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Aquaporin 1Aquaporin 5Aquaporin 3Aquaporin 4AquaporinsAquaporin 2Aquaporin 6WaterMercuric ChlorideOsmosisAquaglyceroporinsBlood Group AntigensWater-Electrolyte BalanceGlycerolPermeabilityAmino Acid SequenceReverse Transcriptase Polymerase Chain ReactionGene Expression RegulationMolecular Sequence DataCell Membrane PermeabilityKidney Tubules, CollectingPlant TranspirationKidney Concentrating AbilityBiological TransportIon ChannelsRNA, MessengerDiabetes Insipidus, NephrogenicBase SequenceOocytesPlant ProteinsXenopus laevisPolyuriaTranscription, GeneticBlotting, NorthernNeuromyelitis OpticaImmunohistochemistryCloning, MolecularMembrane ProteinsOsmotic PressureRats, Sprague-DawleyProtein BiosynthesisAntidiuretic AgentsCells, CulturedBlotting, WesternDNA, ComplementaryDNA PrimersIn Situ HybridizationRNA StabilityPlant RootsTulipaVapor PressureGene Expression Regulation, PlantCell LineCell MembraneCistaceaeKidneyEye ProteinsBrain EdemaLens, CrystallineMercury CompoundsSequence Homology, Amino AcidOsmolar ConcentrationUp-RegulationVasopressinsRenal AgentsAnguillaBody WaterDehydrationDown-RegulationPolymerase Chain ReactionTime FactorsXenopusKidney MedullaSalivary GlandsMutationMice, KnockoutGlomeromycotaPromoter Regions, GeneticDeamino Arginine VasopressinRats, WistarImmunoblottingMicroscopy, Electron, Scanning TransmissionMycelium3' Untranslated RegionsTissue DistributionSubmandibular GlandLiverAstrocytesRNA-Binding ProteinsProtein TransportMesophyll CellsPropylene GlycolMesembryanthemumTransfectionReceptors, VasopressinRNAProtein IsoformsGene Expression ProfilingGene Expression Regulation, DevelopmentalNucleic Acid Hybridization
Tubular epithelial cellsAlveolar epithelial cellsColonic epithelialProteinsSodium channelCellsExpressionENaCSoluteRenalInhibitorProteinReceptor2016BarrierRegenerationBiologyBrainCellTissueGenesInvasive2022RoleFamilyPhosphorylationDegenerativeNumerousTotalMajorCancerMutationPotentialResultsEvidenceDays
Tubular epithelial cells2
  • PC1 and PC2 are found on the primary cilium, a hair-like structure present on the apical membrane of a cell, in addition to the cell membranes and cell-cell junctions of tubular epithelial cells. (basicmedicalkey.com)
  • Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature, especially in tubular epithelial cells. (biomedcentral.com)
Alveolar epithelial cells1
  • Silent forkhead box protein O1 inhibits H2O2-induced apoptosis of rat alveolar epithelial cells type II [J]. Basic & Clinical Medicine, 2019, 39(4): 519-523. (magtechjournal.com)
Colonic epithelial1
  • The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. (nature.com)
Proteins7
  • Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). (wikipedia.org)
  • Choroid plexus epithelial cells (CPECs) secrete most of the CSF through poorly understood mechanisms that involve aquaporins (AQPs) and various solute transport proteins like the Na+-K+-2Cl- cotransporter 1 (NKCC1). (wright.edu)
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • Integrin trafficking may also guide mRNA to ribosomes associated with the protrusive regions of metastatic cells, and thus localise the synthesis of pro-migratory proteins. (gla.ac.uk)
  • A major aim of our research is to characterise the mechanisms by which integrin-associated proteins command mRNA transport and translation during the invasive migration of cancer cells. (gla.ac.uk)
Sodium channel1
  • Acutely and chronically, lithium salts produce a natriuresis that is associated with an impaired regulation of the expression of the epithelial sodium channel in the cortical collecting tubule. (medscape.com)
Cells14
  • we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
  • CPs are composed of a monolayer of cuboidal epithelial cells, derived from ependymal cells (EPCs), joined by tight junctions, and surrounding a core of fenestrated capillaries. (wright.edu)
  • Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)
  • We demonstrate that Rspo3 is essential for epithelial repair via induction of Wnt signaling in differentiated cells. (nature.com)
  • The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
  • While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • Thus, we find that endogenous Rspo3 signaling is a critical determinant of cellular fate within the crypt and stimulates rapid recruitment of differentiated cells for epithelial wound healing and crypt regeneration through induction of Wnt signaling. (nature.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • by 3 months, all the fiber cells appeared swollen to a marked degree. (silverchair.com)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Here we report that Nek1 is expressed most strongly in the distinct subset of renal epithelial cells. (biomedcentral.com)
  • Cells can communicate via physical interactions, in- cluding membrane bridge formation, such as tunneling nanotubes and cytonemes, and/or through the release of soluble factors [1-3]. (unicyte.ch)
  • The mucous lining of the LARYNX, consisting of various types of epithelial cells ranging from stratified squamous EPITHELIUM in the upper larynx to ciliated columnar epithelium in the rest of the larynx, mucous GOBLET CELLS, and glands containing both mucous and serous cells. (lookformedical.com)
Expression3
  • Therefore, in the present study, we performed lncRNA and mRNA microarray analyses to explore the lncRNA and mRNA expression profile in response to oligohydramnios in pregnant women. (researchsquare.com)
  • The mRNA expression level of β-catenin was increased after infection, as well as the activity of β-catenin/TCF4. (magtechjournal.com)
  • Over-expression of PRDX6 enhances the migration and invasion of lung cancer cell line A549 [J]. Basic & Clinical Medicine, 2019, 39(3): 365-368. (magtechjournal.com)
ENaC1
  • Lithium can substitute for sodium in several sodium channels, particularly the sodium-hydrogen exchanger in the proximal tubule (NHE3), the sodium/potassium/2chloride exchanger in the thick ascending limb of the loop of Henle (NKCC2), and the epithelial channel of the cortical collecting tubule (ENaC). (medscape.com)
Solute1
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
Renal1
  • Effect of tolvaptan on aquaporin in inner medullary collecting duct cell line and renal tubule function [J]. Basic & Clinical Medicine, 2019, 39(8): 1163-1167. (magtechjournal.com)
Inhibitor1
  • Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
Protein6
  • Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene. (wikipedia.org)
  • Aquaporin-8 (AQP-8) is a water channel protein. (wikipedia.org)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • miR-17-5p induces podocytes apoptosis and inhibits glomerular epithelial protein 1 in mice [J]. Basic & Clinical Medicine, 2019, 39(7): 973-977. (magtechjournal.com)
  • The lumen is the able protein of mRNA hetero-oligomerization). (erik-mill.de)
  • Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
Receptor2
  • The TSEN placement Typically triggers 5' and 3' to the home', proliferating a downstream' vascular maturation on the 5' T and a 5' receptor nucleus on the 3' mitosis. (evakoch.com)
  • download The Post Utopian Imagination: American Culture in 3 genes the activation of from( 50) with receptor to window, written by the Small cell transfer vitamin. (familie-vos.de)
20161
Barrier2
  • The choroid plexuses (CPs) are highly vascularized epithelial structures lying in the brain ventricles, forming the blood-cerebrospinal fluid (CSF) barrier. (wright.edu)
  • As aging progresses, there is an increase in the incidence of cancer and cardiovascular, lung, kidney, and digestive diseases, as well as the occurrence of physiological changes such as decreased bone density, decreased epithelial barrier function, and skin atrophy [ 2 - 6 ]. (impactaging.com)
Regeneration2
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
Biology2
  • A potential role for untranslated p53 mRNA in cancer biology. (otago.ac.nz)
  • Nanomedicine: Nanotechnology, Biology and Medicine, 13 (3). (lincoln.ac.uk)
Brain1
Cell3
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • Several other environmental factors including oxy- gen concentration and mechanical, metabolic, and bio- chemical conditions have been shown relevant in cell differentiation and have been reviewed extensively (Fig. 1) [3]. (unicyte.ch)
  • These two levels serve degraded by a phosphorylation including at least 6 membranes in a such tail that both leaves the 2' disorder ubiquitination and adducts the 3' heart to the 5' cell. (evakoch.com)
Tissue1
  • Thus previous RT-PCR mRNA for AQ4 is likely to represent glial contamination during tissue extraction. (wright.edu)
Genes2
  • Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to analyze the main enrichment pathways of differentially expressed mRNAs. (researchsquare.com)
  • Genes & Development 21 (3): 316-331. (mdc-berlin.de)
Invasive1
  • So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)
20221
Role3
  • Role of aquaporin-4 in cerebral edema and stroke. (benthamscience.com)
  • Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
  • The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in ca. (cn1699.cn)
Family2
  • The qPCR results confirmed that LINC00515 and RP11-388P9.2 were upregulated in OP. Furthermore, the constructed lncRNA-miRNA-mRNA regulatory network revealed tenascin R (TNR), cystic fibrosis transmembrane conductance regulator (CFTR), ATP-binding cassette sub-family A member 12 (ABCA12), and collagen 9A2 (COL9A2) as the candidate targets of LINC00515 and RP11-388P9.2. (researchsquare.com)
  • It took another 15 years for the expansion of the gasotransmitter family to include NO, CO, H 2 S, and NH 3 . (rsc.org)
Phosphorylation1
Degenerative1
Numerous1
  • The quintet of REV1 and POLZ in responsible pre-mRNA transcription ceramide( TLS) prevents that POLI destabilizes a numerous activity with REV1 and POLZ, extracellularly known for POLK and elucidated for vast Y factor cone peptides( Xie et al. (erik-mill.de)
Total1
  • MS is a heterogeneous disease but presentation of characteristic symptoms generally follow stages of neurological deficits (relapses) and these can be reversed during periods of total or partial recovery (remissions) [ 2 , 3 ]. (medsci.org)
Major1
  • multiple promoters major, particularly annealing POLZ to DNA aquaporin kinase( Hara et al. (erik-mill.de)
Cancer1
  • McGinn O, Riley D, Finlay-Schultz J, Paul KV, Kabos P, Sartorius CA. Cytokeratins 5 and 17 Maintain an Aggressive Epithelial State in Basal-Like Breast Cancer. (cuanschutz.edu)
Mutation1
  • Here we combine experimental and theoretical approaches and show that oxidation of Orai1 leads to reduced subunit interaction, slows diffusion and that either oxidized C195 or its oxidomimetic mutation C195D located at the exit of transmembrane helix 3 virtually eliminates channel activation by intramolecular interaction with S239 of transmembrane helix 4, thereby locking the channel in a closed conformation. (nature.com)
Potential1
  • In summary, we revealed the profiles of lncRNA and mRNA in OP. These results might offer potential targets for biological prevention for pregnant women with oligohydramnios detected before delivery and provided a reliable basis for clinical biological treatment in OP. (researchsquare.com)
Results1
  • in these results, 638 lncRNAs and 189 mRNAs were upregulated, and 163 lncRNAs and 178 mRNAs were downregulated. (researchsquare.com)
Evidence1
  • Finally, the inflammatory and demyelinating findings in clinically isolated syndrome (CIS) and the evidence in radiologically isolated syndrome (RIS) are supportive of MS in undiagnosed individuals [ 2 , 3 ]. (medsci.org)
Days1
  • The incubation and fledging durations 23±3 days 43±6 days (Medway 1957;Langham 1980;Lim 2002) Swiftlets engage in yearround breeding activities between the months of October and February (Langham 1980) Construction of a single nest by swiftlets typically requires around 30-45 days during the breeding season, but in the nonbreeding season, this process takes approximately 60-80 days (Aowphol et al. (researchgate.net)