AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone MarrowBone Marrow CellsBone Marrow TransplantationBone Marrow DiseasesBone Marrow ExaminationBone Marrow NeoplasmsHematopoietic Stem CellsBone Marrow PurgingHematopoiesisColony-Forming Units AssayTransplantation, HomologousCell DifferentiationMice, Inbred C57BLCells, CulturedStromal CellsWhole-Body IrradiationAnemia, AplasticTransplantation, AutologousGraft vs Host DiseaseRadiation ChimeraLeukemiaFlow CytometryTime FactorsGranulocytesSpleenAntigens, CD34Hematopoietic Stem Cell TransplantationCell SeparationMicroscopy, Electron, ScanningCell DivisionPhenotypeMegakaryocytesCell CountLeukemia, Myeloid, AcuteTransplantation ChimeraPancytopeniaMice, KnockoutMyelodysplastic SyndromesStem CellsMultiple MyelomaMice, Inbred BALB CImmunophenotypingMicroscopy, ElectronCell LineageLeukemia, MyeloidGraft SurvivalMice, TransgenicGranulocyte Colony-Stimulating FactorT-LymphocytesErythropoiesisCyclophosphamideLeukocyte CountAntigens, CDImmunohistochemistryBlood CellsBlood Cell CountOsteogenesisCell MovementTissue DonorsPrecursor Cell Lymphoblastic Leukemia-LymphomaPrimary MyelofibrosisChimeraLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAntibodies, MonoclonalCell ProliferationBusulfanThymus GlandMolecular Sequence DataCell SurvivalTransplantation ConditioningMacrophagesCell LineHistocompatibility TestingMice, Inbred StrainsClone CellsColony-Stimulating FactorsCell AdhesionGranulocyte-Macrophage Colony-Stimulating FactorDisease Models, AnimalHistocompatibilityCell Culture TechniquesTransplantation, IsogeneicOsteoblastsRNA, MessengerPlasma CellsRecombinant ProteinsBone and BonesHematopoietic SystemPolymerase Chain ReactionStem Cell FactorOsteoclastsLymphocytesTreatment OutcomeAcute DiseaseRecurrenceReverse Transcriptase Polymerase Chain ReactionRemission InductionMutationMice, Inbred C3HHematologic Diseases
Bone marrow failureCytogeneticAbnormalitiesCorrelateMitochondrialTissueBlastsCardiomyopathyMyeloidAcuteSkeletalAnatomicalPeripheralPrevalenceApparentStem cellsMacrophagesDonorsDifferencesTransformationImagingGrossCellularLeukemiaDiagnosisCellsFeaturesAnemiaRadiationSpecificAnalysisNormalBlood flowRiskGroupHumanHigh
Bone marrow failure4
  • Non-FA (or underlying FA) patients harboring heterozygous germline FA gene mutations may also face an increased risk of developing bone marrow failure, primary immunodeficiency disease, and hereditary cancer predisposition syndromes. (frontiersin.org)
  • After two courses of a highly intensive induction chemotherapy regimen with DAC (decitabine) and HAA (homoharringtonine, cytarabine), the patient suffered from severe and persistent bone marrow failure (BMF). (frontiersin.org)
  • Throughout the lifetime of patients with an FA gene mutation, DNA damage increasing accumulates, which would lead to a complex clinically and genetically heterogeneous disorder characterized by developmental abnormalities, bone marrow failure (BMF), immune deficiency, and a high risk of developing various cancers (e.g. (frontiersin.org)
  • Childhood MDS is more commonly associated with inherited bone marrow failure syndromes and other genetic disorders. (medscape.com)
Cytogenetic2
  • The latest classification of acute leukaemia is the MIC (morphologic, immunologic, cytogenetic) classification which integrates morphology with the immunology and karyotype of the leukaemic cells. (sjmccancerradiosurgerycentre.com)
  • Diagnosis of MDS is made based upon evaluation of blood and bone marrow, cytogenetic abnormalities, and blast percentage. (medscape.com)
Abnormalities1
  • In contrast, macrocytic anemias most commonly originate from abnormalities that impair erythroid precursors' maturation in the bone marrow. (eistria.com)
Correlate2
  • 200 nm in diameter under physiological conditions, a possible morphological correlate to previously published changes in the SLE erythrocyte membrane. (degruyter.com)
  • Spearman correlation test was used to correlate immunolabeling, histologic grade, cellular morphology and immunophenotype. (vin.com)
Mitochondrial4
  • Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. (biomedcentral.com)
  • Metabolic statuses of BMMSCs and the mitochondrial activity, transcription and morphology were also examined. (thno.org)
  • Molecularly, in alleviating senescence-associated mitochondrial disorders of BMMSCs, particularly the mitochondrial morphological alterations, RESV upregulates Mitofilin, also known as inner membrane protein of mitochondria (Immt) or Mic60, which is the core component of the mitochondrial contact site and cristae organizing system (MICOS). (thno.org)
  • Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
Tissue5
  • The therapy of choice involves surgical resection with a wide margin of healthy tissue, usually followed by radiation treatment in order to decrease local recurrence ( 2 , 3 ). (spandidos-publications.com)
  • However, owing to recent advances, deep learning is frequently used in biomedical image analysis to detect nuclei, phenotypes or morphological substructues in stained tissue sections. (tissuegnostics.com)
  • Another innovative approach to using AI in medicine is tissue cytometry, used specifically for the segmentation of cells and other morphological tissue structures. (tissuegnostics.com)
  • Therefore, in natural bone remodeling, the bonding phenomenon is limited to submicron interlocking [3], however, the long-term physical stability of the interface between new and old bone, which is crucial for the stability of skeletal tissue, depends on the higher-order morphology properties. (toysis.pics)
  • Oddly enough, the serum MCP-1 Metoclopramide HCl level elevated and peaked at six h after c-lipo pretreatment quickly, suggesting which the MCP-1 made by c-lipo-phagocytized Compact disc68+ Kupffer cells Metoclopramide HCl may recruit Compact disc11b+ macrophages in the periphery and bone tissue marrow. (enmd-2076.com)
Blasts1
Cardiomyopathy2
  • The combination of doxorubicin with ifosfamide is more effective, exhibiting higher response rates than doxorubicin alone, but is associated with severe short- and long-term toxicities, including cardiomyopathy and bone marrow suppression ( 11 - 13 ). (spandidos-publications.com)
  • The dosages of a chemotherapeutic agent cannot be increased because high dosages lead to various side effects like bone marrow suppression, cardiomyopathy, nephrotoxicity, neurotoxicity, and multidrug resistance 8 . (ijpsr.com)
Myeloid1
Acute1
  • Experimental and laboratory reports Morphology of acute myocardial infarction in relation to coronary thrombosis G. Baroldi, M.D. Thrombosis refers to the formation of a thrombus (blood clot) due to dysregulation of normal hemostasis.Certain factors can favor thrombus formation in the venous system, arterial system, or both. (senorcafe.com)
Skeletal1
Anatomical1
  • stage IV--liver and/or spleen involvement or stage V--manifestations in the blood and involvement of bone marrow and/or other organ systems), as well as anatomical classification (multicentric, alimentary, cutaneous, mediastinal or extranodal). (vin.com)
Peripheral2
Prevalence2
  • Histological classification showed high-grade lymphomas prevalence (86,7%), corresponding to morphological subtypes: centroblastic (5), immunoblastic (4), lymphoblastic (2) and anaplastic (2). (vin.com)
  • The prevalence of anemia in population studies of healthy people (excluding pregnant women) depends on the hemoglobin concentration selected as the lower limit of normal. (eistria.com)
Apparent1
  • As the affected cell lines continue to divide and to provide the marrow with dysplastic cells, bone marrow dysfunction becomes apparent. (medscape.com)
Stem cells2
  • The aim of this pre-clinical study was to investigate the effects of intradermal injections of MSC in experimental cutaneous wound repair comparing allogeneic and autologous adipose stem cells (ASCs) and autologous bone marrow-mesenchymal stromal cells (BM-MSCs). (biomedcentral.com)
  • As an alternative, the clone may progressively deteriorate, and the appearance of marrow may return to normal as healthy stem cells repopulate it. (medscape.com)
Macrophages2
  • The polarization effect of WGLWE on bone marrow-derived macrophages (BMDM) was determined. (bvsalud.org)
  • CONCLUSION: Our results indicated that WGLWE alleviated joint inflammation in CIA rats and the underlying mechanism may be related to inducing the transformation of bone marrow-derived M1 macrophages to M2 macrophages, leading to an increase in the secretion of anti-inflammatory factors and a decrease in pro-inflammatory factors. (bvsalud.org)
Donors2
  • These findings were validated by qRT-PCR in an independent cohort consisting of 49 adult AML patients and 4 healthy donors of total bone marrow (bm) referred to as the Ulm cohort with uniform treatment procedure. (nature.com)
  • iPS were generated via a platelet lysate or fetal bovine serum-based culturing protocol from matched dermal, buccal and gingival human fibroblasts, isolated from healthy donors ( n = 2) after informed consent, via episomal plasmid transfection. (biomedcentral.com)
Differences2
  • Significant differences in the morphology of RBCs from healthy humans and patients with systemic lupus erythematosus (SLE) were observed on topographical images. (degruyter.com)
  • The human skeleton is not as sexually dimorphic as that of many other primate species, but subtle differences between sexes in the morphology of the skull, dentition, long bones, and pelvis exist. (wikipedia.org)
Transformation1
  • This state may persist until a clone undergoes further transformation to leukemia and the marrow becomes fibrotic and aplastic. (medscape.com)
Imaging2
  • Total-body Dynamic Imaging and Kinetic Modeling of 18 F-AraG in Healthy Individuals and a Non-Small Cell Lung Cancer Patient Undergoing Anti-PD-1 Immunotherapy. (ucdavis.edu)
  • Due to the high spatial resolution and difficult acoustic windows, cardiovascular magnetic resonance (CMR) imaging is now considered the gold standard technique for RV morphological study. (hindawi.com)
Gross1
Cellular1
  • These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. (biomedcentral.com)
Leukemia1
  • and for leukemia‐free survival were prefibrotic PMF morphology, thrombosis and extreme thrombocytosis (platelets >1 million/μl). (senorcafe.com)
Diagnosis1
  • A diagnosis of light chain amyloidosis was made based on a biopsy of subcutaneous fat or an involved organ with the demonstration of typical Congo red birefringence, the detection of a monoclonal protein in the serum or urine and/or a monoclonal population of plasma cells in the bone marrow [ 13 ]. (hindawi.com)
Cells5
  • The skeleton is the site of haematopoiesis, the development of blood cells that takes place in the bone marrow. (wikipedia.org)
  • Bioincompatible dialysis fluid causes mesothelial cells to undergo uncontrolled mesothelial-to-mesenchymal transition triggered by Transforming growth factor-β1, which leads morphological and functional disruption of membrane. (ukessays.com)
  • In leukaemia, the "flooding" of the bone marrow by leukaemic cells will interfere with the normal production of blood cells. (sjmccancerradiosurgerycentre.com)
  • Due to its poor specificity to the cancer cells damages healthy human cells by inhibiting DNA synthesis or interfering with various metabolism and cell division pathways of rapidly proliferative cells 6, 7 . (ijpsr.com)
  • In the cell morphology analyzes, chromatin condensation and marginalization, changes in the cell membrane, ghost cells and apoptotic bodies were observed as evidence of apoptosis formation. (ijpsonline.com)
Features1
  • The general morphological features of thrombi are as under: Grossly, thrombi can have different shapes, sizes, and composition depending upon the site of origin. (senorcafe.com)
Anemia1
  • Another clinically useful approach to anemia classifications is a change in red blood cell morphology, which often indicates a specific cause. (eistria.com)
Radiation1
  • Any man exposed to a sufficient dose of inorganic arsenic, benzene, radiation, or conventional chemotherapeutic agents develops bone marrow suppression with pancytopenia. (eistria.com)
Specific1
  • MSCs derived from bone marrow (BMMSCs) and the bone-specific, senescence-accelerated, osteoblastogenesis/osteogenesis-defective mice (the SAMP6 strain) were used as experimental models. (thno.org)
Analysis1
  • Mangiferin-loaded poly (lactic-co-glycolic acid) nanoparticles were prepared by single emulsion-solvent evaporation technique and evaluated for yield, particle size, morphology analysis, zeta-potential, drug loading, encapsulation efficiency, in-vitro drug release study and MTT assay on A549 cell line. (ijpsr.com)
Normal2
  • She was healthy, and with a normal history in her early years. (frontiersin.org)
  • It preserves normal blood flow in very small blood vessels in healthy elderly people with normal blood pressure, despite their high-salt diet (1). (milkgenomics.org)
Blood flow1
  • The objective of this in vitro experiment was to investigate the impact of aortic root morphology on blood flow in the aortic sinus and to relate these results to in vivo data obtained in patients with a transcatheter aortic valve implant. (senorcafe.com)
Risk1
Group1
  • Control group consisted of five healthy dogs. (vin.com)
Human1
  • The Summit brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in founding or joining a startup - all aiming to create therapies to vastly extend the healthy human lifespan. (fightaging.org)
High1
  • Increased natural cheese consumption could benefit healthy elderly people even on a high-salt diet. (milkgenomics.org)