  • The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. (ctdbase.org)
  • cancers
  • The prototypic oncoantigen is HER2/neu, a membrane tyrosine kinase similar to the epidermal growth factor receptor (EGFR, or HER-1), expressed in about one-fourth of breast cancers. (wikipedia.org)
  • human
  • Also, TIM-1 expression on human mucosal epithelial cells from the trachea, cornea and conjunctiva demonstrated the correlation of TIM-1 expression feature and viral entry routes. (wikipedia.org)
  • type
  • This report studies the global Mucin 1 market status and forecast, categorizes the global Mucin 1 market size (value & volume) by manufacturers, type, application, and region. (reportsnreports.com)
  • Earlier on the condition was called medullary cystic kidney disease type 1. (wikipedia.org)
  • cells
  • In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. (fishersci.no)
  • 2017
  • The global Mucin 1 market is valued at xx million US$ in 2017 and is expected to reach xx million US$ by the end of 2025, growing at a CAGR of xx.x % between 2018 and 2025. (reportsnreports.com)
  • ligand
  • By using an expression cloning library, IgA has been demonstrated as a specific ligand of TIM-1. (wikipedia.org)
  • expression
  • Interestingly entry of Lassa fever virus, influenza A virus, and SARS coronavirus were not affected by TIM-1 expression. (wikipedia.org)
  • substrates
  • In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122) is an enzyme that catalyzes the chemical reaction UDP-galactose + glycoprotein N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine Thus, the two substrates of this enzyme are UDP-galactose and glycoprotein N-acetyl-D-galactosamine, whereas its two products are UDP and glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine. (wikipedia.org)
  • This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. (wikipedia.org)
  • extracellular
  • In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. (githubusercontent.com)
  • In this classification system, cases of DPAM were characterized by peritoneal lesions composed of abundant extracellular mucin containing scant simple to focally proliferative mucinous epithelium with little cytologic atypia or mitotic activity (in other words, most cells looked fairly normal and there was no evidence of mitosis which would indicate that cells were rapidly dividing), with or without an associated appendiceal mucinous adenoma. (wikipedia.org)
  • epithelium
  • The inflammatory process can cause squamous metaplasia of the conjunctival epithelium, which causes loss of the mucin producing goblet cells, and ends up causing further tear quality problems. (vin.com)
  • species
  • Moreover, as we have also seen, there are molecular alterations in the plasma membrane during early pregnancy which have common aspects across species and here some of the large mucin molecules (such as MUC-1) are particularly instructive. (wikipedia.org)
  • Akkermansia muciniphila is a species of human intestinal mucin-degrading bacterium, the type species for a new genus, Akkermansia, proposed in 2004 by Muriel Derrien and others. (wikipedia.org)
  • A. muciniphila is able to use mucin as its sole source of carbon and nitrogen, is culturable under anaerobic conditions on medium containing gastric mucin, and is able to colonize the gastrointestinal tracts of a number of animal species. (wikipedia.org)
  • beta
  • Cummings, R.D., Trowbridge, I.S., Kornfeld, S.: A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N -acetylglucosaminyltransferase. (springer.com)
  • heat shock
  • CXorf49 is found to be one of the components of a small group of the HL-60 cell proteome that were most prone to form 4-Hydroxy-2-nonenal(HNE) adducts, upon exposure to nontoxic (10 μM) HNE concentrations, along with heat shock 60 kDa protein 1. (wikipedia.org)
  • layers
  • The tear film has three layers, an innermost mucin layer, a middle aqueous layer and an outer lipid layer. (vin.com)
  • response
  • Prof. Ian Frazer, the chairman of Prima's scientific advisory board commented: "There is clear evidence of a cellular response to mucin 1 induced by CVac treatment. (andhranews.net)
  • ICS is a laboratory technique used to evaluate if CVac has induced a desired mucin 1 specific T cell response in patients treated with CVac. (andhranews.net)
  • cause
  • Colorectal cancer is the second most common cause of cancer related death in the developed world [ 1 ], in consequence advances in our understanding and treatment of colorectal cancers can potentially have a huge impact on cancer morbidity and mortality. (biomedcentral.com)
  • less
  • Primary signet ring cell carcinoma of the colon and rectum (PSRCCR) is rare, with a reported incidence of less than 1 percent. (wikipedia.org)
  • A stimulated saliva flow rate less than 0.5 ml per gland in 5 minutes or less than 1 ml per gland in 10 minutes is decreased. (wikipedia.org)
  • properties
  • This significantly influences on the physical, chemical and mechanical properties of the material [1, (inp.nsk.su)
  • free
  • Analysis revealed that ~7 kcal mol-1 of conformational free energy is partitioned as strain in the precursor. (openthesis.org)