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  • opiates
  • Morphine and other opiates have been known to mankind for centuries. (news-medical.net)
  • A team of international researchers headed up by the University of Michigan has used noninvasive transcranial direct current stimulation (tDCS) to release endogenous opioids - the human body's most powerful, euphoria-inducing painkillers that are very similar to opiates such as morphine. (extremetech.com)
  • Morphine along with other opiates is a highly addictive substance which results in a rapid tolerance and an equally rapid form of dependency. (medic8.com)
  • opioid
  • Adverse effects of opioids Common and short term Itch Nausea Vomiting Constipation Drowsiness dry mouth Other Opioid dependence Dizziness Decreased sex drive Loss of appetite impaired sexual function Decreased testosterone levels Depression Immunodeficiency opioid-induced abnormal pain sensitivity Irregular menstruation Increased risk of falls Slowed breathing Like loperamide and other opioids, morphine acts on the myenteric plexus in the intestinal tract, reducing gut motility, causing constipation. (wikipedia.org)
  • The gastrointestinal effects of morphine are mediated primarily by μ-opioid receptors in the bowel. (wikipedia.org)
  • The drug combination morphine/naltrexone (trade name Embeda) was an opioid combination pain medication developed by King Pharmaceuticals for use in moderate to severe pain. (wikipedia.org)
  • morphine being an opioid receptor agonist and naltrexone an opioid receptor antagonist. (wikipedia.org)
  • Novel Opioid Receptor Agonists with Reduced Morphine-like Side Effects. (nih.gov)
  • Morphine-N-oxide (genomorphine) is an active opioid metabolite of morphine. (wikipedia.org)
  • Conversion between extended-release and immediate-release (or "regular") morphine is easier than conversion to or from an equianalgesic dose of another opioid with different half-life, with less risk of altered pharmacodynamics. (wikipedia.org)
  • According to a Cochrane review in 2013, extended-release morphine as a opioid replacement therapy for people with heroin addiction or dependence confers a possible reduction of opioid use and with fewer depressive symptoms but overall more adverse effects when compared to other forms of long-acting opioids. (wikipedia.org)
  • Beyond a certain dose of an opioid (e.g. morphine)increase in does will not increase pain relief? (drugs.com)
  • opioids
  • Clinical studies consistently conclude that morphine, like other opioids, often causes hypogonadism and hormone imbalances in chronic users of both sexes. (wikipedia.org)
  • opium
  • The primary source of morphine is isolation from poppy straw of the opium poppy. (wikipedia.org)
  • Morphine was isolated from opium by the German chemist F.W.A. Sertürner in about 1804. (britannica.com)
  • Morphine is extracted from the dried milky exudate of the unripe seed capsule of the opium poppy ( Papaver somniferum ). (britannica.com)
  • The important constituents of opium are morphine (10 percent), papaverine (1. (britannica.com)
  • Licensing opium poppy cultivation in order to locally manufacture and market Afghan morphine, according to this proposal, would create the economic conditions to empower poverty stricken rural Afghans and cut their ties with the illicit poppy trade. (wikipedia.org)
  • One alternative development policy, put forward by the Senlis Council, proposes licensing poppy cultivation in order to make Afghan morphine and other poppy-based medicines and to avoid diversion of opium to illegal traffickers. (wikipedia.org)
  • Morphine-N-oxide can also form as a decomposition product of morphine outside the body and may show up in assays of opium and poppy straw concentrate. (wikipedia.org)
  • Conway
  • Within a year of Sandman's death, Colley and Conway created Orchestra Morphine, a group of Sandman's friends and colleagues who toured to celebrate the music of the band and to raise funds for the Mark Sandman Music Education Fund. (wikipedia.org)
  • Singer and guitarist Laurie Sargent, a member of Orchestra Morphine and former vocalist for the band Face to Face, later joined Colley and Conway in their first post-Morphine musical endeavor, Twinemen. (wikipedia.org)
  • codeine
  • Codeine-N-oxide Morphine-6-glucuronide Morphine-3-glucuronide Fennessy, M. R. (1968). (wikipedia.org)
  • Synthesis of morphine-like alkaloids in chemistry describes the total synthesis of the natural morphinan class of alkaloids that includes codeine, morphine, oripavine, and thebaine and the closely related semisynthetic analogs buprenorphine, hydrocodone, isocodeine, naltrexone, naloxone, nalbuphine, and oxycodone. (wikipedia.org)
  • Colley
  • Morphine was an American alternative rock group formed by Mark Sandman, Dana Colley, and Jerome Deupree in Cambridge, Massachusetts in 1989. (wikipedia.org)
  • Morphine was formed in 1989 by bassist and vocalist Mark Sandman, a member of the bluesy alternative rock band Treat Her Right, saxophonist Dana Colley, a former member of the local Boston group Three Colors, and drummer Jerome Deupree, who had played with Sandman in the Hypnosonics. (wikipedia.org)
  • semi-synthetic
  • Morphine-6-glucuronide 3-Monoacetylmorphine, the inactive 3,- position blocked by esterization (and thus inactive) of a semi-synthetic prodrug to morphine marking the same activity profile as the drug of this article Morphine-N-oxide Buprenorphine-3-glucuronide Vindenes V, Ripel A, Handal M, Boix F, Mørland J (July 2009). (wikipedia.org)
  • Opana (oxymorphone) is a semi synthetic morphine derivative. (drugs.com)
  • enzyme
  • In enzymology, a morphine 6-dehydrogenase (EC 1.1.1.218) is an enzyme that catalyzes the chemical reaction morphine + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } morphinone + NAD(P)H + H+ The 3 substrates of this enzyme are morphine, NAD+, and NADP+, whereas its 4 products are morphinone, NADH, NADPH, and H+. (wikipedia.org)
  • The systematic name of this enzyme class is morphine:NAD(P)+ 6-oxidoreductase. (wikipedia.org)
  • allergic
  • After an allergic reaction to a diphtheria vaccination, he has his nurse Anna give him morphine to negate the effects. (wikipedia.org)
  • tell your doctor and pharmacist if you are allergic to morphine, any other medications, or any of the ingredients in morphine suppositories. (empowher.com)
  • narcotic
  • The major toxicity from narcotic analgesics, like morphine, is depression of the central nervous system, especially the brain centre controlling respiration. (britannica.com)
  • 1993
  • The B-side of the long-out-of-print 1000-piece pressing of "Cure For Pain" on 7" vinyl called "Sexy Christmas Baby Mine" (1993) rounds out the adventure through Morphine musical history. (wikipedia.org)
  • severe pain
  • Morphine is used primarily to treat both acute and chronic severe pain. (wikipedia.org)
  • Morphine, for example, is an excellent drug for the control of severe pain, but it can depress respiration, and too much of it can cause death. (britannica.com)
  • Morphine is a painkiller, usually for chronic or severe pain as a result of a terminal illness but it is a highly addictive drug which can lead to dependency. (medic8.com)
  • acute
  • Morphine has also traditionally been used in the treatment of acute pulmonary edema. (wikipedia.org)
  • Moreover, the proposal hopes that Afghan morphine can contribute to decreasing the acute global morphine shortage and provide cheap essential poppy-based medicines to countries who currently cannot afford to prescribe them. (wikipedia.org)
  • doses
  • Extended-release morphine can be administered together with "rescue doses" of immediate-release morphine pro re nata in case of breakthrough pain, each generally consisting of 5% to 15% of the 24-hour extended-release dosage. (wikipedia.org)
  • significantly
  • In the setting of breathlessness at rest or on minimal exertion from conditions such as advanced cancer or end-stage cardiorespiratory diseases, regular, low-dose sustained-release morphine significantly reduces breathlessness safely, with its benefits maintained over time. (wikipedia.org)
  • dose
  • Your doctor may adjust your dose of morphine during your treatment to control your pain as well as possible. (empowher.com)
  • methadone
  • Synthetic organic chemistry also has provided a number of compounds (as meperidine , methadone , and pentazocine) that have in part supplanted morphine in medical use. (britannica.com)
  • poppy
  • It will eventually show a report on Morphine showing evidence that it can be cleanly produced from moldy poppy straw which may be cheaper to purchase. (angelfire.com)
  • Afghan morphine or "Poppy for Medicine" is an alternative development solution put forward to combat the poverty and public disenchantment caused by international counter-narcotics eradication policies in Afghanistan. (wikipedia.org)
  • pain
  • Morphine soon began to gain popularity as a pain reliever. (news-medical.net)
  • In its power to reduce the level of physical distress, morphine is among the most important naturally occurring compounds , being of use in the treatment of pain caused by cancer and in cases where other analgesics have failed. (britannica.com)
  • For constant pain, the relieving effect of extended-release morphine given once (for Kadian) or twice (for MS Contin) every 24 hours is roughly the same as multiple administrations of immediate release (or "regular") morphine. (wikipedia.org)
  • Morphine - no pain relief? (drugs.com)
  • Hello everyone, I take morphine exactly as directed by my dr 3 times per day and it does not touch day the pain I suffer from. (drugs.com)
  • It may be that you need morphine plus something like a muscle relaxant and/or an antidepressant/anticonvulsant that also relieves chronic pain like Cymbalta, Lyrica or gabapentin. (drugs.com)
  • Can morphine be taken as a pain relief regiment after aortic valve replacement? (drugs.com)
  • Morphine has a medical application in that it is designed to relieve severe or chronic pain caused by a terminal illness, e.g. cancer. (medic8.com)
  • liver
  • A possible explanation is that morphine-N-oxide is rapidly inactivated in the liver and impairment of inactivation processes or enzymes increases functionality. (wikipedia.org)
  • increases
  • Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior. (nih.gov)
  • However, pretreatment with amiphenazole or tacrine increases the potency of morphine-N-oxide in relation to morphine (intraperitoneally more so than in subcutaneous administration). (wikipedia.org)
  • band
  • Morphine combined blues and jazz elements with more traditional rock arrangements, giving the band an unusual sound. (wikipedia.org)
  • Lips Like Morphine was first released on May 16, 2006 by the Chicago-based band Kill Hannah and then again released in August on the band's album Until There's Nothing Left of Us. (wikipedia.org)
  • known
  • Faithfull performed "Something Better" sung live to a backing track at The Rolling Stones Rock and Roll Circus , but the programme was never televised and no contemporary performance of "Sister Morphine" is known. (wikipedia.org)