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  • genes
  • Mutations in genes directly involved in R-loop biology, such as SETX (senataxin), or unstable DNA expansion eliciting R-loop generation, such as C9ORF72 HRE, can cause DNA damage and ultimately result in motor neuron cell death. (springer.com)
  • Like the caretaker of a condemned building shutting off the lights for the last time, DNA methyltransferases shut off motor neuron genes during apoptosis. (alzforum.org)
  • brainstem
  • Motor nuclei are found throughout the brainstem- medulla , pons , and midbrain -and for developmental reasons are found near the midline of the brainstem. (wikidoc.org)
  • Degeneration
  • As such, motor neuron disease ['ALS'] is both a central and peripheral process clinically involving progressive weakness without sensory deficits and involving degeneration of corticospinal tracts and/or anterior horn cells and/or bulbar nuclei. (bio.net)
  • MND leads to the degeneration of these motor neurones. (mndnsw.asn.au)
  • populations
  • However, Ginsberg said, other motor neuron populations in the spinal cord could also contribute to the spinal cord's mitochondrial malady, and should be tested individually as well. (alzforum.org)
  • Dynamic range adaptation in primary motor cortical populations , Robert G Rasmussen Andrew Schwartz Steven M Chase, eLife , doi: 10.7554/eLife.21409, published 18 April 2017. (medicalnewstoday.com)
  • cells
  • In Lim's assay, the G37R mutant SOD1 killed the majority of cultured neurons within three days, while cells expressing the wild-type dismutase survived. (alzforum.org)
  • Sure enough, Lim observed 50 percent more active, phosphorylated AMPK in cells making mSOD1 compared to wild-type neurons. (alzforum.org)
  • News
  • Compound C kept the neurons alive, but AICAR did not, indicating AMPK activation is bad news for motor neurons with mSOD1, and that dampening its function is protective. (alzforum.org)
  • cell
  • Bennett hypothesized that since motor neurons are the specific cell type that degenerates in ALS, they might contain mtDNA deletions similar to those found in Parkinson disease. (alzforum.org)
  • While it is a cell, a motor neuron has a unique design that best allows it to serve its purpose. (wisegeek.com)
  • The motor neuron cell is unique in design and can rapidly respond to stimuli in order to send a very fast signal via their dendrite system. (wisegeek.com)
  • He hypothesized that when motor neurons die in ALS, the cell uses methylation to turn off survival factors. (alzforum.org)
  • Research
  • Scientists didn't know previously that Dnmts appeared outside the nucleus in neurons, said Courtney Miller of the Scripps Research Institute, Jupiter, Florida, who was not involved in this work. (alzforum.org)
  • New research from Carnegie Mellon University's College of Engineering and the University of Pittsburgh reveals that motor cortical neurons optimally adjust how they encode movements in a task-specific manner. (medicalnewstoday.com)