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Multiple MyelomaDinitrophenolsAntibody FormationMyeloma ProteinsPlasmacytomaAntibodiesAntibody SpecificityAntibodies, MonoclonalHybridomasAutoantibodiesImmunoglobulin GHybrid CellsAntigen-Antibody ReactionsMice, Inbred BALB CBinding Sites, AntibodyImmunoglobulin gamma-ChainsEpitopesImmunoglobulin MImmunoglobulin Light ChainsFluorescent Antibody TechniqueCell LineImmunoglobulin Heavy ChainsCross ReactionsHemolytic Plaque TechniqueNeoplasms, ExperimentalAntibodies, BacterialAntibodies, NeoplasmAntibodies, ViralImmunoglobulinsEnzyme-Linked Immunosorbent AssayAntigensIsoantibodiesgamma-GlobulinsSpleenAntigen-Antibody ComplexHaptensParietal Cells, GastricInsulin AntibodiesAntigens, SurfaceRabbitsTumor Cells, CulturedAntigens, NeoplasmClone CellsAntibody-Producing CellsMolecular WeightImmunoglobulin Variable RegionErythrocytesB-LymphocytesBoronic AcidsPlasma CellsAntibodies, NeutralizingPyrazinesGlutamate DecarboxylaseAntibodies, Anti-IdiotypicAntibodies, AntinuclearImmunizationDinitrobenzenesElectrophoresis, Polyacrylamide GelImmunoglobulin kappa-ChainsHemagglutination TestsAnemia, PerniciousRadiation EffectsT-LymphocytesRh-Hr Blood-Group SystemImmunoglobulin FragmentsRadioimmunoassayDiabetes Mellitus, Type 1Molecular Sequence DataAntibody AffinityFicollBase SequenceBone MarrowCells, CulturedImmunoglobulin ANucleic Acid HybridizationIslets of LangerhansGastritis, AtrophicAntibodies, HeterophileTrinitrobenzenesKineticsLymphocytesNeutralization TestsIntrinsic FactorCell Line, TumorHemocyaninImmune SeraGeeseAutoantigensImmunoenzyme TechniquesAchlorhydriaHypersensitivity, DelayedMice, Inbred StrainsLupus Erythematosus, SystemicFlow CytometryPassive Cutaneous AnaphylaxisVasculitisThalidomideTime FactorsSyndecan-1Interleukin-6
ProteinsExpressionIncreaseActivityReleaseLiterature
Proteins4
  • Heat shock proteins (HSP) are a family of proteins produced by cells in response to exposure to stressful conditions. (wikipedia.org)
  • Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. (wikipedia.org)
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. (justia.com)
Expression3
  • 18:217-242), the β-chemokines regulate the expression of adhesion molecules on endothelial cells and thereby indirectly affect diapedesis and extravasation of immune cells from the circulation into tissues. (justia.com)
  • We observed that all AECs were depending on the presence of the antibody target, that the level of T-cell activation correlated with expression levels of the antibody target, and that our AECs could efficiently deliver the BRLF1 epitope to cancer cell lines from different origins (breast, ovarian, lung, and cervical cancer and a multiple myeloma). (bvsalud.org)
  • All three conjugates were capable of T-cell activation and target-cell killing via proteolytic release of the EBV epitope and expression of the antibody target was a requirement for T-cell activation. (bvsalud.org)
Increase1
  • Nevertheless, many aspects of these antibody conjugates require optimization to increase their efficacy. (bvsalud.org)
Activity2
  • Human MCP-1, MCP-2 and MCP-3 all have chemotactic activity for a variety of cell types, including T lymphocytes and monocytes (Van Coillie et al. (justia.com)
  • Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. (bvsalud.org)
Release2
  • Other shared functions of MCP-1, MCP-2, and MCP-3 include induction of N-acetyl β-D-glucosaminidase release, gelatinase B release, and granzyme A release which are believed to help the cells digest the extracellular matrix components necessary to enable them to migrate into tissues (Van Coillie et al. (justia.com)
  • These so-called antibody-epitope conjugates (AECs) rely on the proteolytic release of the epitopes close to the tumor surface for presentation by HLA class I molecules to eventually redirect and activate virus-specific CD8+ T-cells towards tumor cells. (bvsalud.org)
Literature2
  • MCP-1-specific antibodies have previously been described in the literature (WO 01/89582, WO 01/89565, Luo et al. (justia.com)
  • We also observed variable cell lysis between IgG1 and IgG3, with IgG3 being superior in lysis of human RBCs and Ramos cells, and IgG1 being superior in lysis of Raji and Wien133 cells, demonstrating that a long-standing conundrum in the literature depends on cellular context. (bvsalud.org)