Mrna degradation novel candidate mirnas micro rna that regulates. Medical search. Frequent questions

This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
Over the past few years, emerging numerous bioinformatic tools have been developed to identify candidate disease-causing genes [ 4 ], including microRNA (miRNA) genes. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Finally, iCell-based integration of bulk and single-cell RNA-seq data identifies biological processes perturbed during senescence and predicts 90 new genes involved in its escape. (bvsalud.org)
miRNAs are small non-coding RNAs (~22 nucleotides in length) that regulate the expression of their target genes by translational repression or mRNA degradation ( 13 , 14 ). (spandidos-publications.com)
miRNAs are predicted to control the activity of more than 30% of human genes [ 5 ]. (hindawi.com)
Investigation of hub genes for the development of potential therapeutic targets and candidate biomarkers is warranted. (nature.com)
The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
A large number of miRNAs are encoded in organized intronic clusters within many protein coding genes. (biomedcentral.com)
Here we have examined the expression of mature miRNAs of miR 17-92, miR 106b-25 and miR 23b-24 clusters along with their host genes C13orf25, MCM7 and AMPO respectively in PCa cell lines. (biomedcentral.com)
The expression profiling of miRNAs and host genes was performed in androgen-sensitive MDA PCa 2b and LNCaP as well as in androgen-refractory PC-3 and DU 145 cell culture models of PCa. (biomedcentral.com)
We found significant expression variations between host genes and their resident miRNAs. (biomedcentral.com)
The expressions of C13orf25 and miR 17-92 cluster as well as MCM7 and miR 106b-25 cluster did not reveal statistically significant correlation, thus suggesting that host genes and resident miRNAs may be expressed independent of each other. (biomedcentral.com)
Gene expression modulating miRNAs are encoded in diverse genomic locations including intergenic regions, introns of protein-coding genes and introns/exons of noncoding RNA genes [ 36 ]. (biomedcentral.com)
In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
Their ability to maintain cell and tissue homeostasis is critical, with many miRNA genes implicated in human diseases such as metabolic, inflammatory, and neurodegenerative diseases ( Vishnoi and Rani, 2017 ). (frontiersin.org)
MiRNAs post-transcriptionally silence target genes by binding to the 3′ untranslated region (3'UTR) of messenger RNA (mRNA) [ 10 ]. (biomedcentral.com)
Comparative-genomic analysis of CRISPR and cas genes leads to the hypothesis that the CRISPR-Cas system (CASS) is a mechanism of defense against invading phages and plasmids that functions analogously to the eukaryotic RNA interference (RNAi) systems. (biomedcentral.com)
It is proposed that unique inserts of CRISPR, some of which are homologous to fragments of bacteriophage and plasmid genes, function as prokaryotic siRNAs (psiRNA), by base-pairing with the target mRNAs and promoting their degradation or translation shutdown. (biomedcentral.com)
In addition, miRNA profiling shows enrichment of miRNA-targeted genes in retinoid receptors and PPARGC1α / PPARγ signaling, and antigen presentation pathways. (nature.com)
The present findings reveal that 3 IFN-β-regulated miRs and 37 genes, which are likely their functional targets, were commonly modulated by HCV in three replicon clones. (biomedcentral.com)
In total, 873 lncRNAs and 2480 mRNAs were determined to be differentially expressed genes in RGCs from normal control and FDM guinea pigs. (biomedcentral.com)
Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
Here we examined 145 SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
Because miRNAs may regulate approximately 60% of human genes [ 11 ], the relationship between miRNAs and human diseases has been extensively explored in the last decade. (cdc.gov)
However, to date, there is no report on the identification of microRNA (miRNA) target genes of sugarcane in response to smut pathogen infection by degradome technology. (biomedcentral.com)
A total of 309 target genes were predicted in sugarcane, corresponding to 97 known miRNAs and 112 novel miRNAs, and 337 degradation sites, suggesting that miRNAs can efficiently direct cleavage at multiple sites in the predicted target mRNAs. (biomedcentral.com)
qRT-PCR analysis of the expression level of 13 predicted target genes and their corresponding miRNAs revealed that there was no obvious negative regulatory relationship between miRNAs and their target genes. (biomedcentral.com)
In addition, a number of putative resistance-related target genes regulated by miRNA-mediated cleavage were accumulated in sugarcane during S. scitamineum infection, suggesting that feedback regulation of miRNAs may be involved in the response of sugarcane to S. scitamineum infection. (biomedcentral.com)
This study elucidates the underlying response of sugarcane to S. scitamineum infection, and also provides a resource for miRNAs and their predicted target genes for smut resistance improvement in sugarcane. (biomedcentral.com)
The understanding of how miRNAs regulate the expression of their target genes in response to S. scitamineum infection is limited. (biomedcentral.com)
Using in silico analysis, the authors predicted that the target genes of these 5 miRNAs may involve in the pathways related to shingolipid and fatty acid metabolisms and the vascular signaling. (biomedcentral.com)
Identified genes, miRNAs, and TFs can be possible drug targets that may be used for the therapeutics. (degruyter.com)
The present review focuses on circulating miRNAs in patients with TNBC, with an emphasis on their interaction with the immune response checkpoint genes PD‑1, PD‑L1 and CTLA4. (spandidos-publications.com)
MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate the expression of target genes by either mRNA degradation or translational inhibition. (biomedcentral.com)
miRNAs are either expressed from independent transcriptional units or derive from introns of protein-coding genes or exons or introns of long ncRNAs. (biomedcentral.com)
miRNA genes are transcribed by RNA polymerase II into long primary miRNA transcripts, termed pri-miRNAs that are usually several kilobases long and possess a 5' CAP and a poly(A) tail. (biomedcentral.com)
MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
miRNAs (miRs) are 18- to 25-nucleotide long noncoding RNAs that regulate pathophysiological functions via expression of target genes at the posttranscriptional level. (biomedcentral.com)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
MiRNAs are short (20-22nt) non-coding RNAs that negatively regulate gene expression through either mRNA degradation or translational repression [ 5 ]. (biomedcentral.com)
MicroRNAs (miRNAs) is a large family of endogenous, small noncoding RNAs with 20-25 nucleotides that have emerged as key posttranscriptional regulators of gene expression in mammals, bacteria, and plants [ 1 - 4 ]. (hindawi.com)
The discovery of miRNAs has revolutionized our comprehension of the regulation of gene expression. (hindawi.com)
miRNAs are transcribed as ~70 nucleotide stem-loop precursors and subsequently processed by the cytoplasmic RNase-III type enzyme Dicer to generate ~22 nucleotide mature products which can target and modulate gene expression by inhibiting translation and/or inducing degradation of target mRNAs [ 4 , 6 , 7 ]. (hindawi.com)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
While expression profiling studies of miRNAs are common place, little is known about the host gene and their resident miRNAs coordinated expression in PCa cells. (biomedcentral.com)
Regulatory noncoding microRNAs (miRNAs) play a critical role in the regulation of gene expression [ 5 ] and are potential candidates for studying their role in the progression of PCa to androgen-independent stage. (biomedcentral.com)
miRNAs control gene expression by binding to the complementary sites in the 3' untranslated regions (3' UTRs) of target mRNAs and triggering either translational inhibition or mRNA degradation by a molecular mechanism which is a subject of intense investigation [ 6 - 9 ]. (biomedcentral.com)
However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)
Mature microRNAs (miRNAs) are 21 to 23 nucleotide noncoding RNA molecules that can downregulate multiple gene expression by mRNA degradation or translational repression. (oncotarget.com)
miRNAs are approximately 22-nucleotide non-coding RNAs that participate in post transcriptional gene expression regulation through mRNA degradation, translational inhibition or chromatin-based silencing mechanisms. (sarcomahelp.org)
There are two major, distinct forms of regulatory small RNAs involved in eukaryotic gene silencing: small interfering (si) RNAs and micro (mi) RNAs. (biomedcentral.com)
Evolutionarily conserved, these 17-22 nucleotide long molecules regulate gene expression at post-transcriptional level generally by repressing translation or increasing degradation of messenger RNAs (mRNAs). (biomedcentral.com)
MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
The miRNA-mRNA interactions were verified by dual-luciferase reporter gene assays and experiments using mimics miRNA or their inhibitors. (frontiersin.org)
Despite the well-known fact that primiRNAs are acting as non-protein-coding RNAs, the published data suggest that, in the plant genomes, some pri-miRNAs can also be found in polysomes, and the expression of these miRNA precursors may results in formation of micropeptides which may be involved in regulation of gene expression. (fortunepublish.com)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)
TaqMan qRT-PCR detection and enzyme activity determination showed that S. scitamineum rapidly proliferated and incurred significant enzyme activity changes in the reactive oxygen species metabolic pathway and phenylpropanoid metabolic pathway at 2 d and 5 d after inoculation, which was the best time points to study target gene degradation during sugarcane and S. scitamineum interaction. (biomedcentral.com)
The miRNA-mRNA profiles and bioinformatics study suggested that the SFRP1 gene was potentially regulated by miRNA-1/206 during porcine skeletal muscle development. (biomedcentral.com)
To understand the function of SFRP1 and miRNA-1/206 in swine myogenesis, we first predicted the targets of miRNA-1/206 with the TargetScan and PicTar programs, and analyzed the molecular characterization of the porcine SFRP1 gene. (biomedcentral.com)
Our results indicate that the SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development. (biomedcentral.com)
MicroRNAs (miRNAs), which are endogenous non-coding small RNAs, are involved in the post-transcriptional regulation of gene expression through the suppression of mRNA translation or the degradation of mRNA. (biomedcentral.com)
Anticoagulants such as EDTA prevent blood clotting, but do not prevent changes in gene expression due to induced transcription or regulated turnover of mRNA. (qiagen.com)
MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression in many developmental and cellular processes. (biomedcentral.com)
MicroRNAs (miRNAs) are an abundant class of small (approximately 22 nt) endogenous non-coding RNAs that direct post-transcriptional regulation of gene expression. (biomedcentral.com)
MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). (cdc.gov)

This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
Combination of the top 4 out of 6 promising candidate drugs with BRAF or MEK inhibitors, partially showed synergistic growth inhibition compared to individual BRAF/MEK inhibition. (bvsalud.org)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
In this review, we focus on the use of antisense oligonucleotides (antimiRs) in miRNA inhibition for loss-of-function studies. (biomedcentral.com)
Furthermore, we describe the most commonly used in vivo delivery strategies and discuss different approaches for assessment of miRNA inhibition and potential off-target effects. (biomedcentral.com)
Finally, we summarize recent progress in antimiR mediated pharmacological inhibition of disease-associated miRNAs, which shows great promise in the development of novel miRNA-based therapeutics. (biomedcentral.com)
Chemically modified antimiR oligonucleotides sequester the mature miRNA in competition with cellular target mRNAs leading to functional inhibition of the miRNA and derepression of the direct targets. (biomedcentral.com)

Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous T re-2/ B ub2/ C DC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (elifesciences.org)
Autophagy is a degradation system that involves sequestration of cytoplasmic proteins and organelles by double-layered membranes that form vesicles called autophagosomes. (elifesciences.org)
Fusion of autophagosomes with lysosomes results in degradation of their contents and thereby removes toxic proteins and damaged organelles from cells to maintain homeostasis. (elifesciences.org)
Recently, we have found that a number of microRNAs (miRNAs) and proteins are involved in the response to acupuncture therapy in hypertensive rats. (hindawi.com)
Our bioinformatics study suggests an association between these miRNAs and proteins, which include miR-339 and sirtuin 2 (Sirt2). (hindawi.com)
While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
Exosome contain proteins, miRNAs, and mRNAs, and the exosomal lipid bilayer protects this genetic information from degradation. (biomedcentral.com)
MicroRNAs (miRNAs) guide repressive proteins onto specific target RNAs. (smallrna-bioinformatics.eu)
MicroRNAs constitute a large family of ~21-nt-long RNAs loaded by AGO proteins to form the miRISC complex, which silences specific target mRNAs. (smallrna-bioinformatics.eu)
Exosomes are nanosized extracellular vesicles secreted by most cells, harboring abundant RNAs and proteins that can modulate the biological processes of cells and act as circulating biomarkers for various diseases. (biomedcentral.com)
Hu-antigen R (HUR), a member of the ELAV family, is one of the best known RNA binding proteins (RBPs) that selectively recognizes and binds to adenylate/uridylate-rich elements (AREs) [ 16 ]. (biomedcentral.com)
Specific functional analogies are drawn between several components of CASS and proteins involved in eukaryotic RNAi, including the double-stranded RNA-specific helicase-nuclease (dicer), the endonuclease cleaving target mRNAs (slicer), and the RNA-dependent RNA polymerase. (biomedcentral.com)
Thus, we compared the expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). (biomedcentral.com)
Previously, non-coding RNAs (ncRNAs), including micro-RNAs (miRNAs) and other long non-coding RNAs (lncRNAs), have been generally considered unable to encode proteins both in plants and animals [1-9]. (fortunepublish.com)
They are capable of secreting a broad range of biomolecules such as proteins, nucleic acids, exosomes, microRNAs, and membrane vesicles, collectively known as secretomes. (techscience.com)
These biomarkers are detectable in liquid biopsy, include circulating tumor cells (CTCs), proteins, cell free DNA (cfDNA) and RNA (cfRNA) that recently have acquired interest in cancer for their role in diagnosis and treatment response [ 1 , 3 ]. (scientificarchives.com)
It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)

miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
MicroRNAs (miRNAs) are 21-23 nucleotide RNA molecules that modulate the stability or translational efficiency of target messenger RNAs [ 1 , 2 ]. (oncotarget.com)
Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. (cdc.gov)
Pre-miRNA is exported to the cytoplasm by exportin-5 and cleaved by Dicer (an RNA degrading enzyme) and produces approximately 22 nucleotide RNA duplexes. (archivesofmedicalscience.com)

Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
miRNAs predominantly interact with mRNA targets through imperfect binding to motifs in target mRNA 3′-untranslated regions (3′UTRs) ( Bartel, 2009 ). (elifesciences.org)
The nature of imperfect binding specificity means that a single miRNA can regulate a large number of mRNA targets involved in complex cellular processes, thereby tightly controlling genetic networks during development and in response to stress ( Pocock, 2011 ). (elifesciences.org)
Previously, it has been demonstrated that certain transcriptional targets of SOX4 are associated with cancer development and progression and the processing of microRNAs (miRNAs/miRs) ( 12 ). (spandidos-publications.com)
Therefore, miRNAs are now considered to be important in the development of biomarkers, and may be targets for the diagnosis and treatment of breast cancer patients ( 23 ). (spandidos-publications.com)
Since Sirt2 plays a critical role in multiple important cellular functions, our data imply that acupuncture may act through epigenetic changes and subsequent action on their targets, such as miRNA-339/Sirt2/NF- B/FOXO1 axis. (hindawi.com)
However, the targets of acupuncture-regulated miRNAs are not fully identified and validated and it is unknown whether this is involved in acupuncture's effects. (hindawi.com)
Finally, we identified 76 therapeutic agents, 152 miRNAs targets, and 91 TFs regulatory networks. (nature.com)
The findings may help to provide promising candidate biomarkers and therapeutic targets for AD. (nature.com)
Deregulated miRNAs may function as tumor suppressors such as miR-205 and let-7 [ 6 , 7 ], or oncogenes such as miR-17-92 cluster and miR-214 [ 8 , 9 ], depending on the regulated targets. (oncotarget.com)
Targets are recognized by sequence complementarity, and the biochemical rules for target recognition are well described, allowing precise computational predictions of molecular miRNA targets. (smallrna-bioinformatics.eu)
Consequently, high-throughput molecular biology and computational predictions now largely agree on the lists of miRNA targets, and it may seem that the biological impact of miRNA-guided regulation could be faithfully predicted and modeled. (smallrna-bioinformatics.eu)
Yet these results are contradicted by the observed in vivo phenotypes: while current molecular biology and bio-informatics identify hundreds of targets for each miRNA (suggesting that miRNAs control many biological processes), in vivo genetics shows that miRNA mutants tend to exhibit subtle, discrete phenotypes (usually specific to a given organ and a given biological pathway). (smallrna-bioinformatics.eu)
8 The results demonstrated that miRNA expression signatures were clearly distinct among the tumor types studied, suggesting their possible role in sarcomagenesis, and their potential as diagnostic markers or even therapeutic targets. (sarcomahelp.org)
Bioinformatic analysis was performed in order to identify putative targets of the differentially expressed microRNAs and to explore potential associations with specific biological processes. (biomedcentral.com)
The involvement of miRNAs in drug resistance is just beginning to emerge, and more studies are needed to identify other miRNAs, their molecular targets and the processes they affect. (biomedcentral.com)
Indeed, disease-associated miRNAs represent a new class of targets for the development of miRNA-based therapeutic modalities, which may yield patient benefits unobtainable by other therapeutic approaches. (biomedcentral.com)
This study presented an artificial intelligence pipeline of miRNA-based discovery of biomarkers, therapeutic targets, and repositioning drugs that can be applied to many cancer types. (cdc.gov)

However, recent studies have described an endogenous mechanism of microRNA degradation based on binding specific target RNAs to microRNAs with extensive complementarity. (smallrna-bioinformatics.eu)
The aim of our study was to explore the lncRNA-mediated competing endogenous RNA (ceRNA) network in RGCs during the development of myopia. (biomedcentral.com)
LncRNAs can mechanically act as competitive endogenous RNAs (ceRNAs), which competitively bind with miRNAs to reduce miRNA regulation of their target mRNAs [ 9 ]. (biomedcentral.com)

In metazoans, the miRISC complex binds to perfectly or imperfectly complementary sequences, present most commonly in the 3 ́ UTRs of target mRNAs, causing mRNA translational repression or deadenylation. (smallrna-bioinformatics.eu)
AREs are adenylate uridylate rich regions in 3′ UTRs of mRNAs in mammalian cells and they mediate rapid degradation of mRNAs [ 17 ]. (biomedcentral.com)
Metazoan miRNAs guide the miRISC to partially complementary sites in the 3' UTRs of target mRNAs to promote their translational repression or deadenylation and degradation. (biomedcentral.com)

miRNAs participate in crucial biological processes, including development, differentiation and proliferation ( 15 , 16 ). (spandidos-publications.com)
Gain and loss of function studies have indicated that miRNAs play a critical role in the regulation of all key biological functions such as development, cell proliferation, cell differentiation, and apoptosis [ 3 , 4 ]. (hindawi.com)
The biological processes they regulate may play an important role in understanding early osteoarthritis pathogenesis. (biomedcentral.com)
Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
Like intercellular RNAs, circulating RNAs participate in numerous biological process and express aberrantly under abnormal or pathological status. (scientificarchives.com)
MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. (biomedcentral.com)
Phosphorylation of HSP27 not only regulates its structural organization, but also affects its biological functions [ 13 ]. (biomedcentral.com)

Based on miRBase version 21 released in June 2014 ( http://www.mirbase.org/ ), there are 1,881 miRNA precursors and 2,588 mature miRNAs in humans. (hindawi.com)
Mature miRNAs act via complementarity with their target mRNAs. (frontiersin.org)
With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)

miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
We performed a temporal-spatial expression analysis of SFRP1 mRNA and miRNA-206 in Tongcheng pigs (a Chinese indigenous breed) by quantitative real-time polymerase chain reaction, and conducted the co-expression analyses of SFRP1 and miRNA-1/206. (biomedcentral.com)
The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)

Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
We further show that the evolutionary conservation among paralogs does not imply any coherence in miRNA regulation. (frontiersin.org)
We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)
Up to now, the regulation of microRNA levels has been mainly explained by the regulation of microRNA biogenesis alone, neglecting microRNA turnover pathways. (smallrna-bioinformatics.eu)
This emerging pathway, named TDMD for Target-Directed MicroRNA Degradation, enables highly specific microRNA decay subsequently to the proteolysis of AGO by the ubiquitin-proteasome pathway, and in this way, provides a new layer of microRNA regulation. (smallrna-bioinformatics.eu)
consequently, no major conclusions regarding the expression and regulation of miRNA in LPS could be made. (sarcomahelp.org)
Since complex regulation of the EGFR signaling axis might confound current attempts to inhibit EGFR directly, we searched for microRNAs (miRNAs) that may target the EGFR signaling axis. (oncotarget.com)
Even though transcriptional regulation of hsp27 is well recognized [ 14 ], few papers focus on degradation mechanisms of HSP27 protein. (biomedcentral.com)

MiRNA expression has been shown to be altered in cancerous tissue compared to normal tissue and different miRNAs have been attributed oncogenic and tumour suppressor qualities [ 6 ]. (biomedcentral.com)
There were 11 different miRNAs in exosomes of MHFMD and ESHFMD compared to healthy children, of which 4 were up-regulated and 7 were down-regulated. (biomedcentral.com)
Also, different miRNAs are associated with specific BC molecular subtypes. (spandidos-publications.com)

The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups. (biomedcentral.com)
Changes of miRNAs in exosome have been reported in different disease diagnosis and provided as potential biomarkers. (biomedcentral.com)
Exosomal miRNA expression profiles may provide supplemental biomarkers for diagnosing and subtyping HFMD infections. (biomedcentral.com)
Changes in exosomal miRNAs have been reported in patients diagnosed with Alzheimer's disease (AD), and miRNAs have been shown to provide diagnostic biomarkers [ 26 ]. (biomedcentral.com)
In the search for molecular biomarkers that could reveal pre-clinical phases of the disease, scientists have focused much of their attention on microRNAs (miRNAs), the best characterised family of small non-coding RNAs. (biomedcentral.com)
Recently, circulating RNAs (cfRNAs) are increasing their importance as biomarkers in liquid biopsy for cancer patients both for tumor characterization and development and for setting a monitoring personalized therapy. (scientificarchives.com)
Further analysis of the expression of these circulating miRNAs and their association with prognosis in patients with TNBC treated with immunotherapy should be assessed to evaluate their possible use as non‑invasive predictive biomarkers. (spandidos-publications.com)

Dysregulation of microRNAs (miRs) can contribute to cancer development and progression. (spandidos-publications.com)
To understand the molecular mechanism of SOX4 in breast cancer development and progression, the present study aimed to identify miRNAs that regulate the expression of SOX4, which revealed miR-320 as a potential candidate. (spandidos-publications.com)
Recently, much attention has focused on the impact of microRNAs (miRNAs) on tumorigenesis and cancer progression. (sarcomahelp.org)
miRNA deregulation has been identified in a variety of epithelial origin cancers, where changes in specific miRNAs expression possibly contribute to tumor growth, progression, metastasis, and chemoresistance. (sarcomahelp.org)
Our findings demonstrate that exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. (biomedcentral.com)
Long noncoding RNAs (lncRNAs) play a key role in the occurrence and progression of myopia. (biomedcentral.com)
The quality and quantity changes of circulating RNAs, mainly miRNA, are broadly investigated and associated with the initiation and progression of cancer [ 5 ]. (scientificarchives.com)
Atherosclerosis initiation and progression are driven by many pro-inflammatory and pro-thrombotic microRNAs. (archivesofmedicalscience.com)
MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. (archivesofmedicalscience.com)

miRNAs are considered to play important roles in cell proliferation, apoptosis, and differentiation during mammalian development. (oncotarget.com)
2006. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. (virosin.org)
There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. (biomedcentral.com)
Differential expression of miRNAs has been widely described in breast cancers, and suggests that certain miRNAs, including miR-206 ( 19 ), miR-129 ( 20 ), miR-200 ( 21 ) and miR-34 ( 22 ), may function as oncogenes or tumor suppressors in breast cancer. (spandidos-publications.com)
Recent data show aberrant and altered expression of regulatory noncoding micro (mi) RNAs in prostate cancer (PCa). (biomedcentral.com)
Furthermore, whether expression of a subset of miRNAs is distinct in androgen-responsive and androgen-independent cells is not clear. (biomedcentral.com)
No significant correlation between the miRNA expression and the intrinsic hormone-responsive property of PCa cells was observed. (biomedcentral.com)
Androgen-sensitive MDA PCa 2b cells exhibited the highest level of expression of most miRNAs studied in this report. (biomedcentral.com)
Our results suggest that miRNA expression profiles may not predict intrinsic hormone-sensitive environment of PCa cells. (biomedcentral.com)
Therefore, the role of miRNAs and their differential signature expression patterns in androgen-dependent and androgen-independent PCa cells requires a closer validation. (biomedcentral.com)
It is likely that the intronic miRNAs are processed from the same primary transcript as the precursor mRNAs and thus, their expression levels are regulated by the expression of the host mRNA [ 39 ]. (biomedcentral.com)
Combination of miR-130a and miR-495 inhibited RUNX3 expression at the protein level, but not at the mRNA level. (oncotarget.com)
Differential expression of miRNAs between normal and tumor tissues has been observed in various cancer types, suggesting a possible link between miRNA expression and the development of cancer [ 5 ]. (oncotarget.com)
Different expression of miRNAs in exosomes across all the three groups were screened using miRNA microarray method. (biomedcentral.com)
Further validation indicated that the 4 significant differentially expressed candidate miRNAs (miR-671-5p, miR-16-5p, miR-150-3p, and miR-4281) in exosome showed the same changes as in the microarray analysis, and the expression level of three miRNAs (miR-671-5p, miR-16-5p, and miR-150-3p) were significantly different between MHFMD or ESHFMD and the healthy controls. (biomedcentral.com)
The spatial and temporal distribution of microRNAs in organisms is tightly regulated, and aberrant microRNA expression leads to disease. (smallrna-bioinformatics.eu)
Pharmacologic manipulation of microRNA expression has been undertaken in the form of in vivo miRNA delivery of downregulated miRNAs and "antagomirs" targeting upregulated miRNAs. (sarcomahelp.org)
Not much is known about the expression and deregulation of miRNA in STS generally and in LPS specifically. (sarcomahelp.org)
In a recent study using a microarray approach, 27 STS of seven different histological subtypes were profiled for miRNA expression. (sarcomahelp.org)
Our studies, supported by the Liddy Shriver Sarcoma Initiative, aimed to identify unique miRNA expression profiles of WDLPS and DDLPS with the hope that such signatures could provide insights into our understanding of the molecular determinants driving these two entities. (sarcomahelp.org)
The expression of circSHKBP1 was evaluated using quantitative real-time PCR and RNA in situ hybridization, and the molecular mechanism of circSHKBP1 was demonstrated by western blot, RNA pulldown, RNA immunoprecipitation, luciferase assays and rescue experiments. (biomedcentral.com)
Mechanistically, circSHKBP1 sponged miR-582-3p to increase HUR expression, enhancing VEGF mRNA stability. (biomedcentral.com)
Dynamic Ppargc1a expression in the mouse hair cycle suggests a possible role in regulating hair growth and differentiation. (nature.com)
Characterization of miRNA expression profile provided support for AR , PPAR, retinoic acid signaling and inflammation in miniaturized hair. (nature.com)
To date, the effect produced by HCV on the expression of microRNAs (miRs) involved in the interferon-β (IFN-β) antiviral pathway has not been explored in details. (biomedcentral.com)
RNA sequencing was performed to analyze lncRNA and mRNA expression profiles in RGCs between guinea pigs with form-deprived myopia (FDM) and normal control guinea pigs, and related ceRNA networks were constructed. (biomedcentral.com)
Further study revealed that TPD52 mRNA and miRNA-223 expression was elevated, while the expression of KLF 9 and PKCε was reduced in the blood of ovarian cancer patients. (biomedcentral.com)
The expression level of the SFRP1 was highly varied across numerous pig tissues and it was down-regulated during porcine skeletal muscle development. (biomedcentral.com)
In the female subjects, increased expression of both microRNAs was associated with an increased number of MetS risk components (p = 0.002 for let-7 g and p = 0.022 for miR-221). (biomedcentral.com)
compared the expression profiles of circulating miRNAs between morbidly obese patients and non-obese individuals and found miR-132 and miR-17-5p were significantly decreased in obese subjects [ 14 ]. (biomedcentral.com)
Small interfering RNA-mediated RKIP knockdown revealed similar effects as that of ectopic miR-27a expression, while overexpression of RKIP attenuated the function of miR-27a in lung adenocarcinoma cells. (biomedcentral.com)
Decreased mRNA expression of SMAD-specific E3 ubiquitin-protein ligase 2 (Smurf2), which is involved in ubiquitin degradation of HSP27, was responsible for the increased expression of pHSP27. (biomedcentral.com)
In addition, increased expression of miRNA15b was identified with decreased expression of Smurf2 mRNA in PF models. (biomedcentral.com)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

In addition, due to their rapid and reversible regulatory capacity, miRNAs are prime candidate facilitators of responses to proteotoxic stress. (elifesciences.org)
Circular RNAs (circRNAs) play important regulatory roles in the development of various cancers. (biomedcentral.com)
Recently, it has been proposed that also microRNAs (miRs), a class of small non-coding regulatory RNAs, are involved in the antiviral pathway induced by IFN-β treatment. (biomedcentral.com)

The SFRPs inhibit Wnt receptor binding to down-regulate pathway signaling during development [ 8 ]. (biomedcentral.com)
2011. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. (virosin.org)
Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)
SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2), which is a crucial part of the ubiquitin-proteasome pathway, was suggested to be involved in the degradation of HSP27 [ 15 ] without elucidation of a detailed mechanism. (biomedcentral.com)

The biogenesis of miRNAs begins with a primary transcript, termed the pri-miRNA, and the combined action of Drosha and Dicer ribonucleases generates the mature miRNA species [ 3 ]. (oncotarget.com)
MicroRNA biogenesis is quite complex [ 2 ]. (archivesofmedicalscience.com)

In human SH-SY5Y cells, the luciferase assay implied that Sirt2 was likely a target of miRNA-339. (hindawi.com)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA. (hindawi.com)
miRNAs act as adaptors that employ a silencing complex to target mRNAs by selective base pairing, primarily in the 3′-untranslated region (3′-UTR). (hindawi.com)
Based on published data about target RNA patterns leading to TDMD and phylogenetic conservation, we developed a computational tool for the in silico identification of RNA sites that induce microRNA degradation through TDMD. (smallrna-bioinformatics.eu)
The RISC-siRNA complex then binds to the target mRNA which is cleaved by the slicer nuclease, another crucial component of RISC, to release the RISC-siRNA which acts as a recyclable catalyst [ 9 , 10 ]. (biomedcentral.com)
The bioinformatics analysis predicted SFRP1 to be a target of miRNA-1/206. (biomedcentral.com)
Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)
Despite the evolutionary conservation of miRs, a single miR can target thousands of mRNAs, resulting in a lack of clarity about their true function or place in pathophysiologic events, including those that are central to the development of PF. (biomedcentral.com)

detected miRNAs in the serum and plasma blood components of humans and other animals. (biomedcentral.com)
Here, we employed microarray methods to compare the miRNAs of exosome from serum samples collected from normal children and patients with mild HFMD (MHFMD) and extremely severe HFMD (ESHFMD). (biomedcentral.com)
This study assessed the serum levels of these two microRNAs in subjects with and without metabolic syndrome (MetS). (biomedcentral.com)
The serum microRNA levels were detected in 102 subjects aged 40 to 80 years who were recruited from the general population. (biomedcentral.com)
Furthermore, circulating microRNAs in the serum are resistant to lysis and are stable against RNase, as they are hidden in microparticles, apoptotic bodies, etc. [ 1 ]. (archivesofmedicalscience.com)

For example, a small peptide that is encoded by lncRNA HOXB-AS3 inhibits oncogenesis by regulating alternative splicing and metabolic reprogramming of colon cancer cells [5-7, 17]. (fortunepublish.com)
To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. (jcancer.org)
LncRNA is a non-coding RNA molecule longer than 200 nucleotides [ 3 ] . (jcancer.org)
Even though the role of circulating non coding RNAs as miRNA and lncRNA can be easily understood taking into consideration that can be secreted and persist in biofluid in remarkably stable forms, as "free" or associated to exosomes, less is known concerning the role of circulating mRNA, mainly taking into consideration its instability and the presence of RNase, nevertheless its presence is detected in blood. (scientificarchives.com)

Long noncoding RNAs (lncRNAs) are a class of transcripts containing more than 200 nucleotides [ 7 ]. (biomedcentral.com)

miRNAs play key roles in a broad range of cellular processes and the response to changes in the environment ( Leung and Sharp, 2010 ). (frontiersin.org)
Characterization of lncRNAs has revealed their functional roles in regulating different cellular processes. (biomedcentral.com)
Blood from mouse, rat, and other small animals is conveniently collected in RNAprotect Animal Blood Tubes, which contain a reagent that immediately stabilizes cellular RNA. (qiagen.com)

Circulating RNAs are represented by a broad range of subtypes, such as microRNA (miRNAs), long non coding RNA (lncRNAs), messenger RNAs (mRNAs), transfer RNAs (tRNAs), snRNAs (small nuclear RNAs), snoRNA (small nucleolar RNAs), piwiRNAs (piRNA) and circRNAs (circular RNAs). (scientificarchives.com)

Dysregulation of miRNA could possibly be an important contributing factor to LPS sarcomagenesis, especially to the process of dedifferentiation. (sarcomahelp.org)

DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)

MicroRNAs are a class of small, single-stranded, noncoding RNA (~21-24 nt in length) that occur in the genomes of plants and animals. (biomedcentral.com)

We will discuss the reasons for such a discrepancy, their practical implications in terms of miRNA biology, and potential improvements in the functional assignment of miRNAs. (smallrna-bioinformatics.eu)
This degenerative, age-related joint disease is characterised by a progressive degradation of articular cartilage and concomitant structural and functional change of all joint constituents, including the synovial membrane, the subchondral bone and periarticular tissues [ 4 ]. (biomedcentral.com)
Since then, many studies have been conducted to identify potential candidates among lncRNAs that can encode functional peptides (in a number of papers they are called microproteins, or sPEPs) [4, 5, 12]. (fortunepublish.com)

We identified miR-27a (miR-27a-3p) and its complementary or star (*) strand, miR-27a* (miR-27a-5p), as novel miRNAs targeting EGFR, which were significantly downregulated in multiple HNSCC cell lines. (oncotarget.com)

In this study, we investigated the role of miRNAs targeting RUNX3 in early tumorigenesis. (oncotarget.com)

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (cancerindex.org)
siRNAs are produced from double-stranded RNAs of viruses and transposable elements, which are processed by the dicer nuclease, one of the essential components of the RNA-Induced Silencing Complexes (RISCs) [ 7 - 9 ]. (biomedcentral.com)
Pre-miRNAs are exported to the cytoplasm by Exportin-5 and processed further by Dicer, to ~22 nt double-stranded miRNA duplexes that are loaded into an Argonaute protein in the miRISC and rapidly unwound. (biomedcentral.com)

However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
The level of miR-17-5p inversely correlated with body mass index and it may regulate adipocyte differentiation by targeting Rb2/p130. (biomedcentral.com)

After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)

Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues. (biomedcentral.com)
After being released into the extracellular fluids, miRNAs play roles in cell-to-cell communication within the same tissue or between the same and different cell types in remote tissues by the methods of endocytosis-like internalization or receptor-ligand interactions [ 11 ]. (biomedcentral.com)

miR-27a regulates epithelial-mesenchymal transition (EMT) and cisplatin resistance in vitro and modulates response of lung adenocarcinoma cells to cisplatin in vivo . (biomedcentral.com)
The recent explosion in miRNA research has accelerated the development of several computational and experimental approaches for probing miRNA functions in cell culture and in vivo . (biomedcentral.com)

Previous works focused mostly on miRNA seed matches and other features of the 3′-UTR of transcripts. (frontiersin.org)
The new class of plant small peptide regulators was recently shown to be encoded by primiRNA transcripts which can be transported to cytoplasm in unprocessed mRNA-like form. (fortunepublish.com)

Recent studies have revealed that a group of miRNAs are involved in the neural mechanism of acupuncture treatment in hypertensive rats [ 30 ]. (hindawi.com)
Through this mechanism, a single microRNA can alter the function of multiple mRNAs. (archivesofmedicalscience.com)

This study indicated that the exosomal miRNA from patients with different condition of HFMD express unique miRNA profiles. (biomedcentral.com)

Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. (biomedcentral.com)
Moreover, there is now ample evidence that perturbations in the levels of individual or entire families of miRNAs are strongly associated with the pathogenesis of a wide range of human diseases. (biomedcentral.com)

Supplemented with published RNA-seq and small-RNA-seq data, our workflow allows focusing on cell-specific TDMD inducer candidates. (smallrna-bioinformatics.eu)
Small RNA sequencing was performed using synovial fluid from the metacarpophalangeal joints of both control and early osteoarthritic horses. (biomedcentral.com)
Alternatively, the RNeasy Protect Animal Blood Kit can be used to obtain microRNA (miRNA), either in a total RNA fraction or in a separate small RNA fraction. (qiagen.com)
For purification of small RNA (containing miRNA) and large RNA in 2 separate fractions, the RNeasy MinElute Cleanup Kit (cat. (qiagen.com)

We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups. (biomedcentral.com)
circSHKBP1 is a promising circulating biomarker for GC diagnosis and prognosis and an exceptional candidate for further therapeutic exploration. (biomedcentral.com)
The levels of both circulating microRNAs (let-7 g and miR-221) were higher in subjects with MetS (p = 0.004 and p = 0.01, respectively). (biomedcentral.com)
Malentacchi F, Sorbi F, Cipriani N, Sgromo C, Antonuzzo L, Pillozzi S. Circulating Cell-Free RNA: A New Perspective for Endometrial Cancer. (scientificarchives.com)
Circulating RNAs are represented by, such as for intercellular RNAs, a broad range of subtypes, mainly represented by microRNA (miRNAs), long non coding RNA (lncRNAs) and messanger RNAs (mRNAs). (scientificarchives.com)
Moreover, these findings re-evaluated previous discoveries related to circulating mRNAs, that were found, for the first time in 1999 in plasma of nasopharyngeal carcinoma patients [ 13 ]. (scientificarchives.com)

Recently, the potential therapeutic use of miRNAs has been evaluated due to their dynamic and reversible properties. (hindawi.com)

In this study, we compared microRNA profile in exosomes in 5 MHFMD and 5 ESHFMD as well as in 5 healthy children. (biomedcentral.com)

Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)

Extracellular miRNAs may mediate the intercellular communication. (biomedcentral.com)

Anatomy9

Organisms4

Diseases1

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care1

Genes47

Gene33

Inhibition7

Proteins17

Nucleotide4

Targets18

Endogenous3

UTRs3

Biological7

Mature miRNAs3

Polymerase3

Regulation8

Different miRNAs3

Biomarkers7

Progression9

Apoptosis3

Expression34

Regulatory3

Pathway4

Biogenesis2

Target9

Serum5

LncRNA4

Nucleotides1

Cellular3

Circular RNAs1

Dysregulation1

Proliferation1

Single stranded1

Functional3

Novel miRNAs1

Role of miRNAs1

Dicer3

Differentiation4

Precursor1

Tissues2

Vivo2

Transcripts2

Mechanism2

Unique miRNA1

Pathogenesis2

Small4

Circulating6

Therapeutic1

Exosomes1

Oncogenic1

Intercellular1