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  • clinical
  • The severity of Parkinson's Disease symptoms changes faster than researchers thought, so clinical trials should be designed differently. (patientslikeme.com)
  • idiopathic
  • Munot, 2012) More significantly, mutations in RNF213 are strongly associated with the classic East Asian, bilateral, idiopathic familial disease presenting in adulthood and may be present in up to 70% of all East Asian familial cases of moyamoya. (rarediseases.org)
  • On the one hand, moyamoya disease corresponds to isolated moyamoya angiopathy, defined as being "idiopathic" according to the Guidelines of the Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis. (dovepress.com)
  • pathways
  • Identification of the genes involved in moyamoya disease and several monogenic moyamoya syndromes unraveled different pathways involved in the development of this angiopathy. (dovepress.com)
  • Studying genes and pathways involved in monogenic moyamoya syndromes may help to give insights into pathophysiological models and discover potential candidates for medical treatment strategies. (dovepress.com)
  • sickle cell di
  • Secondary moyamoya disease occurs in association with a number of different underlying disorders or conditions, including certain infections involving the central nervous system, neurofibromatosis type I, sickle cell disease, and Down syndrome, although there is now a long list of conditions now published in the medical literature with which moyamoya disease is associated. (rarediseases.org)
  • artery
  • Unfortunately, Moyamoya disease is a progressive condition, and currently no medication can reverse the artery damage in the brain. (go.com)
  • Moyamoya disease is a rare, progressive blood vessel (vascular) disorder in which the carotid artery in the skull becomes blocked or narrowed, reducing blood flow to your brain. (mayoclinic.org)
  • The disease causes constrictions primarily in the internal carotid artery , which travels from the neck up to the Circle of Willis inside the skull just under the brain. (thefullwiki.org)
  • In moyamoya, the inner layer of the carotid artery overgrows inward to constrict the artery, and the artery also fills with blood clots, which cause strokes. (thefullwiki.org)
  • Coronary artery disease in moyamoya disease (MMD) have been described sporadically in several case reports. (ahajournals.org)
  • And only 2 (9.5%) showed calcification which might means that atherosclerosis burden is low in coronary artery disease with MMD. (ahajournals.org)
  • syndrome
  • Moyamoya is also associated with certain conditions, such as Down syndrome, sickle cell anemia, neurofibromatosis type 1 and hyperthyroidism. (mayoclinic.org)
  • National Organization
  • Admission is $7, and proceeds from the event will go to NORD, the National Organization for Rare Diseases, an organization raising money and awareness of conditions too rare to have their own charities. (unionleader.com)
  • phenotypic
  • It is likely that the phenotypic arteriopathy of moyamoya actually represents a common end-pathway of a number of pathophysiologically distinct processes. (rarediseases.org)