Gastrointestinal abnormalities related to altered motility (constipation, diarrhea, and, occasionally, megacolon) are common and thought to result from diffuse intestinal ganglioneuromatosis. (msdmanuals.com)
Not only are stomach contractions improved but so is motility in the entire tract motility, opening the door to treating constipation disorders. (vin.com)
Toxic megacolon is a life-threatening condition characterized by nonobstructive segmental or pancolonic dilatation of at least 6 cm with systemic toxicity. (medscape.com)
[ 2 ] Although inflammatory bowel disease (IBD) is a common reason for toxic megacolon, other etiologies including infections, inflammation, bowel ischemia, radiation, and certain medications can lead to the development of this condition. (medscape.com)
[ 1 ] Patients with these conditions do not develop signs of systemic toxicity and, therefore, do not fall into the category of having toxic megacolon (see the image below). (medscape.com)
Although the precise pathophysiology of toxic megacolon is unproven, several factors may contribute to its development and precipitation. (medscape.com)
The microscopic hallmark of toxic megacolon is inflammation extending beyond the mucosa into the muscularis propria. (medscape.com)
Whereas the typical ulcerative colitis inflammatory response is limited to the mucosa, toxic megacolon is characterized by severe inflammation extending into the smooth muscle layer, thus paralyzing the colonic smooth muscle and leading to dilatation. (medscape.com)
As inflammation progresses into the smooth-muscle layers of the colon, NO and local inflammatory modulators appear to be involved in toxic megacolon pathogenesis. (medscape.com)
Neutrophils invade the muscle layer in toxic megacolon and directly damage the myocytes by the release of proteolytic enzymes, cytokines, and leukotriene B 4 . (medscape.com)
[ 8 ] According to a study by Schworer et al, patients with toxic megacolon were successfully treated with NO synthase inhibitor. (medscape.com)
In addition, metabolic abnormalities (eg, hypokalemia, hypomagnesemia, hypoproteinemia), impaired epithelial integrity of the colon, and altered motor function and are frequently found in patients with toxic megacolon. (medscape.com)
Toxic megacolon is associated with fever, abdominal distention, and tenderness. (medscape.com)
Toxic megacolon places the patient at risk for colonic perforation, gram-negative sepsis, and massive hemorrhage. (medscape.com)
Severe or untreated enterocolitis can also lead to toxic megacolon, another life-threatening complication. (rarediseases.org)
Our dedication to research in GI motility ensures that our patients have access to the most advanced diagnostic technologies and innovative clinical therapies for these disorders. (ucsd.edu)
We help treat symptoms commonly associated with intestinal motility disorders such as bloating, nausea, abdominal discomfort, weight loss, and diarrhea. (ucsd.edu)
There are several types of motility disorders that can occur in the stomach, such as gastroparesis and dumping syndrome. (ucsd.edu)
The phrase " intestinal motility disorders " applies to abnormal intestinal contractions, such as spasms and intestinal paralysis, and is used to describe a variety of disorders in which the gut has lost its ability to coordinate muscular activity because of endogenous or exogenous causes. (medscape.com)
The pathogenesis of primary intestinal motility disorders probably is multifactorial, but neither biochemical abnormality nor structural abnormality has been demonstrated commonly, except in some forms of intestinal pseudo-obstruction. (medscape.com)
Motility disorders of the gastrointestinal (gi) tract are a common clinical problem in companion animals. (github.io)
Oxybutynin should be used with caution in the frail elderly, patients with Parkinson's disease and children who are at greater risk of occurrence of adverse reactions to the product, and in patients with autonomic neuropathy (such as those with Parkinson's disease), severe gastro-intestinal motility disorders, hepatic or renal impairment. (medicinep.com)
Gastrointestinal disorders: Anticholinergic medicinal products may decrease gastrointestinal motility and should be used with caution in patients with gastrointesti- nal obstructive disorders, intestinal atony and ulcerative colitis. (medicinep.com)
Because it promotes colonic motility, it can also successfully treat megacolon in dogs . (wagwalking.com)
It is still available today for off label veterinary use, mostly to treat megacolon. (github.io)
Nausea1
It is used to treat nausea due to motility problems in the stomach, though it does not treat the nausea sensation directly in the brain as does its cousin, metoclopramide. (vin.com)
Bowel motility2
Bowel motility refers to how well the digestive system can move contents through it. (livescience.com)
If you constantly suppress the need to poop, you do run the risk of altered bowel motility in the future, or possibly needing laxatives or other things to stimulate your colon to work again," he said. (livescience.com)
Feline Megacolon1
Cisapride has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon . (vin.com)
Colonic inertia3
Megacolon is secondary to colonic inertia (functional obstruction) or outlet obstruction (mechanical obstruction). (acvs.org)
The most common cause of colonic inertia is idiopathic (meaning unknown cause) megacolon. (acvs.org)
Biofeedback may not be effective for the etiology of colonic inertia in chronic megacolon, although it has been successful in treating functional outlet obstruction. (healthygutjourney.com)
Idiopathic1
Idiopathic megacolon is a disease in cats where the colon loses its normal motility and becomes progressively larger. (acvs.org)
Anticholinergics1
Drugs that disturb colonic motility (such as anticholinergics or opioid analgesics) contribute to the development of this condition. (wikipedia.org)
Colon10
Megacolon is a term used to describe a very dilated, flaccid, incompetent colon. (acvs.org)
Megacolon itself is not a specific disease entity, but it will usually result in obstipation (inability to defecate), since feces is retained in the colon in a larger diameter than is able to pass through the pelvis. (acvs.org)
If they're eating and not pooping, the colon can become dangerously distended, a condition called "megacolon. (livescience.com)
Megacolon could occur in babies due to lack of nerves in the colon (the condition is called Hirschprung s disease), or in adults due to a parasitic infection (the condition is called Chagas disease). (medindia.net)
or does Linus seem to have a 'colon motility' problem as the locum thinks? (askavetquestion.com)
or does Linus indeed have a 'history' that suggests a colon motility problem? (askavetquestion.com)
It increases the motility of the colon, esophagus, stomach, and small intestine, speeding up the digestive process. (wagwalking.com)
Megacolon is believed to be caused by an improper development or malfunction of the colon/cecum. (vgr1.com)
[1] Complications may include abnormal dilation of the colon ( megacolon ), inflammation of the eye, joints, or liver, and colon cancer . (wikizero.com)
Cisapride represents an improvement over metoclopramide in that the entire GI tract from stomach to colon can gain improved motility. (vin.com)
Obstruction1
Infants with aganglionic megacolon show tympanitic abdominal distention and symptoms of intestinal obstruction. (nurseslabs.com)
Aganglionic1
Cases of aganglionic megacolon are seen in approximately 1 per 5000 live births. (nurseslabs.com)
If the stomach's motility becomes abnormal, the stomach cannot grind or move food properly. (vin.com)
Mucosal2
Another nervous intrinsic plexus in the GI tract (Meissner plexus or submucosal plexus) helps to modify mucosal absorption and secretion without influencing motility. (medscape.com)
Intrinsic factors include an abnormality in the mucosal defense, such as achlorhydria, impairment of intestinal motility, and alteration of normal enteric flora. (isid.org)
Stomach3
Gastrointestinal (GI) motility refers to the movement of food from the mouth through the pharynx (throat), esophagus, stomach, small and large intestines, and out of the body. (ucsd.edu)
It stimulates smooth muscle contraction, which aids in emptying of the stomach and promoting motility of the small and large intestine. (github.io)
It is particularly helpful in patients who have adverse neurologic reactions to metoclopramide but still require stomach motility treatment. (vin.com)
Diagnosis1
Diagnosis of megacolon is based on history and physical exam , and is confirmed with radiographs (x-rays) of the abdomen. (acvs.org)
Megaesophagus1
This medication is commonly used to treat conditions associated with gastrointestinal motility, such as megaesophagus , stasis, and reflux. (wagwalking.com)
Diarrhea1
If too great a motility effect is created, diarrhea and cramping may result. (vin.com)
Chronic1
When it comes to chronic megacolon, dietary and pharmacological methods should be used to increase intestinal motility. (healthygutjourney.com)
Acute1
Acute megacolon can also lead to ischemic necrosis in massively dilated intestinal segments. (wikipedia.org)
Contraction2
The complex patterns of contraction and relaxation necessary for proper motility of the gastrointestinal (GI) tract are generated in the nerves and muscles within the GI walls. (medscape.com)
The rhythm of contraction is called the stomach's motility. (vin.com)
Peristaltic1
It stimulates peristaltic reflex, intestinal secretions, and GI motility. (arogga.com)
Acetylcholine1
Resolax 1 indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine. (arogga.com)