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  • cancers
  • The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers. (wikipedia.org)
  • mucosal
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)
  • Bovine
  • Bovine submaxillary mucin coatings Verotoxin-producing Escherichia coli Marin, F. D. R. (wikipedia.org)
  • Bovine submaxillary mucin (BSM) coatings are a surface treatment provided to biomaterials intended to reduce the growth of disadvantageous bacteria and fungi such as S. epidermidis, E. coli, and Candida albicans. (wikipedia.org)
  • However, it is the mucin from bovine and porcine sources that have been used in several biomaterial applications. (wikipedia.org)
  • Gastric
  • Native mucin extract from normal gastric mucosa and from gastric diffuse carcinoma. (abcam.com)
  • A gel-forming mucin that is predominantly associated with the gastric epithelium. (jove.com)
  • cell
  • MUC-4 mucins consist of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. (wikipedia.org)
  • As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
  • When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
  • The repulsive forces applied by the mucin creates anti-adhesive properties which can suppress cell adhesion to surfaces. (wikipedia.org)
  • Expression
  • In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. (mdpi.com)
  • however, for many types of cancer, mucin expression becomes altered (down-regulated, up-regulated or newly expressed). (atlasgeneticsoncology.org)
  • Therefore, the over-expression of mucins may be implicated in the exfoliation, dissemination and invasion of the cancer cells (Hollingsworth and Swanson, 2004). (atlasgeneticsoncology.org)
  • extracellular
  • These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. (wikipedia.org)
  • surfaces
  • Mucins interact with surfaces in a unique way due to the amphiphilic properties the molecules exhibit. (wikipedia.org)
  • Most mucins adsorb to solid surfaces fairly easily without surface preparation due to the attractive interaction of the surface with the non-glycosylated region of the molecule. (wikipedia.org)
  • Surface force measurements reveal that long range steric repulsion forces exist between mucin coated surfaces and can be detected at a distance of up 100 nm or more. (wikipedia.org)
  • The efficiency of mucin adherence to hydrophobic surfaces has been analyzed by applying a coating of mucin and measuring the number of mucins remaining on the hydrophobic material after rinsing. (wikipedia.org)
  • tandem repeats
  • Mucins share a common structural feature which is a tandem repeat domain comprising a variable number of tandem repeats (VNTRs) of identical or highly similar sequences rich. (springer.com)
  • The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. (wikipedia.org)