Mouse strains c3h mice inbred c3h. Medical search. Frequent questions

Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
Genome scan for trabecular bone density, from a cross between strains C57BL/6J and C3H. (jax.org)
Hepatic and renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) strain paralleled enzyme activity and concentration, in agreement with a recent report. (jci.org)
Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). (prosci-inc.com)
For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
In the present study a nest-building protocol was established using four different inbred mouse strains (CD1, BALB/c, C57Bl/6J, C3H) before assessing AD and FTD tau transgenic mice of Line 1 (L1) and Line 66 (L66) in this paradigm. (bvsalud.org)
C57BL/6 (B6), C57BL/10 (B10), and SJL mice showed markedly suppressed secondary anti-DNP responses when infected. (uky.edu)
The most dramatic observation was that both Dmd(mdx) and Dmd(mdx3cv) mice showed extreme fatigue after testing, while mice from the same C57BL strains appeared unaffected. (ox.ac.uk)
We have applied our method to a sample set of 3 inbred strains: BALB/c, C57BL/6 and C3H and observed differences in subclass-specific and strainspecific N-glycosylation of IgG, suggesting a significant genetic component in the regulation of Fclinked IgG N-glycosylation. (irb.hr)
E1-deleted adenoviral vectors expressing the bacterial beta-galactosidase gene were inoculated into the brain of unprimed and primed C3H.He or C57BL/6J mice housed under either conventional or specific-pathogen-free (SPF) conditions. (ox.ac.uk)
C3H.He mice consistently made higher antibody responses than C57BL/6J mice. (ox.ac.uk)
HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
J:235854 lists J:27148 as the reference for these mice but then describes them as "B6C3F1" when the mice in the given reference were C57BL/6J mice fostered on C3Hf/Nctr mice. (jax.org)
Immune and stress responses in C57BL/6 and C3H/HeN mouse strains following photoperiod manipulation. (nel.edu)
Gatien M, Hotchkiss A, Neigh G, Dhabhar F, Nelson R. Immune and stress responses in C57BL/6 and C3H/HeN mouse strains following photoperiod manipulation. (nel.edu)
Age- and sex-related differences in alcohol and nicotine effects in C57BL/6J mice. (musc.edu)
Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice. (musc.edu)
Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice. (musc.edu)
Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice. (musc.edu)
Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice. (musc.edu)
Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. (musc.edu)
Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. (musc.edu)
Chronic intermittent ethanol exposure and withdrawal alters (3a,5a)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice. (musc.edu)
Forced swim stress increases ethanol consumption in C57BL/6J mice with a history of chronic intermittent ethanol exposure. (musc.edu)
Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. (musc.edu)
Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice. (musc.edu)
In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
C57BL/6 lymph node cells were incubated simultaneously with FITC Mouse Anti-Mouse Vβ 5.1, 5.2 T-Cell Receptor (Cat. (bdbiosciences.com)
Specifically, inheritance patterns derived from low-responsive C3H/HeJ (C3) and high-responsive C57BL/6J (B6) mouse strains suggest that differential hypercapnic ventilatory sensitivity (HCVS) is controlled by two independent genes. (johnshopkins.edu)
For example, C57BL/6J-Chr 4 A /NaJ is a consomic strain in which the Chromosome 4 from the A/J strain has been placed on a C57BL/6J background. (findmice.org)
Large deletion on the Y-chromosome long arm (Yq) of C57BL/6JBomTac inbred mice. (jax.org)
Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Mice, Inbred C57BL" by people in this website by year, and whether "Mice, Inbred C57BL" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)

Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
and CBA and A/J. Very similar frequencies are found for lipoprotein-reactive B cells in BALB/c, BALB/c ν/ν, C3H/Tif, and C3H/HeJ mice. (silverchair.com)
BALB/c mice were more proficient than CD1 and C3H mice, while all strains displayed similar nest-building behaviour by day 7. (bvsalud.org)
In contrast, the suppression did not occur in BALB/c mice. (uky.edu)
However, in BALB/c mice, the responses were not affected even by inoculation with 1 × 10 4 organisms. (uky.edu)
The difference in the suppressive effect of infection between B6 and BALB/c mice was also observed in the primary anti-DNP antibody responses to DNP-KLH. (uky.edu)
Both H-2-linked and -nonlinked genes appeared to be responsible for the regulation of the immunosuppression, since the suppressive effect of infection in B10.D2 mice, which have the B10 background and the same H-2 haplotype as BALB/c, was weaker than that of B10 mice, but stronger than in BALB/c mice. (uky.edu)

There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
We performed a systematic review of the literature describing strain and organ specific response to injury in order to determine whether genetic susceptibility plays a role in fibrogenesis. (biomedcentral.com)
There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice. (jax.org)
Inbred strains of mice differ in susceptibility to colitis-associated colorectal cancer (CA-CRC). (jax.org)
We tested 10 inbred strains of mice for their response to azoxymethane/dextran sulfate sodium-induced CA-CRC and identified a bimodal inter-strain distribution pattern when tumor multiplicity was used as a phenotypic marker of susceptibility. (jax.org)
FVB/NJ hyper-susceptibility was detected as early as 8-week post-treatment initiation with FVB/NJ mice developing 5.5-fold more tumors than susceptible A/J or resistant B6 control mice. (jax.org)
Linkage analysis by whole genome scan in informative (FVB/NJxC3H/HeJ)F2 mice identified a novel susceptibility locus designated as C olon c ancer s usceptibility 6 (Ccs6) on proximal mouse chromosome 6. (jax.org)
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)

Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)

One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
The suppressive effect of Toxoplasma infection on initiation of memory cells to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH) was drastically different among inbred strains of mice. (uky.edu)

abstract = "Genetic determinants confer variation between inbred mouse strains with respect to the magnitude and pattern of ventilation during hypercapnic challenge. (johnshopkins.edu)

The MPDt systematically characterizes biochemical and behavioral phenotypes of 40 commonly used and genetically diverse inbred mouse strains. (jax.org)
Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. (wikipedia.org)
To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
Anhedonia and low nesting scores in L66 mice are indicative of apathy-like phenotypes. (bvsalud.org)
The SHIRPA protocol was proposed as a rapid, comprehensive screening method for qualitatively abnormal phenotypes in the mouse (Rogers et al. (ox.ac.uk)
The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)
Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. (musc.edu)

MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. (duke.edu)
Congenic strains are derived by backcrossing to a parental inbred strain for at least ten generations while selecting for retention of a specific locus from the donor strain. (findmice.org)

One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. (wikipedia.org)
Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
Mice homozygous for FVB/NJ alleles at this locus had increased tumor multiplicity compared to homozygous C3H/HeJ mice. (jax.org)
We provide two-locus correlograms that can be used to detect and correct for non-syntenic association and to reduce error rates in QTL mapping studies that exploit RI strains. (nervenet.org)
However, the chromosomal location of the NOS gene was consistent with an insulin-dependent diabetes locus identified in an analysis of nonobese diabetic (NOD) mice. (duke.edu)
A strain that differs from its progenitor inbred strain at only one locus. (findmice.org)
Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. (colorado.edu)
A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)

This causes the genes to become homozygous (same strain) at nearly all the loci on the chromosomes. (uwm.edu)
Two strains may be bred together to produce a mixture of the genes of each strain. (uwm.edu)
Using the inbred mouse as a model organism, QTL mapping has become a very important tool for finding the genes that regulate complex human diseases, including atherosclerosis, diabetes, obesity, asthma and hypertension. (jax.org)
Because of cross-species concordance, QTL and their underlying candidate genes can first be identified, cost-effectively, in mice and then the genes can be tested relatively easily in humans and verified in mice. (jax.org)
A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. (wikipedia.org)
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)

Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)

The FVB/NJ strain was particularly susceptible showing a higher tumor burden than any other susceptible strains (12.5-week post-treatment initiation). (jax.org)

A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
Recombination frequencies using previously mapped loci allowed assignment of the 5'DI gene to mouse chromosome 4 and identified its approximate chromosomal position. (jci.org)
Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)
Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)

Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. (musc.edu)

Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. (wikipedia.org)
Differences evident between the L1 and L66 tau transgenic mouse models are likely due to the different human tau species expressed in these mice. (bvsalud.org)
There were no differences in any finding due to mouse strain. (microbiologyresearch.org)

Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)

Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)

A coisogenic strain arises when a mutation occurs in an inbred strain. (findmice.org)

The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5. (prosci-inc.com)
Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
Mice were NOT carriers of infectious MMTV but were susceptible to it. (jax.org)
Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)

More laboratory mice are used in research every year than any other animal species. (uwm.edu)
The increased role of QTL mapping and favored status of the inbred mouse in that role, are due to the improvement and development of genetic research tools (many of them pioneered by The Jackson Laboratory) to manipulate the mouse genome. (jax.org)
In addition, powerful databases like the Mouse Genome Informatics (MGI) database, the JAX® Mice database and the Mouse Phenome Database - all maintained at The Jackson Laboratory - are constantly improving to facilitate QTL mapping in the mouse. (jax.org)
The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains of mice (e.g. (cdc.gov)
This laboratory has previously reported a murine model of Serpulina hyodysenteriae infection in which mice fed a defined diet, Teklad 85420 (TD), developed caecal lesions more consistently than mice fed a conventional rodent chow (CRC). (microbiologyresearch.org)

Inbred mouse strains differ in their capacity to deiodinate iododioxin and iodothyronines, with strains segregating into high or low activity groups. (jci.org)
In this approach, two inbred strains that differ in fibrotic response are crossed and the F1 offspring are either mated together (intercross) or to one of the parental strains (backcross). (biomedcentral.com)

Southern analyses using a 5'DI probe identified a restriction fragment length variant that segregated with 5'DI activity in 33 of 35 recombinant inbred strains derived from four different pairs of high and low activity parental strains. (jci.org)
Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)

Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1. (jci.org)
By using interspecific backcross mice, the gene for inducible NOS (Nosi) was mapped to mouse chromosome 11. (duke.edu)
An inbred strain that contains a single entire chromosome from another strain. (findmice.org)

On the genetic background of the inbred strain C3H heterozygous mutant mice showed a pathological increase of the plasma urea concentration. (uni-muenchen.de)
This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)

She and co-researchers found significant concordance among mouse, human and rat hypertension QTL, 4 between mouse and human HDL cholesterol QTL, 6 between rat and human kidney disease QTL, 7 between mouse and human atherosclerosis QTL, 8 and among various species for osteoporosis, inflammatory bowel disease, type II diabetes and asthma QTL. (jax.org)
Three mammalian species are reservoir competent: the white-footed mouse ( Peromyscus leucopus ), raccoon ( Procyon lotor ), and gray squirrel ( Sciurus carolinensis ), although serologic and molecular evidence has suggested that numerous other small, medium, and large mammals may also be reservoirs ( 1 , 3 ). (cdc.gov)

Plastic restraint devices can be used to hold mice and other rodents for longer periods of time. (uwm.edu)

These results demonstrate that the characteristic severe lesions associated with S. hyodysenteriae infection in mice can occur 1 day after oral challenge in mice fed Teklad diet 85420. (microbiologyresearch.org)

As expected, antibody titres to both adenovirus and beta-galactosidase were higher in primed mice than in unprimed mice after intracranial inoculation. (ox.ac.uk)

The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)

for mouse, Chromosomes 1-19. (findmice.org)

Annotation of mouse strain C3H/HeJ genome assembly provided by GENCODE consortium. (jax.org)

Recombinant inbred strains derived from crosses between high and low activity strains exhibit segregation characteristic of a single allele difference. (jci.org)
For example, CBACa.C3- Kit W-x /J is an inbred strain of CBA/Ca background onto which the Kit W-x allele from C3H/HeJ has been placed. (findmice.org)

Frequencies of mitogen-reactive B cells in the mouse. (silverchair.com)
No LPS-reactive cells but normal frequencies of lipoprotein-reactive cells were found in C3H/HeJ mice, genetically nonreactive to LPS. (silverchair.com)
SJL mice had significantly lower frequencies of LPS- and of lipoprotein-reactive B cells (1 in approximately 30 B cells). (silverchair.com)

However urea secretion via the kidneys was impaired, since the mutants showed significantly lower urine urea levels compared to the wildtype mice. (uni-muenchen.de)

Phenotypic and genotypic characterization of the ENU-induced mutant mouse line HST001 for use in nephrological research A dominant mutation was established in the line HST001 within the Munich ENU mouse mutagenesis project. (uni-muenchen.de)
Im Rahmen des Münchener ENU-Maus-Mutagenese-Projekts wurde eine dominante Mutation in C3H-Mäusen identifiziert, die zu einer pathologischen Erhöhung der Harnstoffkonzentration im Blut führt. (uni-muenchen.de)

Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
For additional definitions useful for understanding mouse genetics and informatics, and for links to other biological glossaries online, see the MGI Glossary . (findmice.org)
Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)

Inbred strains have been extensively used in research. (wikipedia.org)
Genotypes of more than 100 RI strains were extensively error checked and regenotyped. (nervenet.org)

Scholars@Duke publication: The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. (duke.edu)

In mice previously sensitized to adenovirus, the leukocyte infiltrate in the brain was dominated by CD8+ T cells, whereas in unprimed mice CD4+ T cells were present at higher levels. (ox.ac.uk)

Most QTL have been mapped in model organisms such as the mouse and the rat. (jax.org)
In B6 mice, an injection with 1 × 10 2 organisms of T. gondii induced a suppressed elicitation of the memory cells to DNP-KLH. (uky.edu)

In contrast, AP-Variant 1 does not infect the white-footed mouse, DBA/2, and severely immunocompromised (SCID) mice ( 8 ). (cdc.gov)

LPS-reactive B cells yielding IgM- and IgG-PFC responses could be found in mesenteric lymph nodes, bone marrow, thymus, thoracic duct, and peripheral blood of 6- to 8-wk old mice. (silverchair.com)
Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)
The infected DBA/2 and C3H/He mice produced moderately suppressed responses. (uky.edu)
Dive into the research topics of 'Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (jci.org)

A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)

The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)

An inbred strain that contains a small genetic region (ideally a single gene) from another strain, but which is otherwise identical to the original inbred strain. (findmice.org)

Pathobiology of aging mice and GEM: background strains and experimental design. (jax.org)
Group lesion scores over the entire experimental period were significantly higher in mice fed TD (mean total lesion index = 13) than in mice fed CRC (mean total lesion index = 8.8). (microbiologyresearch.org)
Suenaga I. , Yamazaki T. Experimental Treponema hyodysenteriae infection of mice. (microbiologyresearch.org)

Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (musc.edu)
In addition, MRL-lpr/lpr peritoneal macrophages had an enhanced capacity to produce nitric oxide in vitro as well as increased nitric oxide synthase activity, and certain tissues from MRL-lpr/lpr mice had increased expression of inducible nitric oxide synthase (NOS) mRNA and increased amounts of material immunoreactive for inducible NOS. (duke.edu)
Y00864 is the GenBank ID for a mouse Kit mRNA sequence. (findmice.org)

These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)
Variation in the immune response to adenoviral vectors in the brain: influence of mouse strain, environmental conditions and priming. (ox.ac.uk)
MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune complex glomerulonephritis. (duke.edu)

For those examinations heterozygous mutant mice were mated to C3H mice and the offspring were divided in the two groups of mutant and wildtype littermates according to the concentration of plasma urea. (uni-muenchen.de)
At the age of 4 weeks the body weight of the mutant mice and the wildtype mice showed no difference. (uni-muenchen.de)
After 6 weeks the mutant mice grew more slowly leading to a significantly lower body weight compared to the wildtype littermates. (uni-muenchen.de)
Beside that they showed lower plasma concentrations of triglycerides and glucose and a lower activity of amylase than the wildtype mice. (uni-muenchen.de)

Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. (musc.edu)
Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. (musc.edu)
Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. (musc.edu)
Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. (musc.edu)
Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. (musc.edu)

Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. (uchicago.edu)

Mice (n = 4) were killed for necropsy at the same five time points after infection and their caeca were homogenised and examined by quantitative bacteriology with media selective for S. hyodysenteriae. (microbiologyresearch.org)
Finally, quantitative bacteriological results indicated that there was no significant difference in the number of cfu of S. hyodysenteriae isolated from mice fed TD and those fed CRC. (microbiologyresearch.org)

Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)

This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. (wikipedia.org)

Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. (wikipedia.org)

The mutant mice showed reduced numbers 91 of erythrocytes as well as decreased values for hemoglobin concentration, mean corpuscular volume and hematocrit. (uni-muenchen.de)

Regarding the relative organ weights the mutant mice showed significantly higher values for the spleen and the brain. (uni-muenchen.de)
The mutant mice had significantly higher plasma concentrations of urea and total protein as well as a higher activity of the alkaline phosphatase. (uni-muenchen.de)

Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. (ouhsc.edu)

Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice. (ox.ac.uk)

That similarity has become all the more evident in the past 15 years as comparative genomics has demonstrated that the location of mouse and other model animal QTL can predict the location of homologous QTL in humans. (jax.org)
J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. (jax.org)
In this genetic model of differential HCVS, the results suggest that a genomic basis for varied hypercapnic chemoreception or transduction confers greater afferent neuronal activity in the caudal NTS for high-responsive B6 mice compared with low-responsive C3 mice. (johnshopkins.edu)
Bacteriological results further indicate that the enhancement of lesion formation in this model is not due to any significant effect of the diet on numbers of spirochaetes in the caeca of infected mice. (microbiologyresearch.org)
Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)

which is true of inbred strains, since they normally have at least 98.6% similarity by generation 20. (wikipedia.org)

Results suggest that white-tailed deer harbor a variant strain not associated with human infection, but contrary to published reports, white-tailed deer are not a reservoir for strains that cause human disease. (cdc.gov)
Mice (n = 5) from each group were killed and examined on days, 1, 2, 4, 9 or 17 after infection. (microbiologyresearch.org)

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