Mouse olfactory epithelium. Medical search. Frequent questions

Odorant receptors bind odorants in the airspace, which are made soluble by the serous secretions from olfactory glands located in the lamina propria of the mucosa. (wikipedia.org)
Tubuloalveolar serous secreting glands lying in the lamina propria of the olfactory mucosa. (wikipedia.org)
Ongoing work explores how epithelial cells of the sinuses and olfactory mucosa participate in the immune response and contribute to chronic inflammation. (hopkinsmedicine.org)
The main olfactory system originates from the olfactory mucosa and projects to the main olfactory bulb (MOB), while the VNO, described by Jacobson in 1813 ( Trotier and Doving, 1998 ) projects to the accessory olfactory bulb (AOB, see Figure 2 ). (frontiersin.org)
sponse of the nasal olfactory mucosa, with the mouse metabolism studies have indicated major differences being much more sensitive. (cdc.gov)
olfactory mucosa was mostly spared. (cdc.gov)

Olfactory epithelium consists of four distinct cell types: Olfactory sensory neurons Supporting cells Basal cells Brush cells The olfactory receptor neurons are sensory neurons of the olfactory epithelium. (wikipedia.org)
The axons of the olfactory sensory neurons congregate to form the olfactory nerve (CN I). Once the axons pass through the cribriform plate, they terminate and synapse with the dendrites of mitral cells in the glomeruli of the olfactory bulb. (wikipedia.org)
The embryonic olfactory epithelium consists of fewer cell types than in the adult, including apical and basal progenitor cells, as well as immature olfactory sensory neurons. (wikipedia.org)
The axons of the immature olfactory sensory neurons, along with a mixed population of migratory cells, including immature olfactory ensheathing cells and gonadotropin-releasing hormone neurons form a "migratory mass" that travels towards the olfactory bulb. (wikipedia.org)
Olfactory receptors are supposed to act not only as molecular sensors for odorants but also as cell recognition molecules guiding the axons of olfactory neurons to their appropriate glomerulus in the olfactory bulb. (jneurosci.org)
On serial sections through the olfactory bulb of mOR37-transgenic mouse lines, double-labeling experiments demonstrated that distinct immunoreactive glomeruli corresponded to glomeruli that were targeted by neurons expressing a particular member of the mOR37 receptor subfamily. (jneurosci.org)
These data indicate that olfactory receptor (OR) proteins are indeed present in the axonal processes and nerve terminals of olfactory sensory neurons, thus supporting the notion that ORs may participate in the molecular processes underlying the fasciculation and targeting of olfactory axons. (jneurosci.org)
Focusing initially on the functioning of olfactory neurons and olfactory epithelial cells, in the months ahead the researchers will devote part of their time and effort to an investigation of the correlation between infection by SARS-CoV-2 and the development of anosmia, the technical term for loss of smell. (fapesp.br)
We could use in situ hybridization [ a technique that detects target mRNAs in individual cells in a section of tissue ] to determine whether olfactory neurons survive infection. (fapesp.br)
Olfactory sensory neurons. (guidetopharmacology.org)
Specifically, investigating the role of immature olfactory sensory neurons (OSN) in olfaction. (kozailab.com)
Low survival rate of young adult-born olfactory sensory neurons in the undamaged mouse olfactory epithelium. (kozailab.com)
Trpc2-expressing sensory neurons in the main olfactory epithelium payday 2 auto player script the mouse. (rederm.sk)
Two types of olfactory sensory neurons are present. (biomedcentral.com)
Both types bear cilia as well as microvilli at their apical endings and express the typical markers for olfactory neurons. (biomedcentral.com)
The density of these olfactory neurons varies along the nasal cavity. (biomedcentral.com)
In addition, solitary chemosensory cells innervated by trigeminal nerve fibres, are intermingled with olfactory sensory neurons. (biomedcentral.com)
The olfactory system contains two morphological distinct types of ciliated olfactory receptor neurons. (biomedcentral.com)
In mammals, the olfactory system contains ciliated and microvillous olfactory receptor neurons (OSNs). (biomedcentral.com)
In many mammals these neurons are segregated in two compartments: ciliated OSNs are housed in the main olfactory epithelium detecting chemicals related mostly to food and microvillous OSNs in the so-called vomeronasal organ (VNO) detecting mostly (but not limited to) social cues [ 1 ]. (biomedcentral.com)
Thus, to further examine the contribution of GIRK channel subunits on resting membrane potential in POMC neurons, we generated POMC-hrGFP mice with global deletion of either GIRK1 or GIRK2. (pafr-inhibitor.com)
The most highly mitotic colony-forming HBCs demonstrate multipotency, spontaneously generating more ICAM-positive presumptive HBCs, a combination of olfactory neuroglial progenitors, and neurons of olfactory and potentially nonolfactory phenotypes. (syr.edu)
As humans age, the number of olfactory neurons steadily decreases. (medscape.com)
In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)

The sensory epithelium (SE), the lumen (L) and the vessel (V) are indicated. (frontiersin.org)
Olfactory sensory epithelium. (guidetopharmacology.org)
Electron microscopy and immunocytochemistry were used to examine the sensory epithelium of the nasal cavity of the American alligator. (biomedcentral.com)
Almost the entire nasal cavity is lined with olfactory (sensory) epithelium. (biomedcentral.com)

The accessory olfactory system may complement the main olfactory system and may contribute different perceptual features to the construction of a unitary representation, which merges the different chemosensory qualities. (frontiersin.org)
(B) A coronal section of the main olfactory epithelium, dorsal to the upper right. (frontiersin.org)
The arrows indicate the projections from the MOE to the main olfactory bulb (right) and from the VNO to the AOB (left). (frontiersin.org)
A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. (uni-saarland.de)
Turtles employ the main olfactory epithelium and the VNO to detect air-borne and/or water-soluble chemicals. (biomedcentral.com)

To scrutinize the hypothesis that olfactory receptor proteins may also be present in the axonal processes and the nerve terminals, serial sections through the olfactory bulb were probed with the antibodies. (jneurosci.org)
their axonal projections converge onto one medial and one lateral glomerulus in the olfactory bulb. (jneurosci.org)
in the cilia recognizing odorous molecules from the environment and in the axons recognizing molecular cues in the olfactory bulb. (jneurosci.org)
We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m 2 (mean = 28.58 ± 6.64). (frontiersin.org)
(C) A horizontal section through the main and accessory olfactory bulb. (frontiersin.org)
The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron-soot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. (cdc.gov)

The main aim of the project is to study the genes that encode the olfactory receptors [ proteins that bind to odorant molecules ]. (fapesp.br)
The olfactory and the vomeronasal receptors detect a variety of odours including food-related and social signals. (biomedcentral.com)
Within the neural stem cell niche of the mouse olfactory epithelium, we identified a combination of extracellular matrix (ECM) receptors that regulate adhesion and mitosis in non-neural stem cells [intercellular adhesion molecule-1 (ICAM-1), β 1 , β 4 , and α-1, -3, and -6 integrins] and on horizontal basal cells (HBCs), candidate olfactory neuro-epithelial progenitors. (syr.edu)
Using ECM receptors as our guide, we recreated a defined microenvironment in vitro that mimics olfactory basal lamina and, when supplemented with epidermal growth factor, transforming growth factor α, and leukemia inhibitory factor, allows us to preferentially expand multiple clonal adherent colony phenotypes from individual ICAM-1 + and ICAM-1+/β 1 integrin+-selected HBCs. (syr.edu)
It is a specialized pseudostratified neuroepithelium containing the primary olfactory receptors. (medscape.com)
To stimulate the olfactory receptors, airborne molecules must pass through the nasal cavity with relatively turbulent air currents and contact the receptors. (medscape.com)

Since alligators seem to detect both volatile and water-soluble odour cues, I tested whether different sensory cell types are present in the olfactory epithelium. (biomedcentral.com)

While some of these basal cells divide rapidly, a significant proportion remain relatively quiescent and replenish olfactory epithelial cells as needed. (wikipedia.org)

The olfactory epithelium is a specialized epithelial tissue inside the nasal cavity that is involved in smell. (wikipedia.org)
The most sensitive site in rodents and monkeys following inhalation exposure is the respiratory epithelium in the anterior part of the nasal cavity. (europa.eu)
The nasal cavity of all vertebrates houses multiple chemosensors, either innervated by the Ist (olfactory) or the Vth (trigeminal) cranial nerve. (biomedcentral.com)

In the nose, the incidences of basal cell hyperplasia were significantly increased in all exposed groups of males and females, and the incidences of degeneration of the olfactory epithelium were increased in 1000 ppm males and females and 300 ppm females. (europa.eu)
chioloalveolar tumors, as well as degeneration and atrophy of nasal olfactory epithelium. (cdc.gov)

Development of the olfactory placode requires the presence underlying neural crest-derived mesenchymal tissue. (wikipedia.org)
The specification of the olfactory placode tissue involves signaling of multiple gene networks, beginning with signals from bone morphogenetic proteins (BMP), retinoic acid (RA), and fibroblast growth factor (FGF), specifically FGF8. (wikipedia.org)
In this study, antibodies were generated against unique epitopes of distinct OR types and used in immunohistochemical experiments to visualize the receptor proteins in whole-mount preparations and tissue sections of the olfactory system. (jneurosci.org)
Only kidney and nasal epithelium show specific tissue affinities at these early time intervals. (europa.eu)
The most sensitive tissue was the larynx, with squamous metaplasia observed in rats and mice at the lowest exposure concentration of 0.3 mg/m3. (nih.gov)
In actual fact, the gene varies depending on the tissue where it is located (cerebral cortex, cerebellum, olfactory epithelium, etc. (evolutionnews.org)

Odorants can also be perceived by entering the nose posteriorly through the nasopharynx to reach the olfactory receptor via retronasal olfaction. (medscape.com)

Analogous to neural glial cells, the supporting cells are non-neural cells in the olfactory epithelium that are located in the apical layer of the pseudostratified ciliated columnar epithelium. (wikipedia.org)
The olfactory placode forms as two thickenings of non-neural region of embryonic ectoderm. (wikipedia.org)
In mice, the olfactory placode derives from an anterior portion of the neural tube, ~9-9.5 days into development and not long after the closure of the neural plate. (wikipedia.org)
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. (scirp.org)
Our findings visually demonstrate that inhaled ultrafine iron-soot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation. (cdc.gov)
Here, by analysing Sox2 conditional knockout mouse embryos and chick embryos deprived of Sox2 in the olfactory epithelium using CRISPR-Cas9, we show that Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. (unimib.it)
However, neural correlates of hypo- or anosmia in olfactory disorder patients are poorly known. (elsevierpure.com)
The primary aim of this study is to characterize the bottom-up process of the neural dynamics across peripheral and central brain regions in anesthetized mice. (elsevierpure.com)
We particularly focused on the neural oscillations of local field potential (LFP) in olfactory epithelium (OE), olfactory blub (OB), prefrontal cortex (PFC), and hippocampus (HC) during an olfactory oddball paradigm in urethane anesthetized mice. (elsevierpure.com)
HBCs thus possess a conserved adhesion receptor expression profile similar to non-neural stem cells, preferential self-replication in an in vitro environment mimicking their in vivo niche, and contain subpopulations of cells that can produce multiple differentiated neuronal and glial progeny from within and beyond the olfactory system in vitro. (syr.edu)
In neonates, this area is a dense neural sheet, but, in children and adults, the respiratory and olfactory tissues interdigitate. (medscape.com)

Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. (nih.gov)

This concept implies that olfactory receptor proteins are located in sensory cilia and in the axons. (jneurosci.org)
Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. (frontiersin.org)

Resting on or near the basal lamina of the olfactory epithelium, basal cells are stem cells capable of division and differentiation into either supporting or olfactory cells. (wikipedia.org)

nasal olfactory epithelium in rats and mice. (cdc.gov)
Alpha-methylstyrene was tested in a guideline study for carcinogenicity in rats and mice (NTP, 2007). (europa.eu)
The NOAEC for systemic effects not occurring at the site of first contact in long-term inhalation studies in rats and mice is 15 ppm. (europa.eu)
Ten male and ten female rats and mice from each group were evaluated on day 32. (nih.gov)
Necrotizing inflammation was observed in the larynx and trachea of rats and mice at concentrations as low as 5 mg/m 3 , and a similar lesion was present in the bronchi at exposure concentrations of 50 mg/m 3 or higher. (nih.gov)
Rats and mice exposed to 30 mg/m3 lost weight during the first exposure week and then gained weight at the same rate as controls. (nih.gov)
Numerous studies have demonstrated marked differ- fects on terminal bronchioles are seen, but effects in ences in toxicity between rats and mice to styrene ex- the nasal olfactory epithelium do occur, although to posure, especially by inhalation. (cdc.gov)
in styrene metabolism between rats and mice. (cdc.gov)

Therefore, olfactory herpesvirus infection differed from contamination from the adjacent respiratory epithelium immunologically. (bioinf.org)
The SARS-CoV-2 receptor ACE2 was extensively detected by IHC within turbinate epithelium, with decreased detection in lower respiratory tract epithelium and alveolar macrophages. (cdc.gov)

It was found that between embryonic days E10.5 and E16.5 Pax6 is autonomously required for cells to contribute fully not only to the corneal epithelium, where Pax6 is expressed at high levels, but also to the to the corneal stroma and endothelium, where the protein is detected at very low levels. (ed.ac.uk)
At the end of the embryonic stage, the epithelium develops into a pseudostratified columnar epithelium and begins secondary neurogenesis. (wikipedia.org)
Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
Neurogenesis in the vertebrate olfactory epithelium persists from embryonic stages through adulthood. (unimib.it)

The question whether OR proteins are indeed present in the axons and nerve terminals of OSNs is thus of fundamental importance toward an understanding of the functional wiring in the olfactory system. (jneurosci.org)
Here we use optical imaging techniques to visualize odorant-evoked neurotransmitter release from the olfactory nerve into the brain's olfactory bulbs in vivo in mice. (rutgers.edu)
In this study optical imaging revealed significant reductions in odorant-evoked release from the olfactory nerve at a cadmium chloride dose two orders of magnitude less than that required to induce morphological changes in the nerve in the same animals, demonstrating that it is a more sensitive technique for assessing the consequences of intranasal neurotoxicant exposure. (rutgers.edu)
Head anatomy with olfactory nerve. (medscape.com)

Identification of the mouse beta'-COP Golgi component as a spermatocyte autoantigen in scleroderma and mapping of its gene Copb2 to mouse chromosome 9. (nih.gov)
Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 ( Uchl1 ), a gene involved in brain function and neurodegenerative diseases 11 . (nature.com)
The team of Peter Mombaerts is pursuing a genetic approach to understand the mechanisms of odorant receptor gene choice and of axonal wiring in the mouse olfactory system. (mpg.de)
We have recently applied the NanoString digital platform to study expression of mouse odorant receptor genes, which form with 1,200 members the largest gene family in the mouse genome. (biomedcentral.com)
Gene-wise statistical analyses of gene expression data, for which the significance relative to a fold change threshold is important, give reproducible and reliable results on NanoString data of mouse odorant receptor genes. (biomedcentral.com)
Gene expression studies often seek to identify genes that are Differentially Expressed (DE) between RNA samples from two types of biological conditions, such as gene knockout mice compared to wild-type mice. (biomedcentral.com)

At higher exposure levels also the olfactory epithelium, larynx or trachea were affected. (europa.eu)
In 13-week studies, all rats, all female mice, and all but 2 male mice exposed at the top concentration survived to the end of the studies (target exposure concentrations of 0, 0.3, 1, 3, 10, and 30 mg/m3, 10 animals per group). (nih.gov)
Mice were exposed for 6 hr/day, 5 days/week for 5 consecutive weeks (25 total exposure days). (cdc.gov)
Intranasal exposure to cadmium has been related to olfactory dysfunction in humans and to nasal epithelial damage and altered odorant-guided behavior in rodent models. (rutgers.edu)
After intranasal cadmium exposure, mice were unable to detect the target odor. (rutgers.edu)

Glial-like supporting (or sustentacular) cells are important constituents of the olfactory epithelium that are involved in several physiological processes such as production of endocannabinoids, insulin, and ATP and regulation of the ionic composition of the mucus layer that covers the apical surface of the olfactory epithelium. (sissa.it)
There are two types of supporting cells in the olfactory epithelium: sustentacular cells and microvillar cells. (wikipedia.org)
The sustentacular cells function as metabolic and physical support for the olfactory epithelium. (wikipedia.org)

This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)

Here, we sought to extend our understanding of a possible physiological role of this channel in the olfactory system by asking whether Ca2+ can activate Cl- currents mediated by TMEM16A. (sissa.it)
Altogether, our results establish that TMEM16A-mediated currents are functional in olfactory supporting cells and provide a foundation for future work investigating the precise physiological role of TMEM16A in the olfactory system. (sissa.it)
The olfactory epithelium is the part of the olfactory system directly responsible for detecting odors. (wikipedia.org)
Thus, the olfactory system came into focus as an important contributor to unintentional weight gain. (frontiersin.org)
On this notion, it has been shown that individuals with obesity show several alterations in the olfactory system. (frontiersin.org)
The accessory olfactory system is present in most tetrapods. (frontiersin.org)
The accessory olfactory system may differ in morphology even in closely related species, most probably in relation to functional specialization (for a review, see Salazar and Quinteiro, 2009 ). (frontiersin.org)
The first functional investigation of the accessory olfactory system pointed to a general chemosensation role. (frontiersin.org)
How extensive is the damage done by the coronavirus to the olfactory system, and how long does it last? (fapesp.br)
We could investigate whether these animals exhibit alterations to their olfactory system when infected by the virus," Malnic said. (fapesp.br)
These results suggest that olfactory stimulation induce LFP oscillations both in the peripheral and central nervous systems and suggest the possibility of linkage of LFP oscillations in the brain to the oscillations in the peripheral olfactory system. (elsevierpure.com)
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. (duke.edu)
Tumours in the circulatory system, large intestine and liver were reported in mice exposed via the dietary route as well. (gc.ca)
The olfactory system of Triturus pyrrhogaster , changes morphologically and physiologically when the animals are kept either in a terrestrial or an aquatic environment [ 15 , 16 ]. (biomedcentral.com)
Northern blot analysis suggested that GRH1 and its murine homolog, Ghrl, were expressed in the developing central nervous system, olfactory epithelium, and pancreas. (clusterenergetico.org)

The role Sox2 plays for the development of the olfactory epithelium and neurogenesis within has, however, not been determined. (unimib.it)

By means of immunohistochemistry and double-labeling studies using transgenic mouse lines as well as Western blot analyses, it was demonstrated that the newly generated antibodies specifically recognized the receptor proteins. (jneurosci.org)
This interaction was confirmed in assays from super expressed proteins, through transfection of HEK293T cells with plasmids expressing PrPC and Stub1/CHIP, and from endogenous proteins assays, through mouse brain and olfactory epithelium sampling, corroborating the data from yeast-two-hybrid screen. (ufpr.br)

The segregation and near-exclusion of mutant cells from the nasal epithelium mirrored the behaviour of mutant cells in other developmental contexts, particularly the lens, suggesting that common primary defects may be responsible for diverse Pax6-related phenotypes. (ed.ac.uk)

The lab creates and employs transgenic mouse models of chronic nasal/sinus inflammation to support research in this area. (hopkinsmedicine.org)

Our lab uses multiple approaches, including molecular biology , mouse genetics, mouse behavior and electrophysiology, to study the function of these genes in pain and itch sensation. (hopkinsmedicine.org)
This is a large group of genes expressed only in the cell membranes of the olfactory epithelium. (fapesp.br)
In the mouse a repertoire of ~1100 odorant receptor genes has evolved to detect a very wide variety of chemical structures in the external environment. (mpg.de)
FANTOM5 extends the third and fourth FANTOM atlases by including 4,721 human and 5,127 mouse genes, focusing on primary cells, cell lines and tissues, but that's not all: "The atlas also detected signals from the promoters of short RNA primary transcripts, and long non-coding RNAs . (evolutionnews.org)

There was a significant amount of radioactivity in nasal epithelium and the olfactory lobe of the brain. (europa.eu)

The Sox2-deficient olfactory epithelium displays diminished cell cycle progression and proliferation, a dramatic increase in apoptosis and finally olfactory pit atrophy. (unimib.it)

In the single non-pregnant female, the sites of localization were identical in the adult tissues: brain, nasal epithelium, bone, and renal and hepatic elimination are seen. (europa.eu)

In situ hybridization showed that GRH1 was expressed in the intermediate zone of the developing mouse cerebellum, and heterologous antisense probes hybridized to this region. (clusterenergetico.org)

Diverse techniques in molecular biology , immunology, and physiology are utilized to study epithelial cell innate immunity, olfactory loss, and response to viral infection. (hopkinsmedicine.org)

In this study (design comparable to OECD Guideline 451 without clinical pathology), groups of 50 male and 50 female B6C3F1 mice were exposed by whole body inhalation to alpha-methylstyrene at concentrations of 0, 100, 300 or 600 ppm for 6 hrs per day and 5 days per week (except holidays) for 105 weeks. (europa.eu)
Toxicology studies of cobalt sulfate heptahydrate (99% pure) were conducted by exposing groups of F344/N rats and B6C3F1 mice of each sex to a cobalt sulfate heptahydrate aerosol 6 hours per day, 5 days per week, for 16 days or 13 weeks. (nih.gov)
In a 13-week gavage study, B6C3F1 mice (20 per sex per dose) received MCA (as an acid in deionized water) at doses of 0, 25, 50, 100, 150 or 200 mg/ kg bw per day, 5 days per week. (canada.ca)

In a behavioral psychophysical task, mice were trained to sample from an odor port and make a response when they detected an odorant against a background of room air. (rutgers.edu)

incidences of olfactory epithelial necrosis were also significantly greater in females in the 60 and 120 mg/kg groups than in the vehicle controls on day 32. (nih.gov)

Adult female C57B6 mice were exposed to iron-soot combustion particles at a concentration of 200 µg/m3, which included 40 µg/m3 of iron oxide nanoparticles. (cdc.gov)

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. (duke.edu)

Pax6(-/-) cells in the retinal pigment epithelium could express Trp2, a component of the pigmentation pathway, at E14.5 and a small number went on to differentiate and produce pigment at E16.5. (ed.ac.uk)
Experiments with cultured cells and animal models may also be conducted to understand how the virus acts on the olfactory epithelium. (fapesp.br)
A mouse strain has been genetically modified to express human ACE-2, the protein used by the virus to invade cells. (fapesp.br)
lung Clara cells and nasal olfactory cells (Cruzan et al . (cdc.gov)
α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing. (uni-saarland.de)
The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. (uni-saarland.de)
Intracellular injection of vital dyes into single cells in the salamander olfactory epithelium. (nih.gov)
The latter focused on immature OSN's preferential stimulation of mitral versus tufted cells in the OB, as well as analyzing their activation of specific regions of the olfactory cortex using two-photon microscopy. (kozailab.com)
Various types of receptor cells are present, either segregated in different compartments (e.g. in rodents) or mingled in one epithelium (e.g. fish). (biomedcentral.com)
In the lack of or disturbance with MHC I-CD8 connections the regulatory actions of nTregs had been altered not merely leading to the increased loss of suppression however in their transformation to pathogenic IL-13-making Compact disc4+ T effector cells improving lung allergic replies in receiver mice (5). (siamtech.net)
mice could be achieved by reconstituting CD8+ T cells in deficient hosts suggesting that practical plasticity was still possible after thymic development differentiation and emigration. (siamtech.net)
The sense of smell is mediated through stimulation of the olfactory receptor cells by volatile chemicals. (medscape.com)

The distribution of 14C-test substance was studied in female and 14.5-day-pregnant mice by whole-body autoradiography after administrating 6.5-6.7 mg test substance/kg bw (11-14 uCi/mouse) by oral intubation. (europa.eu)

was subsequently clearly documented by means of genetically manipulated mice that generated a bicistronic mRNA encoding the OR as well as a marker protein. (jneurosci.org)
We have investigated the role of the alternative-splicing factor Sfrs1, an arginine/serine-rich (SR)protein family member, during mouse retinal development. (biologists.com)
In the olfactory bulbs, afferents from the olfactory epithelium could be quantified by their expression of a genetically-encoded fluorescent marker for olfactory marker protein. (rutgers.edu)

Constant flow from the olfactory glands allows old odors to be constantly washed away. (wikipedia.org)

Recent brain connectome studies have evidenced distinct and overlapping brain regions involved in processing olfactory perception. (elsevierpure.com)

Fish olfactory epithelium also contains ciliated and microvillous OSNs [ 2 ], but here both cell types are intermingled in one olfactory epithelium since fish do not have a VNO. (biomedcentral.com)

Complex interactions are now emerging between the main and accessory olfactory systems, both at anatomical and at functional level. (frontiersin.org)
We report here the development and functional characterization of 29nM-affinity mouse SARS-CoV-2 mAbs created by an accelerated immunization and hybridoma screening process. (cdc.gov)

in an inhalation study and only equivocal evidence of metabolism to SO is below the limit of detection in nearly all samples, and the most active sample of lung lung tumors in two of four chronic toxicity/oncogenicity was approximately 100-fold less active than mouse studies by gavage in mice (reviewed in Cruzan et al . (cdc.gov)

Hence, changes in olfactory perception might be involved in unhealthy eating and potentially lead to weight gain. (frontiersin.org)
Furthermore, the bottom-up and top-down processing of olfactory perception have not been well-documented, resulting in difficulty in locating the disease foci of olfactory disorder patients. (elsevierpure.com)

In female mice only, absolute and relative liver weights were significantly increased at the highest dose. (canada.ca)
mice developed severe liver toxicity, which probably tio is less than 1, while in mouse liver the ratio is about contributed to the cause of death. (cdc.gov)

A questionnaire will be used to monitor health workers at Hospital das Clínicas, the general hospital run by the University of São Paulo's Medical School (FM-USP), for the presence of well-established symptoms such as fever, cough and difficulty breathing, as well as olfactory alterations. (fapesp.br)

Anatomy16

Organisms3

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Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology2

Phenomena and Processes4

Disciplines and Occupations1

Health Care1

Mucosa6

Neurons24

Sensory epithelium4

Main olfactory5

Bulb6

Receptors6

Present in the olfactory1

Epithelial cells1

Nasal cavity3

Degeneration2

Tissue6

Reach the olfactory1

Neural11

Immunocytochemistry1

Implies that olfactory2

Basal lamina1

Rats and mice8

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Molecular biology1

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Alterations1