No activity of T cell, B cell and NK cell Reduced complement system activity Dysfunction of macrophage Dysfunction of dendritic cell No leakiness: no incidence of T, B cells with aging No incidence of lymphoma NOG mouse has multiple immunodeficiencies that are principally derived from three strains of mice: 1) NOD/Shi inbred strain, 2) SCID, 3) IL-2Rγnull. (wikipedia.org)
Pathobiology of aging mice and GEM: background strains and experimental design. (jax.org)
HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
Common laboratory inbred mouse strains such as BALB/c and C57Bl6/J form the backbone of much of our pre-clinical work. (ncard.org.au)
Immunodeficient mouse strains are invaluable when assessing the role of immune cell subsets in anti‑tumour immunity. (ncard.org.au)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
BALB7
BALB/cJ : a commonly used inbred mouse stain. (ncard.org.au)
BALB/c based mouse model in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Treg) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. (ncard.org.au)
These animals carry the severe combined immune deficiency mutation ( scid ) on the BALB/c background. (ncard.org.au)
These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)
Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
Mutation6
Lack of functional T and B cells that is derived from a mutation of protein kinase (Prkdc: protein kinase, DNA activated, catalytic polypeptide), which is the causative gene of the scid mutation Lack of NK cells, dendritic cell dysfunctions, and other unknown deficiencies due to inactivation of the IL-2Rγ gene. (wikipedia.org)
Mice homozygous for the Rag1 tm1Mom mutation produce no mature T cells or B cells. (ncard.org.au)
Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironmentsevere combined immune deficient phenotype on Non obese diabetic genetic background. (ncard.org.au)
The beige (Lyst bg) mutation was backcrossed seven generations (N7) to a C.B.17 scid spontaneous mutant background from the Ontario Cancer Institute. (vivobio.com)
The NOD scid Spontaneous mutant model was developed by the Fox Chase Cancer Center by transferring the scid mutation from a C.B-17 congenic background to a diabetes-susceptible non-obese diabetic background. (vivobio.com)
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. (uchicago.edu)
Spontaneous mutant3
The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
Taconic received the NCr nude Spontaneous mutant model from NCI in 1993 after several years of random breeding. (vivobio.com)
The scid-beige Spontaneous mutant model was developed by Dr. Anne Croy et al of the University of Guelph in April 1993 by intercrossing C.B-17 from R. A. Phillips to C57BL/6-bg from the Jackson Laboratory. (vivobio.com)
Nomenclature1
1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
20021
The mice were derived by embryo transfer in 2002 by Taconic US. (vivobio.com)
Immunodeficient3
A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA) in 2000. (wikipedia.org)
The NOG mouse accepts heterologous cells much more easily compared with any other type of immunodeficient rodent models, such as nude mouse and NOD/scid mouse. (wikipedia.org)
NCARD uses a variety of immunodeficient mice, which are mostly sourced from commercial vendors. (ncard.org.au)
Lack1
homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. (ncard.org.au)
Genetic1
Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
Jackson Laboratory1
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
Transgenic3
CD8 TCR transgenic mouse whose CD8 T cells predominantly recognise the MHC class I (H-2K d ) restricted CL4 epitope of PR8 influenza HA protein. (ncard.org.au)
CD4 TCR transgenic mouse whose CD4 T cells predominantly recognise the MHC class II (I‑A d )‑restricted TCR specific for the PR8 influenza HA peptide 126-138 (HNTngvtaacshe) ( PMID: 7889402 ). (ncard.org.au)
Cell populations derived from these transgenic mice can be distinguished from syngeneic host and other mice with the alternate allele via flow cytometry. (ncard.org.au)
Severe1
severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). (ncard.org.au)
Autoimmune1
as autoimmune non-obese-type diabetes mice. (wikipedia.org)
Model3
Asbestos induced mesothelioma mouse model in which expression of the Simian Virus 40 large T antigen (SV40 TAg) is controlled by mesothelin tissue‑specific promoter. (ncard.org.au)
The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY. (uchicago.edu)
Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. (uchicago.edu)
Cells1
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Stock1
JAX stock No# 002216 or C57BL/6J isogenic Rag1 knock-out strain is also available as Stock No. 034159 . (ncard.org.au)
Develop1
Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
Cross1
The NOG mouse was generated in CIEA in 2000 by back-cross mating of C57BL/6J-IL-2Rγnull mouse that was originally developed by Kazuo Sugamura, a professor of Tohoku University, to NOD/Shi-scid mouse that was developed in CIEA. (wikipedia.org)
Function1
Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse. (uchicago.edu)
Shows1
This graph shows the total number of publications written about "Mice, Inbred mdx" by people in this website by year, and whether "Mice, Inbred mdx" was a major or minor topic of these publications. (uchicago.edu)
Research3
Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)
These mice form the basis of the MexTAg research program . (ncard.org.au)
Initially sought as pets, the Granby mice become important in research. (jax.org)
Cancer2
Cancer Infectious Diseases Regenerative Medicine Hematology Humanized mouse Nude mouse SCID mouse M. Ito and, et al. (wikipedia.org)
Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)