Mouse strain. Medical search. Frequent questions

Two strains used most often as a genetic background for transgenic or knockout manipulations, C57BL/6 and 129Sv, and the outbred ICR strain were used. (erowid.org)
C57BL/6 mice exhibited lower baseline PPI levels than 129Sv and ICR mice, and 129Sv mice habituated less than C57BL/6 and ICR mice. (erowid.org)
MDMA decreased PPI in C57BL/6 and ICR, but not 129Sv mice, and RU24969 disrupted habituation in C57BL/6 and 129Sv, but not ICR mice. (erowid.org)
Hepatic and renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) strain paralleled enzyme activity and concentration, in agreement with a recent report. (jci.org)
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests. (stami.no)
RESULTS We found that the young males of the C57BL/6J strain spent more time moving in the OF. (stami.no)
RNA-seq was used to evaluate the psoriasiform phenotype elicited by 6 days of Aldara (5% IMQ) treatment in both sexes of seven mouse strains (C57BL/6 J (B6), BALB/cJ, CD1, DBA/1 J, FVB/NJ, 129X1/SvJ, and MOLF/EiJ). (altmetric.com)
One of the most common strains in mouse modeling is C57BL/6. (biomedcentral.com)
To determine if the phenotype of rTg4510 mice was similarly affected by the introduction of the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 . (biomedcentral.com)
Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. (biomedcentral.com)
These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the phenotype and suggest that the C57BL/6 background does not inherently protect against tauopathy. (biomedcentral.com)
To test the hypothesis that crossing rTg4510 mice to a C57BL/6 strain background is protective against tauopathy, we have compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 on an F1 FVB/N x C57BL/6NTac background (rTg4510 B6 ) (Figure 1 ). (biomedcentral.com)
Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510 B6 ) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). (biomedcentral.com)
Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. (uky.edu)
To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strainANKA.After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. (elsevierpure.com)
In this study, the inbred mouse strains A/J and C57BL/6J were used to determine whether their specific strain differences correlate with differences in susceptibility to respiratory depression and constipation. (pacific.edu)
C57BL/6J mice showed a greater degree of change in several respiratory parameters, resulting in more pronounced respiratory depression. (pacific.edu)
This study demonstrates that the strain differences between A/J and C57BL/6J mice have a major effect on opioid-induced constipation and respiratory depression. (pacific.edu)
Our objective was to expose, by inhalation, lung tumor susceptible (A/J) and resistant C57BL/6J (B6) mice to stainless steel (SS) welding fume containing carcinogenic metals and characterize the lung-inflammatory and tumorigenic response. (cdc.gov)

We used recombinant congenic mouse strains to map asthma susceptibility genes on mouse chromosome 17. (rug.nl)
Susceptibility to noise -induced hearing loss in two congenic mouse strains. (cdc.gov)

At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice. (jax.org)
Mice bearing mutant genes which are phenotypically expressed in the animals. (ucdenver.edu)
The response of MOLF males was aberrant, however, with decreased expression of differentiation-associated genes (elevated in other strains). (altmetric.com)
A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. (wikipedia.org)
Humans share many genes with mice. (wikipedia.org)
Researchers typically use inbred mouse strains, which have identical genes on each chromosome and whose genetics are well established. (spectrumnews.org)

We then started to map asthma susceptibility in the Lmr series of recombinant congenic and subcongenic strains. (rug.nl)
For example, researchers tested 371 mice from 66 new strains for their susceptibility to the fungus Aspergillus fumigatus , which can also infect humans. (spectrumnews.org)
Mouse model demonstrates strain differences in susceptibility to opioi" by Andrew L. Young, Archana Viswanath et al. (pacific.edu)
Importantly, this model reproduces the susceptibility of aging, because compared to young mice, old mice display more severe clinical illness and succumb to disease more frequently. (lu.se)

Mice, Mutant Strains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
This graph shows the total number of publications written about "Mice, Mutant Strains" by people in this website by year, and whether "Mice, Mutant Strains" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Mice, Mutant Strains" by people in Profiles. (ucdenver.edu)

Blue squares indicate phenotypes directly attributed to mutations/alleles in this strain. (jax.org)
The file contains all strain survey measured phenotypes where CBAB6F1 was tested, along with measured means and summary statistics. (jax.org)
We and others have previously reported that this strain background alters the phenotypes of various models, including the JNPL3 model of tauopathy. (biomedcentral.com)
Here we compare the phenotypes of both young and old rTg4510 mice on each strain background. (biomedcentral.com)
Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. (wikipedia.org)
One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. (wikipedia.org)
By maximizing the genetic diversity of mouse strains, researchers can identify the gene variants responsible for various phenotypes and behaviors. (spectrumnews.org)
In another study, researchers documented the various phenotypes and behaviors visible in Collaborative Cross strains. (spectrumnews.org)
These strains show a much wider variety of phenotypes, such as body length or level of anxiety, than those documented for BXD mice, an existing inbred lab strain 2 . (spectrumnews.org)

Recombinant inbred strains derived from crosses between high and low activity strains exhibit segregation characteristic of a single allele difference. (jci.org)
Southern analyses using a 5'DI probe identified a restriction fragment length variant that segregated with 5'DI activity in 33 of 35 recombinant inbred strains derived from four different pairs of high and low activity parental strains. (jci.org)

Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. (nih.gov)

Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. (wikipedia.org)

Key aspects of the IMQ response differed between the two most commonly studied strains (BALB/c and B6). (altmetric.com)
Although IMQ-induced expression shifts mirrored psoriasis, responses in BALB/c, 129/SvJ, DBA, and MOLF mice were more consistent with other human skin conditions (e.g., wounds or infections). (altmetric.com)
Therefore we designed a study to assess the phenotypic differences induced by oxaliplatin treatment in six different mice strains (Balb c, AJ, C57Bl6, FVB, DBA, CD1) aiming at identifying the more and less severely affected. (fupress.net)

Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. (biomedcentral.com)
Numerous transgenic mice expressing wild-type or mutant human tau have been created to model the neuropathology of tauopathies-a group of neurodegenerative diseases characterized by the accumulation of tau protein aggregates. (biomedcentral.com)
The strain background of transgenic mice can also alter disease progression and presentation. (biomedcentral.com)
We carry over 140 strains of immune competent, immune deficient, and transgenic mice. (uclahealth.org)

In benign cases, not nicity in laboratory mice, were forced to evolve by serial all of these symptoms are exhibited. (cdc.gov)
We selected 198 samples for genotyping with the Mouse Diversity array including 36 wild caught mice, 62 wild-derived laboratory strains and 100 classical strains. (jax.org)
Wild caught mice, including representatives from M. m. domesticus, M. m. musculus and M. m. castaneus , were used as references to infer the phylogenetic origin of laboratory strains ( http://msub.csbio.unc.edu/ ). (jax.org)
Our laboratory samples include strains derived from different stocks and by different laboratories as well as 13 sets of classical substrains that are thought to be closely related to each other. (jax.org)
Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (wikipedia.org)
Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). (wikipedia.org)
Mice are currently the laboratory animal species most closely related to humans for which the knockout technique can easily be applied. (wikipedia.org)
A laboratory mouse in which a gene affecting hair growth has been knocked out (left) is shown next to a normal lab mouse. (wikipedia.org)
The Sterne strain has an excellent safety record, and has been used safely worldwide by laboratory staff involved in its preparation and by hundreds of thousands of veterinarians. (cdc.gov)
Routine manipulation of the strain in a microbiology laboratory is not likely to result in exposure. (cdc.gov)
Up to 90 days daily oral crude neem oil treatment (5 g/kg body weight) of laboratory mice did not cause any significant changes in weekly body weight gain, nor in serum liver damage indicators, direct bilirubin or total bilirubin. (who.int)

We breed and house many strains of immunocompromised mice with varying degrees of deficiency, including with NSG, Scid, and Nude mice of varying genotype, including humanized strains. (uclahealth.org)

Recombination frequencies using previously mapped loci allowed assignment of the 5'DI gene to mouse chromosome 4 and identified its approximate chromosomal position. (jci.org)
Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1. (jci.org)

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (jci.org)
that reassured us that we had managed to isolate the strains, and this was then confirmed by additional analyses. (pasteur.fr)
Using these analyses in future studies will further help connect in vitro measurements of the sarcomere function to whole heart function.NEW & NOTEWORTHY A detailed study of how perturbations to sarcomere proteins impact whole heart mechanics in mouse models is a major yet challenging step in furthering our understanding of cardiovascular pathophysiology. (bvsalud.org)

There are six possible calls: homozygous for either allele (A or B), heterozygous (H), VINO (V), deletion (D) and no call (N). There are 117,203 probes with VINOs in at least one of the 198 strains. (jax.org)
Homozygous mice are phenotypically normal. (pkd-rrc.org)
Homozygous mice develop congenital hepatic fibrosis. (pkd-rrc.org)
A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. (wikipedia.org)
White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene. (wikipedia.org)

With the whole viral genome of coronavirus 2019-nCoV having recently been sequenced at the Institut Pasteur, the isolation of strains of coronavirus 2019-nCoV detected in France has now been successfully finalized, in a very short space of time, using the samples taken from the first confirmed French cases. (pasteur.fr)
The researchers extracted the spike protein from the Omicron and genetically engineered it into the ancestral strain of coronavirus which was detected first in the wet market of Wuhan, China. (indiatimes.com)

They documented how this hybrid, genetically modified strain reacted in mice. (indiatimes.com)
A knockout mouse , or knock-out mouse , is a genetically modified mouse ( Mus musculus ) in which researchers have inactivated, or " knocked out ", an existing gene by replacing it or disrupting it with an artificial piece of DNA . (wikipedia.org)

Breeding scheme for producing knockout mice. (wikipedia.org)
Further breeding among the Collaborative Cross strains has the potential to produce unlimited numbers of genetically diverse mice. (spectrumnews.org)

Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta2m(null), and NOD-scid IL2Rgamma(null) as xenograft tumor recipients. (nih.gov)
Melanoma metastases growth is delayed and variable in scid and NOD-scid mice. (nih.gov)
In contrast, NOD-scid beta2m(null) and NOD-scid IL2Rgamma(null) mice show rapid tumor engraftment, although tumor growth is variable in NOD-scid beta2m(null) mice. (nih.gov)
NK cells were detected in all strains except NOD-scid IL2Rgamma(null), and in vitro activated scid, NOD-scid, and NOD-scid beta2m(null) NK cells kill human melanoma lines and primary melanoma cells. (nih.gov)
The absolute NK deficiency in NOD-scid IL2Rgamma(null) animals makes this strain an excellent recipient of melanoma and potentially other human malignancies. (nih.gov)
In cell cultures and in "humanized" NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG, 005557 ) mice, they interfered with the immune system's ability to recruit the synovium-attacking T cells. (jax.org)
Humanized NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ ( 005557 ) mice were particularly critical to the success of this study. (jax.org)

Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. (cdc.gov)

The eradication of infectious virus from the central nervous system (CNS) following infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) is thought to be immune-mediated. (scienceopen.com)
Thanks to the close relationships established with their hosts, some probiotic strains can provide additional benefits: for example, they can mediate either immune responses or barrier functions 10 . (nature.com)
In most strains, IMQ altered gene expression in a manner consistent with human psoriasis, partly due to innate immune activation and decreased homeostatic gene expression. (altmetric.com)
To evaluate whether it also modulates immune function in mice to exert antifungal effects, we investigated the effect of BS-Z15 secondary metabolites on both the innate and adaptive immune functions of mice, and explored its molecular mechanism through blood transcriptome analysis. (biomedcentral.com)
BS-Z15 secondary metabolites were shown to enhance innate and adaptive immune function in mice, laying a theoretical foundation for its development and application in the field of immunity. (biomedcentral.com)
In previous studies, secondary metabolites of B. subtilis strain Z15 (BS-Z15) were found to be highly effective as a broad-spectrum antibacterial in vitro and could act as an elicitor to regulate systemic resistance in plants by inducing the immune response of plants [ 10 ]. (biomedcentral.com)
Many immune competent mouse strains are bred in the vivarium under gnotobiotic conditions and are available for purchase at low cost. (uclahealth.org)
Compared with normal wild type strains which produce both the toxin and the capsule, the Sterne strain is relatively avirulent, however immunization using the Sterne strain is able to stimulate a protective immune response. (cdc.gov)

The researchers also show that classic lab mouse strains have been selected for domesticity, by documenting wild-like behaviors in those bred from the wild-derived strains. (spectrumnews.org)

Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. (bvsalud.org)

Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. (altmetric.com)
Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. (altmetric.com)
Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. (biomedcentral.com)
We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported phenotype. (biomedcentral.com)

Male mice were exposed to air or gas metal arc (GMA)-SS welding fume at 40 mg/m3 x 3 h/day for 6 and 10 days. (cdc.gov)

The researchers have said that the new strain has five times more infectious virus particles than the Omicron variant. (indiatimes.com)
Established almost 40 years ago to breed and house mice specifically for radiation experiments, the UCLA Department of Radiation Oncology's Division of Molecular and Cellular Oncology (DMCO) manages one of the highest quality AALAC-accredited Mouse Cores in the country that now services more than 120 researchers at UCLA. (uclahealth.org)
Researchers either work with mice in the facility or buy mice at very low cost for use in other facilities. (uclahealth.org)
By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function. (wikipedia.org)
Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better understand how a similar gene may cause or contribute to disease in humans. (wikipedia.org)
Researchers are creating a population of inbred lab mice, called the Collaborative Cross , with the potential to produce thousands of genetically diverse strains. (spectrumnews.org)
However, available strains are strikingly genetically identical to one another, greatly limiting the amount of genetic variation that researchers are able to study. (spectrumnews.org)
To address this issue, in 2004, researchers launched a project called the Collaborative Cross to create 1,000 inbred mouse strains from 5 lab strains and 3 derived from wild populations 4 . (spectrumnews.org)
Researchers are also conducting experiments on many of the existing 'nearly inbred' strains of mice. (spectrumnews.org)
Several mice show remarkable resistance to infection, allowing the researchers to hone in on the gene variants responsible for resistance 3 . (spectrumnews.org)

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. (scienceopen.com)
The antibiotics are released in the presence of Salmonella , which is known to produce H 2 S. This approach prevents the quick absorption of antibiotics into the bloodstream, allows localized targeting of the pathogen in the gut, and alleviates disease symptoms in a mouse infection model. (nature.com)
In…mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80 percent," they wrote in a research paper. (indiatimes.com)
It is probably not possible for humans to acquire a Sterne strain infection by the respiratory or oral route. (cdc.gov)
While it is highly unlikely that the Sterne strain will result in infection, cutaneous anthrax can be successfully treated with antimicrobial agents, making it improbable that a localized infection can become severe or fatal. (cdc.gov)
This paper describes a novel mouse model that recreates the transition of pneumococci from asymptomatic carriage to disease upon viral infection. (lu.se)
In this model, mice are first intranasally inoculated with biofilm-grown pneumococci to establish asymptomatic carriage, followed by IAV infection of both the nasopharynx and lungs. (lu.se)

In all strains we performed a multimodal characterization of its neurotoxicity through morphological and morphometrical assessment in caudal nerve and DRG at light and electron microscopy, intra-epidermal nerve fibers density quantification, evaluation of mechanical and cold allodynia/hypoaesteshesia, caudal and digital nerve conduction velocity, activity of wide dynamic range (WDR) neurons of the spinal dorsal horn. (fupress.net)
Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. (nih.gov)

Previous studies have shown that secondary metabolites of Bacillus subtilis strain Z15 (BS-Z15) are effective in treating fungal infections in mice. (biomedcentral.com)
Most are exceptionally "clean" mice that have a defined microbial flora (which means they are gnotobiotic) consisting of 3 organisms: one Bacillus and two Clostridial species and are free of aerobic and Gram-negative bacteria. (uclahealth.org)
What is the Sterne strain (34F2) of Bacillus anthracis ? (cdc.gov)

Natural killer (NK) cell function was examined in each mouse strain using standard (51)Chromium release assays. (nih.gov)

Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. (wikipedia.org)
Millions of knockout mice are used in experiments each year. (wikipedia.org)
Experiments using the first of these mice are published in the August issue of Genomic Research 1 , 2 , 3 . (spectrumnews.org)

To do this, they injected sub-lethally irradiated NSG mice with peripheral blood mononuclear cells (PBMCs). (jax.org)

The first recorded knockout mouse was created by Mario R. Capecchi , Martin Evans , and Oliver Smithies in 1989, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine . (wikipedia.org)

Spontaneous" tumor animal models, which simulate the occurrence of tumors in the general human population, are readily available as are many other transgenic strains. (uclahealth.org)

causing 3-5 million cases of severe illness and 500,000 Alterations in human and mouse lungs have been described reported deaths. (cdc.gov)

Non-transgenic (NT) littermates of rTg4510 B6 (NT B6 ) mice also had greater amounts of cortical and hippocampal phospho-tau at 10.5 months of age when compared to NT littermates of rTg4510 mice. (biomedcentral.com)
Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. (uky.edu)

Recombinant congenic strains are series of strains which have inherited one or more chromosomal fragments from a donor strain and all other DNA from the background strain. (rug.nl)

Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. (nature.com)
This knock-in mouse model has a triple HA tag at the C-terminal tail of PKHD1 and produces a fully functional fibrocystin protein. (pkd-rrc.org)
This mouse model has a deletion of PKHD1 exons 3 through 4. (pkd-rrc.org)
This mouse model lacks PKHD1 exon 67. (pkd-rrc.org)
Torsional and strain dysfunction precede overt heart failure in a mouse model of dilated cardiomyopathy pathogenesis. (bvsalud.org)
This study aims to use advanced echocardiography imaging and analysis techniques to identify previously unappreciated mechanical deficiencies in a mouse model of dilated cardiomyopathy (DCM) before the onset of overt systolic heart failure (HF). (bvsalud.org)
Mice lacking muscle LIM protein expression (MLP-/-) were used to model DCM-linked HF pathogenesis . (bvsalud.org)
This study uses advanced echocardiographic imaging and analysis techniques to reveal previously unappreciated subclinical whole heart mechanical defects in a mouse model of cardiomyopathy . (bvsalud.org)

The Sterne strain is currently the predominant strain used for immunization of domesticated animals against anthrax worldwide, and has been used for this purpose for many decades. (cdc.gov)

The present studies were undertaken to evaluate potential murine strain differences in the effects of serotonergic drugs on PPI and habituation. (erowid.org)

Although 3-wk-old MLP-/- mice showed normal LV ejection fraction (LVEF), these mice displayed abnormal torsional and strain mechanics alongside reduced ß- adrenergic reserve. (bvsalud.org)

For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. (wikipedia.org)
Monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and tumor necrosis factor-alpha (TNF-alpha) were increased in both strains while the B6 also had increased interleukin-6 (IL-6) protein. (cdc.gov)

As with immunocompetent animal models, these mice can also be used for both heterotopic and orthotopic tumor models. (uclahealth.org)
For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 78 weeks after 6 and 10 days of exposure. (cdc.gov)
Under our exposure conditions, GMA-SS exposure resulted in no significant tumor development in A/J mice. (cdc.gov)

Although both adapted viruses evoked diffuse ditional signs typical of either secondary bacterial pneumo- alveolar damage and showed a similar 50% mouse lethal dose and the same peak lung concentration, each had a nia or acute respiratory distress syndrome (ARDS) occur. (cdc.gov)

Our preliminary data suggest that all the strains show signs of OIPN but not the same modifications in the parameters examined. (fupress.net)

C57BL6J mice also showed significantly more constipation than A/J mice with 40 and 60 mg/kg morphine doses. (pacific.edu)
BAL measures of cytotoxicity and damage were similar between the strains and significantly increased at all time points. (cdc.gov)

On the basis divided into aliquots for direct use in pathotyping studies, of these mostly retrospective studies, the pathogenesis of and their titers were determined by standard plaque (sub- infl uenza-associated ARDS is widely viewed as being the type H1N1) or median tissue culture infective dose assays same whatever the infecting strain. (cdc.gov)

Behavioural analysis of four mouse strains in an anxiety test battery. (bvsalud.org)

Murine NKG2D recognition of MICA/B is an important receptor-ligand interaction used by NK cells in immunodeficient strains to limit engraftment of human tumors. (nih.gov)

It also shows that genetic research in mice can generate data relevant to human. (rug.nl)
Kelly, S, McCulloch, J & Horsburgh, K 2001, ' Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion ', Brain Research , vol. 914, pp. 185 - 195. (bris.ac.uk)
First, this research is not gain-of-function research, meaning it did not amplify the Washington state SARS-COV-2 virus strain (original virus from 2020) or make it more dangerous," BU said in a statement following online reports that the university called "false and inaccurate," reported Boston Herald. (indiatimes.com)
Inbred strains have been extensively used in research. (wikipedia.org)
One of the more specific uses of Drosophila inbred strains is the use of Gal4/UAS lines in research. (wikipedia.org)
We are always willing to incorporate new strains that will aid research at UCLA. (uclahealth.org)

The chimera mice are crossed with a normal wildtype mouse (grey). (wikipedia.org)

Can the Sterne strain cause infections in people? (cdc.gov)

Furthermore, microglial activity and morphological changes detected throughout the brains of infected mice were absent from the brains of control mice, and this correlated with the measured cognitive defects. (elsevierpure.com)

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