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PseudopodiaSperm MotilityGastrointestinal MotilityCell MovementDictyosteliumChemotaxisActinsAmoebaMicroscopy, VideoCell AdhesionMicroscopy, Electron, Scanningcdc42 GTP-Binding ProteinMicroscopy, ElectronMovementCytoskeletonrho GTP-Binding ProteinsAnnexin A2PhagocytosisCell Sizerac1 GTP-Binding ProteinCell PolarityMicroscopy, Phase-ContrastMicroscopy, FluorescenceNeoplasm InvasivenessChemotactic FactorsLasers, ExcimerProto-Oncogene Proteins c-crkAstrocytomarac GTP-Binding ProteinsExtracellular MatrixFlagellaLysophospholipidsCell Line, TumorCell MembraneSpermatozoaModels, BiologicalSerumEsophageal Motility DisordersMicroscopy, ConfocalCytoskeletal ProteinsSignal TransductionHepatocyte Growth FactorCells, CulturedCytoplasmCell LineMacrophagesCollagenElectrophoresis, Gel, Two-DimensionalFibroblastsImmunoblotting3T3 CellsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTransfectionCercopithecus aethiopsEnzyme InhibitorsCOS CellsSemen PreservationManometrySperm TailSperm CountSemenGastric EmptyingLocomotionPeristalsisMyxococcus xanthusBacterial ProteinsMyoelectric Complex, MigratingReceptors, Autocrine Motility Factor
AmoebaTypes of pseudopodiaCytoplasmPhagocytosisCytoplasmic extensionsMembraneActin filamentsSpermAmoeboidIrregularLocomotiveLocomotionMediatesMovementCellsRetractionMicrotubuleBulbousDirectionalMyosinFormationSimilarlyExtendArp2ProgressiveFlagellaDemonstrateLeading edgeColonMoveRoleFalse feetFormDirectionControlResearchBody
Amoeba6
  • Generally, several pseudopodia arise from the surface of the body, (polypodial, for example, Amoeba proteus), or a single pseudopod may form on the surface of the body (monopodial, such as Entamoeba histolytica). (wikipedia.org)
  • Here, the amoeba extends the pseudopods (cytoplasmic extensions) which allow them to engulf food material and digest them within the cell. (microscopemaster.com)
  • Using a process called amoeboid movement, protists like Amoeba use their pseudopods to propel themselves. (studysmarter.co.uk)
  • The Amoeba proteus can be ordered from science supply companies and is the classic specimen used in the classroom to demonstrate the pseudopods in action. (godman-inc.com)
  • The pseudopodia of Amoeba are known as lobo-podia due to their blunt, finger-like appearance and rounded tips. (godman-inc.com)
  • Dellinger examined an Amoeba proteus not from the top, but from the side view, and explained how the pseudopodia become attached to the substratum and then due to the contraction of the contractile vacuole, the body gets … Available here 2.Vidyasagar, Aparna. (godman-inc.com)
Types of pseudopodia3
  • Different types of pseudopodia can be classified by their distinct appearances. (wikipedia.org)
  • Some pseudopodial cells are able to use multiple types of pseudopodia depending on the situation: Most of them use a combination of lamellipodia and filopodia to migrate (such as metastatic cancer cells). (wikipedia.org)
  • Delve into the step-by-step process of pseudopodia formation, and explore how different types of pseudopodia function in our biological ecosystem. (studysmarter.co.uk)
Cytoplasm4
  • Filled with cytoplasm, pseudopodia primarily consist of actin filaments and may also contain microtubules and intermediate filaments. (wikipedia.org)
  • Polarized polymerization of actin propels the bacteria through the cytoplasm and into pseudopod-like structures that are engulfed by neighboring cells. (silverchair.com)
  • Pseudopodia, from the Greek 'pseudo-' meaning 'false', and '-podia' meaning 'feet', are temporary, arm-like projections of the cytoplasm used for motion or capturing food. (studysmarter.co.uk)
  • Similarly, when a pseudopod extends, it is filled with cytoplasm, essentially 'pushing' the cell forward. (studysmarter.co.uk)
Phagocytosis2
Cytoplasmic extensions1
Membrane8
  • A pseudopod or pseudopodium (PL: pseudopods or pseudopodia) is a temporary arm-like projection of a eukaryotic cell membrane that is emerged in the direction of movement. (wikipedia.org)
  • It senses extracellular signalling molecules, chemoattractants (e.g. cAMP for Dictyostelium cells), to extend pseudopodia at the membrane area facing the source of these molecules. (wikipedia.org)
  • The actin polymers then push the membrane as they grow, forming the pseudopod. (wikipedia.org)
  • Otherwise, pseudopodia cannot grow on other sides of the membrane than the leading edge because myosin filaments prevent them to extend. (wikipedia.org)
  • Movement using a pseudopod is accomplished through increases in pressure at one point on the cell membrane . (ipfs.io)
  • As the pressure increases the cell membrane is pushed outward creating the pseudopod. (ipfs.io)
  • First, we have found that protein tyrosine phosphorylation is associated with filament formation along the pseudopod membrane. (fsu.edu)
  • 1998. Hydrostatic pressure shows that lammelipodial motility in Ascaris sperm requires membrane-associated major sperm protein filament nucleation and elongation. (fsu.edu)
Actin filaments2
  • The work also showed that migration and pseudopod formation required functioning actin filaments. (rupress.org)
  • When he added cytochalasin B to disrupt actin filaments, the neutrophils could no longer migrate toward a reversed chemical gradient and failed to put out pseudopods. (rupress.org)
Sperm4
  • Movement of sperm is called sperm motility . (ipfs.io)
  • As a major part of differentiation, sperm undergo extensive post-meiotic maturation en route to the oocyte. (silverchair.com)
  • 1998. Structural basis for amoeboid motility in nematode sperm. (fsu.edu)
  • 1998. Amoeboid motility without actin: insights into the molecular mechanism of locomotion using the major sperm protein (MSP) of nematodes. (fsu.edu)
Amoeboid2
  • Mechanisms of amoeboid motility, structure-function relationships of cytoskeletalproteins, signal transduction in motile systems. (fsu.edu)
  • Amoeboid cell motility plays a vital role in physiological and pathological processes ranging from embryonic development and immunological defense to tumor metastasis. (fsu.edu)
Irregular3
  • Reticulopodia are complex structures bearing individual pseudopodia which form irregular nets. (wikipedia.org)
  • Shape: when activated irregular outline due to the presence of pseudopodia which serves for motility. (online-sciences.com)
  • these range from irregular dynamic structures, e.g. lamellipodia, ruffles and pseudopodia, to more localized and highly defined protrusions, e.g. podosomes and invadopodia. (elsevierpure.com)
Locomotive1
  • The key lies in the orchestration of various proteins and cellular structures that ultimately drive the locomotive action of pseudopodia. (studysmarter.co.uk)
Locomotion3
  • Pseudopods can be classified into several varieties according to the number of projections (monopodia and polypodia), and according to their appearance: Lamellipodia are broad and flat pseudopodia used in locomotion. (wikipedia.org)
  • We are also interested in how the cell controls MSP polymerization in vivo because the localized formation of filaments along the leading edge of the pseudopod appears to be the key event in locomotion. (fsu.edu)
  • Unveil the secrets of pseudopodia structure and their significance in locomotion. (studysmarter.co.uk)
Mediates1
  • The Listeria monocytogenes ActA protein mediates actin-based motility by recruiting and stimulating the Arp2/3 complex. (silverchair.com)
Movement6
Cells18
  • Cells which make pseudopods are generally referred to as amoeboids. (wikipedia.org)
  • In Dictyostelium cells, a pseudopodium can form either de novo as normal, or from an existing pseudopod, forming a Y-shaped pseudopodium. (wikipedia.org)
  • The de novo pseudopodia form at different sides than pre-existing ones, they are used by the cells to turn. (wikipedia.org)
  • Ito et al ( 2 ) showed that overexpression of Tβ 4 enhanced the formation of actin-based pseudopodia and cell motility in prostate cancer cells, providing direct evidence that Tβ 4 plays a role in cell migration. (spandidos-publications.com)
  • It was suggested that this optical effect was caused by the morphological change of platelets from discs to spherical cells with pseudopodia ( Latimer et al, 1977 ). (nature.com)
  • however, this region is dispensable for actin-based motility in cells. (silverchair.com)
  • The guidance strategy of a cell varies with the chemotactic gradient: in steep gradients, cells produce pseudopodia directly up the gradient, but in weak gradients, pseudopodia are produced at random, with cells steering by favouring the pseudopod that is furthest up the gradient. (expertfile.com)
  • This continues for 10 minutes after division before the daughter cells revert to normal random motility, indicating that this is a tightly regulated process. (biologists.com)
  • Podosomes are expressed in cells of the monocytic lineage, and most studies point to a role for podosomes in adhesion/motility. (elsevierpure.com)
  • Time lapse imaging revealed that only malignancy cells establishing contacts with fibroblasts develop pseudopodia at the attachment site and progressively acquire an elongated morphology over time (about 70% of SW620 and 50% of HT29 compared to less than 10% in the absence of fibroblasts) (Fig. (abic2004.org)
  • Concomitant to elongation, malignancy cells cultured with fibroblasts massively increased their motility, as monitored by tracking the distance travelled by individual cells (Fig. (abic2004.org)
  • D. Quantification of malignancy cells motility during 48 hours in presence or absence of fibroblasts. (abic2004.org)
  • For instance, knowing how cancer cells move and spread in the body requires a deep understanding of the mechanisms behind pseudopodia. (studysmarter.co.uk)
  • Activation of cdc42 in Swiss 3T3 cells leads to the sequential activation of rac and then rho, suggesting a molecular model for the coordinated control of cell motility by members of the rho family of GTPases. (nih.gov)
  • In comparison to crazy type cells cells possess smaller sized aggregation territories and fruiting physiques improved cell motility amount of aggregation territories cAMP amounts Akt translocation and actin polymerization move quicker move additional toward cAMP are insensitive to keeping track of factor and also have shorter channels [20]. (bioskinrevive.com)
  • The formation of SSPs was followed by cell body translocation in Rac1 nulls unlike in settings where SSPs elongated into long pseudopods and cells regularly changed direction (Movie 2). (ecolowood.com)
  • Therefore Rac1 null cells were impaired in long but not short pseudopod generation leading to a reduction in rate and protrusion lifetime. (ecolowood.com)
  • the oval cells with pseudopods were counted as spreading cells. (pdesignal.com)
Retraction2
  • The Y-shaped pseudopods are used by Dictyostelium to advance relatively straight forward by alternating between retraction of the left or right branch of the pseudopod. (wikipedia.org)
  • A network of actin and myosin filaments that causes contraction of the platelet for motility and for clot retraction. (online-sciences.com)
Microtubule1
  • Scar/WAVE and Arp2/3 complex travel actin assembly for long pseudopod extension which also depends on microtubule dynamics. (ecolowood.com)
Bulbous1
Directional1
  • pseudopods which promote migration rate and directional plasticity. (ecolowood.com)
Myosin1
  • The pseudopodium can then adhere to a surface via its adhesion proteins (e.g. integrins), and then pull the cell's body forward via contraction of an actin-myosin complex in the pseudopod. (wikipedia.org)
Formation3
  • Different physical parameters were shown to regulate the length and time-scale of pseudopodia formation. (wikipedia.org)
  • This way formation of pseudopodium and sol-gel transition enable it to move. (godman-inc.com)
  • DOC 28 KB) Additional file 3: Figure S3: Cumulative effect of BDSF and AHL systems in regulation of bacterial motility, biofilm formation, and protease production. (pdesignal.com)
Similarly1
  • Open in a separate window Physique 2 Cultured dermal, colon and colon cancer associated fibroblasts induce similarly malignancy cell elongation and motility and have equivalent gene expression and activation profilesA. (abic2004.org)
Extend1
Arp21
  • We confirm that the Arp2/3 complex is recruited to the cell perimeter, or into a pseudopod, after cyclic-AMP stimulation and that this is coincident with actin polymerization. (expertfile.com)
Progressive2
  • Progressive with hyaline, finger-like pseudopods. (cdc.gov)
  • Occasionally, in diarrheic specimens, motility may be progressive. (cdc.gov)
Flagella1
  • It is quite possible to imagine an advanced biotechnology that uses an engineered white cell, fibroblast, or macrophage chassis, energized by native oxygen and glucose ( Section 6.3.4 ) and modified mitochondrial powerplants, driven by pseudopodia, cilia or flagella ( Section 9.4 ), communicating and navigating via biochemical signals (Sections 7.2.1 and 8.4.3 ), and even incorporating onboard digital biocomputers ( Section 10.2.3 ) to make microscopic biorobots. (nanomedicine.com)
Demonstrate1
Leading edge1
  • MSP filaments pack the locomotory domain of the cell, the pseudopod, where they are arranged into 15-20 distinct meshworks that span from the leading edge to the base of the pseudopod. (fsu.edu)
Colon1
  • Cultured dermal, normal colon or colon cancer fibroblasts have comparative gene expression and activation profiles and induce comparable malignancy cell elongation and motility Next we tested whether fibroblasts isolated from normal colon (CFB) or colon cancer (CAF) tissues were also able to induce malignancy cell elongation and motility. (abic2004.org)
Move1
  • E. histolytica is able to move using pseudopods. (wikidoc.org)
Role1
  • The ability of VASP to contribute to actin filament nucleation and to regulate actin filament architecture highlights the central role of VASP in actin-based motility. (silverchair.com)
False feet1
Form1
Direction1
  • Y-shaped pseudopods are more frequent than de novo ones, which explain the preference of the cell to keep moving to the same direction. (wikipedia.org)
Control1
Research2
  • In scientific and medical research, understanding how pseudopodia work has been crucial. (studysmarter.co.uk)
  • And when Harry Malech couldn't decide between research on cell motility or infectious disease, his fellowship mentor Richard Root offered up this gem: "You know how to combine that, don't you? (rupress.org)
Body1
  • When the pseudopod moves outward, the rest of the body is pulled forward by cortical tension. (ipfs.io)