Mrna cell migration focal adhesions. Medical search. Frequent questions

Focal adhesion kinase (FAK) and steroid receptor coactivator (c-Src) are signaling proteins that regulate cytoskeletal dynamics and cell motility by influencing actin polymerization and focal adhesion turn-over [ 11 , 12 ]. (biomedcentral.com)
Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase, extracellular signal-regulated kinases 1 and 2, and v-Akt murine thymoma viral oncogene were observed in male MIPβ1KO islets when compared to controls. (oncotarget.com)
β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
PRICKLE1 is phosphorylated by the serine/threonine kinase MINK1 and contributes to TNBC cell motility and invasiveness. (hal.science)
Using a kinase inhibitor, we demonstrate that the enzymatic activity of MINK1 is involved in PRICKLE1-LL5β complex assembly and localization, as well as in cell migration. (hal.science)
focal adhesion kinase from focal contacts. (123dok.org)
This impact is believed to occur via modulation of the phosphorylation of focal adhesion kinase [52] and the expression of matrix metalloproteinases 2 and 9 [52]. (irjs.info)
The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. (famri.org)

EL decreased phosphorylation of FAK and its downstream targets, Src, paxillin, and decreased mRNA expression of cell motility-related genes, RhoA, Rac1, and Cdc42 in lung cancer cells. (biomedcentral.com)
In MCF10A/HER2 cells, TGF-beta enhanced cell motility, FAK phosphorylation, F-actin assembly, and focal adhesion formation and inhibited RhoA activity. (nih.gov)
In cells expressing RPTPkappa RNAi, phosphorylation of Src at Tyr527 was increased and (activating) phosphorylation of Src at Tyr416 was reduced. (nih.gov)

Our data suggest that EL suppresses lung cancer cell motility and invasion by altering FAK activity and subsequent activation of downstream proteins needed for focal adhesion formation and cytoskeletal rearrangement. (biomedcentral.com)
The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)
LL5β anchors microtubules at the cell cortex through its association with CLASP proteins to trigger focal adhesion disassembly. (hal.science)
The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
Furthermore, we describe a functional decrease in proliferative activity in vitro, wound repair, and an increase in focal adhesion proteins in epithelial cells lacking GSDMB, phenotypically rescued by transfection or MTX treatment. (pcrtechnique.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)

We found that the expression level of Ki-67 protein in lung metastatic tumor tissues of mice treated with JFK was significantly reduced, while the infiltration level of CD8+ T lymphocytes and NK cells was significantly increased. (bvsalud.org)
CONCLUSION: These results suggest that JFK may upregulate the proportion of CD4+ T, CD8+ T and NKT cells in peripheral blood, reverse the TCR changes caused by tumor metastasis, and promote the infiltration of CD8+ T and NK cells in tumor tissues, thereby inhibiting the growth of tumors and ultimately reducing the burden of lung cancer metastasis. (bvsalud.org)
But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We compared normal stem cells to CSCs, while previous researchers have compared mature cancer tissues/cells with normal tissues/cells. (irjs.info)
Consistent with the microarray data, real-time RT-PCR confirmed these modulation at the mRNA level in skin tissues from S. lappa -treated mice. (molcells.org)
The results suggested that Gas5 was markedly downregulated in both PTC tissues and PTC cell lines. (oncotarget.com)
Increased levels of POGLUT2 were found in multiple types of cancer tissues and cell lines. (frontiersin.org)
The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)
The Warburg effect shows that a unique metabolic phenotype was identified for cancer cells, featuring that compared to normal tissues, they are characterized by a high rate of glycolytic metabolism. (biomedcentral.com)
We also confirmed the mRNA and protein expression of interested model-related genes from the Human Protein Atlas (HPA) and 10 paired BCa tissues collected by us. (biomedcentral.com)

Gene and protein expression levels of FAK-Src signaling molecules in EL-treated lung cancer cells were determined using PCR arrays, qRT-PCR, and western blotting. (biomedcentral.com)

in either degradation of the target mRNA or translational repression [40]. (irjs.info)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)

This channel is strongly expressed in poorly metastatic B16 cellsBioMed Investigation InternationalCa2+ Ca2+ORAITRPMSTIM1 T-type ERSOCECa2+Ca2+ TRPM8/7/2 SurvivalAutophagyProliferationMigration, invasion, and metastasisApoptosisFigure 1: Ca2+ -influx pathways and their physiological functions in melanoma cells. (icbinhibitor.com)
The anti-migratory and anti-invasive potential of EL for lung cancer cell lines was determined by scratch wound healing and Matrigel® invasion assays. (biomedcentral.com)
Non-toxic concentrations of EL inhibited lung cancer cell migration and invasion in a concentration- and time-dependent manner. (biomedcentral.com)
Therefore, administration of EL may serve as a safe and complementary approach for inhibiting lung tumor cell motility, invasion, and metastasis. (biomedcentral.com)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
These findings imply that both AGR2 downregulation and TGF-ß have a role in focal adhesion formation and cancer cell migration and invasion. (muni.cz)
Lung adenocarcinoma (LUAD) is a classification of lung cancer, and cell invasion and migration of LUAD are the main causes for its high mortality. (biomedcentral.com)
It was uncovered that overexpressing CTHRC1 promoted LUAD cell migration and invasion, and inhibited cell adhesion, while knocked down CTHRC1 had the opposite effect. (biomedcentral.com)
Overexpressed miR-30a-5p suppressed cell invasion/migration, and increased cell adhesion, while overexpressing CTHRC1 as well reversed such impacts. (biomedcentral.com)
In conclusion, it was disclosed in this study that CTHRC1 worked as a cancer promoter in LUAD, and miR-30a-5p could target and downregulate CTHRC1 to regulate cell adhesion, and inhibited LUAD cell invasion and migration. (biomedcentral.com)
As revealed in recent years, CTHRC1 is upregulated in various tumors, and promote cancer cell invasion and migration [ 9 , 10 , 11 ], which also works as a potential biomarker of various cancers. (biomedcentral.com)
MiR-21 continues to be demonstrated to focus on PTEN [52] and leads to the additional modulation of HCC cell migration and invasion. (irjs.info)
Most importantly, miR-10b, the second most over-expressed miRNA in SP-HCCs, has been found to be highly expressed in metastatic breast cancer cells and has been shown to positively Narlaprevir regulate cell migration and invasion [53]. (irjs.info)
MiR-10b inhibits the synthesis of the HOXD10 protein and permits the expression of the pro-metastatic gene product RHOC, which in turn favors cancer cell migration and invasion [53]. (irjs.info)
In short, based on previous studies, we propose that the greatly up-regulated miRNAs may contribute to the rapid proliferation, migration and invasion of SP-HCCs. (irjs.info)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Tumor cells are able to disrupt membrane transport regulators, thereby enhancing migration and invasion. (biomedcentral.com)
positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. (cusabio.cn)
CEACAM6 promoted oral squamous cell carcinoma cell invasion, migration, cytoskeletal rearrangement, and metastasis via interaction with EGFR and enhancing it activation. (cusabio.cn)

While evaluating the anticancer effect of UA/(AS-IV)@PDA-HA in vitro and in vivo, the PDA nanodelivery system significantly improved UA-mediated cytotoxicity and anti-metastatic ability against NSCLC cells. (bvsalud.org)
The role of β1 integrin in maintaining optimal islet function has previously been identified in vitro using cell lines and isolated islets. (oncotarget.com)
The migratory and invasive phenotypes of CRC cells were evaluated by in vitro transwell assays and in vivo metastatic models. (thno.org)
In vitro migration assays, transendothelial migration assays (iTEM), and cell adhesion assays were used to investigate the effects of SPON2 on monocyte/macrophage migration. (biomedcentral.com)
Using the human intestinal epithelial cell line, HT-29, CRISPR-cas9 knockout cells lacking GSDMB were generated and used for in vitro assays for TXT, cell death, and cell migration. (pcrtechnique.com)
In in vitro experiment using HaCaT cells, we found that the S. lappa components, including alantolactone, caryophyllene, costic acid, costunolide and dehydrocostus lactone significantly decreased the expression of PI3Kca but not IL20Rβ in vitro . (molcells.org)
Over-expression of Gas5 remarkably suppressed PTC cells proliferation in vitro and inhibited the growth of tumor cells in vivo likewise. (oncotarget.com)
Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological function assays and in vivo tumor growth study. (frontiersin.org)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

CCK8 was performed to assess the cell viability in human vascular endothelial cells (HVECs). (biomedcentral.com)
In the renal glomeruli, VEGFA is mainly expressed in and secreted from podocytes and tubular epithelial cells, which induces renal injury through binding to the receptor VEGFR, mainly VEGFR2, which is expressed on the surface of endothelial cells [ 8 ]. (biomedcentral.com)
To investigate the structural organisation, dynamics and functional importance of F-actin in endothelial cells (ECs) during angiogenesis in vivo , we generated a transgenic zebrafish line expressing Lifeact-EGFP in ECs. (biologists.com)
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. (cusabio.cn)

We considered the expression of both miRNAs and messenger RNAs (mRNAs) at these time points to improve the identification of regulatory targets of miRNAs. (biomedcentral.com)
By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)
As the G1/S limitation can be absent in SP cells mainly, these cell-cycle managing miRNAs may be in charge of allowing SP cells to quickly undertake G1 stage, enter S stage and proliferate. (irjs.info)
Thus, these two miRNAs may contribute to the stem cell-like properties of SP-HCCs. (irjs.info)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)

cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)

β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. (oncotarget.com)
However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. (oncotarget.com)
We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 integrin knockout mouse model (MIPβ1KO) to investigate β1 integrin function in adult pancreatic beta-cells. (oncotarget.com)
This data demonstrates that β1 integrin is required for the maintenance of glucose homeostasis through postnatal beta-cell function and expansion. (oncotarget.com)
In addition, SPON2 promotes cytoskeletal remodeling and transendothelial migration of monocytes by activating integrin β1/PYK2 axis. (biomedcentral.com)
Furthermore, blocking the SPON2/integrin β1/PYK2 axis impairs the transendothelial migration of monocytes and cancer-promoting functions of TAMs in vivo. (biomedcentral.com)

It has been suggested that TRPM8 could regulate either proliferation or apoptosis mechanism in prostate cells, based on its intracellular localization [34]. (icbinhibitor.com)

The four panels represent roughly the different steps in the formation and disassembly of focal adhesions. (mechanobio.info)

Moreover, it has been shown thatBioMed Investigation International T-type calcium channels regulate cell motility and migration in fibrosarcoma cells [31]. (icbinhibitor.com)
We hypothesized that EL could inhibit lung cancer cell motility by affecting the FAK-Src signaling pathway. (biomedcentral.com)
However, it is not clear what effect EL has on lung cancer cell motility. (biomedcentral.com)
Therefore, there is a need for less toxic agents that target FAK-Src signaling and inhibit lung cancer cell motility. (biomedcentral.com)
The objective for this research was to identify EL as a less toxic agent to inhibit lung cancer cell motility, and to determine its anti-migratory mechanisms by focusing on FAK-Src signaling and down-stream effects. (biomedcentral.com)
Knocking down PARVB expression in vitrocaused apparent decreases in cell migration and wound healing, implying that PARVB has a crucial role in cellular motility. (refine.bio)
Focal adhesions act as molecular clutches that provide grip to the substrate for the lamellipodium to protrude forward during motility. (mechanobio.info)

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)

PARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma. (refine.bio)
Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis because of its invasive feature and higher frequency to have metastasis. (refine.bio)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

Both the pharmacological blockade and the siRNA-mediated silencing of TRPM8 channels have been shown to induce the apoptotic death of prostate cancer cells [33], indicating a 15(S)-15-Methyl Prostaglandin F2�� Epigenetic Reader Domain crucial role for these channels in Ca2+ homeostasis upkeep. (icbinhibitor.com)
We've got not too long ago reported that T-type pharmacological blockers induce apoptosis in melanoma cells, additionally to minimizing its proliferation [36]. (icbinhibitor.com)
SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, adhesion, and migration of conceptus trophectoderm cells during implantation. (korea.ac.kr)
SPON2 may indirectly induce M2-polarization through upregulating cytokines including IL10, CCL2 and CSF1 expression in tumor cells. (biomedcentral.com)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Primary intestinal biopsy and isolated intestinal epithelial samples from IBD patients and non-IBD controls were evaluated for mRNA and protein expression. (pcrtechnique.com)
The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)

Together with dynactin, dynein regulates centrosomal orientation to establish and maintain cell polarity, controls focal adhesion turnover and anchors microtubules at the leading edge. (biologists.com)

Integrins are important regulators of cellular differentiation, migration, maturation, and survival [ 1 - 3 ]. (oncotarget.com)
The protrusions of the cell edge are shown as green arrows corresponding to points of adhesion maturation (panels 3 and 4). (mechanobio.info)

Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. (nih.gov)
Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation. (xenbase.org)
Taken together, our data suggest that the epithelium-derived increase in GSDMB during IBD has a protective role and promotes specific epithelium adhesion and migration, justifying the potential therapeutic use of GSDMB to optimize intestinal mucosal healing and restoration of homeostasis. (pcrtechnique.com)
This miRNA has been shown to control the G1/S checkpoint gene p57 and, as a result, promotes stem cell transition from G1-phase to S-phase [51]. (irjs.info)
However, the precise molecular mechanisms by which AKT1 promotes cell proliferation and regulates apoptosis ( 18 , 19 ) remain largely unclear. (spandidos-publications.com)

Vinculin expression in focal adhesions upon EL treatment was determined by immunocytochemistry. (biomedcentral.com)
In addition, immunofluorescence showed the formation of stress fibers and vinculin foci in cells without AGR2 and in response to TGF-ß treatment, with synergistic effects observed. (muni.cz)
Vinculin, a plasma protein, links fibers to talin, which is a cell membrane protein. (medscape.com)

Aims Because hepatic malignancy stem cells (HCSCs) are believed to derive from the conversion of hepatic normal stem cells (HNSCs), the identification of the differences that distinguish HCSCs from HNSCs is important. (irjs.info)
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
Development: For advances in developmental biology and stem cells. (lu.se)
Basal and limbal stem cells contribute to mitosis. (medscape.com)
A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
A deficiency of limbal stem cells, from either disease (eg, aniridia) or trauma (eg, chemical burn), can preclude adequate epithelial wound healing. (medscape.com)

In addition, we also found that JFK could significantly increase the proportion of CD4+ T, CD8+ T and NKT cells in the peripheral blood of mice. (bvsalud.org)
To understand a molecular mechanism of endophytic subtype and identify biomarkers, we performed comprehensive microarray analysis for mRNAs from clinical biopsy sampleswhich were classified into subtypes and found overexpression of parvin-beta (PARVB) gene significantly related to endophytic type. (refine.bio)
Morphological analyses demonstrated that beta-cell mass, islet density, and the number of large-sized islets was significantly reduced in male MIPβ1KO mice. (oncotarget.com)
Notely, the model was also significantly correlated with drug sensitivity, immune cell infiltration, and immunotherapy efficacy prediction by the wilcox rank test and chi-square test. (biomedcentral.com)

T cells, MDSCs, and macrophages in the peripheral blood were detected by flow cytometry, and the proliferation and immune cell infiltration of lung metastases were observed by immunohistochemistry and immunofluorescence. (bvsalud.org)
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
Based on the 7 immune infiltration algorithm, we found that Neutrophils, Myeloid dendritic cells, M2 macrophages, Cancer-associated fibroblasts, etc., were more concentrated in the high-risk group. (biomedcentral.com)

Analysis of gene expression data reveals that the concomitant upregulation of levels of mRNA encoding PRICKLE1 and LL5β, which are MINK1 substrates, is associated with poor metastasis-free survival in TNBC patients. (hal.science)
However, recent study represented that miRNA mediates gene expression via targeting 3'-untranslated region (UTR) of mRNA [ 14 ], so as to modulate the progression of various diseases. (biomedcentral.com)
The expression of ELF4 in human CRC samples and CRC cell lines was determined by quantitative real-time PCR, immunohistochemistry and immunoblotting. (thno.org)
At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
By contrast, CD23 expression in mice is limited to B cells, follicular dendritic cells and enterocytes [14, 19, 20]. (treatmentforprostatecancer.info)
Western blotting and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) to evaluate the expression levels of AKT1 in HCC SMMC‑7721 cell line. (spandidos-publications.com)
Molecular mechanisms and the influences of different regulation the expression of AKT1 on HCC cell growth, proliferation were determined by western blotting, MTT and colony formation assays, cell cycle and apoptosis were investigated by flow cytometry. (spandidos-publications.com)
Furthermore, the data of the present study indicated that B‑cell lymphoma 2 and cyclin D1 is involved in the regulation of AKT1 expression. (spandidos-publications.com)
High expression of activated AKT can be detected in HCC, and AKT may promote cell proliferation and regulation of cells apoptosis in HCC ( 20 , 21 ). (spandidos-publications.com)
Subsequent mechanism investigations revealed that AKT1 served a notable function in cell proliferation and anti-apoptosis by directly regulating the expression of phosphatase and tensin homolog (PTEN) and Notch1. (spandidos-publications.com)
Enhanced expression of miR-222-3p promoted the proliferation of PTC cells while knocking down miR-222-3p could inhibit it. (oncotarget.com)
The advanced effects of miR-222-3p on the proliferation of PTC cells could be partly reversed by the upregulation of Gas5 expression. (oncotarget.com)
Taken together, our study identified a tumor suppressive role of Gas5 in PTC cells acting as a ceRNA, effectively becoming a sink for miR-222-3p, modulating the expression of PTEN, which lead to PTEN/AKT pathway activation and proliferation suppression. (oncotarget.com)
Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. (frontiersin.org)
In this study, we aimed to explore the expression of ARL9 mRNA in colon adenocarcinoma, and its effect on the prognosis of patients with colon adenocarcinoma. (biomedcentral.com)
The correlation between clinical characteristics and the mRNA expression level of ARL9 were analyzed. (biomedcentral.com)
The effect of the expression of ARL9 on the proliferation and migration of colon adenocarcinoma was analyzed by the CCK8 method and a cell scratch test, respectively. (biomedcentral.com)
Age and the high mRNA expression of ARL9 were independent risk factors for a poor prognosis in patients with colon adenocarcinoma. (biomedcentral.com)
The mRNA expression of ARL9 is upregulated in colon adenocarcinoma, and higher mRNA expression levels are associated with a poor prognosis. (biomedcentral.com)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression. (ijbs.com)
A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). (cdc.gov)
The mRNA expression patterns of these 26 genes were validated using RT-PCR analyses of independent tissue samples (n = 77) and blood samples (n = 48). (cdc.gov)

Additionally, circRNAs modulate pre-mRNA alternative splicing and possess protein-coding capacity. (ijbs.com)

Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling, and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation. (korea.ac.kr)

Knocking down ARL9 can reduce the proliferation and migration of colon adenocarcinoma cells. (biomedcentral.com)

In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
The GSEA suggested that ARL9 may be able to upregulate cell adhesion, extracellular matrix receptor interactions, tumor-associated pathways, and downregulate the citrate cycle and tricarboxylic acid cycle pathway, which are involved in the development of colon adenocarcinoma. (biomedcentral.com)

Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. (biologists.com)

Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. (cusabio.cn)

Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. (nature.com)
Overexpression of SPON2 has been shown to promote tumor cell migration in colorectal cancer (CRC). (biomedcentral.com)

However, how tumor cells affect TAM accumulation and their pro-tumoral phenotype in invasive CRC has not yet been well established. (biomedcentral.com)
Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)

HA binds specifically to the overexpressed cluster of differentiation 44 (CD44) on the surface of most cancer cells, thereby improving drug targeting. (bvsalud.org)
In the earliest stages of development, the physical properties of the microenvironment can direct cell differentiation, and initiate the coordinated movement of groups of cells to establish the patterns that will define how the body is arranged. (mechanobio.info)

However, it is still unknown whether JFK plays a role in treating lung cancer metastasis by regulating T-cell receptors (TCRs). (bvsalud.org)
MATERIALS AND METHODS: A lung metastasis model was established in C57BL/6J and BALB/c-nude mice by tail vein injection of Lewis lung cancer cells. (bvsalud.org)
Combining chemotherapy and immunotherapy is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis. (bvsalud.org)
MiR-30c-mediated CTHRC1 accelerates the metastasis of LUAD cells [ 16 ]. (biomedcentral.com)

A method based on atomic force microscopy is used to delineate the properties that determine single-molecule adhesion onto solid substrates in aqueous environment. (cipsm.de)

In addition, TRPV1 has been proposed as a beneficial target for killing malignant cells, considering the fact that mitochondrial function was inhibited and apoptosis was induced in pancreatic cancer cells treated with a vanilloid analogue [8, 35]. (icbinhibitor.com)
discovered that inhibition of T-type channels by a selective antagonist or siRNA-mediated gene knockdown not just decreased glioma cell viability but additionally induced apoptosis. (icbinhibitor.com)

Positively and negatively modulating tubulin acetylation in intercalating cells alters the developmental timing such that cells with more acetylation penetrate faster. (xenbase.org)
POGLUT2 was mainly expressed in stromal cells as verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. (frontiersin.org)

Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are ubiquitously expressed in eukaryotic cells during post-transcriptional processes. (ijbs.com)

By combining gene functional and pathway annotation with miRNA-mRNA interactions, we created a PyMT-specific tripartite miRNA-mRNA-pathway network and identified novel functional regulatory programs (FRPs). (biomedcentral.com)
We also identified miRNA-mRNA regulatory modules driving specific cancer-related biological processes. (biomedcentral.com)
We applied a novel clustering method to an annotated miRNA-mRNA regulatory network and identified network modules involved in specific cancer-related biological processes. (biomedcentral.com)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)

After 24-30 hours, mitosis begins to restore epithelial cell population. (medscape.com)

Non-toxic concentrations of EL were identified for A549 and H460 human lung cancer cells by conducting 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Dephenyltetrazolium Bromide (MTT) assays. (biomedcentral.com)
In addition, human epithelial cells transfected with GSDMB constructs and/or stimulated with methotrexate (MTX) were used for relevant functional assays. (pcrtechnique.com)
Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)

Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells. (cusabio.cn)

Hereon, this evaluation will discuss the current understanding concerning the role of unique Ca2+ channels expressed in the plasma membrane of melanoma cells, at the same time because the Ca2+ signaling pathways involved in the course of tumorigenesis and tumor progression.2. (icbinhibitor.com)
We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)

how a cell can detect, measure and respond to the rigidity of its substrate and how these processes apply to larger biological systems. (mechanobio.info)

supplied proof for T-type channel blockers as dual inhibitors of proliferation and migration of human glioblastoma cells [32]. (icbinhibitor.com)

AKT is a key molecule in the PI3K/AKT/mTOR signaling pathway, which has been shown to serve notable functions in the regulation of cell viability and to be closely associated with a variety of disorders caused by dysfunctional cellular proliferation ( 8 , 9 ). (spandidos-publications.com)

Here, we address the role of tubulin acetylation on the penetrative capacity of cells undergoing radial intercalation, which is the process by which cells move apically, insert between outer cells, and join an epithelium . (xenbase.org)
We report for the first time a dramatic increase in full-length epithelium-specific GSDMB in IBD patients compared to healthy controls, who, unlike other members of the gasdermin family, are not involved in program-mediated cell death. (pcrtechnique.com)

VGCCs also play a relevant role within the survival of cancer cells. (icbinhibitor.com)
EL treatment reduced the density and number of F-actin fibers in lung cancer cell lines, and reduced the number and size of focal adhesions. (biomedcentral.com)
Given the protective effects of lignans for healthy lung tissue, and their anti-migratory effects for other cancer types, we hypothesized that EL would inhibit lung cancer cell migration. (biomedcentral.com)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
Recently, AGR2 was identified as a crucial component of the cellular machinery responsible for maintaining the epithelial phenotype, thereby interfering with the induction of mesenchymal phenotype cells by TGF-ß effects in cancer. (muni.cz)
Here, we performed transcriptomic profiling of A549 lung cancer cells with CRISPR-Cas9 mediated AGR2 knockout with and without TGF-ß treatment. (muni.cz)
ABSTRACT Upregulation of the developmental Wnt planar cell polarity (Wnt/PCP) pathway is observed in many cancers and is associated with cancer development. (hal.science)
Similar results were also discovered in 4 cancer cell lines. (biomedcentral.com)
MiR-98 targets CTHRC1 to suppress liver cancer cell progression [ 17 ]. (biomedcentral.com)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. (nature.com)
Not only are transgenes expressed at a level different from that of the same oncogenes in human breast cancer, but also throughout the ductal tree [ 6 ] they do not target the cell types that are the cells of origin in human breast cancer. (biomedcentral.com)
In addition, miR-181a has been demonstrated to be responsible for the genesis of human liver cancer stem/progenitor cells Narlaprevir [55]. (irjs.info)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

Reelin, encoded by the RELN gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell-cell interactions. (wikipedia.org)
but the role of GPR56 in neuronal migration in vivo remains unknown. (jneurosci.org)

We identified significant changes in transcripts associated with focal adhesion and eicosanoid production, in particular arachidonic acid metabolism. (muni.cz)
Since PGE2 is a product of arachidonic acid metabolism, its lowered concentration in media from AGR2-knockout cells was confirmed by ELISA. (muni.cz)

The purpose of the present study was to reveal the effects of AKT1 on the survival and proliferation of HCC cells, and to investigate the mechanisms involved. (spandidos-publications.com)
AKT1 also has a crucial effect on cell survival ( 14 - 17 ). (spandidos-publications.com)

ARL9 mRNA can be used as a prognostic biomarker in patients with colon adenocarcinoma. (biomedcentral.com)

In humans, CD23 is usually expressed on a range of cells including B cells, T cells, monocytes, follicular dendritic cells, intestinal epithelial cells, bone marrow stromal cells and respiratory epithelial cells. (treatmentforprostatecancer.info)

Secondary, mRNA-seq analysis identified Gadd45 as a potential transcriptional target of dGLYAT, as depletion of dGLYAT decreased Gadd45 mRNA level. (sdbonline.org)
Renin, and ACE Inhibitor Efficacy Renin scrretion from the juxtaglomerular cells is enhanced by sodium depletion, which in turn increases the hypotensive effect of ACE inhi· bition. (forextrading-madeeasy.com)

RNA interference (RNAi) of PTPRK accelerated cell cycle progression, enhanced response to epidermal growth factor (EGF), and abrogated TGF-beta-mediated antimitogenesis. (nih.gov)
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. (cusabio.cn)

DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. (hindawi.com)
These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)

Finally, cell fate is also dependent on Ca2+ 587850-67-7 Epigenetics influx and its molecular machinery. (icbinhibitor.com)
Nature Reviews Molecular Cell Biology. (elsevierpure.com)

In panel 2, some adhesions attach to stress fibers and grow in size while some disassemble (yellow with dotted outline) at the lamellipodium-lamellum boundary. (mechanobio.info)
Contraction of actin fibers pulls the cell body forward. (medscape.com)

In HVECs, we found that BV suppresses cell viability in a time and dose dependent manner. (biomedcentral.com)
It was found that GSOs reversed GLU-induced reductions in cell viability and the LDH release rate, and rescued ROS accumulation. (sdbonline.org)

The downregulated DEGs were mainly enriched in digestion, basal part of the cell, and aldo-keto reductase (NADP) activity. (hindawi.com)
These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)

This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)

Anatomy42

Organisms6

Diseases8

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Psychiatry and Psychology1

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science5

Kinase11

Phosphorylation3

Proteins7

Tissues11

Signaling molecules1

Target mRNA2

Invasion22

Vitro9

Endothelial cells4

MiRNAs5

Regulates cell adhesion1

Integrin6

Intracellular1

Disassembly1

Motility7

Extracellular matrix molecules1

Squamous cell carc3

Induce5

Protein expression2

Anchors microtubules1

Maturation2

Promotes5

Vinculin3

Stem cells6

Significantly4

Infiltration4

Expression23

Modulate1

Cytoskeletal1

Knocking1

Receptor3

Actin filaments1

Fibronectin1

Tumor cell migration2

Invasive2

Differentiation2

Metastasis4

Substrates1

Apoptosis2

Positively2

RNAs1

MiRNA4

Epithelial cell1

Assays3

Colorectal1

Pathways2

Substrate1

Proliferation and migration1

Molecule1

Epithelium2

Cancer15

Neuronal migration2

Metabolism2

Survival2

Adenocarcinoma1

Humans1

Depletion2

Progression2

Human2

Molecular2

Fibers2

Viability2

Basal2

Cellular1