DNA, MitochondrialPoint MutationMutationMitochondrial DiseasesOptic Atrophy, Hereditary, LeberMELAS SyndromeMitochondrial MyopathiesMutation, MissenseOptic Atrophies, HereditaryMitochondrial EncephalomyopathiesRNA, Transfer, LeuGenome, MitochondrialDNA Mutational AnalysisMERRF SyndromeNADH DehydrogenasePedigreeMitochondriaLeigh DiseaseGenes, MitochondrialPolymerase Chain ReactionBase SequenceFrameshift MutationElectron Transport Complex IRNA, Transfer, SerElectron Transport Complex IVMitochondrial Proton-Translocating ATPasesMolecular Sequence DataOxidative PhosphorylationMitochondrial ProteinsGerm-Line MutationSequence Analysis, DNAPenetranceOphthalmoplegia, Chronic Progressive ExternalHeterozygotePhenotypeRNA, Transfer, ArgAgingHaplotypesHearing Loss, SensorineuralPolymorphism, Restriction Fragment LengthSequence DeletionHybrid CellsPhylogenyGenotypeMitochondria, MuscleMutation RateReactive Oxygen SpeciesDNA-Directed DNA PolymeraseCell RespirationDeafnessGene DeletionDNA PrimersModels, GeneticExonsAmino Acid SubstitutionPolymorphism, GeneticEvolution, MolecularHearing LossAllelesCell LineSelection, GeneticAge of OnsetMuscle, SkeletalPolymorphism, Single-Stranded ConformationalElectron TransportGenetic VariationAmino Acid SequenceMutagenesis, Site-DirectedMutagenesisCodon, NonsenseHomozygoteCell NucleusGenes, RecessiveFibroblastsOxidative StressFounder EffectGenetic TestingOxygen ConsumptionGenes, DominantCodonProtein Structure, TertiarySuppression, GeneticChromosome MappingDNA-Binding ProteinsEscherichia coliCells, CulturedModels, MolecularMice, Inbred C57BLTranscription FactorsCell Line, TumorSyndromeBinding SitesGenetics, PopulationSequence Homology, Amino AcidDNASequence AlignmentSaccharomyces cerevisiaeGenetic Complementation TestCloning, MolecularNeoplasms