Embryonic and Fetal DevelopmentEmbryo, MammalianGene Expression Regulation, DevelopmentalEmbryonic DevelopmentIn Situ HybridizationGene TargetingBlastocystGrowth and DevelopmentGastrulaMesodermMice, KnockoutMice, Inbred C57BLMice, Mutant StrainsTissue DistributionYolk SacMorphogenesisStem CellsGenes, LethalTranscription FactorsMolecular Sequence DataRNA, MessengerPregnancyEctodermZygoteEndodermMice, TransgenicMice, Inbred StrainsEmbryo LossHomozygotePhenotypeNervous SystemGene ExpressionBase SequenceHomeodomain ProteinsNerve TissueCell DifferentiationSomitesNuclear ProteinsFetal DeathDNA-Binding ProteinsOrgan SpecificityGoosecoid ProteinFetal ProteinsMorulaCell LineageMice, Inbred CBANeural TubeBlotting, NorthernBody PatterningExtremitiesSp2 Transcription FactorAmino Acid SequenceCrosses, GeneticChimeraLimb BudsTranscription, GeneticGene DeletionCentral Nervous SystemRNA ProbesGenes, HomeoboxEyeCleavage Stage, OvumBlastomeresLac OperonGenes, EssentialHeterozygoteMutationGonadsDNA, ComplementaryDigestive SystemGenomic ImprintingReverse Transcriptase Polymerase Chain ReactionMice, Inbred ICRRNANeural Tube DefectsGastrulationTrans-ActivatorsCells, CulturedSOXD Transcription FactorsOocytesHeartBrainRNA, Long NoncodingBranchial RegionTime FactorsFertilityRepressor ProteinsPlacentaOrganogenesisAnimals, NewbornImmunohistochemistryAllelesEmbryonic Stem CellsRNA, UntranslatedFibroblast Growth Factor 8Cardiovascular SystemWnt ProteinsSignal TransductionNeural CrestTestis