Mrna proto oncogene proteins c bcl 6. Medical search. Frequent questions

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. (wikipedia.org)
The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which is widely expressed. (deathbase.org)
bcl-w, a novel member of the bcl-2 family, promotes cell survival. (deathbase.org)

The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome c and ROS, that are important signals in the apoptosis cascade. (wikipedia.org)
Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. (deathbase.org)
Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. (deathbase.org)
These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. (deathbase.org)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Our previous study has shown that downregulation of BCL11A mRNA by small interfering RNA (siRNA) is capable of inducing apoptosis in the SUDHL6 cell line. (biomedcentral.com)
Our previous study has shown that downregulation of BCL11A mRNA by small interfering RNA (siRNA) is capable of inducing apoptosis in B lymphoma cell lines (SUDHL6 and EB1)[ 17 ]. (biomedcentral.com)
Further, we studied the effect of HSP70-2 protein ablation on signaling cascades involved in apoptosis, cell cycle and Epithelial-Mesenchymal-Transition both in culture as well as in-vivo human breast xenograft mouse model. (biomedcentral.com)
BH3 mimetics with high affinity for BCL-XL (BCL-XLi) reduce metabolic activity and induce mitochondrial apoptosis in senescent PA cells at nano-molar concentrations. (ibecbarcelona.eu)

Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. (wikipedia.org)
But simultaneous over-expression of Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma. (wikipedia.org)
In follicular lymphoma, a chromosomal translocation commonly occurs between the fourteenth and the eighteenth chromosomes - t(14;18) - which places the Bcl-2 gene from chromosome 18 next to the immunoglobulin heavy chain locus on chromosome 14. (wikipedia.org)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. (deathbase.org)

This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. (wikipedia.org)
The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
It is involved in theregulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressorand is a candidate for breast tumorigenesis. (immune-source.com)
Spliced X-box binding protein-1 (XBP1s) is a protein that belongs to the cAMP-response element-binding (CREB)/activating transcription factor (ATF) b-ZIP family with a basic-region leucine zipper (bZIP). (mdpi.com)
6, 7 BRCA1 interacts with a variety of proteins and is involved in multiple cellular processes including DNA repair, transcription, and checkpoint control. (bmj.com)
26 The suggested role in TP53 dependent apoptotic signalling 27 and interaction with the ankyrin repeats of proto-oncoprotein BCL3, thereby possibly modulating the activity of transcription factor NFKB, 28 represent BRCA1 independent functions of BARD1. (bmj.com)

The over-expression of the anti-apoptotic Bcl-2 protein in lymphocytes alone does not cause cancer. (wikipedia.org)
Other studies have shown that dendritic cell lifespan may be partly controlled by a timer dependent on anti-apoptotic Bcl-2. (wikipedia.org)
We determined expression of anti-apoptotic BCL-2 members in these models and primary PA. (ibecbarcelona.eu)
Dependence of senescent PA cells on anti-apoptotic BCL-2 members was investigated using a comprehensive set of BH3 mimetics. (ibecbarcelona.eu)

MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
As a group, miRNAs are small (17-27 nucleotides) noncoding RNAs that govern gene expression in a post-transcriptional manner by binding directly to the 3′UTRs of target mRNAs, thereby repressing their translation or inducing their degradation [ 6 ]. (biomedcentral.com)
p100 and p105 can however undergo limited proteolysis to generate p52 and p50, respectively, which can form heterodimers with Rel proteins to form transcriptional activators [ 5 ]. (oncotarget.com)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
BARD1, unlike BRCA1, also contains a centrally located sequence of three ankyrin repeats 11 that are found in many proteins involved in transcriptional regulation. (bmj.com)

However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
Constitutive p50/p65 activity is observed in a large variety of hematological as well as solid tumors [ 6 - 8 ], as a result of an aberrant expression of p50/p65, deletions of the IκBα inhibitor gene or an increased IKK activity [ 9 - 13 ]. (oncotarget.com)
This suggests that the function of RON in these tumors may be multidimensional, not just as a tumor suppressor or oncogene. (spandidos-publications.com)

The phosphorylation of focal adhesion kinase-protein kinase B (FAK-Akt) was upregulated in AML cells treated with netrin-1. (bvsalud.org)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase, Blood Advances, Vol.7, No.6, 1019-1032, 2023. (matci.jp)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. (lookformedical.com)
Background Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. (ibecbarcelona.eu)

The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
E6-AP) is an important member of the ubiquitin proteasome system and a type of ubiquitin protein ligase (E3 enzyme) ( 6 ). (spandidos-publications.com)

IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)
This family of proteins comprises two subfamilies that share a DNA-binding and dimerization domain called the Rel homology domain (RHD) [ 4 ] and form homo- or hetero- dimers. (oncotarget.com)
Heat shock family of proteins (HSPs) is proposed to play pivotal role in breast tumor development owing to their intrinsic molecular chaperone properties [ 5 ]. (biomedcentral.com)

Some evidence suggests that this may result from abnormal expression of Bcl-2 and increased expression of caspase-3. (wikipedia.org)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
The minigene study showed that intronic mutations resulted in abnormal pre-mRNA splicing. (bvsalud.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. (deathbase.org)
While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. (deathbase.org)

To explore its physiological role, we have inactivated the bcl-w gene in the mouse by homologous recombination. (deathbase.org)

Bcl-2 expression is frequent in small cell lung cancer, accounting for 76% cases in one study. (wikipedia.org)
Real-time PCR was performed to assess the expression of FasmRNA, Fas-LmRNA, Bcl-2mRNA of the liver tissues. (nih.gov)
Western blotting was used to detect the Bax protein expression of the liver tissues. (nih.gov)
It may be through decreasing the serum IL-6 and TNF-α levels and FasmRNA, FasLmRNA, Bax protein expression and increasing the Bcl-2 mRNA expression of the liver tissues that XCHT significantly relieved the D-galactosamine -induced liver injury. (nih.gov)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Together these studies reveal a requirement for NCK proteins in mammary gland morphogenesis, and suggest that deregulation of Nck expression could drive breast cancer progression and metastasis. (bvsalud.org)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
Bone cells can sense physical forces and convert mechanical stimulation conditions into biochemical signals that lead to expression of mechanically sensitive genes and proteins. (biomedcentral.com)
The mRNA expression of PLEKHA4 was detected by PCR in glioma samples and controls and in glioma cells treated with lactic acid and glucose. (bvsalud.org)
MicroRNAs (miRNAs) are an endogenous group of small non-coding RNAs that post-transcriptionally repress the expression of protein-coding genes. (biomedcentral.com)
In the present study, we have investigated the possible association of HSP70-2 mRNA and protein expression with various stages, grades and histotypes of breast cancer patients. (biomedcentral.com)
We now know those structures are very relevant to many critical biological processes like gene regulation, expression of telomerase and telomere maintenance, understanding of growth/oncogenes like C-myc, understanding of organismic development, comprehension of certain enigmatic diseases like ALS and possible new cancer treatments. (anti-agingfirewalls.com)
Systematic delivery of CREBZF-mRNA-NPs effectively induced CREBZF expression and activated the positive feedback loop of circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1, which might suppress BC progression in vitro and in vivo. (biomedcentral.com)

Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. (wikipedia.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
The central dogma of molecular biology states that the transfer of genetic information within cells transpires sequentially from DNA to RNA to proteins, whose coding sequences comprise a paltry 1.5-2% of the human genome [ 2 , 3 ]. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
However, it is still poorly understood how genes and proteins in bone cells are orchestrated to respond to mechanical stimulations. (biomedcentral.com)
By carefully developing protein selection filters and statistical models, we were able to identify 42 proteins representing 21 Rat genes that were significantly associated with bone cells' response to quantitative changes between normal loading and fatigue loading conditions. (biomedcentral.com)
It still remains unknown what all the mechanically-sensitive genes and proteins in bone cells under mechanical stress are and how their differential expressions are regulated [ 4 ]. (biomedcentral.com)
Considering that various protein coding genes are targeted by one miRNA, researchers should determine the mechanisms of miR-140-5p mediated phenotypic changes in GC cells. (biomedcentral.com)
Metabolomic extraction of cells A total of 5 105 cells were 607742-69-8 supplier plated onto 6-well discs and cultured in standard medium for 24?hours. (immune-source.com)
18. Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene. (crsociety.org)
Oncogenic MAPK-signaling drives the majority of cells into oncogene-induced senescence (OIS). (ibecbarcelona.eu)
Results Senescent PA cells upregulate BCL-XL upon senescence induction and show dependency on BCL-XL for survival. (ibecbarcelona.eu)
Conclusions Our data demonstrate that BCL-XL is critical for survival of senescent PA tumor cells and provides proof-of-principle for the use of clinically available BCL-XL-dependent senolytics. (ibecbarcelona.eu)

The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate diverse biological processes including cell proliferation and actin dynamics in many tissue types. (bvsalud.org)
Activation from the NLRP3 inflammasome needs set up of NLRP3 and caspase-1 (casp-1) bridged jointly through the adaptor proteins ASC, wherein casp-1 undergoes autoproteolytic digesting. (cancercurehere.com)

Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)

Previous studies established that EBNA3C facilitates degradation of several vital cell cycle regulators, including the retinoblastoma (pRb) and p27(KIP) proteins, by recruitment of the SCF(Skp2) E3 ubiquitin ligase complex. (interleukinreceptor.com)

LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
Three in four patients were alive without progression at 6 months and the median OS was 10.0 months. (mirnaassay.com)
Our findings firstly illustrated that circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated BC progression, and delivering CREBZF mRNA nanoparticles suppressed BC progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer. (biomedcentral.com)
Importantly, circRNAs usually bind miRNAs to modulate the levels of downstream proteins, acting as competing endogenous RNA (ceRNA) and participating in tumor progression [ 11 ]. (biomedcentral.com)
For instance, the biogenesis of circRNA GGNBP2 (cGGNBP2) was mediated by IL-6/STAT3 pathway activation, and IL-6/cGGNBP2-184aa (a protein encoded by cGGNBP2)/STAT3 formed a positive feedback loop to promote tumor progression for intrahepatic cholangiocarcinoma. (biomedcentral.com)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
The overexpression of a membrane protein designated P-glycoprotein (P-gp) is a typical phenotypic marker of pleiotropic drug resistance. (ashpublications.org)

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrixattachment region DNA elements (S/MAR DNA). (immune-source.com)

577Role of Cellular Proteins in RV Replication. (vdocuments.net)

Western blotting was used to detect the expressions of cyclinD1, CDK2, Bcl2, β-catenin and phosphorylation of the key proteins in the MAPK signaling pathway. (bvsalud.org)

Metabolic changes in genetic disorder which renders fructose 1,6 bisphosphatase in liver less sensitive to regulation by fructose 2,6 bisphosphate are level of fructose 1,6 bisphosphate lower than normal, less pyruvate is formed and less ATP generation. (medicosplexus.com)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)

Mice that lack Bcl-w were viable, healthy, and normal in appearance. (deathbase.org)
The phenotype of Bard1 null mice was found to be remarkably similar to that of Brca1 nulls, further emphasising the functional relationship between these two proteins. (bmj.com)

Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. (enquirebio.com)

Two different siRNAs Selleckchem AZD5363 against TRPC1 largely inhibited hypoxia-induced upregulation of VEGF mRNA and protein levels. (interleukinreceptor.com)

The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)

BCL-2 is known to regulate mitochondrial dynamics, and is involved in the regulation of mitochondrial fusion and fission. (wikipedia.org)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)

The two isoforms of Bcl-2, Isoform 1, and Isoform 2, exhibit a similar fold. (wikipedia.org)
However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms. (wikipedia.org)
Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties. (bvsalud.org)

RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)

A small Ca++ binding protein that modifies activity of many enzymes and other proteins in response to changes of Ca++ concentration is known as Calmodulin. (medicosplexus.com)

bcl-2 is an antiapoptotic gene. (medicosplexus.com)

In an important model of premature aging, Werner's Syndrome, the genetic problem seems to be lack of a helicase protein that can unwind G-quadruplexes. (anti-agingfirewalls.com)

3. Simultaneous separation of halophilic proteins and nucleic acids after adsorption onto agarose gels. (crsociety.org)

574Structural Proteins: Translation, Processing, and Assembly. (vdocuments.net)

Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. (deathbase.org)
It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). (enquirebio.com)
YES proto-oncogene 1(YES1), a notable member of SFKs, serves as a seminal regulator of cell growth, adhesion, and differentiation. (biomedcentral.com)
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
11 Both proteins possess an N-terminal RING finger motif and two BRCA1 C-terminal (BRCT) domains present in numerous proteins involved in DNA repair and cell cycle regulation. (bmj.com)

The second subfamily of proteins (p105 and p100) has a C-terminal region that contains multiple copies of ankyrin repeats, instead of a transactivation domain, and can bind to and inhibit Rel proteins. (oncotarget.com)
Scaffoldattachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind toS/MAR. The encoded protein is thought to serve as a molecular base to assemble atranscriptosome complex in the vicinity of actively transcribed genes. (immune-source.com)

mRNA and protein expressions of Ngb and HIF-1α showed positive in different tissues of the yak and cattle telencephalon. (bvsalud.org)

Transmembrane region of proteins is likely to have a stretch of hydrophobic amino acids. (medicosplexus.com)

21 Furthermore, interaction between the BARD1/BRCA1 heterodimer and cleavage stimulation factor subunit 1 (CSTF1, also called CstF-50) represses the polyadenylation machinery, presumably to prevent inappropriate mRNA processing at sites of DNA repair. (bmj.com)

Immunohistochemistry Formalin fixed, paraffin inlayed sections were dewaxed and rehydrated before antigen retrieval by microwaving in citrate buffer pH?6. (immune-source.com)

Anatomy13

Organisms7

Diseases22

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes62

Disciplines and Occupations1

Information Science3

Member of the Bcl-2 family3

Apoptosis9

Lymphoma7

Transcription9

Anti-apoptotic4

Transcriptional5

Tumors4

Kinase12

Ubiquitin protei2

Family of proteins3

Abnormal4

Lymphoid2

Homologous1

Expression15

Cells15

Adaptor proteins2

Mutations2

Degradation1

Progression5

Overexpression2

Gene encodes1

Cellular proteins1

BCL21

Liver1

Kinases1

Mice2

Cyclin D11

VEGF1

Mutant proteins1

Inhibition2

Regulate3

Isoforms3

Induces1

Enzymes1

Antiapoptotic1

Genetic1

Simultaneous1

Translation1

Cell9

Bind2

Tissues1

Amino acids1

Processing1

Antigen1