Muc1 mucin 4. Medical search. Frequent questions

Some EGF-like mucins, plus MUC1 and MUC16, carry SEA domains, a vertebrate invention. (wikipedia.org)
MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)

The effect demonstrated that AB-FUBINACA regardless of their Compact disc4 count number both MUC5B and MUC7 mucins from HIV sufferers unlike those HIV detrimental sufferers didn't inhibit HIV-1 activity and a 100% viral an infection from the CEM SS cells was assessed with the p24 antigen assay after a 30 min incubation period (Amount 1A-C). This is unlike MUC5B and MUC7 mucins from HIV detrimental people [4]. (techblessing.com)
The measurement of mucin-like carcinoma-associated antigen is mainly used to monitor patients with metastatic breast cancer. (athenslab.gr)
The Mucin-like Carcinoma-associated Antigen (MCA) is a high molecular weight glycoprotein, a product of the MUC1 gene. (athenslab.gr)
The mucin-like carcinoma-associated antigen is useful as an indicator for the investigation of metastases, for monitoring the therapeutic response of tumors, for the detection of relapses, and for the staging of tumors. (athenslab.gr)
The mucin-like carcinoma-associated antigen is usually elevated in the second trimester of pregnancy and steadily increases until slightly after childbirth. (athenslab.gr)
Cancer antigen 15-3, or CA 15-3, is an epitope of a large transmembrane glycoprotein named MUC1 that is derived from the MUC1 gene. (medscape.com)
The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
The claims granted by the patent generally cover GeoVax's vector platform for expressing tumor associated antigens in virus-like particles (VLPs) from a Modified Vaccinia Ankara (MVA) viral vector and encompass GeoVax's Mucin 1 (MUC1) tumor-associated antigen immunotherapy candidate. (geovax.com)

The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
We found that mRNAs of secretory Muc2 and membrane-associated Muc1 , Muc3 and Muc4 were expressed in the small intestine. (medsci.org)
Ed mucin) is related with invasive proliferation of the tumors and poor outcome of the patients, whereas the buy 58-49-1 Expression of the MUC2 mucin (intestinal type secretory mucin) is related with the non-invasive proliferation of the tumors and a favorable outcome for the patients [4,5]. (calcium-channel.com)
In the cases with more than two histological types mixed in one lesion, each histological pattern was evaluated independently, according to the Japanese Classification.Ed mucin) is related with invasive proliferation of the tumors and poor outcome of the patients, whereas the expression of the MUC2 mucin (intestinal type secretory mucin) is related with the non-invasive proliferation of the tumors and a favorable outcome for the patients [4,5]. (calcium-channel.com)

Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. (wikipedia.org)
3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
Mucins are characterized by a core protein heavily decorated by many sugar structures [5, 9, 10]. (milkgenomics.org)
The molecular structure of mucin is like a bottle brush flower with its stem representing the mucin protein and the red flowers representing the dense array of sugars attached to the protein (see illustration). (milkgenomics.org)
Sando and colleagues demonstrated that a principal milk fat globule membrane protein is the milk mucin named MUC-1, which is densely decorated with a variety of sugars that also resemble the sugar structures on proteins present on the surface of gut cells [10]. (milkgenomics.org)
MUC1 Protein (Human with mFc Tag) is a highly pure human recombinant MUC1 protein (expressed in HEK293 cells) fused to the Fc region of mouse IgG. (moleculardepot.com)
Physiologically, the MUC1 protein may be involved in cell adhesion by decreasing the degree of cell-to-extracellular matrix and cell-to-cell interactions. (medscape.com)
4] It has been suggested that the MUC1 protein and its overexpression may be causally related to cancer invasion and metastasis. (medscape.com)
Several histopathological variables such as tumour size lymph node status lymphatic or vascular invasion and the tumour grade of differentiation form have been widely used parameters in prognostic evaluations [2 3 In human breast cancer and other malignancies serum tumour markers play an important role in patient management [4 5 Tumour cells display protein molecules on their surfaces. (scienceexhibitions.org)
The Company uses its GV-MVA-VLP™ vaccine platform to express abnormal, aberrantly glycosylated forms of the cell surface-associated MUC1 protein that is associated with a wide range of cancers, including breast, colon, ovarian, prostate, pancreatic, and lung. (geovax.com)

Muc in animals ) is a transmembrane mucin glycoprotein expressed in mucosal epithelial cells and hematopoietic cells . (bvsalud.org)
9: Sirviö E, Mikkonen JJW, Koistinen AP, Miinalainen I, Kullaa AM. Localization of transmembrane mucin MUC1 on the apical surface of oral mucosal cells. (moleculardepot.com)

Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Patients who maintained high immunoreactivity for anti-MUC1 antibody had a better prognosis, whereas those with an increase in anti-MUC3 immunoreactivity had a poorer prognosis, as judged by tumour size, serosal invasion, and metastasis. (bmj.com)
namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
Simultaneously, increased gene expression of physiologically essential molecules such as mucin (MUC1 and MUC3) and brain-derived neurotrophic factor (BDNF) was also observed in this group. (biomedcentral.com)

Conclusions Purified salivary mucins from HIV positive sufferers usually do not inhibit the Helps trojan within an in vitro assay. (techblessing.com)
4] the SDS-PAGE music group appearance Traditional western blotting and amino acidity analysis show the salivary mucins which eluted in the void and included amounts from the Sepharose CL-4B gel purification column to become MUC5B and MUC7 respectively. (techblessing.com)
Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)

The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)

In the present study, we examined the expression profiles of MUC4 as well as MUC1 in early gastric cancer tissues, and found that MUC4 and MUC1 expression in the early gastric cancers would become poor prognostic factors 18055761 by lymph vessel invasion, blood vessel invasion and lymph node metastasis. (calcium-channel.com)
Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori -infected pathogenesis of gastric cancer (GC). (biomedcentral.com)

Anti-MUC1 aptamer: A potential opportunity for cancer treatment. (moleculardepot.com)

Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of breast-cancer patients Int J Cancer. (moleculardepot.com)

Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. (wikipedia.org)
Besides, MUC1 overexpression vector or small interfering RNA (siRNA) was transfected into GC cells to assess the change in TFF2 expression. (biomedcentral.com)
Overexpression of MUC1 in BGC-823 and SGC-7901 cell lines substantially increased the TFF2 expression, whereas knockdown of MUC1 reverted this effect. (biomedcentral.com)
The results of BSP experiments showed that compared with negative vector group, the methylation level of TFF2 was decreased in GC cells transfected with MUC1 overexpression vector. (biomedcentral.com)

Discrimination of MUC1 mucins from other sialyl-Le(a)-carrying glycoproteins produced by colon carcinoma cells using a novel monoclonal antibody Cancer Res. (moleculardepot.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 4 (GAL4) in serum, plasma, tissue homogenates and other biological fluids. (jsce-ip.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Galectin 4 (GAL4) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)

MUC4 was first reported as tracheobronchial mucin [7] and is a membrane-associated mucin [8]. (calcium-channel.com)

Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. (wikipedia.org)
Although the explanation for the shortcoming of mucins from contaminated people to inhibit the trojan isn't known chances are that there surely is an alteration from the glycosylation design and for that reason of charge of mucin in HIV positive sufferers. (techblessing.com)
Many cancer antigens are classified as mucin-like because they contain the same core of the MUC1 gene, with different glycosylation variants. (athenslab.gr)

mRNA expression of Muc1-4 was increased in indomethacin-induced SII, and these increases were prevented by sodium alginate. (medsci.org)
MUC1, FGF2, and HBEGF gene mRNA expression changes may explain the embryo rejection from the uterus and the establishment of a receptive phenotype in fallopian cells. (ijfs.ir)

Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)

Of these mucins, the following classes have been defined by localization: Secreted mucins in humans, with their chromosomal location, repeat size in amino acids (aa), whether they are gel-forming (Y) or not (N), and their tissue expression. (wikipedia.org)
The aims of this study were to determine whether macrophages express MUC1, and, if so, whether MUC1 expression might be associated with macrophage M0/M1/M2 differentiation or phagocytic activity. (bvsalud.org)
Human and mouse MUC1/Muc1 expression was drastically up-regulated in classically activated (M1) macrophages compared with nonactivated (M0) and alternatively activated (M2) macrophages . (bvsalud.org)
These results indicate that MUC1/Muc1 expression by macrophages is predominantly in the M1 subtype, and that MUC1/Muc1 expression in these cells decreases their phagocytic activity in an antiinflammatory manner. (bvsalud.org)
The effects of serum on mucin (MUC-1) expression were observed in cultured conjunctival epithelial cells in vitro. (bmj.com)
Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
Our previous study showed thatMUC4 and MUC1 Expression in Early Gastric CancersFigure 1. (calcium-channel.com)
However, little is known of the molecular mechanism on MUC1 regulating the expression of TFF2 . (biomedcentral.com)
The expression of MUC1 was significantly lower in non-cardia and cardia tumor tissues than that in normal tissues. (biomedcentral.com)
In addition, we found that MUC1 expression was positively associated with TFF2 expression in GC tissues, especially among GC patients with H. pylori infection. (biomedcentral.com)
Moreover, MUC1 was negatively related to the methylation of TFF2 in the co-expression analysis. (biomedcentral.com)
Our results indicated that MUC1 was associated with the methylation of TFF2 , which may have implications for TFF2 expression in GC. (biomedcentral.com)
To address this question, we evaluated the expression of MUC1 mRNA in the lymph node samples of NSCLC to determine micrometastasis. (cusabio.com)
A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening. (expasy.org)
Al-Azemi M, Refaat B, Aplin J, Ledger W. The expression of MUC1 in human fallopian tube during the menstrual cycle and in ectopic pregnancy. (ijfs.ir)
Expression of mucin 1 possessing a 3'-sulfated core1 in recurrent and metastatic breast cancer. (researchmap.jp)

Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design. (immuquest.com)

Background We've previously shown that MUC5B and MUC7 mucins from saliva of HIV detrimental all those inhibit HIV-1 activity by 100% within an in vitro assay. (techblessing.com)
With this thought we made a decision to check out whether MUC5B and MUC7 from saliva of HIV sufferers or with complete blown Helps had an identical inhibitory activity as the MUC5B and MUC7 from HIV detrimental people [4] against the trojan. (techblessing.com)

Such antigens are CA 15-5 commonly used to monitor ovarian cancer, CA 19-9 used to monitor gastrointestinal cancer, CA 50 used to monitor lung and gastrointestinal cancers, CA 72-4 used to monitor gastrointestinal and ovarian cancers, CA 125 used to monitor breast and ovarian cancers, etc. (athenslab.gr)

In the mouth, mucins can also recruit anti-microbial proteins such as statherins and histatine 1, which further reduces risk of infection. (wikipedia.org)
MUC1 is involved in the resolution of inflammation during airway Pseudomonas aeruginosa (Pa) infection by suppressing Toll-like receptor signaling in airway epithelial cells . (bvsalud.org)
A recent study revealed that H. pylori infection induced obviously increased Tff2 methylation levels in Muc1 −/− mice compared with controls. (biomedcentral.com)
6: Dhar P, McAuley J. The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation. (moleculardepot.com)
The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation.Front Cell Infect Microbiol 24;9:117. (immuquest.com)

In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling.Semin Immunol 47:101389 (2020). (immuquest.com)

5: Taylor-Papadimitriou J, Burchell JM, Graham R, Beatson R. Latest developments in MUC1 immunotherapy. (moleculardepot.com)
During the first quarter, GeoVax began an IND-enabling animal study with Dr. Pinku Mukherjee at the University of North Carolina at Charlotte to define the optimal course and schedule of vaccination to define a protocol that can be evaluated in a Phase 1 clinical trial for the Company's MVA-VLP-MUC1 immunotherapy candidate. (geovax.com)

Am J Respir Cell Mol Biol;54(4): 515-23, 2016 Apr. (bvsalud.org)

Mucins (/ˈmjuːsɪn/) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. (wikipedia.org)
Mucins are secreted as massive aggregates of proteins with molecular masses of roughly 1 to 10 million Da. (wikipedia.org)
Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)

The lethal nature of pancreatic cancer is mainly correlated with its late diagnosis, high metastatic capacity to nearby organs, and resistance to therapeutic agents [ 4 ]. (oncotarget.com)

MUC5B, the predominant mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans, a bacterium with the potential to form cavities. (wikipedia.org)
Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans, Helicobacter pylori, and even HIV. (wikipedia.org)

Description: A sandwich ELISA kit for detection of Galectin 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)

Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy. (nwbio.com)
MUC1 mucin in urological malignancy. (moleculardepot.com)

N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)

Size AB-FUBINACA charge and immunoreactivity distinctions between your mucins from HIV positive and negative people and among the mucins from HIV sufferers of different Compact disc4 count number was noticed by SDS-PAGE Traditional western blot and ELISA. (techblessing.com)

The mRNA expressions of MUC1, FGF2, and HBEGF genes in the fallopian tube and endometrial tissues were measured by real-time polymerase chain reaction (PCR) assay. (ijfs.ir)
Description: A sandwich quantitative ELISA assay kit for detection of Rat Galectin 4 (GAL4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (jsce-ip.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutathione S Transferase Alpha 4 (GSTa4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (envite.org)

Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva. (wikipedia.org)

Although alveolar macrophages are recognized as critical mediators of cell-mediated immunity against microorganisms inhaled into the airways, the role of MUC1 in regulating their response is unknown. (bvsalud.org)

Mature mammalian mucins are composed of two distinct regions: The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. (wikipedia.org)

These 2 antibodies target epitopes located on the peptide core of the extracellular domain of MUC1. (medscape.com)

A recent study has shown that, despite the high intrinsic mutability of subexonic repeats, the vast majority of thousands of subexonic repeats remain strongly conserved among mammals 4 . (nature.com)
These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)

Almasmoum H. The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer.Cancer Manag Res. (immuquest.com)

All normal gastric mucosa samples expressed MUC1, MUC5AC, and MUC6. (bmj.com)
Mucin 1 ( MUC1 ) is a kind of cell surface mucins and is abundant in mucosal tissues, especially in normal gastric epithelial cells [ 9 ]. (biomedcentral.com)

The model is then found valid for different redox species composition (either Fe(CN) 6 3- or Fe(CN) 6 3-/4- is used) and for both blank and aptamer modified surfaces. (chihyulai.com)

4: Gao T, Cen Q, Lei H. A review on development of MUC1-based cancer vaccine. (moleculardepot.com)

ASL is made up of two layers an upper viscoelastic layer of mucins secreted by the goblet cells and submucosal glands and a lower periciliary layer made up of large membrane-bound glyocproteins as well as tethered mucins (muc-1 muc-4 and muc-16) [13 14 The periciliary layer is relatively less viscous and acts as a lubricating layer for cilia to beat. (researchtoactionforum.org)

We conducted a correlation analysis of MUC1 and TFF2 in public databases and our adjacent GC tissues. (biomedcentral.com)

demonstrated that MUC1 acted as a negative regulator of the NLRP3 inflammasome activation and protected against H. pylori pathogenesis. (biomedcentral.com)

Human mucins include genes with the HUGO symbol MUC 1 through 22. (wikipedia.org)

Eleven mucins are expressed by the eye surface epithelia, goblet cells and associated glands, even though most of them are expressed at very low levels. (wikipedia.org)

2: Nath S, Mukherjee P. MUC1: a multifaceted oncoprotein with a key role in cancer progression. (moleculardepot.com)

Many scientists report that large populations of different bacterial species are present in the human gut where they aid digestion of food [3, 4]. (milkgenomics.org)
Synthesized peptide derived from the C-terminal region of Human Mucin 1. (cusabio.com)

Finally, MUC1/Muc1 deficiency in macrophages increased reactive oxygen species production and TNF-α release in response to Pa compared with MUC1/Muc1-sufficient cells . (bvsalud.org)

these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. (cusabio.com)

2012 Sep 11 [cited 2018 Jun 4];22(17):R741-52. (prolekarniky.cz)

BS, Pasdar A, Mokhtarzadeh A, Ramezani M. Aptasensors as a new sensing technology developed for the detection of MUC1 mucin: A review. (moleculardepot.com)

METHODS The stability of essential components (EGF, vitamin A, and TGF-β) in preserved serum were examined following preservation at 4°C and −20°C. In a primary clinical trial, 12 patients with Sjögren's syndrome were treated with autologous serum (diluted to 20% with sterile saline) for 4 weeks, and vital staining of the ocular surface was compared before and after treatment. (bmj.com)
The stability of the serum was assessed by measuring the concentration of EGF, TGF-β, and vitamin A in fresh serum samples, and after preservation in the freezer (−20°C) and refrigerator (4°C) for up to 3 months. (bmj.com)
Studied predictive use of mucin 1 (KL-6) serum level as a biomarker in development of bronchopulmonary dysplasia in preterm infants. (cusabio.com)

These findings may be linked to reports that MUC1 plays an important role in the impairment of cell-cell adhesion, the immune response, and/or altered intracellular signalling. (bmj.com)
Toxocara canis family of secreted mucins Tc-MUC-1 to -5, which are implicated in immune evasion. (expasy.org)

Anatomy10

Organisms2

Diseases1

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Information Science3

MUC162

Antigen9

MUC24

Protein10

Transmembrane mucin2

MUC34

Salivary4

Mucosal barriers1

Gastric cancer2

Anti-MUC11

Carcinoma-associated1

Overexpression4

Monoclonal antibody1

Antibody2

MUC41

Apical surface1

Glycosylation3

MRNA expression2

Secretory1

Expression19

Tumor1

MUC72

Cancers1

Infection5

Metastasis2

Immunotherapy2

Respir Cell Mol Biol1

Proteins3

Pancreatic1

MUC5B2

ELISA Kit1

Malignancy2

Oligosaccharides1

Immunoreactivity1

Assay3

Saliva1

Microorganisms1

Distinct1

Antibodies1

Repeats2

Chromosome1

Normal gastric2

Aptamer1

Cancer vaccine1

Membrane-bound1

Tissues1

Regulator1

Genes1

Goblet cells1

Progression1

Human2

Species1

Abnormal1

20181

Detection1

Serum3

Immune2