Mouse genetics. Medical search. Frequent questions

Researchers in genetics and genomics at Boston Children's Hospital and surrounding institutions can access broad array of specialized services, state-of-the-art equipment and expert guidance to expedite their projects. (childrenshospital.org)
Provided through the Kunkel Lab, the Bioinformatics Core provides the computing infrastructure to facilitate information exchange between the different genetics and genomics cores. (childrenshospital.org)
Join us and other colleagues at TAGC 2024 to present your work to a diverse gathering of scientists, discover new findings in genetics and genomics, get inspired by keynote speakers, and advocate for science on Capitol Hill. (mousephenotype.org)
Your degree and research area is bespoke to you, however, our supervisors can provide projects in many areas of current interest in genetics and genomics, ranging from fundamental questions in cell biology to variation and disease in humans. (nottingham.ac.uk)
In 2015, Hilda K. Roderick and her family established the Roderick Lecture Fund, an endowment to honor the late Dr. Thomas H. Roderick, his tremendous contributions to The Jackson Laboratory and his passion for education - particularly the annual McKusick Short Course on human and mammalian genetics and genomics. (jax.org)
She also teaches in Harvard's introductory Life Science course Genetics, Genomics and Evolution to approximately 400 freshmen each year, and has been awarded a Harvard College Professorship for teaching excellence. (jax.org)
We are using these mice as a model for testing novel drugs that could ameliorate drinking and we are exploring their use in informatics-driven genomics studies. (ohsu.edu)

Although genes do have some bearing on obesity risk, they are only one small element of a much wider picture so genetics-based advice alone has the propensity to do more harm than good, according a recent online conference hosted by the American Nutrition. (nutraingredients.com)
Studying the inter-relation between nutritional inputs and genetics has expanded quickly from five or 10 human genes to five or ten thousand or more. (nutraingredients.com)
It offers new options for linking genes and behavior and may change how scientists think about the similarity of their mouse strains. (sciencenews.org)
First came mice, and then recently the first primates got some jellyfish genes implanted into their DNA. (popsci.com)
In a study, researchers used 1,200 outbred mice, which are more similar to a natural population, to test a new cost-effective technique to search for specific genes linked with 66 different physical and behavioral traits. (sciencedaily.com)
Genome-wide association studies -- matching genes to diseases and other traits -- have been a big deal in human genetics for the past decade," said Abraham Palmer, PhD, professor of psychiatry at University of California San Diego School of Medicine. (sciencedaily.com)
Next, the team will engineer mice that specifically lack these genes to determine if the associations are truly causal and to better understand the underlying mechanisms. (sciencedaily.com)
the immune sera of these mice had their own, rather uniform isoelectric focusing spectra whereby structural genes of the low responder strain were expressed to predominant levels in 81% of the hybrids. (silverchair.com)
This mouse carries a trisomy for a large portion of the distal region of the long arm of mouse chromosome 16 that has 60% of all human chromosome 21 homologous genes in this species. (bvsalud.org)

These data are immediately shared among the scientific and medical research community through a bespoke open access database, and summaries are displayed in other online resources, including the Mouse Genome Informatics database and the Wikipedia-based Gene Wiki. (wikipedia.org)
A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. (nih.gov)
Their work utilizes early mouse development as well as various mouse and human stem cell paradigms to dissect basic molecular mechanisms including the role of DNA methylation and other epigenetic modifications in gene and genome regulation. (mpg.de)

Crabbe et al (1996) Nature Genetics 14:98. (ohsu.edu)

Creating Human Tissues to Test Drugs for Rare Diseases Skip the mice. (medscape.com)

Ectodermal dysplasias are a large group of rare genetic disorders characterized by impaired development of hair, teeth, and eccrine glands in humans, mice, and cattle. (gse-journal.org)
A team of researchers at the Max Planck Institute for Molecular Genetics and Charité - Universitätsmedizin Berlin led by human geneticists Malte Spielmann and Stefan Mundlos analyzed clinical samples from patients with genetic developmental disorders with the Hi-C method. (mpg.de)
In about half of the cases a genetic diagnosis is not possible, leaving the patient with the uncertainty of the origin of the problem", says Stefan Mundlos from the Max Planck Institute for Molecular Genetics and Charité - Universitätsmedizin Berlin. (mpg.de)
Population genetics studies the genetic variation that exists in wild populations, and the forces, such as selection, mutation and genetic drift, that shape this variation. (nottingham.ac.uk)
Genetic analysis showed that human and mouse LCMVs were identical and that this LCMV strain was highly divergent from previously characterized LCMV. (cdc.gov)
His lifetime body of research included the effects of radiation on genetic material, behavioral genetics and later bioinformatics, publishing widely in genetics and genealogy. (jax.org)
Our MPhil, MD and PhD in Genetics look at the causes of genetic disease. (ncl.ac.uk)
Other approaches include studies of multiple inbred strains of mice examining the basis for genetic correlations between susceptibilities to different effects of ethanol and different drugs of abuse. (ohsu.edu)
He explores genetic components of chronic metabolic diseases, such as cardiovascular disease and obesity, through integrative genetic studies, also called "systems genetics. (usda.gov)
Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice. (usda.gov)
Genetic basis for susceptibility to noise -induced hearing loss in mice. (cdc.gov)

Our results substantiate the use of a forward-genetics approach for studying sleep behaviours in mice, and demonstrate the role of SIK3 and NALCN in regulating the amount of NREMS and REMS, respectively. (nature.com)

Deficiencies in folic acid dating back up to five generations could have an impact on developmental risk factors and later risk of disease, according to new research in mice. (nutraingredients.com)
Both MN- and Dbx1-specific cadherin inactivation in mice during a critical developmental window results in perinatal lethality due to respiratory failure and a striking reduction in phrenic MN bursting activity. (elifesciences.org)
Developmental genetics of the mouse t-complex. (bvsalud.org)

For instance, a number of studies have used high dose daily treatment with probiotic strains of Lactobacillus to reduce MS-like disease in mice. (nutraingredients-usa.com)
A new study shows substantial differences in how two closely related mouse strains respond to drugs. (sciencenews.org)
Drying the samples, the authors say, does away with the need for cold storage, and they've since refined the method further so that they can store sperm from thousands of different mouse strains in a single three-ring binder. (the-scientist.com)
Offers a range of services to help investigators generate and maintain genetically modified mouse strains. (nationaljewish.org)
The C57BL/6J (B6) and DBA/2J (D2) inbred strains of mice exhibit an age-related hearing loss (AHL) due to a recessive gene (Ahl) that maps to Chromosome 10. (cdc.gov)
The present study demonstrates segregation for the putative Ahl gene and mapping of such a gene to Chromosome 10, consistent with other independent mapping of Ahl for AHL in 10 strains of mice [Johnson et al. (cdc.gov)
All of the available evidence supports a role for the Ahl gene in both AHL and NIHL among these strains of mice. (cdc.gov)
Probiotic strains detect and suppress cholera in mice. (cdc.gov)

In 2016, her primary appointment was transferred to Genetics. (unc.edu)

However, researchers from the University of Vermont (UVM) discovered that the common probiotic species Lactobacillus reuteri may actually increase multiple sclerosis (MS) severity -- at least in a mouse model. (nutraingredients-usa.com)
Researchers utilized the principal autoimmune model of MS, experimental autoimmune encephalomyelitis (EAE) to modulate the gut microbiomes of genetically diverse mice, interrogated by microbiome sequencing and targeted microbiome manipulation. (nutraingredients-usa.com)
To determine which features of these microbiomes conferred higher susceptibility to MS-like disease, the researchers isolated different bacterial species from the complex mix and transferred them to new mice, one at a time. (nutraingredients-usa.com)
While the findings suggest L. reuteri is bad in this particular situation, the researchers noted that this bacterium originally came from a genetically distinct mouse host that was normally resistant to MS-like disease. (nutraingredients-usa.com)
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery. (the-scientist.com)
ABOVE: By freeze-drying mouse sperm on weighing paper and sandwiching the paper between protective plastic sheets, researchers were able to successfully mail the samples between labs in Japan. (the-scientist.com)
Until now, sending mouse sperm to other researchers has required a freezing environment such as liquid nitrogen or dry ice. (the-scientist.com)
Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. (news-medical.net)

Methodology in Mammalian Genetics , Holden-Day, San Francisco. (springer.com)
Their new method, detailed in a study published today (August 5) in iScience , builds on the team's previous work , which involved sending dehydrated mouse sperm stored in glass ampoules to the International Space Station to study how radiation affects mammalian cells. (the-scientist.com)
During his career he co-directed the Annual Short Course on Medical and Experimental Mammalian Genetics. (jax.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Quantitative Genetics of Locomotor Performance and Physiology in House Mice (Mus domesticus), Ph.D. dissertation, University of Wisconsin-Madison. (springer.com)
Exercise physiology of wild and random-bred laboratory house mice and their reciprocal hybrids. (springer.com)

As the team led by human geneticists Stefan Mundlos and Malte Spielmann describe in the current issue of The American Journal of Human Genetics , a method from basic research could improve clinical diagnostics considerably at some point in the future. (mpg.de)

Gregor Mendel was an Austrian monk and botanist whose work with pea plants in the 19th century founded the field of genetics. (elifesciences.org)
The Expanding Field of Genetics in Pediatric Cardiology Marshall Summar talks with clinical geneticists Kim Chapman and Patroula Smpokou about how genetics are guiding therapy in pediatric heart disease. (medscape.com)

Suzuki, A., Sinton, C. M., Greene, R. W. & Yanagisawa, M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. (nature.com)
We are exploring the pharmacological characteristics of the neural circuitry underlying this drinking as well as the behavioral characteristics of these mice. (ohsu.edu)

However, the identity of gut microbes associated with disease risk, their mechanisms of action, and the interactions with host genetics remain unknown. (nutraingredients-usa.com)
Growing research suggests that the gut microbiome modulates risk of MS, but the specific bacterial species, and the role of host genetics, have yet to be determined. (nutraingredients-usa.com)
The findings further highlight the complex interactions between host genetics and environmental factors which drive susceptibility to multiple sclerosis, and suggest that antibiotic or probiotic strategies to prevent or treat multiple sclerosis should take into account host genetics, the pre-existing gut microbiome, and the timing or mode of the intervention. (nutraingredients-usa.com)
Host genetics and the gut microbiome can both influence metabolic phenotypes. (nih.gov)
We identified many microbial taxa whose abundances were influenced by host genetics. (nih.gov)
Our findings indicate that host genetics influence the composition of the human gut microbiome and can do so in ways that impact host metabolism. (nih.gov)

This further suggests that the genetics of the host will determine if a particular microbiome state is "good" or "bad. (nutraingredients-usa.com)
An obese-associated microbiome was amended with Christensenella minuta, a cultured member of the Christensenellaceae, and transplanted to germ-free mice. (nih.gov)
C. minuta amendment reduced weight gain and altered the microbiome of recipient mice. (nih.gov)

Quantitative genetics of sprint running speed and swimming endurance in laboratory house mice ( Mus domesticus ). (springer.com)

For each mutant line, groups of seven male and seven female mice move through a standard analysis pipeline aimed at detecting traits that differ from healthy C57BL/6 mice. (wikipedia.org)
For example, immune sera of BALB/c mice, restricted high responders, and of C57BL/6 mice, heterogeneous low responders, had distinct focusing properties. (silverchair.com)

The Allied Genetics Conference 2024 (TAGC 2024) connects scientists from multiple international biological research communities to share cutting-edge science, foster new collaborations, and strengthen existing relationships. (mousephenotype.org)

Here we report that activation of a humanized Npm1c knock-in allele in mouse hemopoietic stem cells causes Hox gene overexpression, enhanced self renewal and expanded myelopoiesis. (nature.com)
Muscle stem cells were removed from elderly mice and gene expression in those cells was altered in the same way. (labroots.com)
Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells. (ox.ac.uk)
To gain further insight into lncRNA-mRNA miRNA-mediated crosstalk, we reanalyzed transcriptome-wide changes induced by the targeted knockdown of over 100 lncRNA transcripts in mouse embryonic stem cells (mESCs). (ox.ac.uk)

W ith mouse models undergirding so much scientific research, scientists have a vested interest in developing techniques to safely store and transport sperm samples between labs. (the-scientist.com)
In search of a better option, a team of scientists in Japan recently sent mouse sperm that was freeze-dried onto simple weighing paper and stored between two plastic sheets by postcard roughly 200 kilometers, from Kyoto to Yamanashi, where the rehydrated sperm fertilized eggs and produced healthy baby mice. (the-scientist.com)

Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

Figure 1: Conditional mouse model of type A NPM1c mutation. (nature.com)

Yet genomic studies in mice have lagged behind those in humans. (sciencedaily.com)

Figure 2: Increased sleep need and normal wake-promoting response of Sik3 mutant mice. (nature.com)

Based at the Wellcome Trust Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium. (wikipedia.org)
Our research includes the use of knockout mice and zebrafish as laboratory models. (ncl.ac.uk)

Importantly, this model reproduces the susceptibility of aging, because compared to young mice, old mice display more severe clinical illness and succumb to disease more frequently. (lu.se)

The lister mouse uncovers a pathway involved in neurodegeneration and may serves as a model for understanding the molecular mechanisms underlying human neurodegenerative disorders. (nih.gov)
In 1968, Tom, together with local physicians Morris A. Lambdin and James H. Thaidigsman, and cytogeneticist Merrill C. Bunker, founded the Center for Human Genetics in Bar Harbor. (jax.org)
Mouse model for human arginase deficiency. (medlineplus.gov)
A Public Health Role for Human Genetics Two non-profit foundations with distinct missions recently announced that they are joining forces to support polio eradication. (cdc.gov)
One of the obvious advantages in the use of animal models, especially the mouse (Mus musculus), is our ability to perform scientific studies that are technically or ethically not permissible in human beings. (bvsalud.org)

Dr. Lisa Tarantino has been promoted to Full Professor in the Department of Genetics, effective July 1, 2021. (unc.edu)

Response to 30 generations of selection for open-field activity in laboratory mice. (springer.com)
Tom joined The Jackson Laboratory in Bar Harbor as a staff scientist in genetics where he remained for 37 years. (jax.org)
Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. (sciencedaily.com)

This is a collaboration between the Genetics and Metabolism Division of Children's National Health System in Washington D.C. and Medscape Rare Diseases. (medscape.com)
The Genetics and Metabolism Division is the largest of its kind in North America. (medscape.com)

Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)

One third of mice developed delayed-onset AML, suggesting a requirement for cooperating mutations. (nature.com)

This core provides genetically altered mice as well as expert assistance and training in generating and managing transgenic mouse colonies. (childrenshospital.org)
Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)

Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. (nih.gov)

We have also developed new lines of mice selectively bred for binge Drinking in the Dark as a part of the Integrative Neuroscience Initiative on Alcoholism (INIA-Neuroimmune) consortium. (ohsu.edu)

Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

June 14, 2022 A new study reveals that opioid analgesic fentanyl may induce autism-like behaviors in young male and female mice. (sciencedaily.com)

Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

Chow diet in mouse aging studies: Nothing regular about it. (usda.gov)

Genetics of 7,000-year-old skeleton suggests blond hair, pale skin came later. (sciencenews.org)

Mus musculus mice constitute the reservoir of LCMV in nature ( 1 ), but hamsters can also carry the virus. (cdc.gov)
Because M. musculus is the natural host of LCMV, the Public Health Office of Marseille organized a trapping campaign in the vicinity of the patient's house, which resulted in the capture of 20 mice ( M. musculus ) with glue traps. (cdc.gov)

They're not a model system like a mouse or zebrafish, and they don't cure any diseases like naked mole rats . (popsci.com)

LCMV infection was suspected on the basis of the clinical signs and a detailed interview of the mother, in which she indicated that "the house was invaded with mice. (cdc.gov)

The Mouse Genetics Project (MGP) is a large-scale mutant mouse production and phenotyping programme aimed at identifying new model organisms of disease. (wikipedia.org)
Circadian rhythms differ between selected mouse lines: A model to study the role of vasopressin neurons in the suprachiasmatic nuclei. (springer.com)
We are using a combination of electrophysiological and optogenetic techniques in a mouse model of SCI to evaluate the consequences of SCI and passive exercise training on rhythm generating neurons and their connections to downstream targets. (drexel.edu)
Using an established intranasal inhalation exposure model, wild-type (WT) and IL-6 knockout (KO) mice were treated daily with ODE or saline for 3 weeks. (cdc.gov)
This paper describes a novel mouse model that recreates the transition of pneumococci from asymptomatic carriage to disease upon viral infection. (lu.se)
In this model, mice are first intranasally inoculated with biofilm-grown pneumococci to establish asymptomatic carriage, followed by IAV infection of both the nasopharynx and lungs. (lu.se)
One mouse model in particular, the Ts65Dn, has been used preponderantly in the area of DS research. (bvsalud.org)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)

Newborn mice in which phrenic motor neurons lacked a specific combination of cadherins experienced respiratory failure, showing that these proteins were needed for breathing circuits to develop normally. (elifesciences.org)

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

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