ProteinCytokineReceptorsCXCLSubfamilyGeneCCR5CCL2CXCR4InflammatoryPlateletCX3CL1CCL3Receptor familyCellsCysteine residuesCXCR3ChemotacticSerumRecruitmentElicitsProductionActivitySmallReceptorCXCL10Cytokines and chemokinesInterleukinMacrophagesMember of the intercrineCXCL12ProteinsCCL5InflammationCcl1MonocytesRANTESClusterCutaneousCCL27InduceAminoRheumatoid arthritisAttractsCCL22BelongsExpressionProfilesDescriptor
Protein7
- C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. (wikipedia.org)
- Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. (creative-biolabs.com)
- Rabbit polyclonal antibody recognizes the middle region of CCL16(chemokine (C-C motif) ligand 16) protein. (fishersci.com)
- The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
- CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ) is a 7.8 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). (rndsystems.com)
- These class A G-protein coupled receptors (GPCRs) are involved in mammalian signaling pathways and control cell migration toward endogenous CC chemokine ligands, named for the adjacent cysteine motif on their N terminus. (iasp-pain.org)
- The potential causal genes were enriched in biological processes related to type I interferons, interferon gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. (cdc.gov)
Cytokine3
- Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. (creativebiomart.net)
- We selected most pathways Ccl21a participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. (creativebiomart.net)
- TLR2 induction did not enhance TLR2 signaling, as indicated by reduced cytokine production after treatment with TLR2 ligands in Dex- and/or LPS-primed AMs. (frontiersin.org)
Receptors6
- Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
- They represent the first line of defense against pathogens in the lower airspace and recognize microbial ligands via pattern recognition receptors ( 4 , 5 ). (frontiersin.org)
- Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. (thermofisher.com)
- IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. (thermofisher.com)
- Chemokine receptors and their associated ligands are involved in a wide range of diseases and thus have become important drug targets. (iasp-pain.org)
- The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
CXCL1
- For the C-X-C motif chemokine ligand (CXCL) 2 neutralization study,mice were intravenously administered anti-mouse CXCL2 antibody (100 lg/mouse). (kribb.re.kr)
Subfamily1
- This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
Gene1
- IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. (thermofisher.com)
CCR54
- Chemokine receptor 5 (CCR5) has gained attention as therapeutic target in various malignancies. (cancerindex.org)
- C-C motif chemokine receptor 5 (CCR5) is expressed by T lymphocytes, macrophages and monocytes. (sigmaaldrich.com)
- C-C motif chemokine receptor 5 (CCR5) is a receptor for chemokine ligands-3, -4 and -5. (sigmaaldrich.com)
- CCL3 is a ligand for CCR1, CCR4, and the HIV-1 coreceptor CCR5. (goldbio.com)
CCL21
- It is known that C-C motif chemokine ligand 2 (CCL2) is a chemokine which facilitates monocyte movement and positioning. (kcl.ac.uk)
CXCR42
- Motixafortide is an inhibitor of C-X-C motif chemokine receptor 4 (CXCR4) and blocks binding of its cognate ligand, stromal-derived factor-1α (SDF-1α)/C-X-C motif chemokine ligand 12 (CXCL12). (medscape.com)
- The syndrome is cause by mutations in CXCR4, a chemokine receptor expressed by hematopoietic and non-hematopoietic cells. (lu.se)
Inflammatory1
- In contrast to decreased cell recruitment, key inflammatory chemokines were elevated in the lungs of ETOH-RSV mice. (cdc.gov)
Platelet1
- This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules. (wikidoc.org)
CX3CL12
- Description: A sandwich quantitative ELISA assay kit for detection of Human Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
CCL31
- Rat CCL3 is a chemokine containing four conserved cysteine residues, of which the first two are adjacent. (goldbio.com)
Receptor family2
- It belongs to the chemokine receptor family. (sigmaaldrich.com)
- CC chemokine receptor 2 (CCR2) is a part of the chemokine receptor family, an important class of therapeutic targets. (iasp-pain.org)
Cells4
- CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. (wikipedia.org)
- T cells were placed in a transmigration system where chemokines had been treated with and without activated MMP-9. (cdc.gov)
- In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (genome.jp)
- The ligand CXCL12 (SDF-1) is a homeostatic chemokine with a central role in hematopoietic cells homing to and release from bone marrow. (lu.se)
Cysteine residues1
- This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). (creativebiomart.net)
CXCR31
- PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
Chemotactic1
- It elicits its chemotactic effects by binding to the chemokine receptor CCR10. (wikipedia.org)
Serum1
- Increased expression of IL-6 and chemokine (C-X-C motif) ligand 1 in the bronchoalveolar lavage and serum was also dependent on TLR-4 activation. (nih.gov)
Recruitment1
- Lymphocyte recruitment was significantly reduced in the BAL 4 days after RSV infection in ETOH-RSV mice, whereas chemokine levels were the highest in this group at all experimental time points examined in comparison to RSV (p (cdc.gov)
Elicits1
- CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. (creativebiomart.net)
Production1
Activity1
- Two conserved active site (CAS) motifs, I and II, are critical for the catalytic activity ( 3 ). (frontiersin.org)
Small1
Receptor14
- It elicits its chemotactic effects by binding to the chemokine receptor CCR10. (wikipedia.org)
- It specifically binds to chemokine receptor 10 (CCR10). (nih.gov)
- We selected most pathways CCL7 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. (creativebiomart.net)
- CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. (creativebiomart.net)
- Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by sincere in 1.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. (mip-1a.com)
- The chemokine (c-c motif) ligand 20 (CCL20) plays a nonredundant role in the chemoattraction of C-C motif receptor 6 expressing cells (eg, T cells and others). (princeton.edu)
- LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. (nih.gov)
- This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
- Ligand binding induces mincle activation which consequently interacts with the signaling adapter Fc receptor, SYK, and NF-kappa-B. There is also evidence that mincle expressed on macrophages promotes intestinal barrier integrity. (frontiersin.org)
- Binding of the ligand to mincle leads to interaction with the signaling adapter FC receptor gamma chain (FCER1G) ( 3 ). (frontiersin.org)
- The formed receptor complex enables intracellular signaling molecules to dock on the immunoreceptor tyrosine-based activation motif (ITAM) and thereby transduce signaling in immune cells. (frontiersin.org)
- [2] CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1 . (wikidoc.org)
- Sublining FLS expressing human leukocyte antigen-DRA (HLA-DRA) produce C-X-C motif chemokine 12 (CXCL12) and receptor activator of nuclear factor-κB ligand (RANKL) and seems to constitute a pro-inflammatory subset that is associated with inflammation and tertiary lymphoid structures. (intechopen.com)
- Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. (medlineplus.gov)
CXCL104
- To the best of our knowledge, this is the first study showing that cytokines are able to activate NF-κB in Graves thyrocytes and a parallel inhibitory effect of pioglitazone both on CXCL10 chemokine secretion and NF-κB activation. (unipi.it)
- Interferon gamma-induced protein 10 kDa (IP-10) is also known as C-X-C motif chemokine 10 (CXCL10). (blogspot.com)
- Compared with the virus-negative asymptomatic condition, children with severe colds (symptom score =5) showed reduced forced expiratory flow at 25% to 75% of the pulmonary volume (FEF25%-75%), higher nasal messenger RNA expression of C-X-C motif chemokine ligand (CXCL)-10 and melanoma differentiation-associated protein 5, and higher protein abundance of CXCL8, CXCL10 and C-C motif chemokine ligands (CCL)-2, CCL4, CCL20, and CCL24. (cdc.gov)
- Elevated levels of inflammation-related chemokines, including CXCL10, CCL14, CXCL16, CXCL7, and CCL22, in the aqueous humor of AMD patients may suggest a pathogenic role for inflammation. (molvis.org)
Cytokines and chemokines2
- [4] The viruses can invade lung epithelial cells and alveolar macrophages to produce viral nucleic acid, which stimulates the infected cells to release cytokines and chemokines, activating macrophages, dendritic cells, and others. (wikipedia.org)
- We assessed the levels of 17 cytokines and chemokines associated with innate and adaptive (T- and B-cell) responses in CSF of patients with meningoradiculoneuritis, PFP/meningitis, or suspected LNB. (cdc.gov)
Interleukin3
- Concentrations of cutaneous T-cell attracting chemokine, eotaxin, hepatocyte growth factor, interleukin 6 (IL-6), IL-16, and stem cell factor are significantly higher in COPD patients compared with in control patients. (dovepress.com)
- What is the difference between cytokine, interleukin and chemokine? (blogspot.com)
- The aim of the study was to detect the saliva chemokine (C-X-C motif) ligand 13 (CXCL13), macrophage migration inhibitory factor (MIF), and interleukin 35 (IL-35) levels in patients with primary Sjögren's syndrome (pSS) and pSS-associated interstitial lung disease (pSS-ILD), and to explore the relationship between CXCL13, MIF, IL-35 levels, and disease severity. (termedia.pl)
Macrophages2
- As multifunctional regulators, M2 macrophages secrete a high level of programmed death-ligand 1 (PD-L1) to induce checkpoint blockade of T cells, thereby promoting immunosuppressive responses to tumor cells [ 17 ]. (hindawi.com)
- CCL6 is chemotactic for macrophages and lymphocytes and acts as a ligand primarily for CCR1. (goldbio.com)
Member of the intercrine2
- Moreover, the monomeric member of the intercrine beta (chemokine C-C) family tends to augment monocyte anti-tumor activity as well. (creativebiomart.net)
- This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. (antikoerper-online.de)
CXCL121
- VEGF-A) and C-X-C motif chemokine ligand 12 (CXCL12), respectively, the mechanisms that link both processes are still elusive. (nih.gov)
Proteins2
- Chemokines (Greek -kinos, movement) are a family of small cytokines, or proteins secreted by cells. (blogspot.com)
- Chemokines (chemotactic cytokines) are a group of small signaling proteins, 8-10 kDa, that are produced in almost all cell types [ 6 ]. (hindawi.com)
CCL51
- The association between polymorphism of CC chemokine ligand 5 (CCL5) and cancer has been reported in several studies, however, there is no data in papillary thyroid cancer (PTC). (nih.gov)
Inflammation4
- These studies suggest that the presence of AHR ligands during localized inflammation may augment chemokine expression, thus participating in the overall response to pathogens. (princeton.edu)
- [ 7 ] Eosinophilic inflammation starts with the recruitment and migration of eosinophils through the blood circulation into the airway stimulated by the C-C motif chemokine ligand (CCL) 11 and CCL 5. (degruyter.com)
- Chemokine (C-X-C motif) ligand 14 (CXCL14) plays a critical role in maintaining homeostasis and inflammation in the local cell environment and regulating cancer progression. (hindawi.com)
- Chemokines play a critical role in regulating directed chemotaxis of surrounding responsive cells and maintaining homeostasis and inflammation in the local extracellular environment [ 7 ]. (hindawi.com)
Ccl11
- Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. (creativebiomart.net)
Monocytes2
- A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. (harvard.edu)
- Soluble CX3CL1 potently chemoattracts T cells and monocytes , while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. (wikidoc.org)
RANTES1
- Adenosine down-regulated the gene expression of M1 cytokines (IL-1beta, TNF-alpha) and chemokines (CX3CR1, RANTES), as well as cordycepin. (researchgate.net)
Cluster1
- This chemokine resides in a large cluster of CC chemokines on human chromosome 17. (creativebiomart.net)
Cutaneous1
- Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes. (dovepress.com)
CCL271
- Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population. (nih.gov)
Induce1
- The downstream signaling of the complex proceeds inter alia via spleen associated tyrosine kinase (SYK) and the nuclear factor kappa-light-chain-enhancer (NF-κB) to induce the gene expression of pro-inflammatory cytokines, chemokines, and enzymes ( 4 , 5 ). (frontiersin.org)
Amino1
- there are three amino acids separating the initial pair of cysteines in CX3CL1, with none in CC chemokines and only one intervening amino acid in CXC chemokines . (wikidoc.org)
Rheumatoid arthritis1
- Chemokine C-C Motif Ligand 4 Gene Polymorphisms Associated with Susceptibility to Rheumatoid Arthritis. (cdc.gov)
Attracts1
- CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. (wikipedia.org)
CCL221
- [3] Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22 . (wikidoc.org)
Belongs1
- It belongs to the CXC chemokine family. (blogspot.com)
Expression5
- Through the use of macrophage cultures derived from Ahr -/- and Ahr nls/nls mice, it was established that expression of the AHR and its ability to translocate into the nucleus are necessary for AHR ligand-mediated synergistic induction of Ccl20. (princeton.edu)
- Through the use of macrophage cultures derived from Ahr-/- and Ahrnls/nls mice, it was established that expression of the AHR and its ability to translocate into the nucleus are necessary for AHR ligand-mediated synergistic induction of Ccl20. (princeton.edu)
- CCL6 expression is also stimulated by IL-13 and is required for IL-13 stimulation of other chemokines. (goldbio.com)
- To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) patients and to correlate their levels with clinical findings. (molvis.org)
- The aim of this study was therefore to investigate the chemokine expression profiles of wet AMD patients and to correlate their levels with clinical disease phenotypes. (molvis.org)
Profiles3
- This graph shows the total number of publications written about "Chemokine CXCL2" by people in Harvard Catalyst Profiles by year, and whether "Chemokine CXCL2" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Chemokine CXCL2" by people in Profiles. (harvard.edu)
- To the best of our knowledge, chemokine profiles in the aqueous humor of patients with wet AMD have not been described. (molvis.org)
Descriptor1
- Chemokine CXCL2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)