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  • gene
  • The mouse bone morphogenetic protein1 (Bmp1) gene encodes a secreted astacin metalloprotease that cleaves the COOH-propeptide of procollagen I, II and III. (biologists.org)
  • We have disrupted the mouse Bmp1 gene by deleting DNA sequences encoding the active site of the astacin-like protease domain common to all splice variants. (biologists.org)
  • We demonstrate that 5fC-associated nucleosomes at enhancers in the mammalian hindbrain and heart are linked to elevated gene expression. (babraham.ac.uk)
  • There is also interspecies variation in gene expression patterns in early embryos The ICM and the TE will generate distinctly different cell types as implantation starts and embryogenesis continues. (wikipedia.org)
  • In 1991, she discovered the first mammalian imprinted gene, IGF2R, which codes for the insulin-like growth factor. (wikipedia.org)
  • During this time in 1991, she discovered the first imprinted gene in mice, IGF2R. (wikipedia.org)
  • Mice embryos that carried experimentally introduced mutations in the FGD1 gene had skeletal abnormalities affecting bone size, cartilage growth, vertebrae formation and distal extremities. (wikipedia.org)
  • During the blastula stage of development, a significant amount of activity occurs within the early embryo to establish cell polarity, cell specification, axis formation, and regulate gene expression. (wikipedia.org)
  • Normal mammalian somatic cells are diploid: each chromosome (and thus every gene) is present in duplicate (excluding genes from X chromosome absent in Y chromosome). (wikipedia.org)
  • 1994
  • She has been a member of the National Advisory Council of the National Institute of Child Health and Human Development, Co-Chair for Science of the 1994 NIH Human Embryo Research Panel and a member of the 2001/2002 National Academies Panel on Scientific and Medical Aspects of Human Cloning. (wikipedia.org)
  • genes
  • The pluripotency network in the primate epiblast lacks certain regulators that are operative in mouse, but encompasses WNT components and genes associated with trophoblast specification. (babraham.ac.uk)
  • This is where the International Mouse Phenotyping Consortium (IMPC) comes in, with the goal of characterising all 20,000 or so protein-coding mouse genes. (biologists.com)
  • Janet Rossant, CC, FRS, FRSC (born 13 July 1950) is a developmental biologist well known for her contributions to the understanding of the role of genes in embryo development. (wikipedia.org)
  • Rossant has discovered information on embryo development, how multiple types of stem cells are established, and the methods at which genes control development. (wikipedia.org)
  • In this lifetime achievement award, given out once every four years, the society highlighted Rossant's impact in helping researchers understand human embryo development and stem cell origin, as well as developing the technique of introducing targeted mutations into genes of mouse embryos. (wikipedia.org)
  • After Barlow met Hans Lehrach at a scientific meeting in Cold Spring Harbor, she joined his laboratory at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, to isolate mutated mouse genes using techniques developed in this lab. (wikipedia.org)
  • To facilitate this, she has created mouse lines where genes can be manipulated in specific lung cells. (wikipedia.org)
  • reveals
  • Analysis of the amnion of homozygous mutant embryos reveals the absence of the fold that normally tightly encloses the physiological hernia of the gut. (biologists.org)
  • germ
  • The blastula precedes the formation of the gastrula in which the germ layers of the embryo form. (wikipedia.org)
  • mutant
  • Homozygous mutant embryos appear to have a normal skeleton, apart from reduced ossification of certain skull bones. (biologists.org)
  • genome
  • Zygotic genome activation correlates with the presence of polycomb repressive complexes in all three species, while ribosome biogenesis emerges as a predominant attribute in primate embryos, supporting prolonged translation of maternally deposited RNAs. (babraham.ac.uk)
  • Imperial Canc
  • Around 1974, back in Britain, Hogan began her work on mice at the Mill Hill Labs of the Imperial Cancer Research Fund in London under director John Cairns. (wikipedia.org)
  • early mouse
  • At the transcription level, the transcription factors Oct4, Nanog, Cdx2, and Tead4 have all been implicated in establishing and reinforcing the specification of the ICM and the TE in early mouse embryos. (wikipedia.org)
  • stage
  • Embryos were treated at the 2-cell stage with 100 and 200 umol/L of Ex-527, and extracts were collected 12 h later. (selleckchem.com)
  • Studies
  • Studies on parental (mother's and father's) age effect on anxiety-like behaviour of mouse offspring (in collaboration with Teramo University, Italy). (edu.pl)
  • In contrast with Oct4, studies of Nanog-null mice do not show the reversion of the ICM to a TE-like morphology, but demonstrate that loss of Nanog prevents the ICM from generating primitive endoderm. (wikipedia.org)
  • Animals
  • Immunohistochemical analyses reveal that proprioceptive sensory neurons are severely compromised in the lumbar dorsal root ganglia of newborn Swl /+ mice, whereas motor neuron numbers remain unaltered even in aged animals. (jneurosci.org)
  • shown
  • In mice, it was shown that the patterning of the neural tube into rhombomeric segments may regulate spatial and temporal appearance of the central pattern generator. (wikipedia.org)