• The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
  • The introduction of foreign genetic material into mouse genomes by microinjection is an important tool in studying the properties and effects of many genes in vivo. (tubitak.gov.tr)
  • HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. (microbiologyresearch.org)
  • These findings demonstrate that liver-specific CR-1 overexpression in transgenic mice deregulates signaling pathways and genes associated with HCC. (aging-us.com)
  • at the 1986 ISIR-TNO Annual Meeting, September 7-12, 1986, reported the production of transgenic mice carrying mouse interferon beta or gamma genes coupled to the mouse MT-I or heat shock promoters. (justia.com)
  • Gordon and Ruddle, Science, 214:1244 (1981) claimed integration and stable germline transmission of genes injected into mouse pronuclei. (justia.com)
  • Transgenic mice are mice that have had genes from other animals introduced into their cells. (yournewsinshiocton.com)
  • Transgenic mice are mice that have had genes from another species inserted into their DNA. (yournewsinshiocton.com)
  • It retains the native mouse constant region encoding genes while incorporating human variable gene repertoires at the endogenous loci. (gempharmatech.us)
  • NeoMab™ mice utilize human V(D)J genes to encode antibodies, exhibiting gene usage frequency and sequence diversity that closely resemble those of humans. (gempharmatech.us)
  • Genetically modified mice are commonly used for research or as animal models of human diseases, and are also used for research on genes. (wikipedia.org)
  • In 1974 Beatrice Mintz and Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. (wikipedia.org)
  • This method creates a transgenic mouse and is used to insert new genetic information into the mouse genome or to over-express endogenous genes. (wikipedia.org)
  • A humanised mouse can also be created by direct addition of human genes, thereby creating a murine form of human-animal hybrid. (wikipedia.org)
  • For example, genetically modified mice may be born with human leukocyte antigen genes in order to provide a more realistic environment when introducing human white blood cells into them in order to study immune system responses. (wikipedia.org)
  • Mice are a useful model for genetic manipulation and research, as their tissues and organs are similar to that of a human and they carry virtually all the same genes that operate in humans. (wikipedia.org)
  • The most common type is the knockout mouse, where the activity of a single (or in some cases multiple) genes are removed. (wikipedia.org)
  • Transgenic mice generated to carry cloned oncogenes and knockout mice lacking tumor suppressing genes have provided good models for human cancer. (wikipedia.org)
  • 2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)
  • When introduced into mouse brain, the human a-synuclein gene causes the same pathology as in Parkinson's disease patients, ultimately leading to severe movement disorder and death of the experimental animals. (michaeljfox.org)
  • In the present project, we will take advantage of our transgenic pre-clinical model of Parkinson's disease pathology to test experimental drugs. (michaeljfox.org)
  • These results suggest that the slow progression and lack of full-fledged Alzheimer's disease pathology in the hippocampal neurons of APP Sw mice result from the genetic reprogramming of neural cells to cope with increased levels of Aβ. (jneurosci.org)
  • Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice. (medscape.com)
  • CR-1 over-expression significantly increased in vivo xenograft tumor growth of HCC cells in nude mice and in vitro HCC cell proliferation, migration, and invasion. (aging-us.com)
  • Results: We examined R6/1 mice at 18-19 weeks of age using in vivo microdialysis. (lu.se)
  • Through a series of knockout experiments in mice in which one or several of the TR isoforms were deleted, it has been demonstrated that the TR-beta isoforms control central regulation of thyroid-stimulating hormone. (nih.gov)
  • Further, with advances in conditional knockout technologies, otherwise embryonically lethal gene changes can be incorporated leading to the development of new generation transgenics, thus adding significantly to our existing knowledge base. (edu.au)
  • The key difference between transgenic and gene targeted (knockout or knockin) animals is that in knockout and knockin models the genomic changes are targeted, meaning a desired DNA sequence is altered at a specific locus in the target genome via homologous recombination, with an engineered segment of DNA replacing a homologous endogenous segment. (cyagen.com)
  • Gene expression profiles in the hippocampus and cerebellum of 6-month-old APP Sw mice were compared with age-matched controls. (jneurosci.org)
  • In addition, the increased expression of transthyretin and insulin-like growth factor-2 and the increased phosphorylation of Bad in hippocampal neurons were maintained in 12-month-old APP Sw mice when compared with age-matched controls. (jneurosci.org)
  • Therefore, we were interested in early gene expression changes that might mediate neuroprotection in these mice. (jneurosci.org)
  • Thus the present study was designed to determine gene expression profiles in the hippocampus and cerebellum of 6-month-old APP Sw mice compared with age-matched controls and to identify potential mechanisms responsible for protecting neurons from Aβ toxicity. (jneurosci.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
  • These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)
  • This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. (iiarjournals.org)
  • Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). (iiarjournals.org)
  • Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. (microbiologyresearch.org)
  • Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. (microbiologyresearch.org)
  • Dr. Greg Enders developed TetOp16 transgenic mice which would allow for cell, tissue or organ-specific expression of p16INK4a, thereby allowing a broad control of cell proliferation in mice. (foxchase.org)
  • TetOp16 transgenic mice allow for the inducible expression of p16INK4a. (foxchase.org)
  • p16 expression can be induced in a regulated fashion in the doubly transgenic mice by administering antibiotic doxycycline or tetracycline. (foxchase.org)
  • TetOp16 transgenic mice offer a way to selectively manipulate cell proliferation by allowing for temporal and spatial regulation of p16INK4a expression. (foxchase.org)
  • Hepatocyte-specific over-expression of CR-1 in transgenic mice enhanced hepatocyte proliferation after 2/3 partial hepatectomy (2/3 PHx). (aging-us.com)
  • To examine the physiological consequences of GRF expression, we have established strains of transgenic mice containing a fusion gene including the promoter/regulatory region of the mouse metal-lothionein-I (MT-I) gene 13 and the coding region of the human GRF gene 12 . (northwestern.edu)
  • We report that expression of the human GRF precursor protein in these animals results in measurable levels of human GRF and increased levels of mouse growth hormone in plasma and accelerated growth rates relative to control littermates. (northwestern.edu)
  • Unexpectedly, for all stably-transmitting lines examined, MATR3 transgenic mRNA expression was more robust in muscle, with minimal expression in spinal cord. (biomedcentral.com)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • ADMA content and DDAH expression were also visualized in mouse lung tissue by immunohistochemistry. (cdc.gov)
  • There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
  • Materials and methods approach to regulate transgenic expression. (lu.se)
  • Figure 2: Distribution of CAG repeats before and after the major GeneScan peak for various tissues from Msh2 -/- and Msh2 +/+ mice. (nature.com)
  • Figure 3: Levels of CAG repeat instability in various tissues from Msh2 -/- , Msh2 +/- and Msh2 +/+ mice. (nature.com)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • To study the consequences of sustained exposure to Ex-4, we generated metallothionein promoter-exendin-4 (MT-Exendin) mice that continuously express a proexendin-4 transgene in multiple murine tissues. (diabetesjournals.org)
  • One potential way to treat Alzheimer's is through the use of transgenic mice. (yournewsinshiocton.com)
  • Recently, researchers at the University of California, Davis used transgenic mice to study how a gene called APOE influences Alzheimer's Disease. (yournewsinshiocton.com)
  • The team found that deleting the APOE gene reduced the severity of Alzheimer's Disease in mouse models. (yournewsinshiocton.com)
  • Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP Sw ), resulting in high β-amyloid (Aβ) levels in the brain. (jneurosci.org)
  • A Transgenic Mouse Model with Human Growth Hormone" by Benan DİNÇTÜRK, Abdullah TÜRKMENLER et al. (tubitak.gov.tr)
  • The objective of this research was the optimization of transgenic manipulation in the laboratory, by the production of model mice harbouring human growth hormone, and thwe identification of the transgenic mice. (tubitak.gov.tr)
  • Mice overexpressing human α-synuclein under the control of the oligodendrocyte specific proteolipid promoter (PLP-α-syn) display aged-dependent progressive neurodegeneration and have been extensively used in the past to assess MSA-related alterations ( 16 - 19 ). (frontiersin.org)
  • Relevant mouse models of human uveal melanoma still remain to be developed. (molvis.org)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
  • Aim of the second part of this doctoral thesis was to investigate Dsg3-specific cellular and humoral immune responses in a novel human leukocyte antigen (HLA)-DRB1*04:02-transgenic (tg) mouse model of PV under the genetic restriction by HLA-DRB1*04:02. (uni-marburg.de)
  • In summary, this experimental study convincingly confirmed that the PV mouse model reproduces the principle mechanisms of HLA-dependent and human Dsg3-specific induction of CD4+ T and B cell responses observed in PV patients. (uni-marburg.de)
  • In these transgenic mice, the nucleic acid sequence encoding human p16INK4a has been linked to an inducible promoter or an operon capable of activation by the reverse tetracycline-controlled transactivator (rtTA), mediating p16 transcription. (foxchase.org)
  • Unexpectedly, female transgenic mice carrying the MT-GRF fusion gene are fertile, in contrast to female transgenic mice expressing human or rat growth hormone, which are generally infertile. (northwestern.edu)
  • These transgenic mouse strains should provide useful animal models for the study of several types of human growth disorders. (northwestern.edu)
  • A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. (justia.com)
  • Preferably, the human beta interferon gene is introduced into the cells of a mouse. (justia.com)
  • To begin to understand how mutations in MATR3 may cause disease, here we provide initial characterization of transgenic (Tg) mice expressing human wild-type (WT) MATR3 (MATR3 WT ) and ALS-mutant F115C MATR3 (MATR3 F115C ) proteins under the control of the mouse prion promoter (MoPrP). (biomedcentral.com)
  • To readdress this question by rigorous quantitative methods, we analyzed transgenic mice expressing human beta-CTF with the I45F mutation (SPA4CT) under control of the prion protein promoter by stereological techniques. (amsterdamumc.org)
  • Although there has been no cure found within the past decade, researchers are beginning to focus on a new treatment: transgenic mice with human beta-amyloid plaques in their brains. (yournewsinshiocton.com)
  • This strategy results in a powerful model that combines the strengths of the mouse immune system with human-specific variable regions, making it ideal for advancing antibody discovery and research endeavors. (gempharmatech.us)
  • After immunization with human recombinant protein antigens, NeoMab™ mice display antigen-specific serum titers similar to BALB/c mice, reaching approximately 10 5 -10 6 after three immunizations. (gempharmatech.us)
  • Genetically modified mice are used extensively in research as models of human disease. (wikipedia.org)
  • Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)
  • Despite this, amyloid plaques do not develop until 12 months of age, and there is no neuronal loss in mice as old as 16 months. (jneurosci.org)
  • We demonstrate that the R6/2 transgenic mouse model expressing a short fragment of mutant HTT displays hypothalamic neuropathology with discrete loss of the neuronal populations expressing orexin, MCH, CART, and orexin at 12 weeks of age. (lu.se)
  • There was no effect of hypothalamic injections of QA on the neuronal populations expressing orexin, MCH, CART or oxytocin in neither HD mouse model. (lu.se)
  • Using patch clamp recording from CA1 pyramidal cells in hippocampal slices, we have identified robust changes to intrinsic neuronal excitability and action potential waveforms in 2 different Abeta overproducing mouse lines. (neurodegenerationresearch.eu)
  • The brain homogenates of three different tTA/TUL mice (no Dox) and three different tTA/TUL mice fed Dox chow for 7 days, along with non-transgenic brain homogenates and mice transgenic for only the TUL responder transgene were analyzed. (biomedcentral.com)
  • For each construct, we established multiple independent lines of mice that stably transmitted the transgene. (biomedcentral.com)
  • However, the mice did not pass the transgene to their offspring, and the impact and applicability of this experiment were, therefore, limited. (wikipedia.org)
  • This includes free strategy design prior to your purchase, construction of transgenic or targeting vectors (including BAC recombineering), creating and characterizing targeted ES cells, microinjection of mouse or rat embryos, and breeding and genotyping of the resulting animals. (cyagen.com)
  • For enhancer testing in mouse embryos using the LacZ reporter, we also offer LacZ staining of embryos. (cyagen.com)
  • How many embryos are injected for transgenic production, and what is the success rate? (cyagen.com)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • 1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
  • NeoMab™ mice exhibit normal antibody class switching, somatic hypermutation, and B-cell development, with comparable levels of immunoglobulin in their serum to BALB/c background mice. (gempharmatech.us)
  • BRS was significantly changed in PLP-α-syn mice and was age-dependent. (frontiersin.org)
  • QT and QTc intervals were not significantly modified in PLP-α-syn mice. (frontiersin.org)
  • The levels of transgenic mRNA in muscle did not differ between mice from our lead MATR3 F115C line and lead MATR3 WT line, but mice from the lead MATR3 F115C line had significantly higher levels of MATR3 protein in muscle over the lead MATR3 WT line. (biomedcentral.com)
  • Intrastriatal infusion of both KCl and amphetamine rapidly increased the extracellular levels of DA in the dialysates in both R6/1 and wild-type mice, but the increase was significantly greater in the wild-type animals. (lu.se)
  • The striatal tissue levels of DA were significantly decreased in R6/1 mice as compared with their wild-type littermate controls. (lu.se)
  • CS-mediated lung inflammation was significantly attenuated in DDAH transgenic mice compared to in wild-type controls. (cdc.gov)
  • Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. (nature.com)
  • There is substantial evidence that both inflammation and oxidative damage contribute to the pathogenesis of motor neuron degeneration in the G93A SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS). (karger.com)
  • The article discusses how these transgenic mice can help identify interactions between genetic mutations and brain inflammation. (yournewsinshiocton.com)
  • These findings demonstrated that lung ADMA metabolism was altered in mice following CS exposure and suggested that ADMA played a role in CS-mediated inflammation through increasing the presence of inflammatory mediators in lung epithelial cells. (cdc.gov)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • In particular, the transgenic mouse models based on multiple genetic alterations can more accurately address the inherent complexity of PC, not only in revealing the mechanisms of tumorigenesis and progression but also for clinically relevant evaluation of new therapies. (edu.au)
  • The NeoMab™ mouse is developed on the widely used BALB/c genetic background, making it highly suitable for antibody discovery in the industry. (gempharmatech.us)
  • A genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. (wikipedia.org)
  • In 1981 the laboratories of Frank Ruddle from Yale University, Frank Costantini and Elizabeth Lacy from Oxford, and Ralph L. Brinster and Richard Palmiter in collaboration from the University of Pennsylvania and the University of Washington injected purified DNA into a single-cell mouse embryo utilizing techniques developed by Brinster in the 1960s and 1970s, showing transmission of the genetic material to subsequent generations for the first time. (wikipedia.org)
  • Thus, this mouse model is a very useful tool in research studies of cancer, development, tissue renewal, aging, and a variety of chronic diseases that involve cell proliferation. (foxchase.org)
  • By contrast, in transgenic animals an engineered segment of DNA is randomly integrated, such that the inserted DNA could end up almost anywhere in the host genome, and does not normally disrupt the homologous endogenous sequence. (cyagen.com)
  • 20 months were not overtly distinguishable from non-transgenic (NT) littermates based on basic motor phenotype. (biomedcentral.com)
  • We also observed a significant and progressive reduction in the mRNA and protein levels of tyrosine hydroxylase (TH) in R6/1 mice compared to their wild-type littermates. (lu.se)
  • In one of the resulting transgenic lines, called GIN ( G FP-expressing I nhibitory N eurons), EGFP was found to be expressed in a subpopulation of somatostatin-containing GABAergic interneurons in the hippocampus and neocortex. (jneurosci.org)
  • Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
  • In recent years, work with such mice, by ourselves and others has begun to reveal significant disturbances to synchronous network activity in the cortex and hippocampus, brain structures with crucial roles in cognitive function. (neurodegenerationresearch.eu)
  • Neurodegeneration was evaluated by investigating the numbers of hippocampal pyramidal and granule neurons, as well as the number of synaptophysin-immunopositive presynaptic boutons in the hippocampus of 15-month-old SPA4CT mice with design-based stereological techniques. (amsterdamumc.org)
  • Brain atypical proteinase K-resistant prion protein (PrP res ) of porcine PrP transgenic mice infected with an atypical scrapie (SC-PS152) agent (lane 4) versus sheep bovine spongiform encephalopathy (Sheep-BSE) agent (lane 2). (cdc.gov)
  • This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
  • This article reviews the history of BCR/ABL-expressing CML mouse models and the recent findings in the transgenic mice with the CML-phenotype. (eurekaselect.com)
  • How does Cyagen house its mice? (cyagen.com)
  • If you are interested in transgenic mice, do not hesitate to search Cyagen for more information. (yournewsinshiocton.com)
  • For this purpose, a transgenic mouse line expressing a green fluorecescent protein (GFP) under the control of the GAD65 (GAD: glutamate decarboxilase enzyme involved in the synthesis of GABA) promoter will be used. (europa.eu)
  • Our invention relates to the introduction of the interferon gene of another animal species into a host animal, and to the production of a healthy transgenic animal with enhanced viral resistance which it can genetically transmit to its offspring. (justia.com)
  • Electrophoretic profiles and antibody labeling of PrP res detected with monoclonal antibodies Sha31 (A) or 12B2 (B). Profiles produced by atypical scrapie (SCPS152) (lane 3) and sheep-BSE (lane 1) before passage in the porcine mouse model are shown for comparison. (cdc.gov)
  • In this study, transgenic and nontransgenic control mice were generated from C57B6/SJL N2 generation Tg2576 mice backcrossed to C57B6/SJL breeders. (jneurosci.org)
  • We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
  • NF-kappaB binding activity in mouse lung epithelial (LA-4) cells was assessed by a transcription factor-binding assay. (cdc.gov)
  • When beneficial effects on the life span and locomotor behavior are observed for a given drug, the mechanism of action will be elucidated by histological and biochemical analysis of the transgenic mouse brains. (michaeljfox.org)
  • In this study we used a lentiviral vector that drives transgenic populations (BloÈmer et al. (lu.se)
  • To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
  • Transgenic mouse technology enables the study of gene regulation, embryology and development. (tubitak.gov.tr)
  • This study was carried out in 6 and 12 months old transgenic PLP-α-syn and WT male and female mice. (frontiersin.org)
  • In the present study, we wanted to examine whether transgenic HD mice display altered sensitivity to excitotoxicity in the hypothalamus. (lu.se)
  • In this study, we investigated the role of embryonic gene Cripto-1 (CR-1) in hepatocellular carcinoma (HCC) using hepatocyte-specific CR-1-overexpressing transgenic mice. (aging-us.com)
  • Transgenic mice can be used to study diseases in ways that would not be possible with regular mice. (yournewsinshiocton.com)
  • In this study, we have further characterized deficits in the regulation of the nigrostriatal dopaminergic pathway in R6/1 transgenic HD mice. (lu.se)
  • HSP70 immunoreactivity was increased in lumbar spinal cord neurons of celastrol-treated G93A mice. (karger.com)
  • Antibodies obtained from NeoMab™ mice demonstrate an affinity of approximately 10 -10 to 10 -8 (as determined by SPR detection), which is comparable to or even higher than that of FDA-approved therapeutic antibody drugs. (gempharmatech.us)
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
  • In both live and fixed brain preparations from these mice, detailed microanatomical features of EGFP-expressing interneurons were readily observed. (jneurosci.org)
  • In hippocampal area CA1, two previously uncharacterized subtypes of interneurons were identified using the GIN mice: stratum pyramidale interneurons with lacunosum-moleculare axon arborization (P-LM cells) and stratum radiatum interneurons with lacunosum-moleculare axon arborization (R-LM cells). (jneurosci.org)
  • Another mouse has had a gene altered that is involved in glucose metabolism and runs faster, lives longer, is more sexually active and eats more without getting fatter than the average mouse (see Metabolic supermice). (wikipedia.org)
  • These mice displayed a complete hypothyroid phenotype, demonstrating that the unliganded TR mediates the effect of hypothyroidism. (nih.gov)
  • February 12, 1987) observed inhibition of influenza virus in NIH 3T3 mouse cells genetically modified to express the mouse protein Mx. (justia.com)
  • There are two basic technical approaches to produce genetically modified mice. (wikipedia.org)
  • A mouse has been genetically engineered to have increased muscle growth and strength by overexpressing the insulin-like growth factor I (IGF-I) in differentiated muscle fibers. (wikipedia.org)
  • To date, The model mice using the BCR/ABL retroviral bone marrow transduction and transplantation method has provided the most valuable knowledge compared with the other two methods. (eurekaselect.com)
  • We first assessed effects of hypothalamic injections of the excitotoxin quinolinic acid (QA) into wild-type (WT) mice. (lu.se)
  • For these studies, wild-type and DDAH transgenic mice were sham or CS-exposed. (cdc.gov)
  • The formation of extracellular plaques is common to all lines of transgenic mice overexpressing high levels of mutant APP. (jneurosci.org)
  • This protein is one whose production is stimulated by mouse interferon. (justia.com)
  • After four years of research and validation, GemPharmatech's independently developed fully antibody gene humanized mouse model, NeoMab™, is officially entering the market to serve the therapeutic antibody development needs of biotechnology companies and pharmaceutical enterprises. (gempharmatech.us)
  • GemPharmatech exemplifies dedication in furnishing mouse models and support services for the advancement of disease mechanism research, pharmaceutical development, and translational studies. (gempharmatech.us)
  • The BACHD mouse model expressing full-length mutant HTT does not display any hypothalamic neuropathology at 2 months of age. (lu.se)
  • MT-Exendin mice generate antibodies directed against Ex-4, exendin NH 2 -terminal peptide (ENTP), and proexendin-4 as well as antibodies that cross-react with native GLP-1. (diabetesjournals.org)
  • Animal models, especially, transgenic immunocompetent mouse models, have proven to be the best ally in this respect. (edu.au)
  • We pride ourselves on our ability to supply specific-pathogen free mice to animal facilities around the world. (cyagen.com)
  • We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)
  • There are three methods for making chronic myelogenous leukemia (CML) mouse models: xenotransplantation of primary Ph-positive CML cells into immunodeficient mice, BCR/ABL-expressing transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. (eurekaselect.com)
  • Apparently, Kawade had not determined whether the chimeric gene was actually expressed in the mice, but had already been able to express it in cultured cells induced by Cd.sup.2+ or by heat. (justia.com)
  • Embryonic stem cells that recombine with the genomic DNA are selected for and they are then injected into the mice blastocysts. (wikipedia.org)
  • Figure 1: Typical GeneScan traces for sizing of the CAG repeat from heart and striatal tissue of Msh2 -/- and Msh2 +/+ mice. (nature.com)
  • TetOp16 mice can be mated to mice carrying rtTA transgenes in the tissue of interest. (foxchase.org)
  • Conclusions: Our results support earlier observations indicating that the dopaminergic nigrostriatal pathway is severely affected in R6/1 transgenic HD mice. (lu.se)
  • This invention relates to the production of virus-resistant transgenic animals. (justia.com)
  • All of these changes were absent in young animals, and their presence seems to parallel Abeta burden since they arise earlier in the more aggressive PSAPP double transgenic line. (neurodegenerationresearch.eu)
  • When such nucleases (or their DNA or mRNA precursors) designed to target a specific site in the mouse or rat genome are microinjected into fertilized eggs, cleavage at the target site followed by imperfect repair can result in small deletions (and insertions, more rarely) of one or more base pairs. (cyagen.com)
  • The first involves pronuclear injection, a technique developed and refined by Ralph L. Brinster in the 1960s and 1970s, into a single cell of the mouse embryo, where it will randomly integrate into the mouse genome. (wikipedia.org)