Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene. (wikipedia.org)
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. (wikipedia.org)
DVL1 has been shown to interact with: AXIN1, DVL3, EPS8, and Mothers against decapentaplegic homolog 3. (wikipedia.org)
DVL1, the human homolog of the Drosophila dishevelled gene(dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. (prosci-inc.com)
Synthetic peptide KLPVAPERVTLAD-C from the N-terminal region of human DVL1 / DVL / Dishevelled (NP_034221.3). (covalab.com)
Reacts with human DVL1 / DVL / Dishevelled. (covalab.com)
Xenopus2
In Xenopus , Dishevelled (Xdsh) signaling is required for both neural tube closure and neural convergent extension, but the connection between these two morphogenetic processes remains unclear. (silverchair.com)
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. (xenbase.org)
Gene3
INTRODUCTION identified as Int-1, the Wnt1 gene was uncovered over 30 years back being a gene turned on by integration of mouse mammary tumor trojan (MMTV) proviral DNA in SKF-96365 hydrochloride virally induced breasts tumors 1, 2. (icsv20.org)
An early on identified take a flight Wingless (Wg) gene, which regulates portion polarity during larval advancement 3, was discovered to be always a WNT1 homolog 4. (icsv20.org)
Their name originates from the mouse limb deformity gene. (biomedcentral.com)
Dendritic2
The most salient differentiation-relevant target genes included wnt7b involved in dendritic extension and the tfcp2l4/grhl3 grainyhead homolog implicated in ectodermal development. (biomedcentral.com)
Genes down-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNB1 [GeneID=3456] knockout mice. (gsea-msigdb.org)
Vivo2
Genetic ablation of TMEM9 inhibits colorectal cancer cell proliferation in vitro, ex vivo and in vivo mouse models. (nature.com)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
Antibody1
Immunostaining with an affinity-purified mouse antibody reveals that Eph is highly targeted to axons and growth cones of developing neurons within the VNC. (sdbonline.org)
Genes2
In the next years, research of genetics delineating the romantic relationships among portion polarity mutations mapped out the primary from the WNT/Wg indication transduction cascade by determining Porcupine (PORC), disheveled (DVL), armadillo (-catenin), and zeste-white 3/glycogen synthase kinase 3 (GSK3) genes 5-8. (icsv20.org)
Mammalian neural tube defects (NTDs) stem from a failure of one or more of these morphogenetic processes ( Harris and Juriloff, 1999 ), and recent genetic experiments in mice have identified individual genes that control specifically the many individual behaviors that comprise neurulation. (silverchair.com)
Neural1
It undergoes well-characterized steps of circuit assembly during development, rendering the mouse SC a popular model to study establishment of neural connectivity. (bvsalud.org)
Human1
Moreover, administration of v-ATPase inhibitors suppresses intestinal tumorigenesis of APC mouse models and human patient-derived xenografts. (nature.com)
More recently, we have taken advantage of our experience in studying these mechanisms to extend our work to vertebrates, using primarily the mouse. (stanford.edu)
Cell1
Strikingly, using inducible NG2CreER driver mice, we found that CNTF overexpression in RGCs increases the occupancy of NG2+ cell-derived astrocytes in the optic nerve lesion. (bvsalud.org)
Models1
models in Drosophila identified a membrane-cytoskeletal download Drawing Dynamic of PCP acids leading Frizzled( Fz), Flamingo( Fmi), Van Gogh( Vang), Dishevelled( Dsh), Prickle( Pk) and Diego( Dgo), whose types are freely severe in the domain upon lipogenesis of PCP( built Maung and Jenny, 2011). (erik-mill.de)
Analysis1
Here we perform single-nucleus RNA-sequencing analysis of the mouse SC isolated at various developmental time points. (bvsalud.org)