Other than for the first gene promoters immediately outside the deletion, since genes extending 5.6-9.1 Mb away from each end of the deletion show normal expression levels in TgPWS brain, this indicates that the transgene array does not induce silencing and there are no additional linked rearrangements. (biomedcentral.com)
Transgenic14
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Our study evaluated HPV DNA from 17 samples isolated from 4 animals, both wild-type (n = 2) and HPV16-transgenic mice (n = 2). (bvsalud.org)
We analyzed CRTC3-null, KRT14-SCF transgenic, and their crossover mice. (thno.org)
Partial Hepatectomy and Castration of HBV Transgenic Mice Methods Mol Biol. (usc.edu)
Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. (usc.edu)
Autophagy required for hepatitis B virus replication in transgenic mice J Virol. (usc.edu)
Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury PLoS One. (usc.edu)
Transgenic murine models have been developed using the promoter region of the tyrosinase gene to target expression of oncogenes in melanin-producing cells. (wisc.edu)
A mouse model of PWS and AS has a transgenic insertion-deletion (TgPWS/TgAS) of chromosome 7B/C subsequent to paternal or maternal inheritance, respectively. (biomedcentral.com)
CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. (microbiologyresearch.org)
Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. (microbiologyresearch.org)
Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. (microbiologyresearch.org)
HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. (microbiologyresearch.org)
Inhibitors1
Evidence suggests that both cell cycle inhibitors (such as P21 and P27) and promoters (such as cyclins E1 and D1) play a vital role in malignancy progression [37C39]. (geogise.com)
Assay2
To assess the linearity of the assay, samples were spiked with high concentrations of mouse TGF-β1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. (cusabio.com)
The recovery of mouse TGF-β1 spiked to levels throughout the range of the assay in various matrices was evaluated. (cusabio.com)
Polyclonal1
Description: A polyclonal antibody for detection of eIF5A2 from Human, Mouse. (operatiebrp.nl)
Antibody9
The present invention relates to an anti-tyrosinase antibody for inhibiting tyrosinase and use thereof, and more particularly, to an anti-tyrosinase antibody including a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. (justia.com)
The anti-tyrosinase antibody is expected to be effectively utilized for improving skin whitening or treating skin pigmentation disorders by inhibiting tyrosinase activity. (justia.com)
The present invention relates to an anti-tyrosinase antibody for inhibiting tyrosinase and use thereof. (justia.com)
Although skin whitening through inhibition of the activity of tyrosinase is being actively researched, research on an antibody for inhibiting tyrosinase is still lacking. (justia.com)
An object of the present invention is to provide an anti-tyrosinase antibody for inhibiting tyrosinase or an antigen-binding fragment thereof. (justia.com)
Another object of the present invention is to provide a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide is further bound to the anti-tyrosinase antibody or antigen-binding fragment thereof. (justia.com)
Still another object of the present invention is to provide a composition for detecting a tyrosinase antigen containing the antibody or antigen-binding fragment thereof as an active ingredient. (justia.com)
In addition, the present invention provides a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide represented by SEQ ID NO: 7 is further bound to the antibody or antigen-binding fragment thereof. (justia.com)
A micro ELISA plate --- The 96-well plate has been pre-coated with anti-mouse TGF-β1 antibody. (cusabio.com)
Oncogenes1
The study of human papillomavirus (HPV)-induced carcinogenesis uses multiple in vivo mouse models, one of which relies on the cytokeratin 14 gene promoter to drive the expression of all HPV early oncogenes. (bvsalud.org)
Carcinogenesis1
[ 4 , 5 ] UV radiation acts as an initiator and promoter of carcinogenesis in actinic keratosis and squamous cell carcinoma. (medscape.com)
Mutations1
Mutations in the mouse Tyrp1 gene are associated with brown pelage and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3). (wikipedia.org)
Pigmentation2
Although CREB phosphorylation is known to be essential in UVB/cAMP-stimulated melanogenesis, CREB null mice did not show identifiable pigmentation phenotypes. (thno.org)
Therefore, the basic mechanism of drugs for development of whitening cosmetics to prevent pigmentation may include inhibition of the activity of tyrosinase, inhibition of the production of tyrosinase, inhibition of a mediator that promotes the production of melanin, reduction of the produced melanin and inhibition of photooxidation, promotion of excretion of melanin, and UV protection. (justia.com)
Genes1
Melanogenesis-related genes were reduced in CRTC3-deficient cultured melanocytes and tail skin of CRTC3-null mice. (thno.org)
Melanin3
The coat and skin color of CRTC3-null mice was paler due to a reduction in melanin deposition. (thno.org)
Stem cell factor (SCF) introduction by crossing with KRT14-SCF mice increased epidermal melanocytes and melanin deposition in control and CRTC3-null mice, but the skin color remained still light on the CRTC3-null background. (thno.org)
Melanin is produced by the action of tyrosinase on tyrosine, an amino acid. (justia.com)
Control mice2
We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
Thus CRTC3-null mice showed a comparable number of epidermal melanocytes compared to control mice. (thno.org)
Tumors1
Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
Functional2
Studies with APP knockout mice suggest some functional redundancy between these APP homologs that appears to be exerted by motifs other than Aβ. (biomedcentral.com)
These results clearly demonstrate that the N. europaea NE0616 fur homolog is expressed Lazertinib purchase in E. coli in a functional form and is capable of regulating the Fur-dependent fiu promoter in H1780. (plk-receptor.com)
Transcription3
here, it promotes KRT14 transcription by attenuating binding of repressor SP1 to its promoter. (bvsalud.org)
We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten -deficient mouse RPE. (molcells.org)
Previous studies have shown that by inhibiting histone H3 deacetylation round the let-7f-2/miR-98 promoter, HDAC10 suppresses HMGA2 expression which target to CP-640186 cyclin A2 promoter, and further inhibits the transcription of cyclin A2 [30,36]. (geogise.com)
Expression1
Intriguingly, 5' Chrna7 shows 1.7-fold decreased levels in TgPWS and TgAS brain whereas there is a ≥15-fold increase in expression in neonatal liver and spleen of these mouse models. (biomedcentral.com)
Activity3
Tyrp1 is involved in stabilizing of tyrosinase protein and modulating its catalytic activity. (wikipedia.org)
The Chrna7 results are explained by hypothesizing loss of an essential neuronal transcriptional enhancer required for ~80% of allelic Chrna7 promoter activity, while the Chrna7 promoter is upregulated in B lymphocytes by the transgene immunoglobulin enhancer. (biomedcentral.com)
Among these, one of the simplest and most effective ways to obtain a skin whitening effect is inhibition of the activity of tyrosinase. (justia.com)
Human3
Relevant mouse models of human uveal melanoma still remain to be developed. (molvis.org)
These analyses were carried out in primary cultured melanocytes, mouse cell lines, normal human cells, co-cultures, and ex vivo human skin. (thno.org)
Recognizes EIF5A2 from Human, Mouse, Rat. (operatiebrp.nl)
Liver1
Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice J Virol. (usc.edu)
Tissues1
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Protein2
Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme which in humans is encoded by the TYRP1 gene. (wikipedia.org)
This Mouse TGFB1 ELISA Kit was designed for the quantitative measurement of Mouse TGFB1 protein in serum, plasma, cell culture supernates. (cusabio.com)
Molecular1
This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
Pathway1
We've previously proven that the overall tension response (GSR) signaling pathway regulates tension physiology and persistent persistence within a mouse an infection model (Kim GSR pathway. (healthyguide.info)
Skin1
Since tyrosinase is more activated by ultraviolet rays, the skin turns black when exposed to a lot of sunlight. (justia.com)
Present3
In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
This study aimed to determine the HPV16 variant and sublineage present in the K14HPV16 mouse model. (bvsalud.org)
Notably, basal levels of MITF present in CRTC3-null mice were sufficient for melanocytic differentiation/survival. (thno.org)
Cell3
The MCF-10F cell line was analyzed in different stages of transformation that showed gradual phenotypic changes including altered morphology, increase in cell proliferation relative to the control, anchorage-independent growth, and invasive capability before becoming tumorigenic in nude mice. (bvsalud.org)
Nevertheless GDC-0349 ��null mutants possess incongruent phenotypes inside our pet and cell-based an infection tests: unlike ��and ��displays decreased viability in THP-1 macrophage-like cells and it is attenuated at an early on stage of an infection within a mouse model. (healthyguide.info)
During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)
Fusion1
By isolating a Chrna7 -Tg fusion transcript from TgAS mice, we mapped the telomeric deletion breakpoint in Chrna7 intron 4. (biomedcentral.com)
Study2
This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
A new mouse cardiac electrophysiology method was used to study mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+), which results in histological and hemodynamic abnormalities characteristic of familial hypertrophic cardiomyopathy (FHC) and sudden death of uncertain etiology during exercise. (jci.org)
Capable1
The other N. europaea fur homologs (NE0730 and NE1722) were not capable of regulating the fiu promoter in H1780. (plk-receptor.com)
Specific2
These data identify distinct electrophysiologic abnormalities in FHC mice with a specific alpha-myosin mutation, and also validate a novel method to explore in vivo the relationship between specific genotypes and their electrophysiologic phenotypes. (jci.org)
Association of specific single nucleotide variants (SNVs) in the promoter and 3'-Untranslated region of Vascular Endothelial growth factor (VEGF) gene with risk and higher tumour grade of head and neck cancers. (edu.pk)
Levels1
Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog ( Pten )-deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. (molcells.org)