GlycoproteinsHighly glycosylated proteinsMUC1Transmembrane mucinMucosaMUC2High-molecularEpithelial cellsMUC4SecretoryMolecular weightProteinsPancreasTumorProteinGenesMoleculesRepeatsMucusMilkFacilitatesEpitheliumMetastasisCysticExpressionHumanRoleImmuneCellInteractionsFamilyContentProductionComplexFunctionsServeAffectCancer
Glycoproteins4
- Mucins, the main constituents of the mucus layer, are glycoproteins synthesized by goblet cells. (scielo.br)
- Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
- Mucins are high molecular-weight glycoproteins (120-1000 kDa) with sialylated oligosaccharides. (romj.org)
- The role of mucins, high molecular weight glycoproteins that comprise the mucus, in the pathophysiology of cystic fibrosis is currently being investigated. (healthdrugpdf.com)
Highly glycosylated proteins2
- The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. (wikipedia.org)
- Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
MUC19
- The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
- 4] It has been suggested that the MUC1 protein and its overexpression may be causally related to cancer invasion and metastasis. (medscape.com)
- The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
- Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
- Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
- 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
- 3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
- Simultaneously, increased gene expression of physiologically essential molecules such as mucin (MUC1 and MUC3) and brain-derived neurotrophic factor (BDNF) was also observed in this group. (biomedcentral.com)
- The transmembrane mucin MUC1 co- localizes with CFTR. (healthdrugpdf.com)
Transmembrane mucin1
- MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)
Mucosa6
- In the soluble form, MUC-4 appears to lubricate the epithelial mucosa. (wikipedia.org)
- Influence of the application of enemas with oily extract of curcumin ( Curcuma longa ) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream ☆ ☆ Study conducted at Universidade São Francisco (USF), Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Investigação Médica (LIM), Bragança Paulista, SP, Brazil. (scielo.br)
- To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream. (scielo.br)
- Tissue quantification of neutral and acid mucins in the mucosa of the colon with and without fecal stream in rats. (scielo.br)
- Thus, the mucin-coated CP has the potential to contribute to gallstone-associated cholecystitis via oxidative damage of mucosa and epithelium. (romj.org)
- Mucin, a major component of mucosa, is not only absorbed by these particles but is also actively incorporated [2, 4]. (romj.org)
MUC22
- The most overexpressed genes included Fc Fragment of IgG Binding Protein ( FCGBP , logFC = 3.01, pFDR = 0.015), Mucin 2 ( MUC2 , logFC = 2.78, pFDR = 0.015), and Alpha 1B Defensin ( DEFA1B , logFC = 2.73, pFDR = 0.024). (biomedcentral.com)
- Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
High-molecular2
- Like other mucins, MUC-4 is a high-molecular weight glycoprotein. (wikipedia.org)
- Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
Epithelial cells2
- The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
- Mucin glycoprotein expression in IMPN epithelial cells within the cyst lining is routinely used to help characterize these IPMN subtypes by immunohistochemistry [ 12 ]. (gastrores.org)
MUC44
- Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. (wikipedia.org)
- MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. (wikipedia.org)
- MUC4 detection is emerging as a method to diagnose pancreatic cancer, especially since MUC4 is not detectably expressed in normal pancreas and increased expression of MUC-4 suggests a greater progression of the disease. (wikipedia.org)
- namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
Secretory2
Molecular weight1
- MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation. (wikipedia.org)
Proteins2
- Sando and colleagues demonstrated that a principal milk fat globule membrane protein is the milk mucin named MUC-1, which is densely decorated with a variety of sugars that also resemble the sugar structures on proteins present on the surface of gut cells [10]. (milkgenomics.org)
- Earlier it was shown that crystals coated with plasma proteins can stimulate greater chemiluminescent response of polymorphonuclear leukocytes than untreated particles [7], but little is known about effects of adsorbed mucin. (romj.org)
Pancreas1
- MUC-4 is not found in the gallbladder, pancreas, or liver except in abnormal conditions such as cancer. (wikipedia.org)
Tumor3
- MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. (wikipedia.org)
- MUC-4 is thought to play a role in cancer progression by repressing apoptosis and consequently increasing tumor cell proliferation. (wikipedia.org)
- As tumor cells shed this MUC-1 antigen into the bloodstream, it is recognized by 2 monoclonal antibodies in a radioimmunoassay. (medscape.com)
Protein2
- Mucins are characterized by a core protein heavily decorated by many sugar structures [5, 9, 10]. (milkgenomics.org)
- The molecular structure of mucin is like a bottle brush flower with its stem representing the mucin protein and the red flowers representing the dense array of sugars attached to the protein (see illustration). (milkgenomics.org)
Genes1
- Transcriptional regulation of the 11p15 mucin genes. (imrpress.com)
Molecules1
- Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
Repeats3
- A recent study has shown that, despite the high intrinsic mutability of subexonic repeats, the vast majority of thousands of subexonic repeats remain strongly conserved among mammals 4 . (nature.com)
- Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
- These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
Mucus1
Milk1
- Investigations led by Sando, Gaiani, and their colleagues demonstrate that milk also contains a mucin, MUC-1, that takes the fine art of deception and diversion to another level [1, 9, 10]. (milkgenomics.org)
Facilitates1
- In these roles, MUC-4 serves to protect and lubricate the epithelium, which facilitates transport and traps foreign particles. (wikipedia.org)
Epithelium1
Metastasis2
- When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
- In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
Cystic1
- However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
Expression3
- A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening. (expasy.org)
- Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
- This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
Human3
- Many scientists report that large populations of different bacterial species are present in the human gut where they aid digestion of food [3, 4]. (milkgenomics.org)
- CP were incubated in mucin or human serum albumin (HSA) giving CP-Muc and CP-HSA. (romj.org)
- Their hemolytic activity towards human erythrocytes was assayed, and neutrophil lucigenin- and luminol- chemiluminescence (Luc-CL and Lum-CL) response to CP, CP-HSA and CP-Muc was measured. (romj.org)
Role3
- MUC-4 may also have a role in fetal morphogenic development. (wikipedia.org)
- 2 2 Gaudier E, Hoebler C. Physiological role of mucins in the colonic barrier integrity. (scielo.br)
- The proinflammatory effect of mucin-coated particles is still unclear, and our aim was to study the role of mucin sorption in activation of neutrophil respiratory burst. (romj.org)
Immune3
- Toxocara canis family of secreted mucins Tc-MUC-1 to -5, which are implicated in immune evasion. (expasy.org)
- Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. (biomedcentral.com)
- A hallmark of the predominant asthma subtype is the stimulation of the adaptive immune system [ 2 ], specifically a Th2-type response, with involvement of interleukin (IL)-4 and IL-13, as well as antigen-specific immunoglobulin (Ig) type E. Type 2 innate immunity typically involves type 2 innate lymphoid cells, especially in older patients. (biomedcentral.com)
Cell1
- As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
Interactions1
- Adsorption of mucin by hydroxyapatite is related mainly to Ca-dependent electrostatic interactions between calcium ions and COO- of mucin [5]. (romj.org)
Family1
- A family of secreted mucins from the parasitic nematode Toxocara canis bears diverse mucin domains but shares similar flanking six-cysteine repeat motifs. (expasy.org)
Content3
- The content of both mucin subtypes was measured by computerized morphometry. (scielo.br)
- There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. (scielo.br)
- The content of acidic mucins increased in animals treated with 200 mg/kg/day regardless of the intervention time, whereas in those treated with 50 mg/kg/day an increase was observed only after four weeks. (scielo.br)
Production1
- Obviously, sorption of mucin but not that of HSA stimulated generation of reactive oxygen and halogen species with no increase in cytokine production. (romj.org)
Complex1
- The molecular mechanism is thought to be through a MUC-4 complex with ERBB2 receptors, which alters downstream signaling and down regulates CDKN1B. (wikipedia.org)
Functions1
- These investigators concluded that one of the functions of MUC-1 is to bind pathogenic bacteria, thereby diverting these bacteria from binding to gut cells [9]. (milkgenomics.org)
Serve1
- The beta subunit of MUC-4 appears to serve as a ligand that causes the phosphorylation of ErbB2, but does not activate the MAPK or AKT pathways. (wikipedia.org)
Affect1
- MUC-4 may also affect HER2 signaling, and result in its stabilization. (wikipedia.org)
Cancer1
- The lethal nature of pancreatic cancer is mainly correlated with its late diagnosis, high metastatic capacity to nearby organs, and resistance to therapeutic agents [ 4 ]. (oncotarget.com)