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  • cells
  • A greater understanding of the similarities and differences between mouse and human preimplantation development has implications for improving assisted reproductive technologies and for deriving human embryonic stem cells. (jci.org)
  • The fertilized egg first undergoes a series of early cleavage divisions, producing increasing numbers of progressively smaller cells, known as blastomeres, without changing the overall size of the embryo (Figure 1 ). (jci.org)
  • viability
  • Therefore, this article shows only a few selected references to assess viability of diverse organisms such as plants, bacteria, mammalian oocytes, mouse embryos, and human tumor cells, In 1966, Rotman and Papermaster accidentally discovered fluorochromasia while studying intracellular enzymes using fluorogenic substrates. (wikipedia.org)
  • J. Boender (1984) Fluorescein‐diacetate, a fluorescent dye compound stain for rapid evaluation of the viability of mammalian oocytes prior to in vitro studies, Veterinary Quarterly, 6, 236-240 Linda R. Mohr and A. O. Trounson The use of fluorescein diacetate to assess embryo viability in the mouse. (wikipedia.org)
  • 1994
  • She has been a member of the National Advisory Council of the National Institute of Child Health and Human Development, Co-Chair for Science of the 1994 NIH Human Embryo Research Panel and a member of the 2001/2002 National Academies Panel on Scientific and Medical Aspects of Human Cloning. (wikipedia.org)
  • primordial
  • In early embryogenesis of most eutherian mammals, the inner cell mass (abbreviated ICM and also known as the embryoblast in mammals or pluriblast) is the mass of cells inside the primordial embryo that, once fertilized, will eventually give rise to the definitive structures of the fetus. (wikipedia.org)
  • citation needed] In the mouse, primordial germ cells (PGCs) arise in the posterior primitive streak of the embryo and start to migrate around 6.25 days after conception. (wikipedia.org)
  • early
  • There is variation between species of mammals as to number of cells at compaction with bovine embryos showing differences related to compaction as early as 9-15 cells and in rabbits not until after 32 cells. (wikipedia.org)
  • There is also interspecies variation in gene expression patterns in early embryos The ICM and the TE will generate distinctly different cell types as implantation starts and embryogenesis continues. (wikipedia.org)
  • At the transcription level, the transcription factors Oct4, Nanog, Cdx2, and Tead4 have all been implicated in establishing and reinforcing the specification of the ICM and the TE in early mouse embryos. (wikipedia.org)
  • genome
  • Zygotic genome activation correlates with the presence of polycomb repressive complexes in all three species, while ribosome biogenesis emerges as a predominant attribute in primate embryos, supporting prolonged translation of maternally deposited RNAs. (babraham.ac.uk)
  • Imperial Canc
  • Around 1974, back in Britain, Hogan began her work on mice at the Mill Hill Labs of the Imperial Cancer Research Fund in London under director John Cairns. (wikipedia.org)
  • cell
  • This paper addresses that issue with a characterisation of Schwann cell behaviour in the homeostatic and regenerating mouse peripheral nerve. (biologists.org)
  • normal
  • Homozygous mutant embryos appear to have a normal skeleton, apart from reduced ossification of certain skull bones. (biologists.org)
  • study
  • After her graduation, Barlow took up a PhD position at Warwick University, supervised by Derek Burke, to study the interferon response to virus infections in mouse embryos. (wikipedia.org)
  • common
  • We have disrupted the mouse Bmp1 gene by deleting DNA sequences encoding the active site of the astacin-like protease domain common to all splice variants. (biologists.org)
  • studies
  • In contrast with Oct4, studies of Nanog-null mice do not show the reversion of the ICM to a TE-like morphology, but demonstrate that loss of Nanog prevents the ICM from generating primitive endoderm. (wikipedia.org)
  • However
  • However, methylome profiling of F1 and F2 sperm revealed no significant difference between the offspring groups, suggesting that the sperm methylome might not be the major carrier for the transmission of the phenotypes observed in our mouse model. (babraham.ac.uk)
  • course
  • Beddington taught at the newly established Cold Spring Harbor Laboratories summer course on manipulating the mouse embryo from 1986, including two years as co-organiser with Robertson. (wikipedia.org)