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  • bone marrow
  • We developed preclinical models of bone marrow transplantation (BMT) for MM using Vk*MYC myeloma-bearing recipient mice and donor mice that were myeloma naive or myeloma experienced to simulate autologous transplantation. (edu.au)
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. (wikipedia.org)
  • Edelfosine and other ALPs can be used for purging residual leukemic cells from bone marrow transplants. (wikipedia.org)
  • It has been shown that miR-181 is preferentially expressed in the B-lymphoid cells of mouse bone marrow, but also in the retina and brain. (wikipedia.org)
  • human
  • Autoantibodies to insulin have predictive value in both NOD and human T1DM ( 5 , 7 ), and insulin-specific T cells can transfer disease ( 8 ). (jimmunol.org)
  • Mature human mesothelin shares 60% amino acid identity with either mouse or rat mesothelin. (novusbio.com)
  • GMP-grade Recombinant Human Noggin Fc Chimera (Catalog # 3344-GMP) inhibits BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (rndsystems.com)
  • Over aa 19‑509, human mGluR5 is 98% aa identical to mouse, rat, and dog mGluR5. (novusbio.com)
  • Human NPY1R shares 94% and 93% aa sequence identity with mouse and rat NPY1R, respectively. (novusbio.com)
  • Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. (novusbio.com)
  • Western blot shows lysates of T47D human breast cancer cell line. (novusbio.com)
  • Simple Western lane view shows lysates of T47D human breast cancer cell line, loaded at 0.2 mg/mL. (novusbio.com)
  • Here, we show that an endogenous splice variant, VEGF 165 b, is expressed as protein in normal cells and tissues and is circulating in human plasma. (aacrjournals.org)
  • The overall structure of QSulf is followed closely by its orthologues and paralogues, including human and mouse. (wikipedia.org)
  • In addition, a paralogue, Sulf2, sharing 63-65% identity (both mouse and human) with Sulf1 also was discovered through BLAST sequence analysis. (wikipedia.org)
  • The antitumor ether lipid Edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogenactivated protein kinases as potential targets" (PDF). (wikipedia.org)
  • CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. (wikipedia.org)
  • Expression of several stem cell markers, including c-Myc, is elevated in CD47-null endothelial cells and a human T cell line lacking CD47. (wikipedia.org)
  • The localization of individual m6A sites in many mRNAs is highly similar between human and mouse, and transcriptome-wide analysis reveals that m6A is found in regions of high evolutionary conservation. (wikipedia.org)
  • By integrating all m6A sequencing data, a novel database called RMBase has identified and provided ~200,000 N6-Methyladenosines (m6A) sites in the human and mouse genomes. (wikipedia.org)
  • inhibits
  • Exposing cells to aminopterin (a folic acid analogue, which inhibits dihydrofolate reductase, DHFR), makes them unable to use the de novo pathway and become fully auxotrophic for nucleic acids, thus requiring supplementation to survive. (wikipedia.org)
  • receptor
  • CD8+ T cells from mice with controlled myeloma had a distinct T cell receptor (TCR) repertoire and higher clonotype overlap relative to myeloma-free BMT recipients. (edu.au)
  • Interestingly, donor-derived IL-17A acted directly on myeloma cells expressing the IL-17 receptor to induce a transcriptional landscape that promoted tumor growth and immune escape. (edu.au)
  • Moreover, it prevents VEGF 165 -mediated VEGF receptor 2 phosphorylation and signaling in cultured cells. (aacrjournals.org)
  • Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer. (wikipedia.org)
  • This protein and its receptor are both found to be important for B cell development. (wikipedia.org)
  • CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells. (wikipedia.org)
  • The most common Fc receptor on the surface of an NK cell is called CD16 or FcγRIII. (wikipedia.org)
  • Once the Fc receptor binds to the Fc region of IgG, the Natural Killer cell releases cytotoxic factors that cause the death of the target cell. (wikipedia.org)
  • Gene
  • Miami Winter Symposia, Volume 16: From Gene to Protein: Information Transfer in Normal and Abnormal Cells presents the expression and processing of genetic information at the levels of both proteins and nucleic acids. (elsevier.com)
  • Analyses of the variable region of Ig H chain (V H ) and variable region κ L chain genes expressed by six insulin binding mAb show that V gene segments are often germline encoded and are identical with those used by autoantibodies, especially anti-dsDNA, from systemic autoimmune disease in MRL, NZB/W, and motheaten mice. (jimmunol.org)
  • These rearrangements result in increased expression of blood cell development genes by promoting gene transcription and through epigenetic changes. (wikipedia.org)
  • Gene amplication is typically performed using GS-transfected NS0 cells to select for producing cell lines. (wikipedia.org)
  • concentration
  • The greater resistance of HPC-108 cells to thymidine inhibition was related to the finding that they normally contained a much higher concentration of dCTP than did the WEHI-7 cells. (semanticscholar.org)
  • Do not allow the cell concentration to exceed 5 X 10(5) cells/ml. (atcc.org)
  • Maintain cultures at a cell concentration between 3 X 10(4) and 4 X 10(5) cells/ml. (atcc.org)
  • cultures
  • The apparatus was used in an investigation of cyclic changes in the incorporation of labelled precursors into the DNA, RNA, total protein and myeloma protein synthesized in synchronous cultures of a mouse myeloma line. (biochemj.org)
  • Start cultures at 2 X 10 exp5 cells/ml and maintain between 1 X 10 exp5 and 1 X 10 exp6 cells/ml. (atcc.org)
  • Alternatively, cultures can be established by centrifugation with subsequent resuspension at 1 to 2 X 10 exp5 viable cells/ml. (atcc.org)
  • Alternatively, cultures can be established by centrifugation with subsequent resuspension in fresh medium at 1 X 10 exp5 viable cells/ml. (atcc.org)
  • clinical
  • These data provide new insights into the mechanisms of action of transplantation in myeloma and provide rational approaches to improving clinical outcomes. (edu.au)