• Such a genetic approach to the study of ontogeny was pioneered by W addington ( 1940 ) to analyze wing morphogenesis in Drosophila melanogaster and later allowed the understanding of the process of segmentation in this insect ( N ├╝sslein-Volhard and W ieschaus 1980 ). (genetics.org)
  • To form a complex organ, simple tissues must be folded, stretched, compressed, and otherwise sculpted into a precise form in a process called tissue morphogenesis. (mit.edu)
  • One of the most dramatic examples of tissue morphogenesis occurs during embryonic development, when primitive planar tissues are folded to generate separate layers that will give rise to different parts of the body during gastrulation. (mit.edu)
  • Tissue morphogenesis requires that cytoskeletal machines generate forces that change cell shape and deform the tissue. (mit.edu)
  • The molecular mechanism by which the cytoskeleton generates force is not known for many of the diverse cell shape changes and tissue movements that underlie morphogenesis. (mit.edu)
  • Given that tissue morphogenesis fundamentally involves movement, we have developed a system to visualize and quantify the dynamics of molecules, cells, and tissues during gastrulation. (mit.edu)
  • I would like to describe two excellent talks given at BPS 2018, both on tissue morphogenesis, that were not printed in the BPS 2018 abstracts publication. (biophysics.org)
  • Specifically, we are investigating the mechanisms driving their cell-type specification and the coordination with tissue morphogenesis. (mskcc.org)
  • Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. (nih.gov)
  • At a tissue level, ignoring the means of control, morphogenesis arises because of cellular proliferation and motility. (wikipedia.org)
  • There will be invited presentations by leading researchers in craniofacial morphogenesis, and the meeting will also feature sessions on the functional genomics of craniofacial syndromes, development of animal models and the application of tissue engineering in regeneration and repair. (grc.org)
  • This GRC will be held in conjunction with the "Craniofacial Morphogenesis and Tissue Regeneration (GRS)" Gordon Research Seminar (GRS). (grc.org)
  • Using synthetic biology to engineer patterning and morphogenesis will both enhance our basic understanding of how development works, and provide important technologies for advanced tissue engineering. (portlandpress.com)
  • Thus, in addition to maintaining tissue-specific cytodifferentiation and function, a basement membrane promotes the expression of tissue-like morphogenesis. (unt.edu)
  • A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology. (sigmaaldrich.com)
  • Here, we provide a general account of our current understanding of the HCV lifecycle and a review of recent studies focusing on the morphogenesis of HCV particles within cell culture systems. (frontiersin.org)
  • He and his students have developed the first mathematical models for cardiovascular growth and morphogenesis and were the first to measure stress, strain and interstitial pressure in the heart of the early chick embryo. (nanohub.org)
  • Epiblast cavity formation is essential for the morphogenesis and survival of the embryo as it implants in the uterine wall. (rupress.org)
  • 1) Sevan Hopyan gave a talk entitled "Volumetric Morphogenesis in the Mouse Embryo" in the Mechanobiology subgroup on Saturday. (biophysics.org)
  • The complex interplay of these morphogen gradients regulates the activity of genes in different regions of the embryo and ultimately brings about the differentiation of the tissues and organs appropriate to the different regions of the embryo, i.e. morphogenesis. (encyclopedia.com)
  • An important class of molecules involved in morphogenesis are transcription factor proteins that determine the fate of cells by interacting with DNA. (wikipedia.org)
  • 2006 ). Molecular biology based research over the last decade has uncovered numerous transcription factors, signaling networks, and matricellular proteins essential in controlling embryonic morphogenesis (Camenisch et al. (wiley.com)
  • Although many proteins have been identified recently as regulators of dendritic morphogenesis, the intracellular signaling pathways that control these processes are not well understood. (jneurosci.org)
  • Plant morphogenesis is brought about chiefly through differential growth. (britannica.com)
  • Tiller age was an important factor interfering with the morphogenetic responses of marandu palisadegrass, indicating that there is an ontogenetic effect on plant morphogenesis that should be considered further in future studies of this nature. (scielo.br)
  • In addition, being a highly complex plant organ, the gynoecium is well suited to serving as a model system for use in the investigation of plant morphogenesis and development. (frontiersin.org)
  • Developmental signaling pathways implicated in morphogenesis include Wnt, Hedgehog, and ephrins. (wikipedia.org)
  • The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. (mdpi.com)
  • Kristen Kwan, Assistant Professor of Human Genetics, University of Utah will be delivering a seminar on Cellular and Molecular Mechanisms of Optic Cup Morphogenesis on Wednesday, June 24th at Noon in the the Moran Eye Center auditorium. (utah.edu)
  • Hence, a search for genes involved in the control of leaf morphogenesis by attempting to isolate gene products spatially restricted to this organ would identify those related to the execution of leaf functions rather than to the developmental mechanisms responsible for leaf architecture. (genetics.org)
  • Basic science insights will improve knowledge about the mechanisms underlying craniofacial morphogenesis, and translation of these findings will improve the clinical management of developmental disorders of the head and face. (grc.org)
  • The development of natural tissues, organs and bodies depends on mechanisms of patterning and of morphogenesis, typically (but not invariably) in that order, and often several times at different final scales. (portlandpress.com)
  • The aim of this study was to monitor and visualize the subcellular and molecular interactions between endothelial cells (ECs), fibroblasts, and their surrounding microenvironment during vascular morphogenesis in a three-dimensional coculture model. (mdpi.com)
  • Our prior studies established an essential role for Cdc42 in vascular network assembly, demonstrating that the genetic inactivation of Cdc42 yields defective vascular morphogenesis due to impaired migration of endothelial precursor cells. (ahajournals.org)
  • Morphogenesis may be radical by the realization of inventions or entirely new ideas about institutions or technologies, or it may be gradual by elaborating (refining and adding on to) existing structures ( see growth , development , organisation , morphostasis ). (ac.be)
  • We illustrate how Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development, Pitx2 appears to control gonad organ size. (pnas.org)
  • All together our observations indicate that the effects elicited by Pitx2 during the development of the female chick ovary are critical for cell topology, growth, fate, and ultimately organ morphogenesis and function. (pnas.org)
  • Morphogenesis , the shaping of an organism by embryological processes of differentiation of cells, tissues, and organs and the development of organ systems according to the genetic "blueprint" of the potential organism and environmental conditions. (britannica.com)
  • morphogenesis The development, through growth and differentiation, of form and structure in an organism. (encyclopedia.com)
  • morphogenesis (mor-foh- jen -i-sis) n. the development of form and structure of the body and its parts. (encyclopedia.com)
  • Taken together, our findings demonstrate that intrinsic autophagy is an important regulator of lung development and morphogenesis and may contribute to the BPD phenotype when impaired. (jci.org)
  • Cellular morphogenesis is important throughout much of early development in multicellular animals. (sciencemag.org)
  • Our intention was to isolate as many mutants as possible showing abnormal leaves (1) to define the spectrum of possible perturbations in leaf morphogenesis, (2) to determine the number of genes whose mutations disturb the process, and (3) to choose for further studies those mutants whose phenotype and/or genetic interactions with others would suggest they are involved in the control of leaf development. (genetics.org)
  • Morphogenesis also describes the development of unicellular life forms that do not have an embryonic stage in their life cycle, or describes the evolution of a body structure within a taxonomic group. (wikipedia.org)
  • Where Thompson explained animal body shapes as being created by varying rates of growth in different directions, for instance to create the spiral shell of a snail, Turing correctly predicted a mechanism of morphogenesis, the diffusion of two different chemical signals, one activating and one deactivating growth, to set up patterns of development, decades before the formation of such patterns was observed. (wikipedia.org)
  • The longstanding model of gynoecium morphogenesis in Arabidopsis holds that apically localized auxin biosynthesis in the gynoecium results in an apical to basal gradient of auxin that serves to specify along its length the development of style, ovary, and gynophore in a concentration-dependent manner. (frontiersin.org)
  • For a transcription factor to be considered directly involved in heart development, it must be expressed in developing heart tissues and exert an influence on processes that impact the morphogenesis of the developing heart. (ahajournals.org)
  • Here we report that endophilin A1, with a well-established role in clathrin-mediated synaptic vesicle endocytosis at the presynaptic terminal, also localizes to dendritic spines and is required for spine morphogenesis, synapse formation and synaptic function. (sigmaaldrich.com)
  • A longer morphogenetic window can result in a more complex leaf, as is evident in the clausa mutant, whereas a shorter morphogenesis stage results in a simplified leaf form, as in the case of the Arabidopsis simple leaf and the tomato La-2/ + mutant. (biologists.org)
  • Kennedy, B. and Malicki, J. (2009), What drives cell morphogenesis: A look inside the vertebrate photoreceptor. (wiley.com)
  • Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morpho- genesis, despite the enormous growth of interest that occurred nationally and internationally. (springer.com)
  • Dendritic morphogenesis requires an intrinsic differentiation program that is further guided by extracellular cues and electrical activity. (jneurosci.org)
  • Combined with a dynamic and talented team of PhD students trained in microbiology, biotechnology and engineering, we are making inroads into questions of the role of self-organization in cell morphogenesis or how physical principles drive cell shape . (iiserpune.ac.in)
  • The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovas- cular morphogenesis that will serve not only as an important archival and didactic reference source for those who have recently come into the field but also as a guide to the evolution of a field that is clearly coming of age. (springer.com)
  • The Banff International Research Station will host the " Material Evolution from plasticity to morphogenesis" workshop in Banff from June 11, 2017 to June 18, 2017. (birs.ca)
  • During female chick embryogenesis, and in contrast to males where both testes develop symmetrically, asymmetrical gonad morphogenesis results in only one functional ovary. (pnas.org)
  • Morphogenesis of these unique three-dimensional structures was initiated by cell-directed remodelling of the exogenous matrix leading to reorganization of cells into matrixensheathed aggregates by 24 h after plating. (unt.edu)
  • During head and foot regeneration and during budding the first detectable change in the cell distribution is an increase in the number of nerve cells at the site of morphogenesis. (uni-muenchen.de)
  • In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer. (mdpi.com)
  • Liu, X. The Role of S ox Genes in Lung Morphogenesis and Cancer. (mdpi.com)
  • Spore morphogenesis (reviewed by N eiman 2005 ) initiates with enlargement of the outer surface of the spindle pole body (SPB) to form the meiotic outer plaque. (genetics.org)