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  • Lmx1a
  • A genetic cascade controlled by the secreted molecule Sonic hedgehog, including the transcription factors Lmx1a, Msx1 and Nkx6-1, acts in parallel with the Wnt1-regulated network to establish the midbrain dopaminergic progenitor domain. (tum.de)
  • mice
  • The phenotype of the mutant mice verifies the role of this gene in limb and mammary gland development, and, in addition, reveals a previously unknown role for the gene in the yolk sac, a fetal membrane that is the site of hematopoiesis and is essential for survival during gestation. (biologists.org)
  • ES cells provide a unique system for the genetic manipulation and the creation of knockout strains of mice through gene targeting. (ahajournals.org)
  • Progress in recent years led to the identification of many genes that when inappropriately expressed, defective, or absent will result in cleft palate in humans or mice. (frontiersin.org)
  • Overexpression of homeobox Msx1 induced apoptosis of cancer cells harboring nonfunctional wild-type p53 and suppressed growth of human tumor xenografts in nude mice. (aacrjournals.org)
  • The basic findings in mice revealed critical factors that determine the fate of one type of nerve cell progenitor and that set bone marrow stem cells into action. (bio-medicine.org)
  • To investigate whether the identification of determinants underlying the specification of dopamine neurons during development could be exploited for generating dopamine neurons from stem cells, the researchers first looked for genes expressed in the dopamine progenitor cells in the developing midbrains of embryonic mice. (bio-medicine.org)
  • Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH -expressing cells in regions where these factors likely function. (pubmedcentralcanada.ca)
  • mutation
  • In order to develop a mouse model to study the role of this gene during development and disease, we produced a mutation in the mouse ortholog, Tbx3 . (biologists.org)
  • A subtle mutation affecting the epigenome - a set of dynamic factors that influence gene activity - may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. (medicalnewstoday.com)
  • To study one mutation in Exon1 and seven mutations in Exon2 of PAX9 gene in the sample of individuals with missing teeth (probands) and their parents and siblings. (pacific.edu)
  • inactivation
  • The identification of a novel function of Msx1 as a p53 regulator may open new avenues for developing improved molecular therapies for tumors with a nonmutational p53 inactivation mechanism. (aacrjournals.org)
  • correlate
  • Furthermore, nonlinear effects of Fgf8 gene dose on the expression of a subset of genes, including Bmp4 and Msx1, correlate with a holoprosencephaly phenotype and with the nonlinear expression of transcription factors that regulate neocortical patterning. (escholarship.org)
  • to describe unusual clinical cases of non-syndromic CL/P (CL/PNS), diagnosed in a reference service in Minas Gerais, Brazil, and correlate these alterations with possible risk factors. (scielo.br)
  • subset
  • We show that lowering REST levels in ES cells results in the derepression of a subset of neuronal genes that are highly enriched for the canonical RE1 elements and that directly bind REST protein in wild-type ES cells. (biologists.org)
  • molecular
  • The comparisons of gene expression patterns and morphologies suggest that similar molecular cascades are used in the early budding of tooth germs, in the initiation of tooth crown base formation, and in the initiation of each cusp's development. (springer.com)
  • How these environmental factors interact with cellular and molecular events during early development of the embryo is only one of the questions that remain about the intricate developmental processes during palate development. (frontiersin.org)
  • However, the molecular events that alter gene expression to effect melanoblast specification are unknown. (biologists.org)
  • This is mostly a reflex of the complexity and diversity of the molecular mechanisms involved in embryogenesis, with the participation of multiple genes and the influence of environmental factors 10,11 . (scielo.br)
  • neurons
  • GnRH gene expression is limited to a discrete population of neurons that migrate through the nasal region into the hypothalamus during embryonic development. (pubmedcentralcanada.ca)
  • The GnRH gene is expressed in a complex spatiotemporal manner during embryonic development and into postnatal life with several populations of GnRH -expressing neurons originating at different developmental stages and locations. (pubmedcentralcanada.ca)
  • neural
  • The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
  • To determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. (biomedcentral.com)
  • The rostral division of the neural tube into its 3 main sections falls under the control of homeobox (Hox) family of genes. (medscape.com)
  • Loss of REST did not affect the expression of any of ten transcription factor genes known to promote neural commitment and did not affect the expression of several microRNAs, including miR-21 , a putative REST target in ES cells. (biologists.org)
  • By contrast, the expression of genes crucial for neural determination, or that regulate stem cell potential, was unaffected in REST-depleted ES cells. (biologists.org)
  • distinct
  • Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. (genecards.org)
  • Sequence
  • The members of these two clusters share a consensus 7-mer seed sequence and their targeted genes had overlapping functions. (biomedcentral.com)