Loading...
  • amino acids
  • The ankB gene is composed of 549 bp encoding a protein of 183 amino acids that possesses four 33-amino-acid ankyrin repeats that are a hallmark of erythrocyte and brain ankyrins. (asm.org)
  • Monomeric AnkB is a 19.4-kDa protein with a pI of 5.5 that possesses 22 primarily hydrophobic amino acids at residues 3 to 25, predicting an inner-membrane-spanning motif with the N terminus in the cytoplasm and the C terminus in the periplasm. (asm.org)
  • The neo selection cassette was inserted in the opposite orientation at Bam HI and Apa I sites, to disrupt an exon encoding a part of the catalytic domain (corresponding amino acids 207-237 in the p70 s6k protein). (pnas.org)
  • The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. (genecards.org)
  • Molecular
  • o Determination of the molecular mechanism(s) by which agents induce fetal hemoglobin production with the goal of developing more efficient inducers. (nih.gov)
  • adult
  • Expression of apolipoprotein A-I (apoA-I), A-II, and H was previously observed at 16 to 50-fold higher levels in the fetal than the adult mouse lung. (biomedcentral.com)
  • The anticipated mRNAs were demonstrated in K562 cells, but not in any adult human tissues examined by Northern blotting. (biochemj.org)
  • In the mouse, reverse transcription-PCR revealed that the ZFF29 mRNA is present in adult bone marrow and ovary at a higher level than in any other tissues examined. (biochemj.org)
  • RESEARCH OBJECTIVES Appropriate topics for investigation may include, but are not limited to: o Setting up reliable and convenient clonogenic assays for stem cell populations in fetal and adult hematopoietic tissues with the purpose of using such assays to monitor the purification and characterization of hematopoietic stem cells. (nih.gov)
  • o Assembly of mRNA and protein expression profiles in recovered progenitor cell populations derived from fetal and adult normal tissues. (nih.gov)
  • Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in Canals of Hering in adult livers. (rupress.org)
  • We and others have described the isolation and expansion in culture of AFP+ cells from fetal and adult livers of several species ( 8 - 10 ). (rupress.org)
  • We define a novel class of AFP-negative cells in fetal and adult human livers that are precursors to hepatoblasts and have properties consistent with hHpSCs. (rupress.org)
  • We now show that the hHpSCs are located in ductal plates in fetal and neonatal livers and in the proximal branches of the intrahepatic biliary tree, the Canals of Hering, in pediatric and adult livers of all donor ages, with the frequency of hHpSCs remaining relatively constant throughout life. (rupress.org)
  • At the start of the third trimester, these wounds do not restore appendage (hair follicle and Fetal fibroblasts have more surface receptors for HA sebaceous gland) architecture, but still heal with a normal than adult fibroblasts, enhancing fibroblast migration.2 collagen pattern. (pdfmedsearch.com)
  • embryonic
  • These studies suggest that seminoma and EC at least carry epigenetic profiles similar to those of fetal germ cells or embryonic stem (ES) cells. (aacrjournals.org)
  • Here, we disrupted the p70 S6 kinase (p70 s6k ) gene in murine embryonic stem cells to determine the role of this kinase in cell growth, protein synthesis, and rapamycin sensitivity. (pnas.org)
  • To this end, we disrupted the p70 s6k gene in murine embryonic stem (ES) cells to define the function of p70 s6k in protein synthesis and cell growth, and also to define the role of the kinase in rapamycin-sensitive events. (pnas.org)
  • induces
  • This study demonstrates that Ang II in vivo, via the type 1 receptor, directly induces a shift to the fetal phenotype of cardiac myocytes and cardiac remodeling independent of blood pressure elevation. (ahajournals.org)
  • The drug induces accumulation of the dephosphorylated species of 4E-BP1 that binds to a translation initiation factor eIF-4E and suppresses translation initiation of cap-dependent mRNAs. (pnas.org)
  • Translocation of the protein from the nucleus to mitochondria induces apoptosis. (genecards.org)
  • synthesis
  • In contrast, rapamycin inhibited phosphorylation of initiation factor 4E-binding protein 1 (4E-BP1), general mRNA translation, and overall protein synthesis in p70 s6k−/− cells, indicating that these events proceed independently of p70 s6k activity. (pnas.org)
  • This study localizes the function of p70 s6k to ribosomal biogenesis by regulating ribosomal protein synthesis at the level of mRNA translation. (pnas.org)
  • The serine/threonine kinase, p70 s6k , is a unique kinase in higher eukaryotes and one whose function is believed to regulate protein synthesis ( 1 ). (pnas.org)
  • Indeed, addition of rapamycin to cell cultures inhibits protein synthesis and, more specifically, translation of mRNAs encoding ribosomal proteins ( 18 , 19 ), suggesting that p70 s6k and S6 are important in these events. (pnas.org)
  • Thus, the effects of rapamycin on mRNA translation and protein synthesis may be exerted through its inhibition of 4E-BP1 phosphorylation. (pnas.org)
  • Thus, HA allows proliferating cells to avoid Fetal monkey lip incisional wounds heal with restora- inhibitory contacts.13 Hyaluronic acid synthesis precedes tion of normal appendage and dermal collagen architec- mitosis and dissociates the dividing cell from its substra- ture in midgestation. (pdfmedsearch.com)
  • collagen
  • Ventricular transforming growth factor-β1 and types I and III collagen mRNA levels did not increase at 24 hours and began to increase by 1.4-, 2.8-, and 2.1-fold, respectively, at 3 days. (ahajournals.org)
  • Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. (genecards.org)
  • In fetal wounds, collagen is deposited early and is fine and reticular with less cross-linking. (pdfmedsearch.com)
  • Several important differences of fetal vs. postgestational wound-healing response have been determined, such as the presence of less inflammation, higher hyaluronic acid concentration and a greater ratio of collagen type III to type I. Compared with typical wounds, there are also altered ratios of signaling molecules, such as higher ratios of transforming growth factor (TGF)-b3 to TGF-b1 and -b2, and matrix metallo- proteinases to tissue inhibitors of metalloproteinases. (pdfmedsearch.com)
  • Furthermore, fetal fibroblasts do not exhibit TGF-b1-induced collagen production compared with their mature counterparts. (pdfmedsearch.com)
  • genes
  • Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. (genecards.org)
  • Androgens and their nuclear receptor regulate genes necessary for development of the male phenotype, a process that is thought to be modulated by extracellular androgen carrier proteins. (duke.edu)
  • The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. (genecards.org)
  • Patterning genes (homeobox genes) involved in organogenesis are more active in the fetal period and are believed to be the ''first domino'' in the fetal cutaneous wound repair regulatory cascade. (pdfmedsearch.com)
  • The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. (genecards.org)
  • serum
  • In p70 s6k−/− cells, which exhibited no ribosomal S6 phosphorylation, translation of mRNA encoding ribosomal proteins was not increased by serum nor specifically inhibited by rapamycin. (pnas.org)
  • This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. (genecards.org)
  • accumulation
  • Here, sites of apoA-I, A-II, and H mRNA and protein accumulation were determined in mouse fetal lungs by in situ hybridization and immunohistochemistry in late gestation. (biomedcentral.com)
  • Because apoA-I, apoA-II, and apoH were co-regulated with apoC-II both over developmental time and from sample to sample in our previous QPCR study with whole lungs [ 11 ], it would be relevant to determine whether similar patterns of mRNA and protein accumulation sites, including the presence of apolipoproteins in secretory granules, are common features to all these apolipoproteins. (biomedcentral.com)
  • ubiquitin-protei
  • Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. (genecards.org)
  • Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. (genecards.org)
  • Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. (uniprot.org)
  • transcriptional
  • This suggests a level of transcriptional down-regulation, and a post-transcriptional block which might involve other gene products, such as beta2-microglobulin (beta 2m), or proteins involved in generation/transport of peptides. (ox.ac.uk)
  • Several adhesion proteins including zyxin, Hic5 and Trip6 are also nuclear and can exert transcriptional effects. (biochemj.org)
  • receptors
  • Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. (genecards.org)
  • Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. (genecards.org)
  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors. (genecards.org)
  • Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. (genecards.org)
  • hematopoietic
  • The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. (genecards.org)
  • transcripts
  • This was an observational study of steroids, messenger RNA transcripts and proteins in adrenals from up to 109 second trimester fetuses (11 weeks to 21 weeks) at the Universities of Aberdeen and Glasgow. (springer.com)
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. (duke.edu)
  • To investigate ABP-SHBG gene expression in fetal rat liver, we analyzed RNA transcripts and expressed protein. (duke.edu)
  • Alternative splicing results in two transcripts variants that encode the same protein. (genecards.org)
  • regulation
  • The presence of cortisol in fetal adrenals suggests that adrenal regulation of circulating fetal ACTH remains a factor in development of congenital adrenal hyperplasia during the second trimester, while a relative lack of aldosterone explains the salt-wasting disorders frequently seen in extreme pre-term neonates. (springer.com)
  • The sites phosphorylated in vivo are clustered at the carboxyl terminus, and the phosphorylated region of S6 is thought to lie within the cleft where mRNA binds, a location compatible with a role in the regulation of translation ( 15 ). (pnas.org)
  • The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. (genecards.org)
  • It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. (genecards.org)
  • liver
  • Analysis of cDNA clones derived from fetal rat liver cDNA libraries identified two cDNAs encoded by the ABP-SHBG gene that represented alternatively spliced RNAs. (duke.edu)
  • One cDNA had an alternate exon 1, suggesting the function of another promoter in fetal liver. (duke.edu)
  • Data from Northern hybridization experiments suggest the fusion transcript is present in fetal liver RNA. (duke.edu)
  • Polymerase chain reaction experiments with fetal liver cDNA further support the existence of an ABP-HDC fusion transcript, as well as the other alternate mRNA. (duke.edu)
  • Moreover, a Mr 93,000 immunoreactive protein was transiently expressed in fetal liver during the time of ABP and HDC gene expression. (duke.edu)
  • Transplantation of freshly isolated EpCAM+ cells or of hHpSCs expanded in culture into NOD/SCID mice results in mature liver tissue expressing human-specific proteins. (rupress.org)
  • This protein, encoded by the tumor-associated calcium signal transducer 1 gene, is expressed by many carcinomas and serves a regulatory function in certain normal epithelia, including all of those derived from endoderm (liver, lung, pancreas, and intestine) ( 15 , 16 ). (rupress.org)
  • regulatory
  • Alternative splicing also provides an additional regulatory mechanism by which vertebrates can control the expression of tissue‐specific or developmental stage‐specific protein isoforms. (embopress.org)
  • In particular, 4E-BP1 (also termed PHAS1) is another regulatory molecule for mRNA translation. (pnas.org)
  • This cDNA also lacked testicular exon 6 DNA, an alteration that implicates the encoded protein in regulatory functions. (duke.edu)
  • The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. (genecards.org)
  • placenta
  • Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. (springer.com)
  • Together, the fetal adrenal glands and placenta dominate human fetal steroid endocrinology in a manner seen only in higher primates. (springer.com)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • extracellular
  • SPARC, a secreted, extracellular matrix-associated protein implicated in the modulation of cell adhesion and migration, was evaluated as a marker for invasive meningiomas. (aacrjournals.org)
  • The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. (genecards.org)
  • regulate
  • Here we demonstrate that MBNL proteins regulate alternative splicing of two pre‐mRNAs that are misregulated in DM, cardiac troponin T (cTNT) and insulin receptor (IR). (embopress.org)
  • Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. (genecards.org)
  • Integral
  • Integral membrane proteins that associate with ankyrin both in vivo and in vitro include the band III anion exchanger ( 15 ), Na + /K + -ATPase ( 15 ), and multiple sodium channels ( 51 , 52 ). (asm.org)
  • The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. (genecards.org)
  • This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. (genecards.org)
  • family
  • Although the muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), a specific function for these proteins has not been reported. (embopress.org)
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. (genecards.org)
  • Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. (genecards.org)
  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. (genecards.org)
  • The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. (genecards.org)
  • The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. (genecards.org)
  • This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. (genecards.org)
  • transcription
  • There is a unique transcription start site, which predicts major mRNAs composed of 2485 bases for ZFF29a and 1801 bases for ZFF29b. (biochemj.org)
  • The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. (genecards.org)
  • Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity . (genecards.org)
  • tissue
  • DNMT3L protein was strongly expressed in two EC cell lines, but not in the cell lines of somatic tissue origin. (aacrjournals.org)
  • Immunohistochemical analysis showed that DNMT3L protein was present only in EC cells, but not in the other types of TGCT components and cancer cells of somatic tissue origin. (aacrjournals.org)
  • Size
  • Pathological cardiac hypertrophy, induced by hypertension or pressure overload by aortic coarctation, is accompanied not only by quantitative changes (increase in cardiac myocyte size) but also by qualitative changes, including a shift to the fetal phenotype of myocytes 5 12 13 14 15 and cardiac remodeling such as interstitial fibrosis. (ahajournals.org)
  • Expression of the fusion cDNA in COS cells yielded HDC activity and the predicted size protein (Mr = 93,000) on Western immunoblots. (duke.edu)
  • The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. (genecards.org)
  • suppresses
  • This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. (genecards.org)
  • cytoplasmic
  • Such an orientation in the cytoplasmic membrane and, ultimately, periplasmic space was confirmed using AnkB-BlaM and AnkB-PhoA protein fusions. (asm.org)
  • Ankyrins are structural proteins in human erythrocytes and brain that bridge the spectrin exoskeleton to the cytoplasmic surface of the plasma membrane ( 5 ). (asm.org)
  • sensitivity
  • Finally, maternal smoking may alter fetal adrenal sensitivity to ACTH, which could have knock-on effects on post-natal health. (springer.com)
  • cells
  • Miami Winter Symposia, Volume 16: From Gene to Protein: Information Transfer in Normal and Abnormal Cells presents the expression and processing of genetic information at the levels of both proteins and nucleic acids. (elsevier.com)
  • Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. (genecards.org)
  • exhibit
  • Three isozymes of 5 α -R are known to exist (5 α -R1-3) [ 7 ] and two other proteins exhibit 5-alpha reducing capabilities, glycoprotein synaptic 2 (GPSN2), and glycoprotein synaptic 2-like (GPSN2L) proteins. (hindawi.com)