• miRNAs are numbered based on the sequence of the mature RNA. (wikipedia.org)
  • miRNAs are thought to have regulatory roles through complementarity to mRNA. (wikipedia.org)
  • miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
  • MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
  • miRNAs induce gene degradation and suppression of translation, or both, mainly by imperfect binding to miRNA recognition elements (MREs) within the 3′-untranslated region (UTR) of target mRNAs ( 1 ). (frontiersin.org)
  • Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
  • MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
  • MiRNAs are generated by stepwise cleavage via double-stranded ribonuclease III enzymes DROSHA and DICER1 and loaded onto Argonaute (AGO) proteins to pair with target sequences on mRNAs 20 . (nature.com)
  • We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramar. (researchgate.net)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
  • Previously, it has been demonstrated that certain transcriptional targets of SOX4 are associated with cancer development and progression and the processing of microRNAs (miRNAs/miRs) ( 12 ). (spandidos-publications.com)
  • miRNAs are small non-coding RNAs (~22 nucleotides in length) that regulate the expression of their target genes by translational repression or mRNA degradation ( 13 , 14 ). (spandidos-publications.com)
  • Differential expression of miRNAs has been widely described in breast cancers, and suggests that certain miRNAs, including miR-206 ( 19 ), miR-129 ( 20 ), miR-200 ( 21 ) and miR-34 ( 22 ), may function as oncogenes or tumor suppressors in breast cancer. (spandidos-publications.com)
  • To understand the molecular mechanism of SOX4 in breast cancer development and progression, the present study aimed to identify miRNAs that regulate the expression of SOX4, which revealed miR-320 as a potential candidate. (spandidos-publications.com)
  • The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. (degruyter.com)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
  • We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chlamydomonas can regulate gene expression both by destabilization of the mRNA and by translational repression. (freethoughtblogs.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
  • To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
  • The test uses nanoparticles to capture tumor-specific microRNAs (miRNAs) in human serum. (mordorintelligence.com)
  • Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)
  • miRNAs are essential for brain development and function, with multiple miRNAs enriched in specific cell types where they regulate differentiation, structure and neurophysiological properties [ 9 , 10 ]. (researchsquare.com)
  • Expression of various miRNAs is dysregulated in experimental models of status epilepticus and in resected brain tissue from patients with drug-resistant temporal lobe epilepsy [ 11-13 ]. (researchsquare.com)
  • In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
  • MicroRNAs (miRNAs), a class of small, endogenous, non-coding RNAs, are able to regulate gene expression by translational repression or mRNA degradation of the target, thereby affecting critical functions in various physiological processes, ranging from cell proliferation to apoptosis ( 8 , 9 ). (iiarjournals.org)
  • Moreover, some recent studies have demonstrated a relationship between the aberrant expression of miRNAs and CRC susceptibility, prognosis, and responsiveness to treatment ( 10 - 12 ). (iiarjournals.org)
  • In particular, most miRNAs bind to target sequences located within the 3'-untranslated region (3'UTR) of mRNAs, resulting in the cleavage of the target mRNAs or repression of their translation ( 13 ). (iiarjournals.org)
  • Still other RNA molecules, such as tiny microRNAs ( miRNAs ), act as regulators of other genes, and new types of non-protein-coding RNAs are being discovered all the time. (khanacademy.org)
  • miRNAs predominantly interact with mRNA targets through imperfect binding to motifs in target mRNA 3′-untranslated regions (3′UTRs) ( Bartel, 2009 ). (elifesciences.org)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
  • Analysis from the Gene Expression Omnibus datasets supported the mRNA findings. (hindawi.com)
  • We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
  • The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
  • One of the biggest changes in evolutionary theory in the late 20th century was the growing appreciation for the central role of changes in gene expression in macroevolution. (freethoughtblogs.com)
  • Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
  • MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
  • Gene expression programmes drive many of the changes underlying network reorganisation in epileptogenesis, including neurodegeneration, astrogliosis, microgliosis, aberrant neurogenesis and restructured local and distant neuronal contacts, among other changes [ 3-5 ]. (researchsquare.com)
  • A number of post-transcriptional mechanisms fine-tune the gene expression landscape. (researchsquare.com)
  • Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)
  • This is predicted to exert an important influence on the gene expression landscape. (researchsquare.com)
  • MicroRNAs are endogenously expressed, small non-coding RNAs that regulate gene expression by targeting mRNAs for translational repression or degradation. (oncotarget.com)
  • Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. (oeaw.ac.at)
  • Total RNA was isolated from whole lung 24 and 48 hours post final exposure and was further processed for gene expression and microRNA array analysis. (cdc.gov)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
  • The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)
  • Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
  • As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • Consequently, we hypothesized that some cancer-driver genes targeted by miR-31 are up-regulated in HCC as miR-31 was down-regulated in Anisole Methoxybenzene HCC. (nos-nop.org)
  • ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
  • Background: As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3' untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). (iiarjournals.org)
  • For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
  • Expressions of the RcLOX genes were tissue-specific, while every RcLOX gene could be detected in at least one tissue. (bvsalud.org)
  • The expression levels of most RcLOX genes could be up-regulated by aphid infestation, suggesting potential roles in aphid resistance. (bvsalud.org)
  • Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)
  • Conclusion and Clinical Relevance: Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. (cdc.gov)
  • MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. (cdc.gov)
  • Binding of a miRNA to a complementary sequence in a target mRNA is mediated by Argonaute proteins leading to degradation of the mRNA or translational inhibition, thereby lowering protein levels in cells [ 7 ]. (researchsquare.com)
  • The fact that and are up-regulated in HCC led us to hypothesize that normal and expressions are balanced by endogenous miR-31, which selectively regulates and mRNA translation in normal hepatic liver cells. (nos-nop.org)
  • ADAR3 contains an arginine-rich domain, shown in pink, which binds single-stranded RNA. (biomedcentral.com)
  • Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
  • metastatic potential of HCC cells by selectively regulating epithelial-mesenchymal transition (EMT) regulatory proteins such as N-cadherin, E-cadherin, vimentin and fibronectin. (nos-nop.org)
  • HCC tissues derived from chemical-induced rat liver cancer models validated that miR-31 manifestation is significantly down-regulated, and that those cell cycle- and EMT-regulatory proteins are deregulated in rat liver cancer. (nos-nop.org)
  • Overall, we suggest that miR-31 functions like a tumor suppressor by selectively regulating cell cycle and EMT regulatory proteins in human being hepatocarcinogenesis providing a novel target FANCG for the molecular treatment of liver malignancies. (nos-nop.org)
  • This type of RNA is called a messenger RNA ( mRNA ), as it serves as a messenger between DNA and the ribosomes, molecular machines that read mRNA sequences and use them to build proteins. (khanacademy.org)
  • Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous T re-2/ B ub2/ C DC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (elifesciences.org)
  • Dysregulation of microRNAs (miRs) can contribute to cancer development and progression. (spandidos-publications.com)
  • C. Elegans LIN-28 Controls Temporal Cell Fate Progression by Regulating LIN-46 Expression via the 5' UTR of Lin-46 MRNA. (stanford.edu)
  • pubMedId':'34496246','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/34496246','publicationId':'826388','title':'C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA. (stanford.edu)
  • Consequently, the molecular mechanisms that regulate GC development and progression need further exploration. (oncotarget.com)
  • This progression from DNA to RNA to protein is called the " central dogma " of molecular biology. (khanacademy.org)
  • BACKGROUND: Human hydroxysteroid dehydrogenase-like 2 (HSDL2), which regulates cancer progression, is involved in lipid metabolism. (bvsalud.org)
  • However, the role of HSDL2 in cholangiocarcinoma (CCA) and the mechanism by which it regulates CCA progression by modulating ferroptosis are unclear. (bvsalud.org)
  • We find that lin-28 and sequences within the lin-46 5' UTR are required to prevent LIN-46 expression at early larval stages. (stanford.edu)
  • Multiple roles and targets of miR-7 as well as its expression pattern were linked to regulatory mechanisms and pathogenesis in glioblastoma, breast cancer and other types of cancers, as well as in schizophrenia and visual abnormalities. (wikipedia.org)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • p class=\'abstract\'>Lin28/LIN-28 is a conserved RNA-binding protein that promotes proliferation and pluripotency and can be oncogenic in mammals. (stanford.edu)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
  • Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. (cdc.gov)
  • Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
  • In January 2021, Diagenode launched a new small RNA-sequencing solution, D-Plex Small RNA DNBSEQ Kit, compatible with MGI's DNBSEQ sequencers. (mordorintelligence.com)
  • The kit incorporates unique D-Plex technology for library preparation enabling high performance with ultralow RNA inputs and providing diverse small RNA transcript detection. (mordorintelligence.com)
  • A universal method for the rapid isolation of all known classes of functional silencing small RNAs. (oeaw.ac.at)
  • Mammalian Lin28 and C. elegans LIN-28 have been shown to inhibit biogenesis of the conserved cellular differentiation-promoting microRNA let-7 by directly binding to unprocessed let-7 transcripts. (stanford.edu)
  • Eukaryotic RNA transcripts can undergo a range of post-transcriptional modifications, which increase the diversity of the transcriptome without requiring increases in genome size. (biomedcentral.com)
  • Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. (frontiersin.org)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • MiR-31 was significantly down-regulated compared to related non-tumor cells. (nos-nop.org)
  • Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
  • Here, we report that C. elegans LIN-28 represses the expression of LIN-46, a downstream protein in the heterochronic pathway. (stanford.edu)
  • A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production. (oeaw.ac.at)
  • Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. (wikipedia.org)
  • The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
  • Thus, our findings demonstrate the biological importance of the regulation of individual target mRNAs by LIN-28. (stanford.edu)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • Thus, to maintain a balance between host preservation and inflammatory pathology, the immune response and inflammation need to be tightly regulated. (frontiersin.org)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
  • Luciferase reporter assay was performed to verify that miR-455 directly binds to the 3′-noncoding region (UTR) of RAB18 mRNA in Huh7 cells. (hindawi.com)
  • This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. (nih.gov)
  • Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. (elifesciences.org)
  • A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • The double-stranded (ds)RNA-binding domains, shown in purple, determine substrate specificity. (biomedcentral.com)
  • The nature of imperfect binding specificity means that a single miRNA can regulate a large number of mRNA targets involved in complex cellular processes, thereby tightly controlling genetic networks during development and in response to stress ( Pocock, 2011 ). (elifesciences.org)
  • miR-7 is directly regulated by the transcription factor HoxD10. (wikipedia.org)
  • Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma. (hindawi.com)
  • A heterochromatin-dependent transcription machinery drives piRNA expression. (oeaw.ac.at)
  • In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)
  • Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
  • We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • Over-expression of miR-22 has been reported to protect in models of brain injury and additional targets of miR-22 have been identified [ 17 , 18 ]. (researchsquare.com)
  • Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)
  • During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
  • EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)
  • Some viruses use RNA, not DNA, as their genetic material, but aren't technically considered to be alive (since they cannot reproduce without help from a host). (khanacademy.org)
  • Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
  • Objective: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. (cdc.gov)
  • However, the determinants and consequences of LIN-28-mRNA interactions are not well understood. (stanford.edu)
  • A-to-I editing is a mechanism that regulates and diversifies the transcriptome, but the full biological significance of ADARs is not understood. (biomedcentral.com)
  • Results: Comparison of datasets revealed increased Il4, Il13, and Il33 expression in mice exposed to viable versus heat-inactivated conidia. (cdc.gov)
  • Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. (nature.com)
  • Upregulated miR-21 suppresses LPS-induced inflammatory cytokine expression by targeting IL-1 receptor-associated kinase 4 (IRAK4), thereby avoiding excessive inflammatory responses. (frontiersin.org)
  • RNA sequencing analysis of the hippocampus during the period of epileptogenesis revealed a specific suppression of inflammatory signalling in the hippocampus of miR-22-deficient mice. (researchsquare.com)
  • The expression of miR-455 was lower in HCC tissues and cell lines than in nontumor tissues and normal cell line, and downregulation of miR-455 was connected with worse outcome of HCC patients. (hindawi.com)
  • RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
  • All the fresh tissues were snap-frozen in liquid nitrogen and stored at −80°C until RNA extraction. (hindawi.com)
  • A-to-I editing, which is catalyzed by enzymes of the adenosine deaminase acting on RNA (ADAR) family, is most prevalent in the central nervous system (CNS) but occurs in many tissues [ 1 - 3 ]. (biomedcentral.com)
  • METHODS: HSDL2 expression levels in CCA cells and tissues were determined by quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry. (bvsalud.org)
  • The Medicines Manufacturing Innovation Centre launched a collaboration with AstraZeneca, Exactmer, Novartis, and UK Research and Innovation to develop a scalable, sustainable, and more cost-effective medicines manufacturing process for oligonucleotides: short strands of synthetic DNA or RNA. (mordorintelligence.com)
  • The miRNA-mRNA pairing triggers casein kinase 1α (CK1α)-induced phosphorylation and dissociation of AGO2 from the active complex, whereas the ANKRD52-PPP6C phosphatase complex dephosphorylates AGO2 to restore its miRNA loading activity 21 , 22 . (nature.com)
  • Pax6 translation in the lateral wall of the subventricular zone of developed mice is post-transcriptionally regulated by miRNA-7a mediated gene silencing, which is necessary to control the rate of dopaminergic neuron production in the olfactory bulb. (wikipedia.org)
  • Of 415 microRNAs detected, approximately 50% were altered in mice exposed to viable versus heat-inactivated conidia 48 hours post exposure. (cdc.gov)
  • It plays an important role in controlling mRNA expression. (wikipedia.org)
  • While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
  • While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
  • A-to-I editing can also result in the creation or elimination of splice sites, potentially altering the portions of the RNA that remain in the final product. (biomedcentral.com)
  • Additionally, the A-to-I conversion alters base pairing, because inosine pairs preferentially with cytidine, and this potentially affects the secondary structure of the RNA. (biomedcentral.com)