TumorsNeoplasmsTumorLarge cell neuroendocrine carcinomaDifferentiationTumoursCarcinoidPoorly differentiated neuroendocrine carcinomaTumourMetastaticNECsNeoplasmAdenocarcinomaPulmonary neuroendocrineEpithelialMetastasesAggressiveRenal cell carcDiagnosisPure small cell carcPrognosisImmunohistochemicalRhabdoid morphologyHepatocellular carcinomaHistologyDiagnosticMerkelClassificationHistologicMolecularImmunohistochemistryProstaticRecurrenceThyroidNeoplasiaSmall cellCharacteristicsClinicalRare
Tumors18
- More than 99% of primary lung cancers are carcinoma, which are tumors composed of cells that originate from embryonic ectoderm or endoderm, or that feature epithelial characteristics or differentiation. (wikipedia.org)
- Neuroendocrine lung tumors can be grouped into four epithelial and one mesenchymal tumor. (deepdyve.com)
- The epithelial neuroendocrine tumors are further divided into two high-grade carcinomas, large and small cell neuroendocrine carcinomas, and into low-grade typical and intermediate grade atypical carcinoid. (deepdyve.com)
- In this short review, we will focus on the low and intermediate grade neuroendocrine tumors only. (deepdyve.com)
- Neuroendocrine carcinomas are extremely rare in the esophagus as they represent less than 0.04% of all neuroendocrine tumors. (biomedcentral.com)
- Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). (biomedcentral.com)
- With this approach, PanNENs fall into two basic subtypes: well-differentiated pancreatic neuroendocrine tumors (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs) [ 4 ]. (biomedcentral.com)
- With regard to the cellular origin of bronchial squamous-cell carcinomas, there are some clinicopathologic and experimental data indicating a link between neuroendocrine (NE) bronchial tumors and the traditionally non-NE squamous-cell carcinomas. (deepdyve.com)
- Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
- Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
- According to the degree of differentiation, NENs have been divided into well differentiated NENs and poorly differentiated NENs in the 2010 World Health Organization classification of tumors of the digestive system, with the former being termed a neuroendocrine tumor (NET), and the latter, a neuroendocrine carcinoma (NEC) [ 1 ]. (biomedcentral.com)
- Baseline tumor growth rate highlights the heterogeneity of well differentiated gastroenteropancreatic neuroendocrine tumors and predicts for increases in Ki67 index over time. (ucsf.edu)
- Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors. (ukw.de)
- GEP-NENs encompass a wide spectrum of entities, from very indolent tumors to highly aggressive carcinomas. (hunimed.eu)
- Methods of analysis of tumors of the DNS are also presented because some of these techniques are indispensable for the diagnosis of many neuroendocrine neoplasms. (basicmedicalkey.com)
- The current neuroendocrine classification of cells and tumors uses immunohistochemical (IHC), ultrastructural, and molecular biologic features to define members of the DNS ( 6 , 7 and 8 ). (basicmedicalkey.com)
- In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes. (icd10data.com)
- Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
Neoplasms16
- Although rhabdoid variants of LCLC are sometimes referred to as "rhabdoid carcinomas", this particular term should be reserved for examples of "pure" rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) Lung cancers are now considered a large and extremely heterogeneous family of neoplasms that feature widely varying genetic, biological, and clinical characteristics. (wikipedia.org)
- Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumours that compose 1-2% of all pancreatic tumours. (nih.gov)
- Pancreatic neuroendocrine neoplasms (PanNENs) have undergone several classification changes according to consensus guidelines [ 1 ]. (biomedcentral.com)
- Many retrospective studies have confirmed that capecitabine combined with temozolomide is effective in neuroendocrine neoplasms. (viamedica.pl)
- Treatment options for grade 3 neuroendocrine neoplasms are limited, and the overall prognosis is better in the subgroup of patients with grade 3 neuroendocrine tumours. (viamedica.pl)
- It was a retrospective study in the population of patients with diagnosed grade 3 neuroendocrine neoplasms of different origin treated with capecitabine and temozolomide. (viamedica.pl)
- The gastroenteropancreatic (GEP) system is the site of origin of about two thirds of all neuroendocrine neoplasms (NENs) of the human body. (hunimed.eu)
- The cells and neoplasms of the neuroendocrine and paracrine systems make up the DNS. (basicmedicalkey.com)
- and (b) those of epithelial type, which include neuroendocrine neoplasms from many sites. (basicmedicalkey.com)
- Although the term carcinoid tumor has been broadly used to refer to many neoplasms derived from the DNS ( 9 ), this term is being replaced by neuroendocrine neoplasms. (basicmedicalkey.com)
- Many broad-spectrum IHC markers are available to aid in the diagnosis of neuroendocrine neoplasms. (basicmedicalkey.com)
- Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
- These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
- The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
- The main structure of the histological grouping is that Morphology codes specific types of malignant neoplasms are listed as wel as Grouping of morphological codes presents several difficulties. (who.int)
- Thyroid neoplasms arising from follicular cells (adenoma, carcinoma, and follicular/papillary carcinoma) show a broad range of overlapping clinical and cytologic features. (medscape.com)
Tumor11
- Eight major groups of lung carcinomas are recognized in WHO-2004: Squamous cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma Carcinoid tumor Salivary gland-like carcinoma of the lung LCLC-RP are considered variants of large cell carcinoma. (wikipedia.org)
- Election microscopic studies, however, have shown that many LCLC do have ultrastructural characteristics of other tumor types (i.e. adenocarcinoma, squamous cell carcinoma). (wikipedia.org)
- Rhabdoid cells often express protein products suggestive of aggressive, dedifferentiated cells, including neuroendocrine tumor-related products and granulocyte-macrophage colony stimulating factor (GM-CSF). (wikipedia.org)
- While undifferentiated large-cell lung carcinoma is the most common parent lung tumor from which a rhabdoid phenotype evolves, malignant cells with a rhabdoid phenotype are known to occur in many different histological variants of lung cancer, including adenocarcinoma, sarcomatoid carcinoma, squamous cell carcinoma, combined large cell neuroencrine carcinoma, and mucinous bronchioloalveolar carcinoma and combined small cell lung carcinoma. (wikipedia.org)
- Proper and generous tumor sampling along with careful histologic examination allow for recognition of these rare morphologies. (lww.com)
- The only non-epithelial neuroendocrine tumor of the lung is pulmonary paraganglioma. (deepdyve.com)
- Van Treeck BJ, Said S, Yasir S . Epithelioid Malignant Peripheral Nerve Sheath Tumor in the Liver: Report of a Rare Unusual Case with Rhabdoid Morphology and Review of the Literature. (mayoclinic.org)
- Incidental Langerhans cell histiocytosis associated with metastatic neuroendocrine tumor in the adult liver. (ucsf.edu)
- Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap. (ucsf.edu)
- It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
- Follicular thyroid carcinoma (FTC) is a well-differentiated tumor. (medscape.com)
Large cell neuroendocrine carcinoma5
- Here, we describe the case and management of a previously healthy 67-year-old male in his fifth year of remission after treatment for poorly differentiated large cell neuroendocrine carcinoma of the esophagus. (biomedcentral.com)
- Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. (e-acfs.org)
- Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of lung cancer, accounting for 1% to 3% of all lung cancers, and is known for its aggressive behavior [ 1 ]. (e-acfs.org)
- Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
- As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
Differentiation10
- Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
- The rare cases that have neuroendocrine morphology are thought to arise from the neuroendocrine stem cells that are normally present in the prostate or from aberrant differentiation programs during cell transformation. (medscape.com)
- In many cases, prostate carcinomas with squamous differentiation arise after radiation or hormone treatment. (medscape.com)
- Merkel cell carcinoma with divergent differentiation: two case reports. (ox.ac.uk)
- on biopsy, the morphology and immunoprofile suggested MCC with divergent squamous differentiation. (ox.ac.uk)
- These cases illustrate that Merkel cell carcinoma is capable of divergent differentiation, including squamous and adnexal morphologies. (ox.ac.uk)
- It is unclear if the morphologic pattern and appearance of neuroendocrine differentiation varies based on the type of anti-androgen regimen. (healthyprostateclub.com)
- More importantly, given the rise and progress in molecular pathology particularly in fields such as pulmonary adenocarcinomas, it is of great current interest to know any molecular variations in post ADT neuroendocrine differentiation and pure NEPC. (healthyprostateclub.com)
- Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
- In this case report we present a patient with the anti-Hu syndrome associated with an unclassified rhabdornyosarcoma with epitheloid cellular morphology and neuroendocrine differentiation. (uantwerpen.be)
Tumours11
- According to the WHO 2017 classification, they are divided into neuroendocrine tumours (NETs) G3 and neuroendocrine carcinomas (NECs). (nih.gov)
- Most of the studies focused on grade 1 and grade 2 neuroendocrine tumours, mainly of pancreatic origin. (viamedica.pl)
- There are limited data regarding the efficacy capecitabine with temozolomide in grade 3 neuroendocrine tumours. (viamedica.pl)
- The new World Health Organisation 2017 classification distinguished well-differentiated grade 3 neuroendocrine tumours from poorly differentiated grade 3 neuroendocrine carcinomas. (viamedica.pl)
- This study aimed to evaluate response and survival parameters and compare outcomes of treatment of neuroendocrine tumours and carcinomas. (viamedica.pl)
- The study included 32 patients with grade 3 neuroendocrine tumours treated with capecitabine and temozolomide. (viamedica.pl)
- The progression-free survival for patients with neuroendocrine tumours was 15.3 months (95% CI: 3.9-30.4), and for patients with neuroendocrine carcinomas it was 3.3 months (95% CI: 2.5-7.1). (viamedica.pl)
- Median overall survival was 22 months (95% CI: 11.8-22.0) and 4.6 months (95% CI: 2.2-5.9) for patients with tumours and carcinomas, respectively. (viamedica.pl)
- Van Treeck BJ, Dasari S, Kurtin PJ, Theis JD, Nasr SH, Zhang L, Yasir S , Graham RP, McPhail ED, Said S. Somatostatin-derived amyloidosis: a novel type of amyloidosis associated with well-differentiated somatostatin-producing neuroendocrine tumours. (mayoclinic.org)
- Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
- Additionally, we identified six tumours, termed supra-carcinoids, that displayed genuine carcinoid-like morphology, but had clinical and molecular characteristics of LNECs. (who.int)
Carcinoid1
- Histological features that may be observed in GISTs are paranuclear vacuoles, nuclear palisading mimicking schwannoma, neuroendocrine-like morphology mimicking carcinoid or paraganglioma tumour, and skeinoid fibres, hyaline eosinophilic cytoplasmic buildings that are located in little colon GISTs [1 mostly, 2, 13]. (moonphase2018.com)
Poorly differentiated neuroendocrine carcinoma1
- Endoscopic ultrasound-guided biopsy revealed poorly differentiated neuroendocrine carcinoma of the esophagus with metastasis to a diaphragmatic lymph node. (biomedcentral.com)
Tumour3
- The treatment did not overcome the aggressive character of neuroendocrine carcinomas and resulted in low response and survival outcomes in comparison to those achieved in tumour therapy. (viamedica.pl)
- There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
- Similarly, under Carcinoma, specific renamed or deleted in later revisions of tumour classifications. (who.int)
Metastatic4
- Being aware of this unusual and rare presentation of metastatic prostate carcinoma might decrease diagnostic delay and allow earlier treatment. (hindawi.com)
- The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)
- Based on these findings, metastatic carcinoma was suspected. (e-acfs.org)
- Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
NECs3
- Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). (elsevierpure.com)
- Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
- We have also reviewed the literature concerning gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) in this article. (biomedcentral.com)
Neoplasm2
- Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
- By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Adenocarcinoma10
- [ 2 ] Another 25-40% of cases are initially diagnosed as prostatic adenocarcinoma and recur as small cell carcinoma after hormonal therapy. (medscape.com)
- The median interval between initial diagnosis of prostatic adenocarcinoma and recurrence of small cell carcinoma is 25 months. (medscape.com)
- Unlike prostatic adenocarcinoma, small cell carcinoma of the prostate may present with metastases in up to 25% of patients. (medscape.com)
- The distribution of prostatic small cell carcinoma is similar to that of prostatic adenocarcinoma. (medscape.com)
- The risk factors for prostatic small cell carcinoma are related to those for prostatic adenocarcinoma and include age, race, and family history. (medscape.com)
- this finding is not surprising, since many patients actually have prostatic adenocarcinoma with a component of small cell carcinoma. (medscape.com)
- PanNECs can occur with admixed components of other carcinoma types of non-neuroendocrine origin, this can be either ductal adenocarcinoma (PDAC) or acinar cell carcinoma (ACC). (biomedcentral.com)
- Their peculiar morphology can appear infiltrative with a desmoplastic-like background, raising concerns for an infiltrating adenocarcinoma. (bmj.com)
- Conclusions Awareness of this unique morphology is important to avoid overdiagnosing microcarcinoids as invasive adenocarcinoma. (bmj.com)
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Pulmonary neuroendocrine2
- atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
- In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
Epithelial1
- Carcinomas of the lung are thought to arise from the uncontrolled growth of mutated, transformed, multipotent "cancer stem cells" with epithelial characteristics or lineage. (wikipedia.org)
Metastases2
- Unusual prostate carcinoma metastases are usually encountered in the presence of known advanced disease but rarely as the first presentation. (hindawi.com)
- Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
Aggressive1
- A study of differential gene expression profiling of aggressive and nonaggressive follicular carcinomas identified 94 genes that distinguish follicular carcinomas from follicular adenomas (including PBP and CKS2 ) and 4 genes that distinguish aggressive follicular carcinomas from nonaggressive follicular carcinomas ( NID2, TM7SF2, TRIM2, and GLTSCR2 ). (medscape.com)
Renal cell carc2
Diagnosis1
- Describe the WHO criteria for the diagnosis of lobular carcinoma in situ and the uses and limitations of e-cadherin immunohistochemistry in evaluating in-situ lesions of the breast. (cme-video.com)
Pure small cell carc1
- Approximately 50% of patients have pure small cell carcinoma at initial presentation. (medscape.com)
Prognosis1
- The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
Immunohistochemical1
- Yasir S , Fernandez-Castro G, Bajwa N, Block N, Schally A, Cote R, Jorda M. Immunohistochemical expression of receptors for luteinizing hormone-releasing hormone (LHRHR) in muscle-invasive Urothelial carcinoma of urinary bladder: a potential predictive marker for targeted cytotoxic LHRH hybrid analog Surgical and Experimental Pathlogy. (mayoclinic.org)
Rhabdoid morphology1
- d) Large bizarre cells with strap-like, rhabdoid morphology (Pap, ×20). (cytojournal.com)
Hepatocellular carcinoma1
- Yasir S , Chen ZE, Said S, Wu TT, Torbenson M. Biopsies of hepatocellular carcinoma with no reticulin loss: an important diagnostic pitfall. (mayoclinic.org)
Histology1
- A month later, this mass was surgically excised and the histology examination showed a poorly differentiated small cell carcinoma, with histopathologic features of a Merkel cell carcinoma. (springeropen.com)
Diagnostic1
- These data suggest that Rb loss is a critical event in the development of small cell carcinomas and may be a useful diagnostic and potential therapeutic target. (healthyprostateclub.com)
Merkel2
Classification2
- Recent studies have shown beyond doubt that the old classification paradigm of "small cell carcinoma vs. non-small cell carcinoma" is now obsolete, and that the correct "subclassification" of lung cancer cases is necessary to assure that patients receive optimum management. (wikipedia.org)
- The key issues of the current classification are addressed, including the emerging topics about cases with discordant morphology and proliferative index. (hunimed.eu)
Histologic2
- Rare patterns of ChRCC have been described over the last few decades, showing a wide histologic spectrum including those with adenomatoid microcystic pigmented, multicystic, neuroendocrine, small cell, and papillary features. (lww.com)
- Describe current testing guidelines with an optimized approach for histologic and cytologic samples of suspected HPV-related squamous cell carcinoma. (cme-video.com)
Molecular3
- Applied Immunohistochemistry and Molecular Morphology , 21 (4), 292-297. (elsevierpure.com)
- Triple-Negative Apocrine Carcinomas: Toward a Unified Group With Shared Molecular Features and Clinical Behavior. (ucsf.edu)
- The role of morphology in the molecular era will remain significant, as emerging morpho-molecular correlations enable the prediction of underlying molecular changes based on histological subtyping, at least in some types of cancer. (cancerworld.net)
Immunohistochemistry1
- By immunohistochemistry assay, studies showed that loss of Rb occurred almost universally in prostatic small cell carcinomas. (healthyprostateclub.com)
Prostatic2
- [ 3 ] The overall risk of developing prostatic small cell carcinoma increases with age, with disease occurrence typically being in men older than 60 years. (medscape.com)
- The genetic changes specific to prostatic small cell carcinoma have not been studied in great detail. (medscape.com)
Recurrence2
- Case 2 was an 87 year-old female, with a lesion on the leg, originally reported as squamous cell carcinoma, later showing extensive local recurrence. (ox.ac.uk)
- Factors influencing recurrence after surgical treatment for T2 gallbladder carcinoma. (cancercentrum.se)
Thyroid3
- The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with MCC. (springeropen.com)
- FTC originates in follicular cells and is the second most common cancer of the thyroid, after papillary carcinoma. (medscape.com)
- Papillary/follicular carcinoma must be considered a variant of papillary thyroid carcinoma (mixed form), and Hurthle cell carcinoma should be considered a variant of FTC. (medscape.com)
Neoplasia1
- Characterize the common elements of neuroendocrine neoplasia throughout the body. (cme-video.com)
Small cell2
- Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers . (medscape.com)
- Anti-Hu syndrome is a paraneoplastic neurological syndrome, most frequently associated with small cell carcinoma of the lung. (uantwerpen.be)
Characteristics1
- Despite its well-differentiated characteristics, follicular carcinoma may be overtly or minimally invasive. (medscape.com)
Clinical1
- ENSAT registry-based randomized clinical trials for adrenocortical carcinoma. (ukw.de)
Rare2
- Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). (wikipedia.org)
- Squamous cell carcinomas are rare, constituting less than 1% of all prostate carcinomas. (medscape.com)