• Rad-9 has been implicated with most DNA repair mechanisms, and plays a key role as it interacts with multiple proteins within each pathway. (wikipedia.org)
  • Furthermore, Rad-9, either as a free floating protein or part of the 9-1-1 complex, interacts with the rest of the proteins that are part of the base excision repair process, guiding its progression through the various stages. (wikipedia.org)
  • Rad9 was originally found in budding yeast cells but a human homolog has also been found and studies have suggested that the molecular mechanisms of the S and G2 checkpoints are conserved in eukaryotes. (wikipedia.org)
  • The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. (academicinfluence.com)
  • It forms a checkpoint protein complex with Rad1 and Hus1. (wikipedia.org)
  • This is also known as the Rad9-Rad1-Hus1 or 9-1-1 complex. (wikipedia.org)
  • In agreement with this, transcriptional changes following treatment with 1-(S,Rp) include activation of three of the four genes (HUS1, RAD1, RAD17) of the 9-1-1 check point complex clamp and two of the three genes (MRE11, NBN) that form the MRN complex as well as activation of multiple downstream targets. (bvsalud.org)
  • This complex is recruited by checkpoint protein Rad17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. (wikipedia.org)
  • Furthermore, Rad-9, either as a free floating protein or part of the 9-1-1 complex, interacts with the rest of the proteins that are part of the base excision repair process, guiding its progression through the various stages. (wikipedia.org)