Inhibition of Na + /K + ATPase by cardiac glycosides has been shown to potentiate toxic effects of excitatory amino acids and mitochondrial poisons in neurons in vitro. (elsevierpure.com)
Blocked the MPTP-induced1
Deprenyl pretreatment blocked the MPTP-induced impairment of SOR memory. (unboundmedicine.com)
Carbon monoxide2
carbon monoxide or manganese poisoning. (annvio.com)
The FDA currently only recognizes the use of Methylene Blue for treatment of: methemoglobinemia, cyanide poisoning, septic shock, urinary tract infection (prevention,) and carbon monoxide poisoning. (thearcanum.io)
Mice8
however, most of the recent studies indicate that MPTP can result in Parkinsonism-like syndromes in mice (especially chronic syndromes). (wikipedia.org)
However, the combination of BSO with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in preweanling mice and the combination of nigral injections of BSO with intrastriatal injections of MPP+ (1-methyl-4-phenylpyridinium), the active metabolite of MPTP in adult rats, potentiated the toxic effects of MPTP and MPP+ on nigral neurones. (nih.gov)
The purpose of the current study was to evaluate the effects of an MPTP-induced dopaminergic lesion in mice on social odor recognition (SOR) memory. (unboundmedicine.com)
Mice were acutely treated with MPTP and evaluated for memory impairments in the SOR assay and characterized using biochemical and immunohistochemical methods approximately 2 weeks later. (unboundmedicine.com)
MPTP treatment of C57BL/6N mice produced a profound decrease in dopamine levels, dopamine transporter binding and tyrosine hydroxylase immunoreactivity in the striatum. (unboundmedicine.com)
Mice were injected with digoxin (1 mg/kg) or vehicle followed by MPTP (20 mg/kg) or saline 1 h later. (elsevierpure.com)
MPTP caused a significant 35-45% reduction in striatal dopamine levels compared to those in control mice. (elsevierpure.com)
found that when this variant form of ATP5G1 was introduced into the cells of mice, their mitochondria was better at coping with stress conditions, such as low oxygen, low temperature and poisoning. (elifesciences.org)
Manganese1
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. (neurotalk.org)
Neurotoxicity2
The neurotoxicity of MPTP was hinted at in 1976 after Barry Kidston, a 23-year-old chemistry graduate student in Maryland, US, synthesized MPPP with MPTP as a major impurity and self-injected the result. (wikipedia.org)
This result was unexpected and suggests that cardiac glycosides may protect against MPTP neurotoxicity. (elsevierpure.com)
Dopamine3
The present study tested the hypothesis that the systemic administration of the cardiac glycoside, digoxin, potentiates effects of the dopamine neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in vivo. (elsevierpure.com)
However, pretreatment with digoxin completely prevented the MPTP-induced dopamine depletion. (elsevierpure.com)
Inhibiting c-JNKs or their upstream signals may reduce dopamine- mediated neuronal death induced at near MPTP, suggesting a possible medicinal appli- cation for c-JNK inhibitors in PD (Depression et al. (ozdifferent.sk)
Toxicity2
MAOIs prevent the metabolism of MPTP to MPP+ by inhibiting the action of MAO-B, minimizing toxicity, and preventing neural death. (wikipedia.org)
In 1983, four people in Santa Clara County, California, US, were diagnosed with Parkinsonism after having used MPPP contaminated with MPTP, and as many as 120 were reported to have been diagnosed with Parkinson's symptoms. (wikipedia.org)
1984) found that injections of MPTP in squirrel monkeys resulted in Parkinsonism, symptoms of which were subsequently reduced by levodopa, the drug-of-choice in the treatment of Parkinson's disease along with carbidopa and entacapone. (wikipedia.org)
MPTP, a drug that sometimes contaminates heroin, can suddenly cause a severe and irreversible form of Parkinson's. (annvio.com)
Animal Aid has uncovered two shocking charity-funded experiments that involved monkeys being brain-damaged through the use of a toxic chemical called MPTP, overdosed with a Parkinson's disease (PD) drug to induce debilitating side effects, and given the street drug ecstasy, or a derivative. (victimsofcharity.org)
It was contaminated with MPTP, and within three days he began exhibiting symptoms of Parkinson's disease. (umaryland.edu)
Toxic4
MPTP itself is not toxic, and as a lipophilic compound can cross the blood-brain barrier. (wikipedia.org)
Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-phenylpyridinium (MPP+) by the enzyme monoamine oxidase B (MAO-B) of glial cells, specifically astrocytes. (wikipedia.org)
Paraquat is dangerous because it's a restricted-use pesticide that's highly toxic for humans, which is why it comes with the Danger/Poison signal. (schmidtandclark.com)
Parkinsonism2
Injection of MPTP causes rapid onset of Parkinsonism, hence users of MPPP contaminated with MPTP will develop these symptoms. (wikipedia.org)
MPTP causes Parkinsonism in primates, including humans. (wikipedia.org)
Nigrostriatal1
Here we demonstrate that SOR memory is sensitive to MPTP treatment and that it correlates with multiple measures of nigrostriatal integrity. (unboundmedicine.com)
Monkeys5
The Home Office has confirmed that experiments in which monkeys are brain-damaged with MPTP fall into the highest category of severity. (victimsofcharity.org)
It has previously stated that brain-damaging monkeys with MPTP has 'devastating welfare costs' for the animals involved and serious questions arise as to whether the re-use of primates in such harmful experiments would be permitted in the UK, or in the other EU countries governed by the same European directive. (victimsofcharity.org)
Monkeys do not get PD, and the symptoms induced in them by brain-poisoning fail to replicate key features of the disease. (victimsofcharity.org)
Brain-poisoned monkeys gradually recover, whereas PD is a degenerative disease. (victimsofcharity.org)
Dr Marius Maxwell, an Oxford, Cambridge and Harvard-trained neurosurgeon, has strongly criticised, on scientific grounds, the use of brain-poisoned monkeys as a 'model' for PD research. (victimsofcharity.org)
Symptoms4
The physicians first concern is only a temporizing measure until the 20th century, 20 centuries after socrates was executed by poison control centers regarding deet exposures involve minor or no symptoms, and ability to bear children. (oaksofwellington.com)
Several toxins like illegal drugs contaminated with a chemical called MPTP may cause severe Parkinson-like symptoms. (news-medical.net)
In the case of chronic alcohol abuse or lead poisoning, these symptoms (particularly cognition problems) may worsen, in which case medical attention is necessary. (neurology-clinics.com)
The height OSMI-1 cell line of Missouri levels throughout plant food answer triggered significant poisoning as well as plants created the symptoms. (micrornalibrary.com)
Apoptotic1
It is through a counterintuitive mechanism that the excess calcium in the cytosol causes the calcium WITHIN the Mitochondria to build up, opening a pore (called mPTP) in its outer membrane, allowing for the Apoptotic signaling to commence. (substack.com)
Rats1
Rats are almost immune to the adverse effects of MPTP. (wikipedia.org)
Treatment2
Changes in the dopaminergic system parallel those observed in SOR with MPTP treatment impairing recognition memory in the absence of a deficit in odor discrimination during learning. (unboundmedicine.com)
However, OP poisoning cases before treatment showed significant DNA harm, and they didn't aberration display any chromosomal. (healthyconnectionsinc.com)
Found3
The National Institute of Mental Health found traces of MPTP and other pethidine analogs in his lab. (wikipedia.org)
It was found that once MPTP crossed into the brain it started killing brain cells. (news-medical.net)
Another study found that paraquat has a chemical structure very similar to MPTP. (schmidtandclark.com)
Result1
The Parkinson-inducing effects of MPTP were first discovered following accidental injection as a result of contaminated MPPP. (wikipedia.org)
Drug1
While MPTP itself has no psychoactive effects, the compound may be accidentally produced during the manufacture of MPPP, a synthetic opioid drug with effects similar to those of morphine and pethidine (meperidine). (wikipedia.org)
Mitochondrial3
The combination of proteomics (high-density liquid chromatography [LC] coupled to MS) with microarray analysis of the pooled left and right striata from mice previously exposed to MPTP compared with METH exposure, culminated in a large descriptive data set on proteomic changes induced by these mitochondrial poisons. (medscape.com)
The actual fact that poisons impacting mitochondrial function result in impairment of proteasome degradation isn't astonishing also, considering that the proteasome degradation routine is normally ATP-dependent. (innovation-ecosystems-agora.com)
Studies of pet types of PD induced with these poisons claim that mitochondrial dysfunction and oxidative tension are essential pathogenic systems [1]. (abt-888.net)
For example using the raising usage of methyltin as stabilizers in PVC creation in developing countries such as for example in China multiple acute poisoning incidents at work have already been reported lately (Tang 2010). (mdm2-inhibitors.com)
Similarity1
Structural similarity between MPTP and the herbicide paraquat 5 has led to speculation of a possible association between exposure to pesticides and PD. (bmj.com)
Oxidative1
[ 113 ] Since this result could not be replicated in METH-treated animals, it was suggested that MPTP generates a potentially higher degree of oxidative damage and cell death than that of METH. (medscape.com)
Decrease1
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss. (omeka.net)
Protein1
The particular developed in-situ twistable homostructure products permit thorough investigation with the pose angle results within a unit, hence might largely progress your research involving twistronics.Cholera toxic (CT) and Escherichia coli heat-labile enterotoxin (LT) are usually structurally comparable AB5-type necessary protein poisons. (sirtuinsignaling.com)